Evidence Record
evt_NCT00490139_v201_v202_988814f0bff4
NCT00490139 · ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D
Superseded Evidence Record
This page preserves the immutable v0.1.2 record. Its current successor is evt_NCT00490139_v201_v202_b52c8e66b9a0.
Severity is deterministic, reproducible, uncalibrated triage metadata, not validated review priority or proven wrongdoing. This page states what the registry evidence supports and what it does not support.
Triage severity
Triage: Critical Category
Serious Adverse Event Removal
Versions
v201 to v202
Timing
Post Recruitment
Claims Supported
- TrialDiff compared ClinicalTrials.gov record version 201 to version 202 for NCT00490139.
- The JSON Patch for this comparison has hash f299690b0e0e6b476f2e5be30c318b2392320a31c2fcc99b63e7786dea4f15cf.
- The active deterministic rule set hash was 318445b9ad266f51fd10ef378645c753ba7a098e3e4395c3c457750dc5f88d86.
- The deterministic triage label was critical; before timing adjustment it was critical.
- The triage label is uncalibrated metadata, not a validated review-priority finding.
- The patch satisfied these deterministic event-class predicates: outcome_edit_cooccurs_with_results_posting.
- A registry path under serious adverse event results was removed between ClinicalTrials.gov versions 201 and 202.
- The timing context for the from-version record was post_recruitment.
- The deterministic rules that fired were: adverse_event_group_change, arms_or_interventions_change, design_info_change, eligibility_criteria_change, enrollment_count_change, other_adverse_event_addition, other_adverse_event_modification, other_adverse_event_removal, serious_adverse_event_addition, serious_adverse_event_modification, serious_adverse_event_removal.
- The changed JSON Pointer paths were: /protocolSection/statusModule/statusVerifiedDate, /protocolSection/statusModule/lastUpdateSubmitDate, /protocolSection/statusModule/lastUpdatePostDateStruct/date, /protocolSection/descriptionModule/briefSummary, /protocolSection/descriptionModule/detailedDescription, /protocolSection/designModule/designInfo/interventionModel, /protocolSection/designModule/enrollmentInfo/count, /protocolSection/armsInterventionsModule/armGroups/0/label, /protocolSection/armsInterventionsModule/armGroups/0/type, /protocolSection/armsInterventionsModule/armGroups/0/description, /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0, /protocolSection/armsInterventionsModule/armGroups/1/label, /protocolSection/armsInterventionsModule/armGroups/1/description, /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1, /protocolSection/armsInterventionsModule/armGroups/2/label, 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- An outcome path changed between versions 201 and 202 in a patch that also carried a hasResults or resultsSection co-occurrence signal.
Claims Not Supported
- That the amendment was scientifically unjustified.
- That the change constitutes misconduct or wrongdoing.
- That sponsor intent can be inferred from this registry change.
- That the change caused or altered the trial's results.
- That the change was or was not disclosed in a manuscript.
- That TrialDiff determines regulatory compliance or non-compliance.
- That the removed adverse event record was scientifically or legally improper.
- That co-occurrence with results posting proves the outcome edit was harmless, administrative, or substantively benign.
- That event-class membership is a validated global review-priority ranking.
Neutral Review Question
What source document explains the change to the serious adverse event results record?
Citation
TrialDiff Evidence Record evt_NCT00490139_v201_v202_988814f0bff4. ClinicalTrials.gov NCT00490139, versions 201-202. Evidence version 1.
Event Classes
outcome_edit_cooccurs_with_results_posting Changed Paths
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/resultsSection/adverseEventsModule/otherEvents/24/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/24/stats/4
/resultsSection/adverseEventsModule/otherEvents/24/stats/5
/resultsSection/adverseEventsModule/otherEvents/24/stats/6
/resultsSection/adverseEventsModule/otherEvents/24/stats/7
/resultsSection/adverseEventsModule/otherEvents/25/term
/resultsSection/adverseEventsModule/otherEvents/25/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/25/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/25/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/25/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/25/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/25/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/25/stats/4
/resultsSection/adverseEventsModule/otherEvents/25/stats/5
/resultsSection/adverseEventsModule/otherEvents/25/stats/6
/resultsSection/adverseEventsModule/otherEvents/25/stats/7
/resultsSection/adverseEventsModule/otherEvents/26/term
/resultsSection/adverseEventsModule/otherEvents/26/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/26/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/26/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/26/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/26/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/26/stats/4
/resultsSection/adverseEventsModule/otherEvents/26/stats/5
/resultsSection/adverseEventsModule/otherEvents/26/stats/6
/resultsSection/adverseEventsModule/otherEvents/26/stats/7
/resultsSection/adverseEventsModule/otherEvents/27/term
/resultsSection/adverseEventsModule/otherEvents/27/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/27/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/27/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/27/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/27/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/27/stats/4
/resultsSection/adverseEventsModule/otherEvents/27/stats/5
/resultsSection/adverseEventsModule/otherEvents/27/stats/6
/resultsSection/adverseEventsModule/otherEvents/27/stats/7
/resultsSection/adverseEventsModule/otherEvents/28/term
/resultsSection/adverseEventsModule/otherEvents/28/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/28/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/28/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/28/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/28/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/28/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/28/stats/4
/resultsSection/adverseEventsModule/otherEvents/28/stats/5
/resultsSection/adverseEventsModule/otherEvents/28/stats/6
/resultsSection/adverseEventsModule/otherEvents/28/stats/7
/resultsSection/adverseEventsModule/otherEvents/29/term
/resultsSection/adverseEventsModule/otherEvents/29/organSystem
/resultsSection/adverseEventsModule/otherEvents/29/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/29/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/29/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/29/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/29/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/29/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/29/stats/4
/resultsSection/adverseEventsModule/otherEvents/29/stats/5
/resultsSection/adverseEventsModule/otherEvents/29/stats/6
/resultsSection/adverseEventsModule/otherEvents/29/stats/7
/resultsSection/adverseEventsModule/otherEvents/30/term
/resultsSection/adverseEventsModule/otherEvents/30/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/30/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/30/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/30/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/30/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/30/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/30/stats/4
/resultsSection/adverseEventsModule/otherEvents/30/stats/5
/resultsSection/adverseEventsModule/otherEvents/30/stats/6
/resultsSection/adverseEventsModule/otherEvents/30/stats/7
/resultsSection/adverseEventsModule/otherEvents/31/term
/resultsSection/adverseEventsModule/otherEvents/31/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/31/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/31/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/31/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/31/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/31/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/31/stats/4
/resultsSection/adverseEventsModule/otherEvents/31/stats/5
/resultsSection/adverseEventsModule/otherEvents/31/stats/6
/resultsSection/adverseEventsModule/otherEvents/31/stats/7
/resultsSection/adverseEventsModule/otherEvents/32/term
/resultsSection/adverseEventsModule/otherEvents/32/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/32/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/32/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/32/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/32/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/32/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/32/stats/4
/resultsSection/adverseEventsModule/otherEvents/32/stats/5
/resultsSection/adverseEventsModule/otherEvents/32/stats/6
/resultsSection/adverseEventsModule/otherEvents/32/stats/7
/resultsSection/adverseEventsModule/otherEvents/33/term
/resultsSection/adverseEventsModule/otherEvents/33/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/33/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/33/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/33/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/33/stats/4
/resultsSection/adverseEventsModule/otherEvents/33/stats/5
/resultsSection/adverseEventsModule/otherEvents/33/stats/6
/resultsSection/adverseEventsModule/otherEvents/33/stats/7
/resultsSection/adverseEventsModule/otherEvents/34/term
/resultsSection/adverseEventsModule/otherEvents/34/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/34/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/34/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/34/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/34/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/34/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/34/stats/4
/resultsSection/adverseEventsModule/otherEvents/34/stats/5
/resultsSection/adverseEventsModule/otherEvents/34/stats/6
/resultsSection/adverseEventsModule/otherEvents/34/stats/7
/resultsSection/adverseEventsModule/otherEvents/35/term
/resultsSection/adverseEventsModule/otherEvents/35/organSystem
/resultsSection/adverseEventsModule/otherEvents/35/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/35/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/35/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/35/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/35/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/35/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/35/stats/4
/resultsSection/adverseEventsModule/otherEvents/35/stats/5
/resultsSection/adverseEventsModule/otherEvents/35/stats/6
/resultsSection/adverseEventsModule/otherEvents/35/stats/7
/resultsSection/adverseEventsModule/otherEvents/36/term
/resultsSection/adverseEventsModule/otherEvents/36/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/36/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/36/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/36/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/36/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/36/stats/4
/resultsSection/adverseEventsModule/otherEvents/36/stats/5
/resultsSection/adverseEventsModule/otherEvents/36/stats/6
/resultsSection/adverseEventsModule/otherEvents/36/stats/7
/resultsSection/adverseEventsModule/otherEvents/37/term
/resultsSection/adverseEventsModule/otherEvents/37/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/37/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/37/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/37/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/37/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/37/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/37/stats/4
/resultsSection/adverseEventsModule/otherEvents/37/stats/5
/resultsSection/adverseEventsModule/otherEvents/37/stats/6
/resultsSection/adverseEventsModule/otherEvents/37/stats/7
/resultsSection/adverseEventsModule/otherEvents/38/term
/resultsSection/adverseEventsModule/otherEvents/38/organSystem
/resultsSection/adverseEventsModule/otherEvents/38/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/38/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/38/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/38/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/38/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/38/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/38/stats/4
/resultsSection/adverseEventsModule/otherEvents/38/stats/5
/resultsSection/adverseEventsModule/otherEvents/38/stats/6
/resultsSection/adverseEventsModule/otherEvents/38/stats/7
/resultsSection/adverseEventsModule/otherEvents/39/term
/resultsSection/adverseEventsModule/otherEvents/39/organSystem
/resultsSection/adverseEventsModule/otherEvents/39/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/39/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/39/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/39/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/39/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/39/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/39/stats/4
/resultsSection/adverseEventsModule/otherEvents/39/stats/5
/resultsSection/adverseEventsModule/otherEvents/39/stats/6
/resultsSection/adverseEventsModule/otherEvents/39/stats/7
/resultsSection/adverseEventsModule/otherEvents/40/term
/resultsSection/adverseEventsModule/otherEvents/40/organSystem
/resultsSection/adverseEventsModule/otherEvents/40/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/40/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/40/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/40/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/40/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/40/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/40/stats/4
/resultsSection/adverseEventsModule/otherEvents/40/stats/5
/resultsSection/adverseEventsModule/otherEvents/40/stats/6
/resultsSection/adverseEventsModule/otherEvents/40/stats/7
/resultsSection/adverseEventsModule/otherEvents/41/term
/resultsSection/adverseEventsModule/otherEvents/41/organSystem
/resultsSection/adverseEventsModule/otherEvents/41/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/41/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/41/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/41/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/41/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/41/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/41/stats/4
/resultsSection/adverseEventsModule/otherEvents/41/stats/5
/resultsSection/adverseEventsModule/otherEvents/41/stats/6
/resultsSection/adverseEventsModule/otherEvents/41/stats/7
/resultsSection/adverseEventsModule/otherEvents/42/term
/resultsSection/adverseEventsModule/otherEvents/42/organSystem
/resultsSection/adverseEventsModule/otherEvents/42/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/42/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/42/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/42/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/42/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/42/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/42/stats/4
/resultsSection/adverseEventsModule/otherEvents/42/stats/5
/resultsSection/adverseEventsModule/otherEvents/42/stats/6
/resultsSection/adverseEventsModule/otherEvents/42/stats/7
/resultsSection/adverseEventsModule/otherEvents/43/term
/resultsSection/adverseEventsModule/otherEvents/43/organSystem
/resultsSection/adverseEventsModule/otherEvents/43/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/43/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/43/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/43/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/43/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/43/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/43/stats/4
/resultsSection/adverseEventsModule/otherEvents/43/stats/5
/resultsSection/adverseEventsModule/otherEvents/43/stats/6
/resultsSection/adverseEventsModule/otherEvents/43/stats/7
/resultsSection/adverseEventsModule/otherEvents/44/term
/resultsSection/adverseEventsModule/otherEvents/44/organSystem
/resultsSection/adverseEventsModule/otherEvents/44/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/44/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/44/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/44/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/44/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/44/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/44/stats/4
/resultsSection/adverseEventsModule/otherEvents/44/stats/5
/resultsSection/adverseEventsModule/otherEvents/44/stats/6
/resultsSection/adverseEventsModule/otherEvents/44/stats/7
/resultsSection/adverseEventsModule/otherEvents/45/term
/resultsSection/adverseEventsModule/otherEvents/45/organSystem
/resultsSection/adverseEventsModule/otherEvents/45/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/45/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/45/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/45/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/45/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/45/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/45/stats/4
/resultsSection/adverseEventsModule/otherEvents/45/stats/5
/resultsSection/adverseEventsModule/otherEvents/45/stats/6
/resultsSection/adverseEventsModule/otherEvents/45/stats/7
/resultsSection/adverseEventsModule/otherEvents/46/term
/resultsSection/adverseEventsModule/otherEvents/46/organSystem
/resultsSection/adverseEventsModule/otherEvents/46/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/46/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/46/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/46/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/46/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/46/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/46/stats/4
/resultsSection/adverseEventsModule/otherEvents/46/stats/5
/resultsSection/adverseEventsModule/otherEvents/46/stats/6
/resultsSection/adverseEventsModule/otherEvents/46/stats/7
/resultsSection/adverseEventsModule/otherEvents/47/term
/resultsSection/adverseEventsModule/otherEvents/47/organSystem
/resultsSection/adverseEventsModule/otherEvents/47/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/47/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/47/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/47/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/47/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/47/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/47/stats/4
/resultsSection/adverseEventsModule/otherEvents/47/stats/5
/resultsSection/adverseEventsModule/otherEvents/47/stats/6
/resultsSection/adverseEventsModule/otherEvents/47/stats/7
/resultsSection/adverseEventsModule/otherEvents/48/term
/resultsSection/adverseEventsModule/otherEvents/48/organSystem
/resultsSection/adverseEventsModule/otherEvents/48/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/48/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/48/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/48/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/48/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/48/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/48/stats/4
/resultsSection/adverseEventsModule/otherEvents/48/stats/5
/resultsSection/adverseEventsModule/otherEvents/48/stats/6
/resultsSection/adverseEventsModule/otherEvents/48/stats/7
/resultsSection/adverseEventsModule/otherEvents/49/term
/resultsSection/adverseEventsModule/otherEvents/49/organSystem
/resultsSection/adverseEventsModule/otherEvents/49/sourceVocabulary
/resultsSection/adverseEventsModule/otherEvents/49/stats/0/numAffected
/resultsSection/adverseEventsModule/otherEvents/49/stats/1/numAffected
/resultsSection/adverseEventsModule/otherEvents/49/stats/2/numAffected
/resultsSection/adverseEventsModule/otherEvents/49/stats/2/numAtRisk
/resultsSection/adverseEventsModule/otherEvents/49/stats/3/numAffected
/resultsSection/adverseEventsModule/otherEvents/49/stats/4
/resultsSection/adverseEventsModule/otherEvents/49/stats/5
/resultsSection/adverseEventsModule/otherEvents/49/stats/6
/resultsSection/adverseEventsModule/otherEvents/49/stats/7
/resultsSection/adverseEventsModule/otherEvents/50
/resultsSection/adverseEventsModule/otherEvents/50
/resultsSection/moreInfoModule/certainAgreement/otherDetails
/resultsSection/moreInfoModule/pointOfContact/title
/resultsSection/moreInfoModule/pointOfContact/email
View the field-level diff for before/after values on each changed path.
Deterministic Rules
adverse_event_group_changearms_or_interventions_changedesign_info_changeeligibility_criteria_changeenrollment_count_changeother_adverse_event_additionother_adverse_event_modificationother_adverse_event_removalserious_adverse_event_additionserious_adverse_event_modificationserious_adverse_event_removal Provenance
- Package generation
v0.1.2- Succeeded by
- evt_NCT00490139_v201_v202_b52c8e66b9a0
- Patch hash
f299690b0e0e6b476f2e5be30c318b2392320a31c2fcc99b63e7786dea4f15cf- Canonical hash
dd8b5b9bf7b3fc6b2daf6a9d9f6f3c2b5b8eb760063e14629466759d740197a4- Rule set hash
318445b9ad266f51fd10ef378645c753ba7a098e3e4395c3c457750dc5f88d86- From snapshot
eaefff44e42b89da9a16c534e7c13692902ec7dc55ac40b7298d9676e7d211d0- To snapshot
Unavailable- Patch source
- ctgov_internal_history
- Generated at
- 2026-07-31T00:42:12.000Z
- Source URL
- Registry payload
Canonical JSON Preview
Stored payload{
"changed_paths": [
"/protocolSection/statusModule/statusVerifiedDate",
"/protocolSection/statusModule/lastUpdateSubmitDate",
"/protocolSection/statusModule/lastUpdatePostDateStruct/date",
"/protocolSection/descriptionModule/briefSummary",
"/protocolSection/descriptionModule/detailedDescription",
"/protocolSection/designModule/designInfo/interventionModel",
"/protocolSection/designModule/enrollmentInfo/count",
"/protocolSection/armsInterventionsModule/armGroups/0/label",
"/protocolSection/armsInterventionsModule/armGroups/0/type",
"/protocolSection/armsInterventionsModule/armGroups/0/description",
"/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0",
"/protocolSection/armsInterventionsModule/armGroups/1/label",
"/protocolSection/armsInterventionsModule/armGroups/1/description",
"/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1",
"/protocolSection/armsInterventionsModule/armGroups/2/label",
"/protocolSection/armsInterventionsModule/armGroups/2/description",
"/protocolSection/armsInterventionsModule/armGroups/2/interventionNames/1",
"/protocolSection/armsInterventionsModule/armGroups/3/label",
"/protocolSection/armsInterventionsModule/armGroups/3/type",
"/protocolSection/armsInterventionsModule/armGroups/3/description",
"/protocolSection/armsInterventionsModule/armGroups/3/interventionNames/0",
"/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/0",
"/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/1",
"/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/2",
"/protocolSection/armsInterventionsModule/interventions/0/otherNames",
"/protocolSection/armsInterventionsModule/interventions/1/armGroupLabels/0",
"/protocolSection/armsInterventionsModule/interventions/1/armGroupLabels/1",
"/protocolSection/armsInterventionsModule/interventions/1/armGroupLabels/2",
"/protocolSection/outcomesModule/primaryOutcomes/0/measure",
"/protocolSection/outcomesModule/primaryOutcomes/0/description",
"/protocolSection/outcomesModule/secondaryOutcomes/0/measure",
"/protocolSection/outcomesModule/secondaryOutcomes/0/description",
"/protocolSection/outcomesModule/secondaryOutcomes/0/timeFrame",
"/protocolSection/outcomesModule/secondaryOutcomes/1/measure",
"/protocolSection/outcomesModule/secondaryOutcomes/1/description",
"/protocolSection/outcomesModule/secondaryOutcomes/1/timeFrame",
"/protocolSection/outcomesModule/secondaryOutcomes/2/measure",
"/protocolSection/outcomesModule/secondaryOutcomes/2/description",
"/protocolSection/outcomesModule/secondaryOutcomes/2/timeFrame",
"/protocolSection/outcomesModule/secondaryOutcomes/3/measure",
"/protocolSection/outcomesModule/secondaryOutcomes/3/description",
"/protocolSection/outcomesModule/secondaryOutcomes/3/timeFrame",
"/protocolSection/outcomesModule/secondaryOutcomes/4/measure",
"/protocolSection/outcomesModule/secondaryOutcomes/4/description",
"/protocolSection/outcomesModule/secondaryOutcomes/4/timeFrame",
"/protocolSection/outcomesModule/secondaryOutcomes/5",
"/protocolSection/outcomesModule/secondaryOutcomes/6",
"/protocolSection/eligibilityModule/eligibilityCriteria",
"/protocolSection/contactsLocationsModule/locations/2",
"/protocolSection/contactsLocationsModule/locations/2",
"/protocolSection/contactsLocationsModule/locations/2",
"/protocolSection/contactsLocationsModule/locations/4",
"/protocolSection/contactsLocationsModule/locations/4",
"/protocolSection/contactsLocationsModule/locations/4",
"/protocolSection/contactsLocationsModule/locations/6",
"/protocolSection/contactsLocationsModule/locations/6",
"/protocolSection/contactsLocationsModule/locations/6",
"/protocolSection/contactsLocationsModule/locations/6",
"/protocolSection/contactsLocationsModule/locations/11",
"/protocolSection/contactsLocationsModule/locations/12",
"/protocolSection/contactsLocationsModule/locations/12",
"/protocolSection/contactsLocationsModule/locations/13",
"/protocolSection/contactsLocationsModule/locations/13",
"/protocolSection/contactsLocationsModule/locations/13",
"/protocolSection/contactsLocationsModule/locations/13",
"/protocolSection/contactsLocationsModule/locations/16",
"/protocolSection/contactsLocationsModule/locations/16",
"/protocolSection/contactsLocationsModule/locations/16",
"/protocolSection/contactsLocationsModule/locations/16",
"/protocolSection/contactsLocationsModule/locations/19",
"/protocolSection/contactsLocationsModule/locations/20",
"/protocolSection/contactsLocationsModule/locations/22",
"/protocolSection/contactsLocationsModule/locations/22",
"/protocolSection/contactsLocationsModule/locations/22",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/24",
"/protocolSection/contactsLocationsModule/locations/28",
"/protocolSection/contactsLocationsModule/locations/28",
"/protocolSection/contactsLocationsModule/locations/29",
"/protocolSection/contactsLocationsModule/locations/37",
"/protocolSection/contactsLocationsModule/locations/38",
"/protocolSection/contactsLocationsModule/locations/38",
"/protocolSection/contactsLocationsModule/locations/39",
"/protocolSection/contactsLocationsModule/locations/41",
"/protocolSection/contactsLocationsModule/locations/45",
"/protocolSection/contactsLocationsModule/locations/46",
"/protocolSection/contactsLocationsModule/locations/48",
"/protocolSection/contactsLocationsModule/locations/48",
"/protocolSection/contactsLocationsModule/locations/48",
"/protocolSection/contactsLocationsModule/locations/48",
"/protocolSection/contactsLocationsModule/locations/48",
"/protocolSection/contactsLocationsModule/locations/48",
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],
"citation_text": "TrialDiff Evidence Record evt_NCT00490139_v201_v202_988814f0bff4. ClinicalTrials.gov NCT00490139, versions 201-202. Evidence version 1.",
"claims_not_supported": [
"That the amendment was scientifically unjustified.",
"That the change constitutes misconduct or wrongdoing.",
"That sponsor intent can be inferred from this registry change.",
"That the change caused or altered the trial's results.",
"That the change was or was not disclosed in a manuscript.",
"That TrialDiff determines regulatory compliance or non-compliance.",
"That the removed adverse event record was scientifically or legally improper.",
"That co-occurrence with results posting proves the outcome edit was harmless, administrative, or substantively benign.",
"That event-class membership is a validated global review-priority ranking."
],
"claims_supported": [
"TrialDiff compared ClinicalTrials.gov record version 201 to version 202 for NCT00490139.",
"The JSON Patch for this comparison has hash f299690b0e0e6b476f2e5be30c318b2392320a31c2fcc99b63e7786dea4f15cf.",
"The active deterministic rule set hash was 318445b9ad266f51fd10ef378645c753ba7a098e3e4395c3c457750dc5f88d86.",
"The deterministic triage label was critical; before timing adjustment it was critical.",
"The triage label is uncalibrated metadata, not a validated review-priority finding.",
"The patch satisfied these deterministic event-class predicates: outcome_edit_cooccurs_with_results_posting.",
"A registry path under serious adverse event results was removed between ClinicalTrials.gov versions 201 and 202.",
"The timing context for the from-version record was post_recruitment.",
"The deterministic rules that fired were: adverse_event_group_change, arms_or_interventions_change, design_info_change, eligibility_criteria_change, enrollment_count_change, other_adverse_event_addition, other_adverse_event_modification, other_adverse_event_removal, serious_adverse_event_addition, serious_adverse_event_modification, serious_adverse_event_removal.",
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},
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"value": "Disease-Free Survival (DFS) was defined as the interval between randomization and the date of first occurrence of disease recurrence (local, regional or distant), a contralateral invasive breast cancer, a second primary cancer or death without recurrence.\nOnly deaths occurring in participants whose clinical follow-up was ongoing at the time of death and who had no recurrence, contralateral breast cancer (CBC) or second primary malignancy (SPM) reported prior to death were considered as death without recurrence.\nDFS was estimated using the Kaplan Meier method.\nThe percentile data values presented here indicate the percentage (95, 90, 85, 80 and 75 percent) of participants who had disease free survival for the indicated years."
},
{
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},
{
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},
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{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/2/measure",
"value": "Overall Survival (OS) at the 10-Year Follow-Up"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/2/description",
"value": "Overall Survival (OS) was defined as the time from randomization until death due to any cause.\nParticipants who had not died were censored at the last date they were known to be alive, or date of withdrawal of consent.\nOS was calculated in years as (date of death minus the date of randomization +1) divided by 365.25.\nThe percentile data values presented here indicate the percentage (99, 98, 95 and 90 percent) of participants who survived for the indicated years."
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/2/timeFrame",
"value": "From randomization until death due to any cause, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/3/measure",
"value": "Analysis of Time to Recurrence (TTR)"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/3/description",
"value": "Time to Recurrence (TTR) was defined as the the time from randomization to breast cancer recurrence, ignoring second primary cancers (including contralateral breast cancers and non-breast second malignancies) and counting deaths without recurrence as a competing risk."
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/3/timeFrame",
"value": "From randomization until the date of the first occurrence of a disease recurrence, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/4/measure",
"value": "Analysis of Time to Distant Recurrence (TTDR)"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/4/description",
"value": "Time to Distant Recurrence (TTDR) was defined as the the time from randomization to first distant breast cancer recurrence, ignoring locoregional recurrences and second primary cancers, (including contralateral breast cancers and non-breast second malignancies ) and counting deaths without recurrence as a competing risk."
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/4/timeFrame",
"value": "From randomization until the date of the first occurrence of distant recurrence, assessed up to approximately 10 years"
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/5",
"value": {
"description": "Time to Central Nervous System (CNS) recurrence was defined as the time from randomization to first CNS recurrence.\nBoth brain metastasis and meningitis carcinomatosa were considered.",
"measure": "Analysis of Time to Central Nervous System (CNS) Recurrence",
"timeFrame": "From randomization until the first central nervous system recurrence, assessed up to approximately 10 years"
}
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/6",
"value": {
"description": "The cumulative incidence of brain metastases as the first site of breast cancer recurrence among treatment arms was assessed using a hierarchy of primary type and location of first DFS event in cases where more than one event was identified simultaneously.\nBecause diagnostic procedures for different types of recurrence could not be performed on exactly the same day, any diagnoses noted within a two month (60 day) period of the first reported event was considered as identified simultaneously for purposes of defining the type of the first event and the date of event was be regarded as the earliest of the relevant events.",
"measure": "Cumulative Incidence of Brain Metastases",
"timeFrame": "From randomization until the date of the first occurrence of a disease recurrence, assessed up to approximately 10 years"
}
},
{
"op": "replace",
"path": "/protocolSection/eligibilityModule/eligibilityCriteria",
"value": "<p>Key Inclusion Criteria:</p><ul><li>Patients >= 18 years of age with histologically confirmed, non-metastatic, operable and over expression/amplification of HER2 (3+ by IHC and/or FISH positive) primary breast cancer, treated with definitive surgery, with baseline LVEF >= 50%, known hormone receptor status (ER/PgR or ER alone) and ECOG performance status =< 1, were included.</li><li>For Designs 1 and 2: Patients must have had received at least four cycles of an approved anthracycline-based (neo-) adjuvant chemotherapy regimen or a protocol specified exception.</li><li>Approved, signed written informed consent obtained prior to any study specific screening procedures.</li></ul><p>Key Exclusion Criteria:</p><ul><li>History of any prior (ipsi- and/or contralateral) invasive breast carcinoma, past (less than 10 years) or current history of malignant neoplasms, any clinically staged T4 tumor, or bilateral tumors.</li><li>Concurrent anti-cancer treatment, except hormonal therapy or radiotherapy for the present breast cancer;</li><li>Patients with positive or suspicious internal mammary nodes identified by sentinel node technique, which had not been irradiated or would not be irradiated, or patients with supraclavicular lymph node involvement.</li><li>Any prior anti-HER therapy, which includes agents that target other members of the HER family of receptors, e.g.\ngefitinib (Iressa)</li><li>(Neo-) or adjuvant chemotherapy using peripheral stem cell or bone marrow stem cell support;</li><li>Serious cardiac illness or medical conditions.</li><li><p>Any of the following abnormal laboratory tests immediately prior to randomization:</p><ol><li>Serum total bilirubin >1.5 x upper limit of normal (ULN).\nIn the case of known Gilbert's syndrome, a higher serum total bilirubin (<2 x ULN) was allowed;</li><li>Alanine amino transferase (ALT) or aspartate amino transferase (AST) >2.5 x ULN;</li><li>Alkaline phosphatase (ALP) >2.5 x ULN;</li><li>Serum creatinine >2.0 x ULN;</li><li>Total white blood cell count (WBC) <2.5 x 10^9/L;</li><li>Absolute neutrophil count <1.5 x 10^9/L;</li><li>Platelets <100 x 10^9/L.</li></ol></li><li>Women of childbearing potential and male patients with partners of childbearing potential, who are unable or unwilling to use adequate contraceptive measures during study treatment, and pregnant or lactating women.</li><li>Concomitant use of CYP3A4 inhibitors or inducers.</li></ul>"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/2"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/2"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/2"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/4"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/4"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/4"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/6"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/6"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/6"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/6"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/11"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/12"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/12"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/13"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/13"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/13"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/13"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/16"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/16"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/16"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/16"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/19"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/20"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/22"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/22"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/22"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/24"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/28"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/28"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/29"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/37"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/38"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/38"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/39"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/41"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/45"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/46"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/48"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/49"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/50"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/50"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/52"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/52"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/54"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/55"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/55"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/56"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/57"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/57"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/57"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/57"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/57"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/58"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/58"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/58"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/58"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/59"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/59"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/60"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/60"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/60"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/62"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/63"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/63"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/63"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/63"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/64"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/66",
"value": {
"city": "Rockford",
"country": "United States",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 42.27113,
"lon": -89.094
},
"state": "Illinois",
"zip": "61104"
}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/69"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/71"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/71"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/72"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/74"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/75"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/75"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/77"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/82"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/82"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/84"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/85"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/86"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/86"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/87"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/88"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/89"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/90"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/90"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/91"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/93"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/93"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/95"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/95"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/95"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/96"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/97"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/98"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/105"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/106"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/109"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/109"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/110"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/110"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/110"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/111"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/114"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/114"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/114"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/114"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/114"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/116"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/116"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/116"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/117"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/118"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/118"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/119"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/119"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/119"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/119"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/120"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/122"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/123"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/123"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/124"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/124"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/124"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/124"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/126"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/126"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/126"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/126"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/130"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/130"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/137"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/137"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/137"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/138"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/139"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/140"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/141"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/141"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/143"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/144"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/154"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/155"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/157"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/157"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/158"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/159"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/159"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/159"
},
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},
{
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{
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},
{
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},
{
"op": "add",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
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},
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},
{
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},
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}
},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
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}
},
{
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}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/719"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/719"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/719"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/719"
},
{
"op": "replace",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/721/city",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/721/geoPoint/lat",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/721/geoPoint/lon",
"value": -108.15213
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/722/city",
"value": "Toluca"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/722/zip",
"value": "50080"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/722/geoPoint/lat",
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{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/722/geoPoint/lon",
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{
"op": "remove",
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/723"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/725"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/728/city",
"value": "Hilversum"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/728/zip",
"value": "1213 XZ"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/728/geoPoint/lat",
"value": 52.22333
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/728/geoPoint/lon",
"value": 5.17639
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{
"op": "add",
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}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/734"
},
{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "remove",
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},
{
"op": "replace",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/753/zip",
"value": "13"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/754/zip",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/757/city",
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{
"op": "add",
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/760"
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{
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},
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"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/780"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/782"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/790"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/795"
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{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/798/city",
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{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/798/geoPoint",
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}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/803"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/804"
},
{
"op": "add",
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{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/811/city",
"value": "Alcoy"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/811/zip",
"value": "03804"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/811/country",
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},
{
"op": "add",
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/812"
},
{
"op": "remove",
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},
{
"op": "add",
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"zip": "08907"
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/817"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/821"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/821"
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"op": "remove",
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/826"
},
{
"op": "add",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/831/city",
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{
"op": "remove",
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},
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"op": "add",
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"value": {
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"lon": -16.25462
},
"zip": "38320"
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/846/city",
"value": "Vizcaya"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/846/zip",
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{
"op": "remove",
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},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/848"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/851"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/870"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/872",
"value": {
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"country": "Thailand",
"facility": "Novartis Investigative Site",
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},
"zip": "90110"
}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/875"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/881"
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{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/881"
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{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/881"
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"op": "remove",
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"op": "remove",
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"op": "remove",
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{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/882"
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{
"op": "remove",
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{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/882"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/882"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/885",
"value": {
"city": "Cardiff",
"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 51.48,
"lon": -3.18
},
"zip": "CF14 2TL"
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/886",
"value": {
"city": "Chelmsford",
"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 51.73575,
"lon": 0.46958
},
"zip": "CM1 7ET"
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/890",
"value": {
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"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
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"lon": -3.19648
},
"zip": "EH4 2XU"
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/895",
"value": {
"city": "Huddersfield",
"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 53.64904,
"lon": -1.78416
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"zip": "HD3 3EA"
}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/899"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/902"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/902"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/906/city",
"value": "Manchester"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/906/zip",
"value": "M20 4BX"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/906/geoPoint/lat",
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},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/906/geoPoint/lon",
"value": -2.23743
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/908",
"value": {
"city": "Northwood",
"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 51.61162,
"lon": -0.42454
},
"zip": "HA6 2RN"
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/910",
"value": {
"city": "Oxford",
"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
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},
"zip": "OX3 7LJ"
}
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/912/city",
"value": "Poole"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/914",
"value": {
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"country": "United Kingdom",
"facility": "Novartis Investigative Site",
"geoPoint": {
"lat": 53.76282,
"lon": -2.70452
},
"zip": "PR2 9HT"
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/915",
"value": {
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"country": "United Kingdom",
"facility": "Novartis Investigative Site",
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}
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/919"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/923"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/preAssignmentDetails",
"value": "Based on the IDMC results from 18 August 2011, any patient enrolled onto Lapatinib arm were considered for a new treatment strategy based on discussion with their physician."
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
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{
"op": "replace",
"path": "/resultsSection/participantFlowModule/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/groups/2/description",
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},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/0/comment",
"value": "All randomized participants were included in the Intent-to-Treat (IIT) Population"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/type",
"value": "Safety Population"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/achievements/0/numSubjects",
"value": "2061"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/achievements/1/numSubjects",
"value": "2076"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/achievements/2/numSubjects",
"value": "2056"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/achievements/3/numSubjects",
"value": "2076"
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/1/comment",
"value": "All randomized participants who were administered at least one dose of investigational targeted treatment"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/type",
"value": "COMPLETED"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/achievements/0/numSubjects",
"value": "1132"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/achievements/1/numSubjects",
"value": "1184"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/achievements/2/numSubjects",
"value": "1179"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/achievements/3/numSubjects",
"value": "1192"
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/2/comment",
"value": "Deaths and participants who completed survival follow-up"
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/milestones/3",
"value": {
"achievements": [
{
"groupId": "FG000",
"numSubjects": "961"
},
{
"groupId": "FG001",
"numSubjects": "907"
},
{
"groupId": "FG002",
"numSubjects": "921"
},
{
"groupId": "FG003",
"numSubjects": "905"
}
],
"type": "NOT COMPLETED"
}
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/0/type",
"value": "Lost to Follow-up"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/0/reasons/0/numSubjects",
"value": "249"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/0/reasons/1/numSubjects",
"value": "216"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/0/reasons/2/numSubjects",
"value": "205"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/0/reasons/3/numSubjects",
"value": "229"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/1/type",
"value": "Withdrawal by Subject"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/1/reasons/0/numSubjects",
"value": "333"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/1/reasons/1/numSubjects",
"value": "322"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/1/reasons/2/numSubjects",
"value": "396"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/1/reasons/3/numSubjects",
"value": "295"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/2/type",
"value": "Patient did not sign ICF 12"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/2/reasons/0/numSubjects",
"value": "169"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/2/reasons/1/numSubjects",
"value": "176"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/2/reasons/2/numSubjects",
"value": "139"
},
{
"op": "replace",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/2/reasons/3/numSubjects",
"value": "167"
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/3",
"value": {
"reasons": [
{
"groupId": "FG000",
"numSubjects": "98"
},
{
"groupId": "FG001",
"numSubjects": "96"
},
{
"groupId": "FG002",
"numSubjects": "85"
},
{
"groupId": "FG003",
"numSubjects": "95"
}
],
"type": "Data unavailable due to regulatory issues"
}
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/4",
"value": {
"reasons": [
{
"groupId": "FG000",
"numSubjects": "14"
},
{
"groupId": "FG001",
"numSubjects": "13"
},
{
"groupId": "FG002",
"numSubjects": "14"
},
{
"groupId": "FG003",
"numSubjects": "14"
}
],
"type": "Data unavailable due to lapsed ethical consent"
}
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/periods/0/dropWithdraws/5",
"value": {
"reasons": [
{
"groupId": "FG000",
"numSubjects": "98"
},
{
"groupId": "FG001",
"numSubjects": "84"
},
{
"groupId": "FG002",
"numSubjects": "82"
},
{
"groupId": "FG003",
"numSubjects": "105"
}
],
"type": "Other reasons as defined per protocol"
}
},
{
"op": "add",
"path": "/resultsSection/participantFlowModule/recruitmentDetails",
"value": "This study was conducted in 969 centers in 44 countries worldwide."
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/groups/2/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lap 1500 mg daily for 52 weeks.</li><li>Design 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.</li><li>Design 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/unitOfMeasure",
"value": "Participants"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/6/title",
"value": "Native Hawaiian or Other Pacific"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/title",
"value": "Other Race"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/categories/0/measurements/0/value",
"value": "14"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/categories/0/measurements/1/value",
"value": "14"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/categories/0/measurements/2/value",
"value": "23"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/categories/0/measurements/3/value",
"value": "14"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/9/categories/0/measurements/4/value",
"value": "65"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/10/title",
"value": "Unknown/Missing"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/10/categories/0/measurements/0/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/10/categories/0/measurements/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/10/categories/0/measurements/3/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/10/categories/0/measurements/4/value",
"value": "1"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "remove",
"path": "/resultsSection/baselineCharacteristicsModule/measures/2/classes/11"
},
{
"op": "add",
"path": "/resultsSection/baselineCharacteristicsModule/measures/3",
"value": {
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "BG000",
"value": "890"
},
{
"groupId": "BG001",
"value": "886"
},
{
"groupId": "BG002",
"value": "903"
},
{
"groupId": "BG003",
"value": "897"
},
{
"groupId": "BG004",
"value": "3576"
}
],
"title": "Negative"
},
{
"measurements": [
{
"groupId": "BG000",
"value": "1203"
},
{
"groupId": "BG001",
"value": "1205"
},
{
"groupId": "BG002",
"value": "1197"
},
{
"groupId": "BG003",
"value": "1200"
},
{
"groupId": "BG004",
"value": "4805"
}
],
"title": "Positive"
}
]
}
],
"description": "HR status was determined from the percentage of Estrogen Receptor (ER) and Progesterone Receptor (PgR) cells stained positive: a) Positive: if the percentage of cells stained positive is >= 1% for either ER or PgR; b) Negative: if the percentage of cells stained positive is < 1% for both ER and PgR",
"paramType": "COUNT_OF_PARTICIPANTS",
"title": "Hormone Receptor (HR) Status",
"unitOfMeasure": "Participants"
}
},
{
"op": "add",
"path": "/resultsSection/baselineCharacteristicsModule/measures/4",
"value": {
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "BG000",
"value": "1155"
},
{
"groupId": "BG001",
"value": "1143"
},
{
"groupId": "BG002",
"value": "1168"
},
{
"groupId": "BG003",
"value": "1147"
},
{
"groupId": "BG004",
"value": "4613"
}
],
"title": "Sequential"
},
{
"measurements": [
{
"groupId": "BG000",
"value": "938"
},
{
"groupId": "BG001",
"value": "948"
},
{
"groupId": "BG002",
"value": "932"
},
{
"groupId": "BG003",
"value": "950"
},
{
"groupId": "BG004",
"value": "3768"
}
],
"title": "Concurrent"
}
]
}
],
"description": "Timing of (neo)adjuvant chemotherapy was defined as follows: Design 1 - sequentially (all chemotherapy completed prior to randomization) versus Design 2 - concurrently with targeted therapy (taxane medication administered with targeted treatment after randomization).\nSubjects treated concurrently but without anthracycline (Design 2B) were regarded as part of Design 2 for all stratified analyses.",
"paramType": "COUNT_OF_PARTICIPANTS",
"title": "Timing of Chemotherapy",
"unitOfMeasure": "Participants"
}
},
{
"op": "add",
"path": "/resultsSection/baselineCharacteristicsModule/measures/5",
"value": {
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "BG000",
"value": "168"
},
{
"groupId": "BG001",
"value": "170"
},
{
"groupId": "BG002",
"value": "167"
},
{
"groupId": "BG003",
"value": "181"
},
{
"groupId": "BG004",
"value": "686"
}
],
"title": "Not applicable (neoadjuvant chemotherapy)"
},
{
"measurements": [
{
"groupId": "BG000",
"value": "845"
},
{
"groupId": "BG001",
"value": "842"
},
{
"groupId": "BG002",
"value": "841"
},
{
"groupId": "BG003",
"value": "844"
},
{
"groupId": "BG004",
"value": "3372"
}
],
"title": "Node negative (no neoadjuvant chemotherapy)"
},
{
"measurements": [
{
"groupId": "BG000",
"value": "617"
},
{
"groupId": "BG001",
"value": "617"
},
{
"groupId": "BG002",
"value": "620"
},
{
"groupId": "BG003",
"value": "603"
},
{
"groupId": "BG004",
"value": "2457"
}
],
"title": "1-3 positive nodes (no neoadjuvant chemotherapy)"
},
{
"measurements": [
{
"groupId": "BG000",
"value": "463"
},
{
"groupId": "BG001",
"value": "462"
},
{
"groupId": "BG002",
"value": "472"
},
{
"groupId": "BG003",
"value": "469"
},
{
"groupId": "BG004",
"value": "1866"
}
],
"title": ">= 4 positive nodes (no neoadjuvant chemotherapy)"
}
]
}
],
"description": "Axillary Lymph Node Status was categorized as: a) Not applicable (neoadjuvant chemotherapy); b) Node negative (no neoadjuvant chemotherapy); c) 1-3 positive nodes (no neoadjuvant chemotherapy); d) >= 4 positive nodes (no neoadjuvant chemotherapy)",
"paramType": "COUNT_OF_PARTICIPANTS",
"title": "Axillary Lymph Node Status",
"unitOfMeasure": "Participants"
}
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/title",
"value": "Disease-Free Survival (DFS) at the Primary Analysis"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/description",
"value": "Disease-Free Survival (DFS) was defined as the interval between randomization and the date of first occurrence of disease recurrence (local, regional or distant), a contralateral invasive breast cancer, a second primary cancer or death without recurrence.\nOnly deaths occurring in participants whose clinical follow-up was ongoing at the time of death and who had no recurrence, contralateral breast cancer (CBC) or second primary malignancy (SPM) reported prior to death were considered as death without recurrence.\nDFS was estimated using the Kaplan Meier method.\nThe percentile data values presented here indicate the percentage (95, 90, 85, 80 and 75 percent) of participants who had disease free survival for the indicated years."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nDFS data for the Lapatinib alone arm include date collected up to the first interim analysis (data cut-off 11th July 2011), as the Lapatinib arm was discontinued prior to the primary analysis due to futility.\nAll the other arms include data up to median follow-up of 4.5 years."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/unitOfMeasure",
"value": "Years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/classes/3/categories/0/measurements/2/value",
"value": "NA"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/classes/3/categories/0/measurements/2/comment",
"value": "DFS data for the Lapatinib alone arm include date collected up to the first interim analysis (data cut-off 11th July 2011), as the Lapatinib arm was discontinued prior to the primary analysis due to futility"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/classes/4/categories/0/measurements/2/value",
"value": "NA"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/classes/4/categories/0/measurements/2/comment",
"value": "DFS data for the Lapatinib alone arm include date collected up to the first interim analysis (data cut-off 11th July 2011), as the Lapatinib arm was discontinued prior to the primary analysis due to futility"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/statisticalMethod",
"value": "Log Rank"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/ciPctValue",
"value": "95"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/ciLowerLimit",
"value": "0.71"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/ciUpperLimit",
"value": "1.00"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/estimateComment",
"value": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status."
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/0/ciNumSides",
"value": "TWO_SIDED"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/statisticalMethod",
"value": "Log Rank"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/statisticalComment",
"value": "Stratification was by chemotherapy timing, hormone receptor status, and axillary lymph node status."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/ciPctValue",
"value": "95"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/ciLowerLimit",
"value": "0.81"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/ciUpperLimit",
"value": "1.13"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/estimateComment",
"value": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status."
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/1/ciNumSides",
"value": "TWO_SIDED"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/0/analyses/2"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/title",
"value": "Disease-Free Survival (DFS) at the 10-Year Follow-Up"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/description",
"value": "Disease-Free Survival (DFS) was defined as the interval between randomization and the date of first occurrence of disease recurrence (local, regional or distant), a contralateral invasive breast cancer, a second primary cancer or death without recurrence.\nOnly deaths occurring in participants whose clinical follow-up was ongoing at the time of death and who had no recurrence, contralateral breast cancer (CBC) or second primary malignancy (SPM) reported prior to death were considered as death without recurrence.\nDFS was estimated using the Kaplan Meier method.\nThe percentile data values presented here indicate the percentage (95, 90, 85 and 80 percent) of participants who had disease free survival for the indicated years."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/unitOfMeasure",
"value": "Years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/timeFrame",
"value": "From randomization until the date of the first occurrence of disease recurrence, a contralateral invasive breast cancer, a second primary cancer, or death from any cause, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/2/title",
"value": "Lapatinib"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/2/description",
"value": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/3/title",
"value": "Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/denoms/0/counts/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/denoms/0/counts/3/value",
"value": "2097"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/0/title",
"value": "95th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/0/categories/0/measurements/0/value",
"value": "1.89"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/0/categories/0/measurements/1/value",
"value": "1.27"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/0/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/0/categories/0/measurements/2/value",
"value": "1.49"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/1/title",
"value": "90th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/1/categories/0/measurements/0/value",
"value": "3.21"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/1/categories/0/measurements/1/value",
"value": "2.80"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/1/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/1/categories/0/measurements/2/value",
"value": "2.63"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/2/title",
"value": "85th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/2/categories/0/measurements/0/value",
"value": "5.92"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/2/categories/0/measurements/1/value",
"value": "4.85"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/2/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/2/categories/0/measurements/2/value",
"value": "4.43"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/3/title",
"value": "80th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/3/categories/0/measurements/0/value",
"value": "8.99"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/3/categories/0/measurements/1/value",
"value": "9.18"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/3/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/3/categories/0/measurements/2/value",
"value": "7.42"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/4"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/classes/4"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/1/analyses",
"value": [
{
"ciLowerLimit": "0.77",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.02",
"estimateComment": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.887"
},
{
"ciLowerLimit": "0.80",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.05",
"estimateComment": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.914"
}
]
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/title",
"value": "Overall Survival (OS) at the Primary Analysis"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/description",
"value": "Overall Survival (OS) was defined as the time from randomization until death due to any cause.\nParticipants who had not died were censored at the last date they were known to be alive, or date of withdrawal of consent.\nOS was calculated in years as (date of death minus the date of randomization +1) divided by 365.25.\nThe percentile data values presented here indicate the percentage (99, 98, 97, 96, 95 and 90 percent) of participants who survived for the indicated years."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nZero participants were analyzed in the lapatinib arm, as the Independent Data Monitoring Committee discontinued the lapatinib-alone arm due to futility at the time of the first interim analysis (lapatinib participants were then offered trastuzumab)."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/unitOfMeasure",
"value": "Years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/timeFrame",
"value": "From randomization until death due to any cause (median follow-up of 4.5 years)"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/2/title",
"value": "Lapatinib"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/2/description",
"value": "<p>Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.</p><p>Design 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant antiestrogen therapy when clinically indicated.</p>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/3/title",
"value": "Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/denoms/0/counts/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/denoms/0/counts/3/value",
"value": "2097"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/0/title",
"value": "99th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/0/categories/0/measurements/0/value",
"value": "1.7"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/0/categories/0/measurements/1/value",
"value": "1.2"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/0/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/1/title",
"value": "98th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/1/categories/0/measurements/0/value",
"value": "2.2"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/1/categories/0/measurements/1/value",
"value": "1.6"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/1/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/1/categories/0/measurements/2/value",
"value": "2.1"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/title",
"value": "97th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/0/value",
"value": "2.8"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/1/value",
"value": "2.2"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/1/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/2/value",
"value": "2.6"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/2/categories/0/measurements/2/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/title",
"value": "96th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/0/value",
"value": "3.4"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/1/value",
"value": "2.9"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/1/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/2/value",
"value": "3.0"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/3/categories/0/measurements/2/comment"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/4",
"value": {
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "3.9"
},
{
"groupId": "OG001",
"value": "3.7"
},
{
"groupId": "OG003",
"value": "3.6"
}
]
}
],
"title": "95th Percentile"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes/5",
"value": {
"categories": [
{
"measurements": [
{
"comment": "There were not enough data (insufficient follow-up) to be able to compute this data point.",
"groupId": "OG000",
"value": "NA"
},
{
"comment": "There were not enough data (insufficient follow-up) to be able to compute this data point.",
"groupId": "OG001",
"value": "NA"
},
{
"groupId": "OG003",
"value": "5.9"
}
]
}
],
"title": "90th Percentile"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/analyses",
"value": [
{
"ciLowerLimit": "0.62",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.03",
"estimateComment": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"pValue": "0.078",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.80",
"statisticalComment": "Stratification was by chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"statisticalMethod": "Log Rank"
},
{
"ciLowerLimit": "0.71",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.16",
"estimateComment": "The estimate of the treatment hazard ratio (tras followed by lap versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"pValue": "0.433",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.91",
"statisticalComment": "Stratification was by chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"statisticalMethod": "Log Rank"
}
]
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/title",
"value": "Overall Survival (OS) at the 10-Year Follow-Up"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/description",
"value": "Overall Survival (OS) was defined as the time from randomization until death due to any cause.\nParticipants who had not died were censored at the last date they were known to be alive, or date of withdrawal of consent.\nOS was calculated in years as (date of death minus the date of randomization +1) divided by 365.25.\nThe percentile data values presented here indicate the percentage (99, 98, 95 and 90 percent) of participants who survived for the indicated years."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/unitOfMeasure",
"value": "Years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/timeFrame",
"value": "From randomization until death due to any cause, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/2/title",
"value": "Lapatinib"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/2/description",
"value": "<p>Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.</p><p>Design 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant antiestrogen therapy when clinically indicated.</p>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/3/title",
"value": "Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/denoms/0/counts/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/denoms/0/counts/3/value",
"value": "2097"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/0/title",
"value": "99th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/0/categories/0/measurements/0/value",
"value": "1.68"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/0/categories/0/measurements/1/value",
"value": "1.17"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/0/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/0/categories/0/measurements/2/value",
"value": "1.75"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/1/title",
"value": "98th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/1/categories/0/measurements/0/value",
"value": "2.19"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/1/categories/0/measurements/1/value",
"value": "1.60"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/1/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/1/categories/0/measurements/2/value",
"value": "2.07"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/title",
"value": "95th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/0/value",
"value": "3.92"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/1/value",
"value": "3.52"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/1/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/2/value",
"value": "3.65"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/2/categories/0/measurements/2/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/title",
"value": "90th Percentile"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/0/value",
"value": "8.31"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/1/value",
"value": "8.49"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/1/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/2/value",
"value": "6.72"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/classes/3/categories/0/measurements/2/comment"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/3/analyses",
"value": [
{
"ciLowerLimit": "0.70",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.03",
"estimateComment": "The estimate of the treatment hazard ratio (lap plus tras versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.853"
},
{
"ciLowerLimit": "0.71",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.04",
"estimateComment": "The estimate of the treatment hazard ratio (tras followed by lap versus tras) was based on the Cox proportional hazards model adjusting for the stratification factors of chemotherapy timing, hormone receptor status, and axillary lymph node status.",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.863"
}
]
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/title",
"value": "Analysis of Time to Recurrence (TTR)"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/description",
"value": "Time to Recurrence (TTR) was defined as the the time from randomization to breast cancer recurrence, ignoring second primary cancers (including contralateral breast cancers and non-breast second malignancies) and counting deaths without recurrence as a competing risk."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/paramType",
"value": "COUNT_OF_PARTICIPANTS"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/unitOfMeasure",
"value": "Participants"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/timeFrame",
"value": "From randomization until the date of the first occurrence of a disease recurrence, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/2/title",
"value": "Lapatinib"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/2/description",
"value": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/3/title",
"value": "Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/denoms/0/counts/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/denoms/0/counts/3/value",
"value": "2097"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/0/value",
"value": "243"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/1/value",
"value": "275"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/1/comment"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/2/value",
"value": "298"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/measurements/2/comment"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/0/title",
"value": "Local, regional, or distant recurrence"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/1",
"value": {
"measurements": [
{
"groupId": "OG000",
"value": "43"
},
{
"groupId": "OG001",
"value": "38"
},
{
"groupId": "OG003",
"value": "46"
}
],
"title": "Death as a competing risk"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/classes/0/categories/2",
"value": {
"measurements": [
{
"groupId": "OG000",
"value": "1807"
},
{
"groupId": "OG001",
"value": "1778"
},
{
"groupId": "OG003",
"value": "1753"
}
],
"title": "Censored"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/4/analyses",
"value": [
{
"ciLowerLimit": "0.68",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "0.96",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityComment": "Time to recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.811"
},
{
"ciLowerLimit": "0.79",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.10",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityComment": "Time to recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.930"
}
]
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/title",
"value": "Analysis of Time to Distant Recurrence (TTDR)"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/description",
"value": "Time to Distant Recurrence (TTDR) was defined as the the time from randomization to first distant breast cancer recurrence, ignoring locoregional recurrences and second primary cancers, (including contralateral breast cancers and non-breast second malignancies ) and counting deaths without recurrence as a competing risk."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/populationDescription",
"value": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/paramType",
"value": "COUNT_OF_PARTICIPANTS"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/unitOfMeasure",
"value": "Participants"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/timeFrame",
"value": "From randomization until the date of the first occurrence of distant recurrence, assessed up to approximately 10 years"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/0/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/1/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/2/title",
"value": "Lapatinib"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/2/description",
"value": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated."
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/3/title",
"value": "Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/groups/3/description",
"value": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/denoms/0/counts/0/value",
"value": "2093"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/denoms/0/counts/1/value",
"value": "2091"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/denoms/0/counts/2/value",
"value": "0"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/denoms/0/counts/3/value",
"value": "2097"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/title"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/0/measurements/0/value",
"value": "213"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/0/measurements/1/value",
"value": "238"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/0/measurements/2/groupId",
"value": "OG003"
},
{
"op": "replace",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/0/measurements/2/value",
"value": "250"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/0/title",
"value": "Distant recurrence"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/1",
"value": {
"measurements": [
{
"groupId": "OG000",
"value": "45"
},
{
"groupId": "OG001",
"value": "41"
},
{
"groupId": "OG003",
"value": "54"
}
],
"title": "Death as a competing risk"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/0/categories/2",
"value": {
"measurements": [
{
"groupId": "OG000",
"value": "1835"
},
{
"groupId": "OG001",
"value": "1812"
},
{
"groupId": "OG003",
"value": "1793"
}
],
"title": "Censored"
}
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/1"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/1"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/1"
},
{
"op": "remove",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/classes/1"
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/5/analyses",
"value": [
{
"ciLowerLimit": "0.71",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.02",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityComment": "Time to distant recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.852"
},
{
"ciLowerLimit": "0.81",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.16",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityComment": "Time to distant recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.968"
}
]
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/6",
"value": {
"analyses": [
{
"ciLowerLimit": "0.74",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.31",
"groupIds": [
"OG000",
"OG003"
],
"nonInferiorityComment": "Time to CNS recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.986"
},
{
"ciLowerLimit": "0.74",
"ciNumSides": "TWO_SIDED",
"ciPctValue": "95",
"ciUpperLimit": "1.31",
"groupIds": [
"OG001",
"OG003"
],
"nonInferiorityComment": "Time to CNS recurrence was analyzed using competing risks methodology with death (without event) as a competing risk.",
"nonInferiorityType": "SUPERIORITY_OR_OTHER_LEGACY",
"paramType": "Hazard Ratio (HR)",
"paramValue": "0.980"
}
],
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "91"
},
{
"groupId": "OG001",
"value": "91"
},
{
"groupId": "OG003",
"value": "95"
}
],
"title": "CNS recurrence"
},
{
"measurements": [
{
"groupId": "OG000",
"value": "114"
},
{
"groupId": "OG001",
"value": "117"
},
{
"groupId": "OG003",
"value": "142"
}
],
"title": "Death as a competing risk"
},
{
"measurements": [
{
"groupId": "OG000",
"value": "1888"
},
{
"groupId": "OG001",
"value": "1883"
},
{
"groupId": "OG003",
"value": "1860"
}
],
"title": "Censored"
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2093"
},
{
"groupId": "OG001",
"value": "2091"
},
{
"groupId": "OG002",
"value": "0"
},
{
"groupId": "OG003",
"value": "2097"
}
],
"units": "Participants"
}
],
"description": "Time to Central Nervous System (CNS) recurrence was defined as the time from randomization to first CNS recurrence.\nBoth brain metastasis and meningitis carcinomatosa were considered.",
"groups": [
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>",
"id": "OG000",
"title": "Lapatinib Plus Trastuzumab"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>",
"id": "OG001",
"title": "Trastuzumab Followed by Lapatinib"
},
{
"description": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated.",
"id": "OG002",
"title": "Lapatinib"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>",
"id": "OG003",
"title": "Trastuzumab"
}
],
"paramType": "COUNT_OF_PARTICIPANTS",
"populationDescription": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility.",
"reportingStatus": "POSTED",
"timeFrame": "From randomization until the first central nervous system recurrence, assessed up to approximately 10 years",
"title": "Analysis of Time to Central Nervous System (CNS) Recurrence",
"type": "SECONDARY",
"unitOfMeasure": "Participants"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/7",
"value": {
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "50"
},
{
"groupId": "OG001",
"value": "52"
},
{
"groupId": "OG003",
"value": "48"
}
]
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2093"
},
{
"groupId": "OG001",
"value": "2091"
},
{
"groupId": "OG002",
"value": "0"
},
{
"groupId": "OG003",
"value": "2097"
}
],
"units": "Participants"
}
],
"description": "The cumulative incidence of brain metastases as the first site of breast cancer recurrence among treatment arms was assessed using a hierarchy of primary type and location of first DFS event in cases where more than one event was identified simultaneously.\nBecause diagnostic procedures for different types of recurrence could not be performed on exactly the same day, any diagnoses noted within a two month (60 day) period of the first reported event was considered as identified simultaneously for purposes of defining the type of the first event and the date of event was be regarded as the earliest of the relevant events.",
"groups": [
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>",
"id": "OG000",
"title": "Lapatinib Plus Trastuzumab"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>",
"id": "OG001",
"title": "Trastuzumab Followed by Lapatinib"
},
{
"description": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated.",
"id": "OG002",
"title": "Lapatinib"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>",
"id": "OG003",
"title": "Trastuzumab"
}
],
"paramType": "COUNT_OF_PARTICIPANTS",
"populationDescription": "Intent-to-Treat (ITT) Population.\nThe Lapatinib alone arm was discontinued prior to primary analysis due to futility.",
"reportingStatus": "POSTED",
"timeFrame": "From randomization until the date of the first occurrence of a disease recurrence, assessed up to approximately 10 years",
"title": "Cumulative Incidence of Brain Metastases",
"type": "SECONDARY",
"unitOfMeasure": "Participants"
}
},
{
"op": "add",
"path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/8",
"value": {
"classes": [
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "1"
},
{
"groupId": "OG001",
"value": "2"
},
{
"groupId": "OG002",
"value": "1"
},
{
"groupId": "OG003",
"value": "2"
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2093"
},
{
"groupId": "OG001",
"value": "2091"
},
{
"groupId": "OG002",
"value": "2100"
},
{
"groupId": "OG003",
"value": "2097"
}
],
"units": "Participants"
}
],
"title": "Pre-treatment deaths"
},
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "6"
},
{
"groupId": "OG001",
"value": "5"
},
{
"groupId": "OG002",
"value": "12"
},
{
"groupId": "OG003",
"value": "3"
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2061"
},
{
"groupId": "OG001",
"value": "2076"
},
{
"groupId": "OG002",
"value": "2056"
},
{
"groupId": "OG003",
"value": "2076"
}
],
"units": "Participants"
}
],
"title": "On-treatment deaths"
},
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "189"
},
{
"groupId": "OG001",
"value": "190"
},
{
"groupId": "OG002",
"value": "250"
},
{
"groupId": "OG003",
"value": "228"
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2055"
},
{
"groupId": "OG001",
"value": "2071"
},
{
"groupId": "OG002",
"value": "2044"
},
{
"groupId": "OG003",
"value": "2073"
}
],
"units": "Participants"
}
],
"title": "Post-treatment deaths"
},
{
"categories": [
{
"measurements": [
{
"groupId": "OG000",
"value": "196"
},
{
"groupId": "OG001",
"value": "197"
},
{
"groupId": "OG002",
"value": "263"
},
{
"groupId": "OG003",
"value": "233"
}
]
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2093"
},
{
"groupId": "OG001",
"value": "2091"
},
{
"groupId": "OG002",
"value": "2100"
},
{
"groupId": "OG003",
"value": "2097"
}
],
"units": "Participants"
}
],
"title": "All deaths"
}
],
"denoms": [
{
"counts": [
{
"groupId": "OG000",
"value": "2093"
},
{
"groupId": "OG001",
"value": "2091"
},
{
"groupId": "OG002",
"value": "2100"
},
{
"groupId": "OG003",
"value": "2097"
}
],
"units": "Participants"
}
],
"description": "<p>Pre-treatment deaths were collected from day of participant's informed consent to the day before first dose of study medication.</p><p>On-treatment deaths were collected from first dose of study medication to 30 days after last dose of study medication (on-treatment), up to approximately 56 weeks.</p><p>Deaths were collected in the post treatment survival follow up from 31 days after last dose of study medication until the end of the study, up to approximately 10 years.</p>",
"groups": [
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: oral lapatinib (OL) 1000 milligrams (mg) daily with trastuzumab (tras) (8 milligrams per kilogram [mg/kg] intravenous [IV] loading dose [LD], followed by 6 mg/kg IV every 3 weeks [E3W]) for 52 weeks (wks).</li><li>Design 2: OL 750 mg daily plus wkly tras (4 mg/kg LD, followed by 2 mg/kg IV) concomitantly (conc.)\nwith wkly paclitaxel (pac) 80 mg per squared meter (mg/m^2) IV or docetaxel (doc) 75 mg/m^2 IV E3W for 12 wks.\nAfter completion of pac or doc, par.\nreceived OL at an increased dose of 1000 mg daily in combination with tras (6 mg/kg without a LD) E3W for 40 wks.</li><li>Design 2B: OL 750 mg plus wkly tras (4 mg/kg IV LD, followed by 2 mg/kg IV wkly) conc.\nwith doc 75 mg/m^2 E3W and carboplatin (carb) AUC6 IV for 18 wks.\nAfter completion of doc and carb, par.\nreceived tras E3W (6 mg/kg without a LD) plus OL 1000 mg daily for 34 wks.</li></ul>",
"id": "OG000",
"title": "Lapatinib Plus Trastuzumab"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: weekly tras for 12 weeks (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly), followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks for 12 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 34 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV loading dose, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV for 18 weeks, followed by a 6-week washout period, followed by oral lap 1500 mg daily for 28 weeks.</li></ul>",
"id": "OG001",
"title": "Trastuzumab Followed by Lapatinib"
},
{
"description": "Participants received treatment per one of the following three designs.\nDesign 1: oral lap 1500 mg daily for 52 weeks.\nDesign 2: oral lap 750 mg daily concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received oral lap at an increased dose of 1500 mg daily for 40 weeks.\nDesign 2B: oral lap 750 mg daily concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, oral lap was given at an increased dose of 1500 mg for 34 weeks.\nParticipants also received adjuvant radiotherapy and adjuvant anti-estrogen therapy when clinically indicated.",
"id": "OG002",
"title": "Lapatinib"
},
{
"description": "<p>Participants received treatment per one of three designs and adjuvant radiotherapy / adjuvant anti-estrogen therapy when clinically indicated.</p><ul><li>Design 1: tras 8 mg/kg IV LD, followed by 6 mg/kg IV every 3 weeks for 52 weeks.</li><li>Design 2: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with weekly paclitaxel 80 mg/m^2 IV or docetaxel 75 mg/m^2 IV every 3 weeks, for 12 weeks.\nAfter completion of paclitaxel or docetaxel, participants received tras (6 mg/kg without a LD every 3 weeks for 40 weeks.</li><li>Design 2B: weekly tras (4 mg/kg IV LD, followed by 2 mg/kg IV weekly) concomitantly with docetaxel 75 mg/m^2 every 3 weeks and carboplatin AUC6 IV, for 18 weeks.\nAfter completion of docetaxel and carboplatin, participants received tras every 3 weeks (6 mg/kg without a LD) for 34 weeks.\n"</li></ul>",
"id": "OG003",
"title": "Trastuzumab"
}
],
"paramType": "COUNT_OF_PARTICIPANTS",
"populationDescription": "Intent-to-Treat (ITT) Population.",
"reportingStatus": "POSTED",
"timeFrame": "Pre-treatment deaths: Up to 14 days prior to treatment. On-treatment deaths: Up to 56 weeks. Post-treatment deaths: up to 10 years.",
"title": "All Collected Deaths",
"type": "POST_HOC",
"unitOfMeasure": "Participants"
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/timeFrame",
"value": "Adverse Events (AEs) were collected from first dose of study medication until the last dose plus 30 days post-treat follow-up, assessed up to approximately 56 weeks. Deaths were recorded from study start date until end of survival follow-up phase (end of study), assessed up to approximately 10 years."
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/description",
"value": "Deaths in the post-treatment survival follow-up were not considered adverse events.\nThe total number at risk in the post-treatment survival included patients who entered this period.\nAll-cause Mortality was assessed for all participants enrolled in the study, while Serious and Other Adverse Events were assessed for all participants who received at least one dose of the study medication."
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/title",
"value": "Lapatinib Plus Trastuzumab"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/description",
"value": "Lapatinib plus Trastuzumab: Events up to 30 days post-treatment"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/seriousNumAffected",
"value": 379
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/otherNumAffected",
"value": 1930
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/deathsNumAffected",
"value": 7
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/0/deathsNumAtRisk",
"value": 2093
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/1/description",
"value": "Trastuzumab followed by Lapatinib: Events up to 30 days post-treatment"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/1/seriousNumAffected",
"value": 299
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/1/otherNumAffected",
"value": 1862
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/1/deathsNumAffected",
"value": 7
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/1/deathsNumAtRisk",
"value": 2091
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/description",
"value": "Lapatinib: Events up to 30 days post-treatment"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/seriousNumAffected",
"value": 394
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/seriousNumAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/otherNumAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/deathsNumAffected",
"value": 13
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/2/deathsNumAtRisk",
"value": 2100
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/3/description",
"value": "Trastuzumab: Events up to 30 days post-treatment"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/3/seriousNumAffected",
"value": 251
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/eventGroups/3/otherNumAffected",
"value": 1649
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/3/deathsNumAffected",
"value": 5
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/3/deathsNumAtRisk",
"value": 2097
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/4",
"value": {
"deathsNumAffected": 189,
"deathsNumAtRisk": 2055,
"description": "Lapatinib plus Trastuzumab (Post-Treatment) - Deaths in the post-treatment survival follow-up were not considered adverse events.",
"id": "EG004",
"otherNumAffected": 0,
"otherNumAtRisk": 0,
"seriousNumAffected": 0,
"seriousNumAtRisk": 0,
"title": "Lapatinib Plus Trastuzumab (Post-Treatment)"
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/5",
"value": {
"deathsNumAffected": 190,
"deathsNumAtRisk": 2071,
"description": "Trastuzumab followed by Lapatinib (Post-Treatment) - Deaths in the post-treatment survival follow-up were not considered adverse events.",
"id": "EG005",
"otherNumAffected": 0,
"otherNumAtRisk": 0,
"seriousNumAffected": 0,
"seriousNumAtRisk": 0,
"title": "Trastuzumab Followed by Lapatinib (Post-Treatment)"
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/6",
"value": {
"deathsNumAffected": 250,
"deathsNumAtRisk": 2044,
"description": "Lapatinib (Post-Treatment) - Deaths in the post-treatment survival follow-up were not considered adverse events.",
"id": "EG006",
"otherNumAffected": 0,
"otherNumAtRisk": 0,
"seriousNumAffected": 0,
"seriousNumAtRisk": 0,
"title": "Lapatinib (Post-Treatment)"
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/eventGroups/7",
"value": {
"deathsNumAffected": 228,
"deathsNumAtRisk": 2073,
"description": "Trastuzumab (Post-Treatment) - Deaths in the post-treatment survival follow-up were not considered adverse events.",
"id": "EG007",
"otherNumAffected": 0,
"otherNumAtRisk": 0,
"seriousNumAffected": 0,
"seriousNumAtRisk": 0,
"title": "Trastuzumab (Post-Treatment)"
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/term",
"value": "AGRANULOCYTOSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/0/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/term",
"value": "ANAEMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/0/numAffected",
"value": 7
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/1/numAffected",
"value": 6
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/2/numAffected",
"value": 13
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/3/numAffected",
"value": 7
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/1/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/term",
"value": "EOSINOPHILIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/2/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/term",
"value": "FEBRILE NEUTROPENIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/0/numAffected",
"value": 10
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/1/numAffected",
"value": 6
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/2/numAffected",
"value": 12
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/3/numAffected",
"value": 3
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/3/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/term",
"value": "IRON DEFICIENCY ANAEMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/4/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/term",
"value": "LEUKOPENIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/0/numAffected",
"value": 20
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/1/numAffected",
"value": 4
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/2/numAffected",
"value": 13
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/3/numAffected",
"value": 7
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/5/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/term",
"value": "NEUTROPENIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/0/numAffected",
"value": 37
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/1/numAffected",
"value": 21
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/2/numAffected",
"value": 36
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/3/numAffected",
"value": 20
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/6/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/term",
"value": "PANCYTOPENIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/7/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/term",
"value": "THROMBOCYTOPENIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/organSystem",
"value": "Blood and lymphatic system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/0/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/3/numAffected",
"value": 7
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/8/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/term",
"value": "ACUTE CORONARY SYNDROME"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/stats/1/numAffected",
"value": 0
},
{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/9/stats/3/numAffected",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/13/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/13/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/13/stats/0/numAffected",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/13/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/14/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/14/stats/0/numAffected",
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{
"op": "replace",
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{
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{
"op": "replace",
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"op": "add",
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},
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{
"op": "add",
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/15/sourceVocabulary",
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/15/stats/1/numAffected",
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{
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{
"op": "replace",
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"op": "add",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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},
{
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{
"op": "replace",
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{
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{
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"op": "replace",
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{
"op": "add",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/19/organSystem",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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"op": "replace",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/22/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/22/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/22/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/22/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/22/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/term",
"value": "INTRACARDIAC THROMBUS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/23/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/term",
"value": "LEFT VENTRICULAR DYSFUNCTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/0/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/1/numAffected",
"value": 5
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/2/numAffected",
"value": 4
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/3/numAffected",
"value": 4
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/24/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/term",
"value": "MYOCARDIAL INFARCTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/0/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/25/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/term",
"value": "MYOCARDIAL ISCHAEMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/3/numAffected",
"value": 1
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/26/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/term",
"value": "PALPITATIONS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/4",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/27/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/term",
"value": "PERICARDIAL EFFUSION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/3/numAffected",
"value": 1
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/28/stats/6",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/term",
"value": "PERICARDITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/stats/3/numAffected",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/29/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/term",
"value": "SUPRAVENTRICULAR TACHYCARDIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/3/numAffected",
"value": 0
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/30/stats/7",
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"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/term",
"value": "VENTRICULAR ARRHYTHMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/3/numAffected",
"value": 0
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/31/stats/6",
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}
},
{
"op": "add",
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"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/term",
"value": "VENTRICULAR EXTRASYSTOLES"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/32/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/term",
"value": "VENTRICULAR TACHYCARDIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/organSystem",
"value": "Cardiac disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/4",
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"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/33/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/term",
"value": "GILBERT'S SYNDROME"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/organSystem",
"value": "Congenital, familial and genetic disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/34/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/term",
"value": "TINNITUS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/organSystem",
"value": "Ear and labyrinth disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/35/stats/3/numAffected",
"value": 0
},
{
"op": "add",
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{
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"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/77/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/77/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/77/stats/2/numAtRisk",
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{
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/78/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/78/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/78/stats/2/numAtRisk",
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{
"op": "add",
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},
{
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/79/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/79/stats/2/numAtRisk",
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{
"op": "add",
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{
"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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},
{
"op": "add",
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{
"op": "add",
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{
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{
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{
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{
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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{
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},
{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/83/term",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/83/sourceVocabulary",
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},
{
"op": "replace",
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},
{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
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},
{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
"op": "replace",
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},
{
"op": "add",
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{
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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},
{
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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{
"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
{
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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"op": "add",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/89/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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},
{
"op": "add",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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"op": "add",
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},
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"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/91/organSystem",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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"path": "/resultsSection/adverseEventsModule/seriousEvents/134/stats/3/numAffected",
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{
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{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/135/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/135/stats/2/numAtRisk",
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"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/136/stats/3/numAffected",
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{
"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/137/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/137/stats/3/numAffected",
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{
"op": "add",
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"op": "add",
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"op": "add",
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},
{
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/138/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/138/stats/2/numAtRisk",
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{
"op": "add",
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"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/139/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/139/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/140/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/140/stats/0/numAffected",
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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"op": "add",
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{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/141/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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"op": "add",
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{
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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},
{
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{
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{
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{
"op": "replace",
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"op": "add",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
"op": "replace",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/148/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "replace",
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{
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"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/term",
"value": "HERPES ZOSTER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/1/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/2/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/165/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/term",
"value": "IMPLANT SITE CELLULITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/166/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/term",
"value": "INFECTED CYST"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/167/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/term",
"value": "INFECTED LYMPHOCELE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/168/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/term",
"value": "INFECTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/0/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/169/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/term",
"value": "INFECTIVE EXACERBATION OF CHRONIC OBSTRUCTIVE AIRWAYS DISEASE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/170/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/term",
"value": "INFLUENZA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/171/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/term",
"value": "INTERVERTEBRAL DISCITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/172/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/term",
"value": "LARGE INTESTINE INFECTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/173/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/term",
"value": "LARYNGITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/174/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/term",
"value": "LOCALISED INFECTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/175/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/term",
"value": "LOWER RESPIRATORY TRACT INFECTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/0/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/1/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/176/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/term",
"value": "LYMPH GLAND INFECTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/177/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/term",
"value": "LYMPH NODE ABSCESS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/178/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/term",
"value": "LYMPHANGITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/2/numAtRisk",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/179/stats/7",
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}
},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/180/sourceVocabulary",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/182/organSystem",
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{
"op": "replace",
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/182/stats/3/numAffected",
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{
"op": "add",
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{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/183/stats/2/numAtRisk",
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{
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{
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{
"op": "replace",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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"op": "replace",
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{
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{
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/195/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/195/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/195/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/195/stats/1/numAffected",
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{
"op": "replace",
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},
{
"op": "replace",
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{
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{
"op": "add",
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/196/stats/3/numAffected",
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},
{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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},
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/197/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/197/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/197/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/197/stats/2/numAtRisk",
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{
"op": "add",
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}
},
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},
{
"op": "replace",
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{
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},
{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/198/stats/2/numAtRisk",
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},
{
"op": "replace",
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},
{
"op": "add",
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}
},
{
"op": "add",
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},
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"op": "add",
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{
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},
{
"op": "replace",
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{
"op": "replace",
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},
{
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},
{
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/199/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/199/stats/3/numAffected",
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},
{
"op": "add",
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},
{
"op": "add",
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},
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"op": "add",
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},
{
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/200/organSystem",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/200/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/200/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/200/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/200/stats/3/numAffected",
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},
{
"op": "add",
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},
{
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},
{
"op": "add",
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},
{
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{
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{
"op": "replace",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/201/stats/2/numAtRisk",
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{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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{
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},
{
"op": "replace",
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{
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},
{
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},
{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
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{
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},
{
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{
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},
{
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{
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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},
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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},
{
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{
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},
{
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{
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{
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{
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{
"op": "replace",
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},
{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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"op": "add",
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{
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"op": "replace",
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{
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{
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"op": "replace",
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"op": "add",
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{
"op": "replace",
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{
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{
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{
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{
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{
"op": "replace",
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{
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{
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{
"op": "replace",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/213/stats/3/numAffected",
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{
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"op": "add",
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/214/organSystem",
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},
{
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{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
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{
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{
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{
"op": "replace",
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},
{
"op": "replace",
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{
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{
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{
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{
"op": "replace",
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{
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{
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},
{
"op": "replace",
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},
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{
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{
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{
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"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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{
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{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/224/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/224/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/term",
"value": "WOUND INFECTION BACTERIAL"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/organSystem",
"value": "Infections and infestations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/225/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/term",
"value": "ALCOHOL POISONING"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/226/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/term",
"value": "ANKLE FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/227/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/term",
"value": "CARBON MONOXIDE POISONING"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/228/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/term",
"value": "CONCUSSION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/229/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/term",
"value": "CONTUSION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/230/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/term",
"value": "FIBULA FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/231/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/term",
"value": "FOOT FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/232/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/term",
"value": "FOREIGN BODY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/233/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/term",
"value": "FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/234/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/term",
"value": "FRACTURED COCCYX"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/235/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/term",
"value": "HIP FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/236/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/term",
"value": "HUMERUS FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/237/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/term",
"value": "INFUSION RELATED REACTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/238/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/term",
"value": "LIGAMENT INJURY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/239/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/term",
"value": "LIGAMENT SPRAIN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/240/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/term",
"value": "LOWER LIMB FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/241/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/term",
"value": "MULTIPLE INJURIES"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/242/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/term",
"value": "PELVIC FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/243/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/term",
"value": "RADIATION FIBROSIS - LUNG"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/244/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/term",
"value": "RADIATION PNEUMONITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/245/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/term",
"value": "RADIATION SKIN INJURY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/1/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/246/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/term",
"value": "RADIUS FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/247/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/term",
"value": "RIB FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/1/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/248/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/term",
"value": "ROAD TRAFFIC ACCIDENT"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/249/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/term",
"value": "SEROMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/1/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/250/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/term",
"value": "SPINAL COMPRESSION FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/251/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/term",
"value": "SPINAL FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/252/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/term",
"value": "STERNAL FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/253/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/term",
"value": "SUBDURAL HAEMORRHAGE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/254/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/term",
"value": "THERMAL BURN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/255/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/term",
"value": "TIBIA FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/256/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/term",
"value": "UPPER LIMB FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/257/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/term",
"value": "WOUND COMPLICATION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/258/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/term",
"value": "WRIST FRACTURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/organSystem",
"value": "Injury, poisoning and procedural complications"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/259/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/term",
"value": "ALANINE AMINOTRANSFERASE INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/260/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/term",
"value": "AMYLASE INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/261/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/term",
"value": "BLOOD ALKALINE PHOSPHATASE INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/262/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/term",
"value": "BLOOD BILIRUBIN INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/263/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/term",
"value": "BLOOD CREATININE INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/264/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/term",
"value": "BLOOD MAGNESIUM DECREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/265/stats/7",
"value": {
"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/266/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/term",
"value": "BLOOD UREA INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/267/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/term",
"value": "BLOOD URINE PRESENT"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/268/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/term",
"value": "BODY TEMPERATURE INCREASED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/269/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/term",
"value": "COAGULATION TEST ABNORMAL"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/270/stats/7",
"value": {
"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/term",
"value": "EASTERN COOPERATIVE ONCOLOGY GROUP PERFORMANCE STATUS WORSENED"
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/organSystem",
"value": "Investigations"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/2/numAtRisk",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/4",
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"groupId": "EG004",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/271/stats/5",
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{
"op": "add",
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{
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},
{
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"path": "/resultsSection/adverseEventsModule/seriousEvents/272/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/stats/3/numAffected",
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},
{
"op": "add",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/stats/5",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/272/stats/6",
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},
{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/273/stats/5",
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},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/2/numAtRisk",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/5",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/274/stats/6",
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}
},
{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/stats/2/numAtRisk",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/275/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/276/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/276/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/276/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/276/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/277/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/277/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/277/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/277/stats/2/numAffected",
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{
"op": "replace",
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{
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}
},
{
"op": "add",
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},
{
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},
{
"op": "add",
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/278/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/278/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/278/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/279/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/279/stats/2/numAtRisk",
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/280/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/281/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/281/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/281/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/281/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/281/stats/2/numAtRisk",
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{
"op": "add",
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"op": "add",
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/282/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/282/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/282/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/282/stats/0/numAffected",
"value": 2
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/282/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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{
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/283/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/283/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/283/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/283/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/284/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/284/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/284/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/284/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/284/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/285/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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"op": "add",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/286/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/286/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/286/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/286/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/286/stats/2/numAtRisk",
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{
"op": "replace",
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"op": "add",
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{
"op": "add",
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"path": "/resultsSection/adverseEventsModule/seriousEvents/301/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/301/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/301/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/term",
"value": "BONE PAIN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/302/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/term",
"value": "CHEST WALL NECROSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/303/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/term",
"value": "COSTOCHONDRITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/304/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/term",
"value": "LUMBAR SPINAL STENOSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/305/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/term",
"value": "MUSCULOSKELETAL CHEST PAIN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/306/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/term",
"value": "MYALGIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/0/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/307/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/term",
"value": "MYOSITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/308/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/term",
"value": "OSTEOARTHRITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/309/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/term",
"value": "OSTEOPOROSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/310/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/term",
"value": "PAIN IN EXTREMITY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/311/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/term",
"value": "SCLERODERMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/312/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/term",
"value": "SPONDYLOLISTHESIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/313/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/term",
"value": "SYNOVIAL CYST"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/314/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/term",
"value": "SYNOVITIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/organSystem",
"value": "Musculoskeletal and connective tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/315/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/term",
"value": "ACUTE LYMPHOCYTIC LEUKAEMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/316/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/term",
"value": "ACUTE PROMYELOCYTIC LEUKAEMIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/317/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/term",
"value": "ADENOCARCINOMA OF COLON"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/318/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/term",
"value": "BENIGN BREAST NEOPLASM"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/319/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/term",
"value": "BENIGN OVARIAN TUMOUR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/320/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/term",
"value": "BLADDER NEOPLASM"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/321/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/term",
"value": "BORDERLINE OVARIAN TUMOUR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/322/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/term",
"value": "BREAST CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/0/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/1/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/2/numAffected",
"value": 3
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/3/numAffected",
"value": 4
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/323/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/term",
"value": "BREAST CANCER IN SITU"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/324/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/term",
"value": "COLON CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/325/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/term",
"value": "ENDOMETRIAL ADENOCARCINOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/326/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/term",
"value": "GASTRIC CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/327/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/term",
"value": "GASTROINTESTINAL CARCINOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/328/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/term",
"value": "GASTROINTESTINAL STROMAL TUMOUR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/329/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/term",
"value": "HAEMANGIOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/330/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/term",
"value": "INTRADUCTAL PAPILLOMA OF BREAST"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/331/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/term",
"value": "INTRADUCTAL PROLIFERATIVE BREAST LESION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/332/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/term",
"value": "LEIOMYOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/333/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/term",
"value": "LEIOMYOSARCOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/334/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/term",
"value": "LENTIGO MALIGNA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/335/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/term",
"value": "LIPOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/336/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/term",
"value": "MALIGNANT MELANOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/337/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/term",
"value": "MELANOCYTIC NAEVUS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/338/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/term",
"value": "MENINGIOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/339/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/term",
"value": "MENINGIOMA BENIGN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/340/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/term",
"value": "METASTASES TO CENTRAL NERVOUS SYSTEM"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/341/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/term",
"value": "NEUROENDOCRINE TUMOUR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/342/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/term",
"value": "OVARIAN ADENOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/343/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/term",
"value": "OVARIAN CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/344/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/term",
"value": "OVARIAN GERM CELL TERATOMA BENIGN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/345/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/term",
"value": "OVARIAN NEOPLASM"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/346/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/term",
"value": "PANCREATIC CARCINOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/347/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/term",
"value": "PAPILLARY THYROID CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/348/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/term",
"value": "PARATHYROID TUMOUR BENIGN"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/349/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/term",
"value": "PLASMA CELL MYELOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/350/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/term",
"value": "RECTAL CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/351/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/term",
"value": "SMALL CELL LUNG CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/352/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/term",
"value": "SQUAMOUS CELL CARCINOMA OF THE VULVA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/353/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/term",
"value": "SUPERFICIAL SPREADING MELANOMA STAGE UNSPECIFIED"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/354/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/term",
"value": "THYROID CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/3/numAffected",
"value": 2
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/355/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/term",
"value": "TRANSITIONAL CELL CARCINOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/356/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/term",
"value": "UTERINE CANCER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/357/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/term",
"value": "UTERINE LEIOMYOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/organSystem",
"value": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/358/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/term",
"value": "AMYOTROPHIC LATERAL SCLEROSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/organSystem",
"value": "Nervous system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/359/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/term",
"value": "BRAIN HYPOXIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/organSystem",
"value": "Nervous system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/360/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/term",
"value": "CEREBELLAR ATAXIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/organSystem",
"value": "Nervous system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/361/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/term",
"value": "CEREBROVASCULAR ACCIDENT"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/organSystem",
"value": "Nervous system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/362/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/term",
"value": "DIZZINESS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/organSystem",
"value": "Nervous system disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/363/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/364/term",
"value": "EPILEPSY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/364/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/364/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
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{
"op": "replace",
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{
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{
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{
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{
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{
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{
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{
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{
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{
"op": "add",
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},
{
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{
"op": "replace",
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{
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{
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{
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},
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{
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{
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{
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{
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{
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{
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/380/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
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},
{
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{
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},
{
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/381/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/381/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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{
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/382/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/382/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/382/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/382/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/382/stats/3/numAffected",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/383/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/383/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/383/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/383/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/383/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/384/stats/3/numAffected",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
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{
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{
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/385/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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{
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},
{
"op": "add",
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}
},
{
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/386/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/386/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/386/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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{
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{
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{
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{
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{
"op": "replace",
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{
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{
"op": "add",
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},
{
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},
{
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{
"op": "replace",
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{
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{
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{
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{
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{
"op": "replace",
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{
"op": "add",
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},
{
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},
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{
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
{
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{
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{
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},
{
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/390/sourceVocabulary",
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{
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"path": "/resultsSection/adverseEventsModule/seriousEvents/390/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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{
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{
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/392/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/392/sourceVocabulary",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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},
{
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/393/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/393/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/393/stats/1/numAffected",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/393/stats/3/numAffected",
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{
"op": "add",
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{
"op": "add",
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{
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/394/organSystem",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/term",
"value": "ACUTE KIDNEY INJURY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/395/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/term",
"value": "CALCULUS URINARY"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/396/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/term",
"value": "NEPHRITIC SYNDROME"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/397/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/term",
"value": "NEPHROLITHIASIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/1/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/398/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/term",
"value": "RENAL COLIC"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/399/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/term",
"value": "RENAL FAILURE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/4",
"value": {
"groupId": "EG004",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/400/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/term",
"value": "URETHRAL OBSTRUCTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/5",
"value": {
"groupId": "EG005",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/6",
"value": {
"groupId": "EG006",
"numAtRisk": 0
}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/401/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/term",
"value": "URINARY BLADDER HAEMORRHAGE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/organSystem",
"value": "Renal and urinary disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/402/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/term",
"value": "ADENOMYOSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/403/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/term",
"value": "BREAST CALCIFICATIONS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/404/stats/6",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/term",
"value": "BREAST DISORDER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/405/stats/7",
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"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/term",
"value": "BREAST FIBROSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/406/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/term",
"value": "BREAST HAEMATOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/407/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/term",
"value": "BREAST INFLAMMATION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/408/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/term",
"value": "BREAST NECROSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/409/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/term",
"value": "BREAST SWELLING"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/4",
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"groupId": "EG004",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/5",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/6",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/410/stats/7",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/term",
"value": "ENDOMETRIAL HYPERPLASIA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/stats/2/numAffected",
"value": 1
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/stats/2/numAtRisk",
"value": 2056
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{
"op": "add",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/411/stats/5",
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{
"op": "add",
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},
{
"op": "add",
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"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/stats/2/numAtRisk",
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{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/412/stats/5",
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},
{
"op": "add",
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},
{
"op": "add",
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"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/1/numAffected",
"value": 4
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/2/numAffected",
"value": 1
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/3/numAffected",
"value": 3
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/4",
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"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/413/stats/6",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/organSystem",
"value": "Reproductive system and breast disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/stats/2/numAtRisk",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/414/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/term",
"value": "PELVIC PAIN"
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/stats/2/numAtRisk",
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{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/415/stats/5",
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},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/stats/1/numAffected",
"value": 0
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/416/stats/5",
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},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/417/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/418/organSystem",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/418/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/418/stats/2/numAffected",
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{
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"path": "/resultsSection/adverseEventsModule/seriousEvents/418/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/419/term",
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},
{
"op": "replace",
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{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/419/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/419/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/419/stats/2/numAtRisk",
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{
"op": "add",
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},
{
"op": "add",
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},
{
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},
{
"op": "add",
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},
{
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/420/organSystem",
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{
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"path": "/resultsSection/adverseEventsModule/seriousEvents/420/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/420/stats/2/numAtRisk",
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{
"op": "add",
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/421/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/421/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/421/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/421/stats/2/numAtRisk",
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{
"op": "add",
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},
{
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/422/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/422/stats/2/numAtRisk",
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/423/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/424/organSystem",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/424/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/424/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/424/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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{
"op": "add",
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},
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"op": "add",
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{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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"op": "replace",
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"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/440/stats/6",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/440/stats/7",
"value": {
"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/term",
"value": "PULMONARY GRANULOMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/organSystem",
"value": "Respiratory, thoracic and mediastinal disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/2/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/6",
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"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/441/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/term",
"value": "PULMONARY MASS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/organSystem",
"value": "Respiratory, thoracic and mediastinal disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/442/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/organSystem",
"value": "Respiratory, thoracic and mediastinal disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/443/stats/7",
"value": {
"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/term",
"value": "PULMONARY THROMBOSIS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/organSystem",
"value": "Respiratory, thoracic and mediastinal disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/4",
"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/6",
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"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/444/stats/7",
"value": {
"groupId": "EG007",
"numAtRisk": 0
}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/organSystem",
"value": "Respiratory, thoracic and mediastinal disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/sourceVocabulary",
"value": "MedDRA (24.1)"
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/4",
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"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/6",
"value": {
"groupId": "EG006",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/445/stats/7",
"value": {
"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/term",
"value": "ACNE"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/0/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/446/stats/6",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/term",
"value": "ANGIODERMATITIS"
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/3/numAffected",
"value": 1
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/447/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/2/numAffected",
"value": 2
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/2/numAtRisk",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/448/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/stats/2/numAtRisk",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/449/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/term",
"value": "DERMATITIS ACNEIFORM"
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/3/numAffected",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/450/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/term",
"value": "ERYTHEMA"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/3/numAffected",
"value": 0
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/5",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/451/stats/6",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/term",
"value": "EXFOLIATIVE RASH"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/organSystem",
"value": "Skin and subcutaneous tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/stats/2/numAtRisk",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/452/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/term",
"value": "HYPERTROPHIC SCAR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/organSystem",
"value": "Skin and subcutaneous tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/0/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/3/numAffected",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/453/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/term",
"value": "NAIL DISORDER"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/organSystem",
"value": "Skin and subcutaneous tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/1/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/2/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/3/numAffected",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/454/stats/7",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/organSystem",
"value": "Skin and subcutaneous tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/3/numAffected",
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},
{
"op": "add",
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"value": {
"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/455/stats/7",
"value": {
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/term",
"value": "PHOTOSENSITIVITY REACTION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/organSystem",
"value": "Skin and subcutaneous tissue disorders"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/sourceVocabulary",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/2/numAtRisk",
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},
{
"op": "add",
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"groupId": "EG004",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/5",
"value": {
"groupId": "EG005",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/456/stats/7",
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"groupId": "EG007",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/term",
"value": "PRURITUS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/457/stats/6",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/term",
"value": "RASH"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/0/numAffected",
"value": 4
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/1/numAffected",
"value": 4
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/2/numAffected",
"value": 7
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/2/numAtRisk",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/4",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/5",
"value": {
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/6",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/458/stats/7",
"value": {
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/term",
"value": "RASH MACULO-PAPULAR"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/stats/2/numAtRisk",
"value": 2056
},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/stats/5",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/459/stats/6",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/stats/0/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/stats/2/numAtRisk",
"value": 2056
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/stats/3/numAffected",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/460/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/461/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/461/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/461/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/461/stats/2/numAtRisk",
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},
{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/461/stats/5",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/term",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/sourceVocabulary",
"value": "MedDRA (24.1)"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/stats/1/numAffected",
"value": 1
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/462/stats/3/numAffected",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/463/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/463/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/463/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/463/stats/2/numAtRisk",
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},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/464/organSystem",
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},
{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/464/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/stats/2/numAtRisk",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/465/stats/3/numAffected",
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},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/stats/0/numAffected",
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{
"op": "replace",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/stats/2/numAffected",
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{
"op": "replace",
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{
"op": "add",
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}
},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/stats/5",
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},
{
"op": "add",
"path": "/resultsSection/adverseEventsModule/seriousEvents/466/stats/6",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/term",
"value": "EMBOLISM VENOUS"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/stats/2/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/467/stats/2/numAtRisk",
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{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/term",
"value": "FLUSHING"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/stats/0/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/stats/1/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/468/stats/2/numAtRisk",
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{
"op": "add",
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}
},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/term",
"value": "HYPERTENSION"
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/sourceVocabulary",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/stats/0/numAffected",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/stats/1/numAffected",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/stats/2/numAffected",
"value": 0
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/stats/2/numAtRisk",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/469/stats/3/numAffected",
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{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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},
{
"op": "add",
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}
},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/470/term",
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{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/470/organSystem",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/470/sourceVocabulary",
"value": "MedDRA (24.1)"
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{
"op": "replace",
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},
{
"op": "replace",
"path": "/resultsSection/adverseEventsModule/seriousEvents/470/stats/2/numAffected",
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},
{
"op": "replace",
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"op": "replace",
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{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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"op": "replace",
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},
{
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{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
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{
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},
{
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},
{
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{
"op": "replace",
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{
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{
"op": "replace",
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{
"op": "replace",
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{
"op": "replace",
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},
{
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},
{
"op": "replace",
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},
{
"op": "replace",
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{
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{
"op": "replace",
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{
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},
{
"op": "replace",
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{
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},
{
"op": "replace",
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{
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{
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},
{
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},
{
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},
{
"op": "replace",
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{
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},
{
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{
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{
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},
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{
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},
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{
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