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NCT00099437

Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.

Version 49 to 50 · AstraZeneca

Patch inspector

Version 49 to 50

25 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2021-12-31",
    "old_value": "2021-03-31",
    "delta_days": 275,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:00:11+00
Raw hash
d28c7510f293b39cac3aecf3c35fa9e3b11779cd5dbfd092ebacf2c8a5284439
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2021-03-31
After
2021-12-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 21 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "85222",
  "city": "Casa Grande",
  "state": "Arizona",
  "country": "United States",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 32.8795,
    "lon": -111.75735
  }
}
add /protocolSection/contactsLocationsModule/locations/1
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "92708",
  "city": "Fountain Valley",
  "state": "California",
  "country": "United States",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 33.70918,
    "lon": -117.95367
  }
}
add /protocolSection/contactsLocationsModule/locations/4
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "33308",
  "city": "Fort Lauderdale",
  "state": "Florida",
  "country": "United States",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 26.12231,
    "lon": -80.14338
  }
}
remove /protocolSection/contactsLocationsModule/locations/21
Triage: Uncategorized
Uncategorized Operation 8
Before
{
  "zip": "B-4000",
  "city": "Liège",
  "country": "Belgium",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 50.63373,
    "lon": 5.56749
  }
}
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "14784-400",
  "city": "Barretos",
  "country": "Brazil",
  "facility": "Research Site",
  "geoPoint": {
    "lat": -20.55722,
    "lon": -48.56778
  }
}
add /protocolSection/contactsLocationsModule/locations/26
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "40170-070",
  "city": "Salvador",
  "country": "Brazil",
  "facility": "Research Site",
  "geoPoint": {
    "lat": -12.97563,
    "lon": -38.49096
  }
}
add /protocolSection/contactsLocationsModule/locations/28
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "city": "Antofagasta",
  "country": "Chile",
  "facility": "Research Site",
  "geoPoint": {
    "lat": -23.65094,
    "lon": -70.39752
  }
}
add /protocolSection/contactsLocationsModule/locations/41
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "4400",
  "city": "Nyíregyháza",
  "country": "Hungary",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 47.95539,
    "lon": 21.71671
  }
}
add /protocolSection/contactsLocationsModule/locations/42
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "8000",
  "city": "Székesfehérvár",
  "country": "Hungary",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 47.18995,
    "lon": 18.41034
  }
}
add /protocolSection/contactsLocationsModule/locations/44
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "110 029",
  "city": "Ansārinagar",
  "country": "India",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 28.5666,
    "lon": 77.21422
  }
}
add /protocolSection/contactsLocationsModule/locations/45
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "462001",
  "city": "Bhopal",
  "country": "India",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 23.25469,
    "lon": 77.40289
  }
}
add /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "576 104",
  "city": "Manipal",
  "country": "India",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 13.35,
    "lon": 74.78333
  }
}
add /protocolSection/contactsLocationsModule/locations/51
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "400012",
  "city": "Mumbai",
  "country": "India",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 19.07283,
    "lon": 72.88261
  }
}
add /protocolSection/contactsLocationsModule/locations/58
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "zip": "16132",
  "city": "Genova",
  "country": "Italy",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 45.21604,
    "lon": 11.87211
  }
}
add /protocolSection/contactsLocationsModule/locations/64
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "01090",
  "city": "México",
  "country": "Mexico",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 31.00435,
    "lon": -108.15213
  }
}
add /protocolSection/contactsLocationsModule/locations/72
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "zip": "350040",
  "city": "Krasnodar",
  "country": "Russia",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 45.04534,
    "lon": 38.98178
  }
}
add /protocolSection/contactsLocationsModule/locations/86
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "812 50",
  "city": "Bratislava",
  "country": "Slovakia",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 48.14816,
    "lon": 17.10674
  }
}
add /protocolSection/contactsLocationsModule/locations/87
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "949 01",
  "city": "Nitra",
  "country": "Slovakia",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 48.30763,
    "lon": 18.08453
  }
}
add /protocolSection/contactsLocationsModule/locations/88
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "917 75",
  "city": "Trnava",
  "country": "Slovakia",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 48.37773,
    "lon": 17.58603
  }
}
add /protocolSection/contactsLocationsModule/locations/89
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "15006",
  "city": "A Coruña",
  "country": "Spain",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 43.37135,
    "lon": -8.396
  }
}
add /protocolSection/contactsLocationsModule/locations/101
Triage: Uncategorized
Uncategorized Operation 25
After
{
  "zip": "46023",
  "city": "Ternopil",
  "country": "Ukraine",
  "facility": "Research Site",
  "geoPoint": {
    "lat": 49.55404,
    "lon": 25.59067
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2021-02
After
2021-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2021-02-08
After
2021-03-12
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2021-03-03
After
2021-04-08
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2021-12-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-03-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-04-08"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "85222",
      "city": "Casa Grande",
      "state": "Arizona",
      "country": "United States",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 32.8795,
        "lon": -111.75735
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1",
    "value": {
      "zip": "92708",
      "city": "Fountain Valley",
      "state": "California",
      "country": "United States",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 33.70918,
        "lon": -117.95367
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4",
    "value": {
      "zip": "33308",
      "city": "Fort Lauderdale",
      "state": "Florida",
      "country": "United States",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 26.12231,
        "lon": -80.14338
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/21"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22",
    "value": {
      "zip": "14784-400",
      "city": "Barretos",
      "country": "Brazil",
      "facility": "Research Site",
      "geoPoint": {
        "lat": -20.55722,
        "lon": -48.56778
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/26",
    "value": {
      "zip": "40170-070",
      "city": "Salvador",
      "country": "Brazil",
      "facility": "Research Site",
      "geoPoint": {
        "lat": -12.97563,
        "lon": -38.49096
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/28",
    "value": {
      "city": "Antofagasta",
      "country": "Chile",
      "facility": "Research Site",
      "geoPoint": {
        "lat": -23.65094,
        "lon": -70.39752
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/41",
    "value": {
      "zip": "4400",
      "city": "Nyíregyháza",
      "country": "Hungary",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 47.95539,
        "lon": 21.71671
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/42",
    "value": {
      "zip": "8000",
      "city": "Székesfehérvár",
      "country": "Hungary",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 47.18995,
        "lon": 18.41034
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/44",
    "value": {
      "zip": "110 029",
      "city": "Ansārinagar",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 28.5666,
        "lon": 77.21422
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/45",
    "value": {
      "zip": "462001",
      "city": "Bhopal",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 23.25469,
        "lon": 77.40289
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/49",
    "value": {
      "zip": "576 104",
      "city": "Manipal",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 13.35,
        "lon": 74.78333
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/51",
    "value": {
      "zip": "400012",
      "city": "Mumbai",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 19.07283,
        "lon": 72.88261
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/58",
    "value": {
      "zip": "16132",
      "city": "Genova",
      "country": "Italy",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 45.21604,
        "lon": 11.87211
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/64",
    "value": {
      "zip": "01090",
      "city": "México",
      "country": "Mexico",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 31.00435,
        "lon": -108.15213
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/72",
    "value": {
      "zip": "350040",
      "city": "Krasnodar",
      "country": "Russia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 45.04534,
        "lon": 38.98178
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/86",
    "value": {
      "zip": "812 50",
      "city": "Bratislava",
      "country": "Slovakia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 48.14816,
        "lon": 17.10674
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/87",
    "value": {
      "zip": "949 01",
      "city": "Nitra",
      "country": "Slovakia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 48.30763,
        "lon": 18.08453
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/88",
    "value": {
      "zip": "917 75",
      "city": "Trnava",
      "country": "Slovakia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 48.37773,
        "lon": 17.58603
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/89",
    "value": {
      "zip": "15006",
      "city": "A Coruña",
      "country": "Spain",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 43.37135,
        "lon": -8.396
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/101",
    "value": {
      "zip": "46023",
      "city": "Ternopil",
      "country": "Ukraine",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 49.55404,
        "lon": 25.59067
      }
    }
  }
]