Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.

[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2008-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2009-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2008-04-29"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2008-04-30"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct",
    "value": {
      "date": "2009-04",
      "type": "ESTIMATED"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty",
    "value": {
      "oldNameTitle": "Francisco Sapunar - Medical Science Director",
      "oldOrganization": "AstraZeneca"
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/13/city",
    "value": "Brasschaat"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/13/geoPoint/lat",
    "value": 51.2912
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/13/geoPoint/lon",
    "value": 4.49182
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "city": "Brussels (anderlecht)",
      "country": "Belgium",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 50.85045,
        "lon": 4.34878
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "city": "Brussels (jette)",
      "country": "Belgium",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 50.85045,
        "lon": 4.34878
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/19"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/21/city",
    "value": "Londrina"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/21/geoPoint/lat",
    "value": -23.31028
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/21/geoPoint/lon",
    "value": -51.16278
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21/state",
    "value": "Paraná"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/22/city",
    "value": "Recife"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/22/geoPoint/lat",
    "value": -8.05389
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/22/geoPoint/lon",
    "value": -34.88111
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22/state",
    "value": "Pernambuco"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/city",
    "value": "Porto Alegre"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lat",
    "value": -30.03283
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lon",
    "value": -51.23019
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/23/state",
    "value": "Rio Grande do Sul"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/24/city",
    "value": "Barretos"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/24/geoPoint/lat",
    "value": -20.55722
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/24/geoPoint/lon",
    "value": -48.56778
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/24/state",
    "value": "São Paulo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/25/city",
    "value": "São Paulo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/25/geoPoint/lat",
    "value": -23.5475
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/25/geoPoint/lon",
    "value": -46.63611
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/25/state",
    "value": "São Paulo"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/27"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/29",
    "value": {
      "city": "Cali",
      "state": "Valle del Cauca Department",
      "country": "Colombia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 3.43054,
        "lon": -76.5199
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/31/city",
    "value": "V Uvalu 84"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/31/country",
    "value": "Czechia"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/31/geoPoint"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/31/state",
    "value": "PRAHA 5"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/39/city",
    "value": "Hyderabad"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/39/geoPoint/lat",
    "value": 17.38405
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/39/geoPoint/lon",
    "value": 78.45636
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/39/state",
    "value": "ANDH PRAD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/40/city",
    "value": "Bhopal"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/40/state",
    "value": "MADH PRAD"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/40/geoPoint",
    "value": {
      "lat": 23.25469,
      "lon": 77.40289
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/city",
    "value": "Ansārinagar"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/geoPoint/lat",
    "value": 28.5666
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/geoPoint/lon",
    "value": 77.21422
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/41/state",
    "value": "NEW Dehli"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/42",
    "value": {
      "city": "Jaipur",
      "state": "Rajasthan",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 26.91962,
        "lon": 75.78781
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/43",
    "value": {
      "city": "MARG Jaipur",
      "state": "Rajasthan",
      "country": "India",
      "facility": "Research Site"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/44",
    "value": {
      "city": "Vellore",
      "state": "Tamil Nadu",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 12.9184,
        "lon": 79.13255
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/45",
    "value": {
      "city": "India",
      "country": "India",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 23.01533,
        "lon": 75.36261
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/47/city",
    "value": "Kolkata"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/47/geoPoint/lat",
    "value": 22.56263
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/47/geoPoint/lon",
    "value": 88.36304
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/49/city",
    "value": "Bergamo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/49/country",
    "value": "Italy"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/49/geoPoint/lat",
    "value": 45.69601
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/49/geoPoint/lon",
    "value": 9.66721
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/49/state",
    "value": "BG"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/city",
    "value": "Carpi"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/geoPoint/lat",
    "value": 44.78237
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/geoPoint/lon",
    "value": 10.8777
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/50/state",
    "value": "MO"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/51/city",
    "value": "Aviano"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/51/geoPoint/lat",
    "value": 46.07056
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/51/geoPoint/lon",
    "value": 12.59472
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/51/state",
    "value": "PN"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/52/city",
    "value": "Prato"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/52/geoPoint/lat",
    "value": 43.8805
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/52/geoPoint/lon",
    "value": 11.09699
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/52/state",
    "value": "PRATO"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/53/city",
    "value": "Reggio Emilia"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/53/geoPoint/lat",
    "value": 44.69825
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/53/geoPoint/lon",
    "value": 10.63125
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/53/state",
    "value": "RE"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/54/city",
    "value": "Varese"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/54/geoPoint/lat",
    "value": 45.82058
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/54/geoPoint/lon",
    "value": 8.82511
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/54/state",
    "value": "VA"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/55/city",
    "value": "Floriana"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/55/country",
    "value": "Malta"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/55/geoPoint/lat",
    "value": 35.89583
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/55/geoPoint/lon",
    "value": 14.50833
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/city",
    "value": "Mexico City"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/country",
    "value": "Mexico"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/geoPoint/lat",
    "value": 19.42847
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/geoPoint/lon",
    "value": -99.12766
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/56/state",
    "value": "Mexico City"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/57/city",
    "value": "Biaystok"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/57/country",
    "value": "Poland"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/57/geoPoint"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/58/city",
    "value": "Lodz"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/58/country",
    "value": "Poland"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/58/geoPoint/lat",
    "value": 51.77058
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/58/geoPoint/lon",
    "value": 19.47395
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/59/city",
    "value": "Późna"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/59/country",
    "value": "Poland"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/59/geoPoint/lat",
    "value": 51.84442
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/59/geoPoint/lon",
    "value": 14.61868
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/60",
    "value": {
      "city": "Obninsk",
      "state": "Kaluga Oblast",
      "country": "Russia",
      "facility": "Research Site",
      "geoPoint": {
        "lat": 55.10993,
        "lon": 36.61238
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/62/city",
    "value": "Kazan, Tatarstan"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/62/geoPoint"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/63"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/66"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/70/city",
    "value": "Málaga"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/70/country",
    "value": "Spain"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/70/geoPoint/lat",
    "value": 36.72016
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/70/geoPoint/lon",
    "value": -4.42034
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/70/state",
    "value": "Andalusia"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/71/city",
    "value": "Seville"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/71/country",
    "value": "Spain"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/71/geoPoint/lat",
    "value": 37.38283
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/71/geoPoint/lon",
    "value": -5.97317
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/71/state",
    "value": "Andalusia"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/72/city",
    "value": "Salamanca"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/72/country",
    "value": "Spain"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/72/geoPoint/lat",
    "value": 40.96882
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/72/geoPoint/lon",
    "value": -5.66388
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/72/state",
    "value": "Castille and León"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/73/state",
    "value": "Galicia"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/74/state",
    "value": "Madrid"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/75/city",
    "value": "Oviedo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/75/geoPoint/lat",
    "value": 43.36029
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/75/geoPoint/lon",
    "value": -5.84476
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/75/state",
    "value": "Principality of Asturias"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/76"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/76"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/76"
  }
]