Back to trial

NCT00490139

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Version 110 to 111 · Novartis Pharmaceuticals

Patch inspector

Version 110 to 111

71 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:01:50+00
Raw hash
71f1f496a89ec26109a9239733dc007ef7bbd1fceb80ddd81feeca2a71d45960
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 68 ops
add /protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
After
info@clinicaltrialsforgsk.com
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "94538",
  "city": "Fremont",
  "state": "California",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.54827,
    "lon": -121.98857
  }
}
remove /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 6
Before
{
  "zip": "94538",
  "city": "Fremont",
  "state": "California",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.54827,
    "lon": -121.98857
  }
}
add /protocolSection/contactsLocationsModule/locations/34
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "94588",
  "city": "Pleasanton",
  "state": "California",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.66243,
    "lon": -121.87468
  }
}
remove /protocolSection/contactsLocationsModule/locations/36
Triage: Uncategorized
Uncategorized Operation 8
Before
{
  "zip": "94588",
  "city": "Pleasanton",
  "state": "California",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.66243,
    "lon": -121.87468
  }
}
add /protocolSection/contactsLocationsModule/locations/47
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "80218",
  "city": "Denver",
  "state": "Colorado",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.73915,
    "lon": -104.9847
  }
}
remove /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 10
Before
{
  "zip": "80218",
  "city": "Denver",
  "state": "Colorado",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.73915,
    "lon": -104.9847
  }
}
add /protocolSection/contactsLocationsModule/locations/80
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "33805",
  "city": "Lakeland",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 28.03947,
    "lon": -81.9498
  }
}
remove /protocolSection/contactsLocationsModule/locations/82
Triage: Uncategorized
Uncategorized Operation 12
Before
{
  "zip": "33805",
  "city": "Lakeland",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 28.03947,
    "lon": -81.9498
  }
}
add /protocolSection/contactsLocationsModule/locations/120
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "60611",
  "city": "Chicago",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.85003,
    "lon": -87.65005
  }
}
remove /protocolSection/contactsLocationsModule/locations/122
Triage: Uncategorized
Uncategorized Operation 14
Before
{
  "zip": "60611",
  "city": "Chicago",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.85003,
    "lon": -87.65005
  }
}
add /protocolSection/contactsLocationsModule/locations/146
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "61350",
  "city": "Ottawa",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.34559,
    "lon": -88.84258
  }
}
remove /protocolSection/contactsLocationsModule/locations/148
Triage: Uncategorized
Uncategorized Operation 16
Before
{
  "zip": "61350",
  "city": "Ottawa",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.34559,
    "lon": -88.84258
  }
}
add /protocolSection/contactsLocationsModule/locations/156
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "61354",
  "city": "Peru",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.32753,
    "lon": -89.12897
  }
}
remove /protocolSection/contactsLocationsModule/locations/158
Triage: Uncategorized
Uncategorized Operation 18
Before
{
  "zip": "61354",
  "city": "Peru",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.32753,
    "lon": -89.12897
  }
}
add /protocolSection/contactsLocationsModule/locations/169
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "46202",
  "city": "Indianapolis",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
remove /protocolSection/contactsLocationsModule/locations/171
Triage: Uncategorized
Uncategorized Operation 20
Before
{
  "zip": "46202",
  "city": "Indianapolis",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
add /protocolSection/contactsLocationsModule/locations/177
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "46601",
  "city": "South Bend",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.68338,
    "lon": -86.25001
  }
}
remove /protocolSection/contactsLocationsModule/locations/179
Triage: Uncategorized
Uncategorized Operation 22
Before
{
  "zip": "46601",
  "city": "South Bend",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.68338,
    "lon": -86.25001
  }
}
add /protocolSection/contactsLocationsModule/locations/181
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "52722",
  "city": "Bettendorf",
  "state": "Iowa",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.52448,
    "lon": -90.51569
  }
}
remove /protocolSection/contactsLocationsModule/locations/183
Triage: Uncategorized
Uncategorized Operation 24
Before
{
  "zip": "52722",
  "city": "Bettendorf",
  "state": "Iowa",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.52448,
    "lon": -90.51569
  }
}
add /protocolSection/contactsLocationsModule/locations/268
Triage: Uncategorized
Uncategorized Operation 25
After
{
  "zip": "49007",
  "city": "Kalamazoo",
  "state": "Michigan",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 42.29171,
    "lon": -85.58723
  }
}
remove /protocolSection/contactsLocationsModule/locations/270
Triage: Uncategorized
Uncategorized Operation 26
Before
{
  "zip": "49007",
  "city": "Kalamazoo",
  "state": "Michigan",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 42.29171,
    "lon": -85.58723
  }
}
add /protocolSection/contactsLocationsModule/locations/285
Triage: Uncategorized
Uncategorized Operation 27
After
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
remove /protocolSection/contactsLocationsModule/locations/287
Triage: Uncategorized
Uncategorized Operation 28
Before
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
add /protocolSection/contactsLocationsModule/locations/299
Triage: Uncategorized
Uncategorized Operation 29
After
{
  "zip": "56303",
  "city": "Saint Cloud",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 45.5608,
    "lon": -94.16249
  }
}
replace /protocolSection/contactsLocationsModule/locations/301/status
Triage: Uncategorized
Uncategorized Operation 30
Before
RECRUITING
After
NOT_YET_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/301/city
Triage: Uncategorized
Uncategorized Operation 31
Before
Saint Cloud
After
Saint Louis Park
replace /protocolSection/contactsLocationsModule/locations/301/zip
Triage: Uncategorized
Uncategorized Operation 32
Before
56303
After
55416
replace /protocolSection/contactsLocationsModule/locations/301/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 33
Before
45.5608
After
44.9483
replace /protocolSection/contactsLocationsModule/locations/301/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 34
Before
-94.16249
After
-93.34801
remove /protocolSection/contactsLocationsModule/locations/303
Triage: Uncategorized
Uncategorized Operation 35
Before
{
  "zip": "55416",
  "city": "Saint Louis Park",
  "state": "Minnesota",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.9483,
    "lon": -93.34801
  }
}
add /protocolSection/contactsLocationsModule/locations/304
Triage: Uncategorized
Uncategorized Operation 36
After
{
  "zip": "55102",
  "city": "Saint Paul",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.94441,
    "lon": -93.09327
  }
}
remove /protocolSection/contactsLocationsModule/locations/306
Triage: Uncategorized
Uncategorized Operation 37
Before
{
  "zip": "55102",
  "city": "Saint Paul",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.94441,
    "lon": -93.09327
  }
}
add /protocolSection/contactsLocationsModule/locations/335
Triage: Uncategorized
Uncategorized Operation 38
After
{
  "zip": "63141",
  "city": "St Louis",
  "state": "Missouri",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
remove /protocolSection/contactsLocationsModule/locations/337
Triage: Uncategorized
Uncategorized Operation 39
Before
{
  "zip": "63141",
  "city": "St Louis",
  "state": "Missouri",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
add /protocolSection/contactsLocationsModule/locations/341
Triage: Uncategorized
Uncategorized Operation 40
After
{
  "zip": "59405",
  "city": "Great Falls",
  "state": "Montana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 47.50024,
    "lon": -111.30081
  }
}
remove /protocolSection/contactsLocationsModule/locations/343
Triage: Uncategorized
Uncategorized Operation 41
Before
{
  "zip": "59405",
  "city": "Great Falls",
  "state": "Montana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 47.50024,
    "lon": -111.30081
  }
}
add /protocolSection/contactsLocationsModule/locations/355
Triage: Uncategorized
Uncategorized Operation 42
After
{
  "zip": "68131",
  "city": "Omaha",
  "state": "Nebraska",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.25626,
    "lon": -95.94043
  }
}
remove /protocolSection/contactsLocationsModule/locations/357
Triage: Uncategorized
Uncategorized Operation 43
Before
{
  "zip": "68131",
  "city": "Omaha",
  "state": "Nebraska",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.25626,
    "lon": -95.94043
  }
}
add /protocolSection/contactsLocationsModule/locations/374
Triage: Uncategorized
Uncategorized Operation 44
After
{
  "zip": "08901",
  "city": "New Brunswick",
  "state": "New Jersey",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 40.48622,
    "lon": -74.45182
  }
}
remove /protocolSection/contactsLocationsModule/locations/376
Triage: Uncategorized
Uncategorized Operation 45
Before
{
  "zip": "08901",
  "city": "New Brunswick",
  "state": "New Jersey",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 40.48622,
    "lon": -74.45182
  }
}
add /protocolSection/contactsLocationsModule/locations/384
Triage: Uncategorized
Uncategorized Operation 46
After
{
  "zip": "87106",
  "city": "Albuquerque",
  "state": "New Mexico",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 35.08449,
    "lon": -106.65114
  }
}
remove /protocolSection/contactsLocationsModule/locations/386
Triage: Uncategorized
Uncategorized Operation 47
Before
{
  "zip": "87106",
  "city": "Albuquerque",
  "state": "New Mexico",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 35.08449,
    "lon": -106.65114
  }
}
add /protocolSection/contactsLocationsModule/locations/396
Triage: Uncategorized
Uncategorized Operation 48
After
{
  "zip": "11030",
  "city": "Manhasset",
  "state": "New York",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 40.79788,
    "lon": -73.69957
  }
}
remove /protocolSection/contactsLocationsModule/locations/398
Triage: Uncategorized
Uncategorized Operation 49
Before
{
  "zip": "11030",
  "city": "Manhasset",
  "state": "New York",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 40.79788,
    "lon": -73.69957
  }
}
add /protocolSection/contactsLocationsModule/locations/427
Triage: Uncategorized
Uncategorized Operation 50
After
{
  "zip": "58122",
  "city": "Fargo",
  "state": "North Dakota",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.87719,
    "lon": -96.7898
  }
}
remove /protocolSection/contactsLocationsModule/locations/429
Triage: Uncategorized
Uncategorized Operation 51
Before
{
  "zip": "58122",
  "city": "Fargo",
  "state": "North Dakota",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.87719,
    "lon": -96.7898
  }
}
remove /protocolSection/contactsLocationsModule/locations/460
Triage: Uncategorized
Uncategorized Operation 52
Before
{
  "zip": "43537",
  "city": "Maumee",
  "state": "Ohio",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.56283,
    "lon": -83.65382
  }
}
remove /protocolSection/contactsLocationsModule/locations/460
Triage: Uncategorized
Uncategorized Operation 53
Before
{
  "zip": "43623",
  "city": "Maumee",
  "state": "Ohio",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.56283,
    "lon": -83.65382
  }
}
remove /protocolSection/contactsLocationsModule/locations/464
Triage: Uncategorized
Uncategorized Operation 54
Before
{
  "zip": "43616",
  "city": "Oregon",
  "state": "Ohio",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.64366,
    "lon": -83.48688
  }
}
add /protocolSection/contactsLocationsModule/locations/467
Triage: Uncategorized
Uncategorized Operation 55
After
{
  "zip": "43560",
  "city": "Sylvania",
  "state": "Ohio",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.71894,
    "lon": -83.71299
  }
}
remove /protocolSection/contactsLocationsModule/locations/469
Triage: Uncategorized
Uncategorized Operation 56
Before
{
  "zip": "44883",
  "city": "Tiffin",
  "state": "Ohio",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.1145,
    "lon": -83.17797
  }
}
remove /protocolSection/contactsLocationsModule/locations/472
Triage: Uncategorized
Uncategorized Operation 57
Before
{
  "zip": "43617",
  "city": "Toledo",
  "state": "Ohio",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.66394,
    "lon": -83.55521
  }
}
remove /protocolSection/contactsLocationsModule/locations/473
Triage: Uncategorized
Uncategorized Operation 58
Before
{
  "zip": "43623",
  "city": "Toledo",
  "state": "Ohio",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.66394,
    "lon": -83.55521
  }
}
add /protocolSection/contactsLocationsModule/locations/481
Triage: Uncategorized
Uncategorized Operation 59
After
{
  "zip": "73112",
  "city": "Oklahoma City",
  "state": "Oklahoma",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 35.46756,
    "lon": -97.51643
  }
}
add /protocolSection/contactsLocationsModule/locations/493
Triage: Uncategorized
Uncategorized Operation 60
After
{
  "zip": "97227",
  "city": "Portland",
  "state": "Oregon",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
remove /protocolSection/contactsLocationsModule/locations/495
Triage: Uncategorized
Uncategorized Operation 61
Before
{
  "zip": "97227",
  "city": "Portland",
  "state": "Oregon",
  "status": "COMPLETED",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 45.52345,
    "lon": -122.67621
  }
}
add /protocolSection/contactsLocationsModule/locations/542
Triage: Uncategorized
Uncategorized Operation 62
After
{
  "zip": "38301",
  "city": "Jackson",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 35.61452,
    "lon": -88.81395
  }
}
remove /protocolSection/contactsLocationsModule/locations/544
Triage: Uncategorized
Uncategorized Operation 63
Before
{
  "zip": "38301",
  "city": "Jackson",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 35.61452,
    "lon": -88.81395
  }
}
add /protocolSection/contactsLocationsModule/locations/598
Triage: Uncategorized
Uncategorized Operation 64
After
{
  "zip": "98122",
  "city": "Seattle",
  "state": "Washington",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 47.60621,
    "lon": -122.33207
  }
}
remove /protocolSection/contactsLocationsModule/locations/600
Triage: Uncategorized
Uncategorized Operation 65
Before
{
  "zip": "98122",
  "city": "Seattle",
  "state": "Washington",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 47.60621,
    "lon": -122.33207
  }
}
add /protocolSection/contactsLocationsModule/locations/617
Triage: Uncategorized
Uncategorized Operation 66
After
{
  "zip": "54702",
  "city": "Eau Claire",
  "state": "Wisconsin",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.81135,
    "lon": -91.49849
  }
}
remove /protocolSection/contactsLocationsModule/locations/619
Triage: Uncategorized
Uncategorized Operation 67
Before
{
  "zip": "54702",
  "city": "Eau Claire",
  "state": "Wisconsin",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "US GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "877-379-3718"
    },
    {
      "name": "EU GSK Clinical Trials Call Center",
      "role": "CONTACT",
      "email": "info@clinicaltrialsforgsk.com",
      "phone": "0800 007 5189"
    }
  ],
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.81135,
    "lon": -91.49849
  }
}
add /protocolSection/contactsLocationsModule/locations/1166
Triage: Uncategorized
Uncategorized Operation 68
After
{
  "zip": "022328",
  "city": "Bucharest",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Romania",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.43225,
    "lon": 26.10626
  }
}
remove /protocolSection/contactsLocationsModule/locations/1168
Triage: Uncategorized
Uncategorized Operation 69
Before
{
  "zip": "022328",
  "city": "Bucharest",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Romania",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 44.43225,
    "lon": 26.10626
  }
}
add /protocolSection/contactsLocationsModule/locations/1265
Triage: Uncategorized
Uncategorized Operation 70
After
{
  "zip": "10400",
  "city": "Bangkok",
  "status": "COMPLETED",
  "country": "Thailand",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 13.75398,
    "lon": 100.50144
  }
}
remove /protocolSection/contactsLocationsModule/locations/1267
Triage: Uncategorized
Uncategorized Operation 71
Before
{
  "zip": "10400",
  "city": "Bangkok",
  "status": "COMPLETED",
  "country": "Thailand",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 13.75398,
    "lon": 100.50144
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2011-01-13
After
2011-01-22
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2011-01-17
After
2011-01-25
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
remove /protocolSection/identificationModule/secondaryIdInfos
Triage: Uncategorized
Uncategorized Operation 1
Before
[
  {
    "id": "BIG 2-06/N063D/MAC13"
  }
]
Raw JSON Patch 
[
  {
    "op": "remove",
    "path": "/protocolSection/identificationModule/secondaryIdInfos"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2011-01-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2011-01-25"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/email",
    "value": "info@clinicaltrialsforgsk.com"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "zip": "94538",
      "city": "Fremont",
      "state": "California",
      "status": "COMPLETED",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.54827,
        "lon": -121.98857
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/16"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/34",
    "value": {
      "zip": "94588",
      "city": "Pleasanton",
      "state": "California",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.66243,
        "lon": -121.87468
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/36"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/47",
    "value": {
      "zip": "80218",
      "city": "Denver",
      "state": "Colorado",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 39.73915,
        "lon": -104.9847
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/49"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/80",
    "value": {
      "zip": "33805",
      "city": "Lakeland",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 28.03947,
        "lon": -81.9498
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/82"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/120",
    "value": {
      "zip": "60611",
      "city": "Chicago",
      "state": "Illinois",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.85003,
        "lon": -87.65005
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/122"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/146",
    "value": {
      "zip": "61350",
      "city": "Ottawa",
      "state": "Illinois",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.34559,
        "lon": -88.84258
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/148"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/156",
    "value": {
      "zip": "61354",
      "city": "Peru",
      "state": "Illinois",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.32753,
        "lon": -89.12897
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/158"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/169",
    "value": {
      "zip": "46202",
      "city": "Indianapolis",
      "state": "Indiana",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 39.76838,
        "lon": -86.15804
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/171"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/177",
    "value": {
      "zip": "46601",
      "city": "South Bend",
      "state": "Indiana",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.68338,
        "lon": -86.25001
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/179"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/181",
    "value": {
      "zip": "52722",
      "city": "Bettendorf",
      "state": "Iowa",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.52448,
        "lon": -90.51569
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/183"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/268",
    "value": {
      "zip": "49007",
      "city": "Kalamazoo",
      "state": "Michigan",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 42.29171,
        "lon": -85.58723
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/270"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/285",
    "value": {
      "zip": "55805",
      "city": "Duluth",
      "state": "Minnesota",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 46.78327,
        "lon": -92.10658
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/287"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/299",
    "value": {
      "zip": "56303",
      "city": "Saint Cloud",
      "state": "Minnesota",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 45.5608,
        "lon": -94.16249
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/301/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/301/city",
    "value": "Saint Louis Park"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/301/zip",
    "value": "55416"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/301/geoPoint/lat",
    "value": 44.9483
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/301/geoPoint/lon",
    "value": -93.34801
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/303"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/304",
    "value": {
      "zip": "55102",
      "city": "Saint Paul",
      "state": "Minnesota",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 44.94441,
        "lon": -93.09327
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/306"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/335",
    "value": {
      "zip": "63141",
      "city": "St Louis",
      "state": "Missouri",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 38.62727,
        "lon": -90.19789
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/337"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/341",
    "value": {
      "zip": "59405",
      "city": "Great Falls",
      "state": "Montana",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 47.50024,
        "lon": -111.30081
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/343"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/355",
    "value": {
      "zip": "68131",
      "city": "Omaha",
      "state": "Nebraska",
      "status": "COMPLETED",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.25626,
        "lon": -95.94043
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/357"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/374",
    "value": {
      "zip": "08901",
      "city": "New Brunswick",
      "state": "New Jersey",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 40.48622,
        "lon": -74.45182
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/376"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/384",
    "value": {
      "zip": "87106",
      "city": "Albuquerque",
      "state": "New Mexico",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 35.08449,
        "lon": -106.65114
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/386"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/396",
    "value": {
      "zip": "11030",
      "city": "Manhasset",
      "state": "New York",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 40.79788,
        "lon": -73.69957
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/398"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/427",
    "value": {
      "zip": "58122",
      "city": "Fargo",
      "state": "North Dakota",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 46.87719,
        "lon": -96.7898
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/429"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/460"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/460"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/464"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/467",
    "value": {
      "zip": "43560",
      "city": "Sylvania",
      "state": "Ohio",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.71894,
        "lon": -83.71299
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/469"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/472"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/473"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/481",
    "value": {
      "zip": "73112",
      "city": "Oklahoma City",
      "state": "Oklahoma",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 35.46756,
        "lon": -97.51643
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/493",
    "value": {
      "zip": "97227",
      "city": "Portland",
      "state": "Oregon",
      "status": "COMPLETED",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 45.52345,
        "lon": -122.67621
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/495"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/542",
    "value": {
      "zip": "38301",
      "city": "Jackson",
      "state": "Tennessee",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 35.61452,
        "lon": -88.81395
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/544"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/598",
    "value": {
      "zip": "98122",
      "city": "Seattle",
      "state": "Washington",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 47.60621,
        "lon": -122.33207
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/600"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/617",
    "value": {
      "zip": "54702",
      "city": "Eau Claire",
      "state": "Wisconsin",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "US GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "877-379-3718"
        },
        {
          "name": "EU GSK Clinical Trials Call Center",
          "role": "CONTACT",
          "email": "info@clinicaltrialsforgsk.com",
          "phone": "0800 007 5189"
        }
      ],
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 44.81135,
        "lon": -91.49849
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/619"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1166",
    "value": {
      "zip": "022328",
      "city": "Bucharest",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "Romania",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 44.43225,
        "lon": 26.10626
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1168"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1265",
    "value": {
      "zip": "10400",
      "city": "Bangkok",
      "status": "COMPLETED",
      "country": "Thailand",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 13.75398,
        "lon": 100.50144
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1267"
  }
]