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NCT00490139

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Version 144 to 145 · Novartis Pharmaceuticals

Patch inspector

Version 144 to 145

23 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:02:09+00
Raw hash
87120f8ff5c732d54d779f86dd00bf96e817daaf1f1ef36e0272d99b9d451ef4
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
remove /protocolSection/armsInterventionsModule/armGroups/2/interventionNames/0
Triage: High
Arm Intervention Change Operation 3
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Lapatinib
remove /protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/1
Triage: High
Arm Intervention Change Operation 4
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Arm 3: Trastuzumab followed by Lapatinib
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 19 ops
replace /protocolSection/contactsLocationsModule/locations/556/city
Triage: Uncategorized
Uncategorized Operation 5
Before
Hamm-heessen
After
Hamm-Heessen
replace /protocolSection/contactsLocationsModule/locations/598/city
Triage: Uncategorized
Uncategorized Operation 6
Before
Henstedt-ulzburg
After
Henstedt-Ulzburg
replace /protocolSection/contactsLocationsModule/locations/661/city
Triage: Uncategorized
Uncategorized Operation 7
Before
Carpi (mo)
After
Carpi (MO)
replace /protocolSection/contactsLocationsModule/locations/662/city
Triage: Uncategorized
Uncategorized Operation 8
Before
Meldola (fc)
After
Meldola (FC)
replace /protocolSection/contactsLocationsModule/locations/665/city
Triage: Uncategorized
Uncategorized Operation 9
Before
Aviano (pn)
After
Aviano (PN)
replace /protocolSection/contactsLocationsModule/locations/680/city
Triage: Uncategorized
Uncategorized Operation 10
Before
Rozzano (mi)
After
Rozzano (MI)
replace /protocolSection/contactsLocationsModule/locations/681/city
Triage: Uncategorized
Uncategorized Operation 11
Before
Saronno (va)
After
Saronno (VA)
replace /protocolSection/contactsLocationsModule/locations/682/city
Triage: Uncategorized
Uncategorized Operation 12
Before
Treviglio (bg)
After
Treviglio (BG)
replace /protocolSection/contactsLocationsModule/locations/686/city
Triage: Uncategorized
Uncategorized Operation 13
Before
Candiolo (to)
After
Candiolo (TO)
replace /protocolSection/contactsLocationsModule/locations/687/city
Triage: Uncategorized
Uncategorized Operation 14
Before
Monserrato (ca)
After
Monserrato (CA)
replace /protocolSection/contactsLocationsModule/locations/690/city
Triage: Uncategorized
Uncategorized Operation 15
Before
Fano (pesaro Urbino)
After
Fano (Pesaro Urbino)
replace /protocolSection/contactsLocationsModule/locations/691/city
Triage: Uncategorized
Uncategorized Operation 16
Before
Fermo (ap)
After
Fermo (AP)
replace /protocolSection/contactsLocationsModule/locations/694/city
Triage: Uncategorized
Uncategorized Operation 17
Before
Lido Di Camaiore (lu)
After
Lido Di Camaiore (LU)
replace /protocolSection/contactsLocationsModule/locations/696/city
Triage: Uncategorized
Uncategorized Operation 18
Before
Poggibonsi (siena)
After
Poggibonsi (Siena)
replace /protocolSection/contactsLocationsModule/locations/718/city
Triage: Uncategorized
Uncategorized Operation 19
Before
México D.f.
After
México D.F.
replace /protocolSection/contactsLocationsModule/locations/812/city
Triage: Uncategorized
Uncategorized Operation 20
Before
Alcoy/alicante
After
Alcoy/Alicante
replace /protocolSection/contactsLocationsModule/locations/813/city
Triage: Uncategorized
Uncategorized Operation 21
Before
Barakaldo (vizcaya)
After
Barakaldo (Vizcaya)
replace /protocolSection/contactsLocationsModule/locations/821/city
Triage: Uncategorized
Uncategorized Operation 22
Before
Hospitalet de Llobregat (barcelona)
After
Hospitalet de Llobregat (Barcelona)
replace /protocolSection/contactsLocationsModule/locations/822/city
Triage: Uncategorized
Uncategorized Operation 23
Before
La Laguna (santa Cruz de Tenerife)
After
La Laguna (Santa Cruz de Tenerife)
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2012-03-15
After
2012-03-22
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2012-03-19
After
2012-03-26
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2012-03-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2012-03-26"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/armGroups/2/interventionNames/0"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/1"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/556/city",
    "value": "Hamm-Heessen"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/598/city",
    "value": "Henstedt-Ulzburg"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/661/city",
    "value": "Carpi (MO)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/662/city",
    "value": "Meldola (FC)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/665/city",
    "value": "Aviano (PN)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/680/city",
    "value": "Rozzano (MI)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/681/city",
    "value": "Saronno (VA)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/682/city",
    "value": "Treviglio (BG)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/686/city",
    "value": "Candiolo (TO)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/687/city",
    "value": "Monserrato (CA)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/690/city",
    "value": "Fano (Pesaro Urbino)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/691/city",
    "value": "Fermo (AP)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/694/city",
    "value": "Lido Di Camaiore (LU)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/696/city",
    "value": "Poggibonsi (Siena)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/718/city",
    "value": "México D.F."
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/812/city",
    "value": "Alcoy/Alicante"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/813/city",
    "value": "Barakaldo (Vizcaya)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/821/city",
    "value": "Hospitalet de Llobregat (Barcelona)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/822/city",
    "value": "La Laguna (Santa Cruz de Tenerife)"
  }
]