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NCT00490139

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Version 197 to 198 · Novartis Pharmaceuticals

Patch inspector

Version 197 to 198

17 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_count_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:02:35+00
Raw hash
bce53c4361b013f7143fd6aa23eaf317e6c55bdba3dfa8aca6240f3967ab1f69
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 5
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
8385
After
8381
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 12 ops
add /protocolSection/contactsLocationsModule/locations/145
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "61615-7822",
  "city": "Peoria",
  "state": "Illinois",
  "country": "United States",
  "facility": "Novartis Investigative Site",
  "geoPoint": {
    "lat": 40.69365,
    "lon": -89.58899
  }
}
remove /protocolSection/contactsLocationsModule/locations/604
Triage: Uncategorized
Uncategorized Operation 7
Before
{
  "zip": "54915",
  "city": "Appleton",
  "state": "Wisconsin",
  "country": "United States",
  "facility": "Novartis Investigative Site",
  "geoPoint": {
    "lat": 44.26193,
    "lon": -88.41538
  }
}
replace /protocolSection/contactsLocationsModule/locations/811/zip
Triage: Uncategorized
Uncategorized Operation 8
Before
69009
After
69337
replace /protocolSection/contactsLocationsModule/locations/844/zip
Triage: Uncategorized
Uncategorized Operation 9
Before
59300
After
59322
replace /protocolSection/contactsLocationsModule/locations/1276/zip
Triage: Uncategorized
Uncategorized Operation 10
Before
410-769
After
10408
replace /protocolSection/contactsLocationsModule/locations/1278/zip
Triage: Uncategorized
Uncategorized Operation 11
Before
110-774
After
003722
replace /protocolSection/contactsLocationsModule/locations/1279/zip
Triage: Uncategorized
Uncategorized Operation 12
Before
120-752
After
03080
replace /protocolSection/contactsLocationsModule/locations/1280/zip
Triage: Uncategorized
Uncategorized Operation 13
Before
135-710
After
06351
replace /protocolSection/contactsLocationsModule/locations/1363/city
Triage: Uncategorized
Uncategorized Operation 14
Before
Bristol
After
Nottingham
replace /protocolSection/contactsLocationsModule/locations/1363/zip
Triage: Uncategorized
Uncategorized Operation 15
Before
BS2 8ED
After
NG5 1PB
replace /protocolSection/contactsLocationsModule/locations/1363/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 16
Before
51.45523
After
52.9536
replace /protocolSection/contactsLocationsModule/locations/1363/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 17
Before
-2.59665
After
-1.15047
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2018-10
After
2019-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2018-10-04
After
2019-05-14
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2018-11-01
After
2019-05-21
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
add /protocolSection/identificationModule/secondaryIdInfos
Triage: Uncategorized
Uncategorized Operation 1
After
[
  {
    "id": "CLAP016B2301",
    "type": "OTHER",
    "domain": "Novartis"
  }
]
Raw JSON Patch 
[
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos",
    "value": [
      {
        "id": "CLAP016B2301",
        "type": "OTHER",
        "domain": "Novartis"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2019-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2019-05-14"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2019-05-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 8381
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/145",
    "value": {
      "zip": "61615-7822",
      "city": "Peoria",
      "state": "Illinois",
      "country": "United States",
      "facility": "Novartis Investigative Site",
      "geoPoint": {
        "lat": 40.69365,
        "lon": -89.58899
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/604"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/811/zip",
    "value": "69337"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/844/zip",
    "value": "59322"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1276/zip",
    "value": "10408"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1278/zip",
    "value": "003722"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1279/zip",
    "value": "03080"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1280/zip",
    "value": "06351"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1363/city",
    "value": "Nottingham"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1363/zip",
    "value": "NG5 1PB"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1363/geoPoint/lat",
    "value": 52.9536
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1363/geoPoint/lon",
    "value": -1.15047
  }
]