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NCT00490139

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Version 27 to 28 · Novartis Pharmaceuticals

Patch inspector

Version 27 to 28

65 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_earlier_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "earlier",
    "new_value": "2010-06",
    "old_value": "2012-06",
    "delta_days": 731,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_earlier_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "earlier",
    "new_value": "2010-06",
    "old_value": "2012-06",
    "delta_days": 731,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:01:06+00
Raw hash
85cbc0f263d9df5430d3f373d7bfaa191fbd0677dfb8e2a534c03a99f5605b53
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 1
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2012-06
After
2010-06
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2012-06
After
2010-06
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 61 ops
add /protocolSection/contactsLocationsModule/locations/10
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "92354",
  "city": "Loma Linda",
  "state": "California",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Thomas Godfrey",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 34.04835,
    "lon": -117.26115
  }
}
add /protocolSection/contactsLocationsModule/locations/40
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "33805",
  "city": "Lakeland",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Madhavi Venigalla",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 28.03947,
    "lon": -81.9498
  }
}
add /protocolSection/contactsLocationsModule/locations/55
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "60201",
  "city": "Evanston",
  "state": "Illinois",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Douglas Merkel",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 42.04114,
    "lon": -87.69006
  }
}
add /protocolSection/contactsLocationsModule/locations/120
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "21204",
  "city": "Towson",
  "state": "Maryland",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Rima Couzi",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 39.4015,
    "lon": -76.60191
  }
}
add /protocolSection/contactsLocationsModule/locations/164
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "63109",
  "city": "St Louis",
  "state": "Missouri",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Bethany Sleckman",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
add /protocolSection/contactsLocationsModule/locations/184
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "03833",
  "city": "Exeter",
  "state": "New Hampshire",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Danny Sims",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 42.98148,
    "lon": -70.94783
  }
}
add /protocolSection/contactsLocationsModule/locations/186
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "03246",
  "city": "Laconia",
  "state": "New Hampshire",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Charles Catcher",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 43.52785,
    "lon": -71.47035
  }
}
add /protocolSection/contactsLocationsModule/locations/198
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "27599",
  "city": "Chapel Hill",
  "state": "North Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Lisa Carey",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 35.9132,
    "lon": -79.05584
  }
}
add /protocolSection/contactsLocationsModule/locations/200
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "27534",
  "city": "Goldsboro",
  "state": "North Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "James Atkins",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 35.38488,
    "lon": -77.99277
  }
}
add /protocolSection/contactsLocationsModule/locations/203
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "27889",
  "city": "Washington",
  "state": "North Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Jennie Crews",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 35.54655,
    "lon": -77.05217
  }
}
add /protocolSection/contactsLocationsModule/locations/244
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "73104",
  "city": "Oklahoma City",
  "state": "Oklahoma",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Howard Ozer",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 35.46756,
    "lon": -97.51643
  }
}
add /protocolSection/contactsLocationsModule/locations/245
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "73120",
  "city": "Oklahoma City",
  "state": "Oklahoma",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Howard Ozer",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 35.46756,
    "lon": -97.51643
  }
}
add /protocolSection/contactsLocationsModule/locations/258
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "17822-2001",
  "city": "Danville",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Albert Bernath",
      "role": "CONTACT",
      "phone": "877-379-3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Center",
  "geoPoint": {
    "lat": 40.96342,
    "lon": -76.61273
  }
}
replace /protocolSection/contactsLocationsModule/locations/309/status
Triage: Uncategorized
Uncategorized Operation 18
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/327/status
Triage: Uncategorized
Uncategorized Operation 19
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/336/status
Triage: Uncategorized
Uncategorized Operation 20
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/341/status
Triage: Uncategorized
Uncategorized Operation 21
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/423
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "12808",
  "city": "Prague",
  "status": "RECRUITING",
  "country": "Czechia",
  "contacts": [
    {
      "name": "G C",
      "role": "CONTACT",
      "phone": "1"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 50.08804,
    "lon": 14.42076
  }
}
add /protocolSection/contactsLocationsModule/locations/424
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "12808",
  "city": "Prague",
  "status": "RECRUITING",
  "country": "Czechia",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 50.08804,
    "lon": 14.42076
  }
}
add /protocolSection/contactsLocationsModule/locations/440
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "11619",
  "city": "Tallinn",
  "status": "RECRUITING",
  "country": "Estonia",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 59.43696,
    "lon": 24.75353
  }
}
replace /protocolSection/contactsLocationsModule/locations/450/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
After
TERMINATED
remove /protocolSection/contactsLocationsModule/locations/450/contacts
Triage: Uncategorized
Uncategorized Operation 26
Before
[
  {
    "name": "GSK Clinical Trials Call Centre",
    "role": "CONTACT",
    "phone": "1 877 379 3718"
  }
]
replace /protocolSection/contactsLocationsModule/locations/451/status
Triage: Uncategorized
Uncategorized Operation 27
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/468/status
Triage: Uncategorized
Uncategorized Operation 28
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/469/status
Triage: Uncategorized
Uncategorized Operation 29
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/470/status
Triage: Uncategorized
Uncategorized Operation 30
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/519
Triage: Uncategorized
Uncategorized Operation 31
After
{
  "zip": "14197",
  "city": "Berlin",
  "status": "RECRUITING",
  "country": "Germany",
  "contacts": [
    {
      "name": "GSK Clinical Trials C",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 52.52437,
    "lon": 13.41053
  }
}
replace /protocolSection/contactsLocationsModule/locations/544/status
Triage: Uncategorized
Uncategorized Operation 32
Before
RECRUITING
After
NOT_YET_RECRUITING
add /protocolSection/contactsLocationsModule/locations/569
Triage: Uncategorized
Uncategorized Operation 33
After
{
  "zip": "15517",
  "city": "Fürstenwalde",
  "status": "RECRUITING",
  "country": "Germany",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 52.36067,
    "lon": 14.06185
  }
}
add /protocolSection/contactsLocationsModule/locations/606
Triage: Uncategorized
Uncategorized Operation 34
After
{
  "zip": "07743",
  "city": "Jena",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Germany",
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 50.92878,
    "lon": 11.5899
  }
}
replace /protocolSection/contactsLocationsModule/locations/614/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/614/contacts
Triage: Uncategorized
Uncategorized Operation 36
Before
[
  {
    "name": "GSK Clinical Trials Call Centre",
    "role": "CONTACT",
    "phone": "1 877 379 3718"
  }
]
add /protocolSection/contactsLocationsModule/locations/620
Triage: Uncategorized
Uncategorized Operation 37
After
{
  "zip": "04129",
  "city": "Leipzig",
  "status": "RECRUITING",
  "country": "Germany",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 51.33962,
    "lon": 12.37129
  }
}
add /protocolSection/contactsLocationsModule/locations/727
Triage: Uncategorized
Uncategorized Operation 38
After
{
  "zip": "151 23",
  "city": "Athens",
  "status": "RECRUITING",
  "country": "Greece",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 37.98376,
    "lon": 23.72784
  }
}
replace /protocolSection/contactsLocationsModule/locations/737/status
Triage: Uncategorized
Uncategorized Operation 39
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/737/contacts
Triage: Uncategorized
Uncategorized Operation 40
After
[
  {
    "name": "GSK Clinical Trials Call Centre",
    "role": "CONTACT",
    "phone": "1 877 379 3718"
  }
]
replace /protocolSection/contactsLocationsModule/locations/739/status
Triage: Uncategorized
Uncategorized Operation 41
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/789/status
Triage: Uncategorized
Uncategorized Operation 42
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/816
Triage: Uncategorized
Uncategorized Operation 43
After
{
  "zip": "09042",
  "city": "Monserrato (CA)",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 39.25642,
    "lon": 9.1444
  }
}
replace /protocolSection/contactsLocationsModule/locations/840/status
Triage: Uncategorized
Uncategorized Operation 44
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/859/status
Triage: Uncategorized
Uncategorized Operation 45
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/875/status
Triage: Uncategorized
Uncategorized Operation 46
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/876/status
Triage: Uncategorized
Uncategorized Operation 47
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/908
Triage: Uncategorized
Uncategorized Operation 48
After
{
  "zip": "0407",
  "city": "Oslo",
  "status": "RECRUITING",
  "country": "Norway",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "G",
  "geoPoint": {
    "lat": 59.91273,
    "lon": 10.74609
  }
}
add /protocolSection/contactsLocationsModule/locations/932
Triage: Uncategorized
Uncategorized Operation 49
After
{
  "zip": "10-699",
  "city": "Olsztyn",
  "status": "NOT_YET_RECRUITING",
  "country": "Poland",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 53.78376,
    "lon": 20.49272
  }
}
replace /protocolSection/contactsLocationsModule/locations/940/status
Triage: Uncategorized
Uncategorized Operation 50
Before
NOT_YET_RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/940/contacts
Triage: Uncategorized
Uncategorized Operation 51
Before
[
  {
    "name": "GSK Clinical Trials Call Centre",
    "role": "CONTACT",
    "phone": "1 877 379 3718"
  }
]
remove /protocolSection/contactsLocationsModule/locations/945
Triage: Uncategorized
Uncategorized Operation 52
Before
{
  "zip": "022328",
  "city": "Bucharest",
  "status": "NOT_YET_RECRUITING",
  "country": "Romania",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 44.43225,
    "lon": 26.10626
  }
}
replace /protocolSection/contactsLocationsModule/locations/1001/status
Triage: Uncategorized
Uncategorized Operation 53
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1002/status
Triage: Uncategorized
Uncategorized Operation 54
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1003/status
Triage: Uncategorized
Uncategorized Operation 55
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1005/status
Triage: Uncategorized
Uncategorized Operation 56
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1008/status
Triage: Uncategorized
Uncategorized Operation 57
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1011/status
Triage: Uncategorized
Uncategorized Operation 58
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1024/status
Triage: Uncategorized
Uncategorized Operation 59
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1031/status
Triage: Uncategorized
Uncategorized Operation 60
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1032/status
Triage: Uncategorized
Uncategorized Operation 61
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/1037
Triage: Uncategorized
Uncategorized Operation 62
After
{
  "zip": "15705",
  "city": "Santiago",
  "status": "RECRUITING",
  "country": "Spain",
  "contacts": [
    {
      "name": "GSK Clinical Trials Call Centre",
      "role": "CONTACT",
      "phone": "1 877 379 3718"
    }
  ],
  "facility": "GSK Clinical Trials Call Centre",
  "geoPoint": {
    "lat": 37.9358,
    "lon": -4.13866
  }
}
replace /protocolSection/contactsLocationsModule/locations/1044/status
Triage: Uncategorized
Uncategorized Operation 63
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1069/status
Triage: Uncategorized
Uncategorized Operation 64
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/1088/status
Triage: Uncategorized
Uncategorized Operation 65
Before
NOT_YET_RECRUITING
After
RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2008-07-03
After
2008-07-15
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2008-07-04
After
2008-07-16
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2010-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2010-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2008-07-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2008-07-16"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/10",
    "value": {
      "zip": "92354",
      "city": "Loma Linda",
      "state": "California",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Thomas Godfrey",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 34.04835,
        "lon": -117.26115
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/40",
    "value": {
      "zip": "33805",
      "city": "Lakeland",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Madhavi Venigalla",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 28.03947,
        "lon": -81.9498
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/55",
    "value": {
      "zip": "60201",
      "city": "Evanston",
      "state": "Illinois",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Douglas Merkel",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 42.04114,
        "lon": -87.69006
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/120",
    "value": {
      "zip": "21204",
      "city": "Towson",
      "state": "Maryland",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Rima Couzi",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 39.4015,
        "lon": -76.60191
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/164",
    "value": {
      "zip": "63109",
      "city": "St Louis",
      "state": "Missouri",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Bethany Sleckman",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 38.62727,
        "lon": -90.19789
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/184",
    "value": {
      "zip": "03833",
      "city": "Exeter",
      "state": "New Hampshire",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Danny Sims",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 42.98148,
        "lon": -70.94783
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/186",
    "value": {
      "zip": "03246",
      "city": "Laconia",
      "state": "New Hampshire",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Charles Catcher",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 43.52785,
        "lon": -71.47035
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/198",
    "value": {
      "zip": "27599",
      "city": "Chapel Hill",
      "state": "North Carolina",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Lisa Carey",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 35.9132,
        "lon": -79.05584
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/200",
    "value": {
      "zip": "27534",
      "city": "Goldsboro",
      "state": "North Carolina",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "James Atkins",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 35.38488,
        "lon": -77.99277
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/203",
    "value": {
      "zip": "27889",
      "city": "Washington",
      "state": "North Carolina",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Jennie Crews",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 35.54655,
        "lon": -77.05217
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/244",
    "value": {
      "zip": "73104",
      "city": "Oklahoma City",
      "state": "Oklahoma",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Howard Ozer",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 35.46756,
        "lon": -97.51643
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/245",
    "value": {
      "zip": "73120",
      "city": "Oklahoma City",
      "state": "Oklahoma",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Howard Ozer",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 35.46756,
        "lon": -97.51643
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/258",
    "value": {
      "zip": "17822-2001",
      "city": "Danville",
      "state": "Pennsylvania",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Albert Bernath",
          "role": "CONTACT",
          "phone": "877-379-3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Center",
      "geoPoint": {
        "lat": 40.96342,
        "lon": -76.61273
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/309/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/327/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/336/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/341/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/423",
    "value": {
      "zip": "12808",
      "city": "Prague",
      "status": "RECRUITING",
      "country": "Czechia",
      "contacts": [
        {
          "name": "G C",
          "role": "CONTACT",
          "phone": "1"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 50.08804,
        "lon": 14.42076
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/424",
    "value": {
      "zip": "12808",
      "city": "Prague",
      "status": "RECRUITING",
      "country": "Czechia",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 50.08804,
        "lon": 14.42076
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/440",
    "value": {
      "zip": "11619",
      "city": "Tallinn",
      "status": "RECRUITING",
      "country": "Estonia",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 59.43696,
        "lon": 24.75353
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/450/status",
    "value": "TERMINATED"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/450/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/451/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/468/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/469/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/470/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/519",
    "value": {
      "zip": "14197",
      "city": "Berlin",
      "status": "RECRUITING",
      "country": "Germany",
      "contacts": [
        {
          "name": "GSK Clinical Trials C",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 52.52437,
        "lon": 13.41053
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/544/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/569",
    "value": {
      "zip": "15517",
      "city": "Fürstenwalde",
      "status": "RECRUITING",
      "country": "Germany",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 52.36067,
        "lon": 14.06185
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/606",
    "value": {
      "zip": "07743",
      "city": "Jena",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "Germany",
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 50.92878,
        "lon": 11.5899
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/614/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/614/contacts"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/620",
    "value": {
      "zip": "04129",
      "city": "Leipzig",
      "status": "RECRUITING",
      "country": "Germany",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 51.33962,
        "lon": 12.37129
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/727",
    "value": {
      "zip": "151 23",
      "city": "Athens",
      "status": "RECRUITING",
      "country": "Greece",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 37.98376,
        "lon": 23.72784
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/737/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/737/contacts",
    "value": [
      {
        "name": "GSK Clinical Trials Call Centre",
        "role": "CONTACT",
        "phone": "1 877 379 3718"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/739/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/789/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/816",
    "value": {
      "zip": "09042",
      "city": "Monserrato (CA)",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 39.25642,
        "lon": 9.1444
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/840/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/859/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/875/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/876/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/908",
    "value": {
      "zip": "0407",
      "city": "Oslo",
      "status": "RECRUITING",
      "country": "Norway",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "G",
      "geoPoint": {
        "lat": 59.91273,
        "lon": 10.74609
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/932",
    "value": {
      "zip": "10-699",
      "city": "Olsztyn",
      "status": "NOT_YET_RECRUITING",
      "country": "Poland",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 53.78376,
        "lon": 20.49272
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/940/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/940/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/945"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1001/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1002/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1003/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1005/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1008/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1011/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1024/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1031/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1032/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1037",
    "value": {
      "zip": "15705",
      "city": "Santiago",
      "status": "RECRUITING",
      "country": "Spain",
      "contacts": [
        {
          "name": "GSK Clinical Trials Call Centre",
          "role": "CONTACT",
          "phone": "1 877 379 3718"
        }
      ],
      "facility": "GSK Clinical Trials Call Centre",
      "geoPoint": {
        "lat": 37.9358,
        "lon": -4.13866
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1044/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1069/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1088/status",
    "value": "RECRUITING"
  }
]