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NCT00490139

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Version 61 to 62 · Novartis Pharmaceuticals

Patch inspector

Version 61 to 62

19 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2013-01",
    "old_value": "2010-06",
    "delta_days": 945,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2013-05",
    "old_value": "2010-06",
    "delta_days": 1065,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:01:24+00
Raw hash
e78951fad6d8a4942fad0920524008be3bf6dfd9826133cab1d460c9a797667e
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 1
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2010-06
After
2013-01
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2010-06
After
2013-05
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 15 ops
add /protocolSection/contactsLocationsModule/locations/25
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "94588",
  "city": "Pleasanton",
  "state": "California",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.66243,
    "lon": -121.87468
  }
}
remove /protocolSection/contactsLocationsModule/locations/27
Triage: Uncategorized
Uncategorized Operation 6
Before
{
  "zip": "94588",
  "city": "Pleasanton",
  "state": "California",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.66243,
    "lon": -121.87468
  }
}
add /protocolSection/contactsLocationsModule/locations/39
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "80218",
  "city": "Denver",
  "state": "Colorado",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.73915,
    "lon": -104.9847
  }
}
remove /protocolSection/contactsLocationsModule/locations/41
Triage: Uncategorized
Uncategorized Operation 8
Before
{
  "zip": "80218",
  "city": "Denver",
  "state": "Colorado",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 39.73915,
    "lon": -104.9847
  }
}
replace /protocolSection/contactsLocationsModule/locations/64/status
Triage: Uncategorized
Uncategorized Operation 9
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/161
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "52722",
  "city": "Bettendorf",
  "state": "Iowa",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.52448,
    "lon": -90.51569
  }
}
remove /protocolSection/contactsLocationsModule/locations/163
Triage: Uncategorized
Uncategorized Operation 11
Before
{
  "zip": "52722",
  "city": "Bettendorf",
  "state": "Iowa",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 41.52448,
    "lon": -90.51569
  }
}
add /protocolSection/contactsLocationsModule/locations/201
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "67214",
  "city": "Wichita",
  "state": "Kansas",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.69224,
    "lon": -97.33754
  }
}
remove /protocolSection/contactsLocationsModule/locations/203
Triage: Uncategorized
Uncategorized Operation 13
Before
{
  "zip": "67214",
  "city": "Wichita",
  "state": "Kansas",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 37.69224,
    "lon": -97.33754
  }
}
add /protocolSection/contactsLocationsModule/locations/256
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
remove /protocolSection/contactsLocationsModule/locations/258
Triage: Uncategorized
Uncategorized Operation 15
Before
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
replace /protocolSection/contactsLocationsModule/locations/315/status
Triage: Uncategorized
Uncategorized Operation 16
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/533
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "54601",
  "city": "La Crosse",
  "state": "Wisconsin",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 43.80136,
    "lon": -91.23958
  }
}
remove /protocolSection/contactsLocationsModule/locations/535
Triage: Uncategorized
Uncategorized Operation 18
Before
{
  "zip": "54601",
  "city": "La Crosse",
  "state": "Wisconsin",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "facility": "GSK Investigational Site",
  "geoPoint": {
    "lat": 43.80136,
    "lon": -91.23958
  }
}
replace /protocolSection/contactsLocationsModule/locations/1256/zip
Triage: Uncategorized
Uncategorized Operation 19
Before
PO3 6AD
After
PO6 3LY
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2009-09-11
After
2009-09-17
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2009-09-14
After
2009-09-21
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2013-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2013-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2009-09-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2009-09-21"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/25",
    "value": {
      "zip": "94588",
      "city": "Pleasanton",
      "state": "California",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.66243,
        "lon": -121.87468
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/27"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/39",
    "value": {
      "zip": "80218",
      "city": "Denver",
      "state": "Colorado",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 39.73915,
        "lon": -104.9847
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/41"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/64/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/161",
    "value": {
      "zip": "52722",
      "city": "Bettendorf",
      "state": "Iowa",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.52448,
        "lon": -90.51569
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/163"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/201",
    "value": {
      "zip": "67214",
      "city": "Wichita",
      "state": "Kansas",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.69224,
        "lon": -97.33754
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/203"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/256",
    "value": {
      "zip": "55805",
      "city": "Duluth",
      "state": "Minnesota",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 46.78327,
        "lon": -92.10658
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/258"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/315/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/533",
    "value": {
      "zip": "54601",
      "city": "La Crosse",
      "state": "Wisconsin",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 43.80136,
        "lon": -91.23958
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/535"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1256/zip",
    "value": "PO6 3LY"
  }
]