ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2010-02-25"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2010-03-01"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/2",
    "value": {
      "type": "EXPERIMENTAL",
      "label": "Arm 3: Trastuzumab followed by Lapatinib",
      "interventionNames": [
        "Biological: Trastuzumab",
        "Drug: Lapatinib"
      ]
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/armGroups/4"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/24",
    "value": {
      "zip": "94040",
      "city": "Mountain View",
      "state": "California",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.38605,
        "lon": -122.08385
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/26"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/32",
    "value": {
      "zip": "94588",
      "city": "Pleasanton",
      "state": "California",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.66243,
        "lon": -121.87468
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/34"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/89",
    "value": {
      "zip": "30342",
      "city": "Atlanta",
      "state": "Georgia",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 33.749,
        "lon": -84.38798
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/91"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/102",
    "value": {
      "zip": "31405",
      "city": "Savannah",
      "state": "Georgia",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 32.08354,
        "lon": -81.09983
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/104"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/177",
    "value": {
      "zip": "52402",
      "city": "Cedar Rapids",
      "state": "Iowa",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 42.00833,
        "lon": -91.64407
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/179"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/181",
    "value": {
      "zip": "50309",
      "city": "Des Moines",
      "state": "Iowa",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 41.60054,
        "lon": -93.60911
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/183"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/216",
    "value": {
      "zip": "67214",
      "city": "Wichita",
      "state": "Kansas",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 37.69224,
        "lon": -97.33754
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/218"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/227",
    "value": {
      "zip": "04074",
      "city": "Scarborough",
      "state": "Maine",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 43.57814,
        "lon": -70.32172
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/229"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/288",
    "value": {
      "zip": "56303",
      "city": "Saint Cloud",
      "state": "Minnesota",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 45.5608,
        "lon": -94.16249
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/290"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/372",
    "value": {
      "zip": "11030",
      "city": "Manhasset",
      "state": "New York",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 40.79788,
        "lon": -73.69957
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/374"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/381",
    "value": {
      "zip": "14623",
      "city": "Rochester",
      "state": "New York",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 43.15478,
        "lon": -77.61556
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/401",
    "value": {
      "zip": "58501",
      "city": "Bismarck",
      "state": "North Dakota",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 46.80833,
        "lon": -100.78374
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/403"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/528/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/566",
    "value": {
      "zip": "98122",
      "city": "Seattle",
      "state": "Washington",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 47.60621,
        "lon": -122.33207
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/568"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/572",
    "value": {
      "zip": "98405",
      "city": "Tacoma",
      "state": "Washington",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 47.25288,
        "lon": -122.44429
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/574"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/595",
    "value": {
      "zip": "53233",
      "city": "Milwaukee",
      "state": "Wisconsin",
      "status": "RECRUITING",
      "country": "United States",
      "facility": "GSK Investigational Site",
      "geoPoint": {
        "lat": 43.0389,
        "lon": -87.90647
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/597"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/653/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/699/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/782/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1038/city",
    "value": "Carpi (MO)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1040/city",
    "value": "Meldola (FC)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1043/city",
    "value": "Aviano (PN)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1050/city",
    "value": "Alzano Lombardo (BG)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1062/city",
    "value": "Rozzano (MI)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1064/city",
    "value": "Treviglio (BG)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1067/city",
    "value": "Candiolo (TO)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1068/city",
    "value": "Monserrato (CA)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1073/city",
    "value": "Fermo (AP)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1077/city",
    "value": "Lido Di Camaiore (LU)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1082/city",
    "value": "Prato (PO)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1086/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1087/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1088/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1089/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1090/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1091/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1092/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1093/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1094/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1095/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1096/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1097/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1098/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1099/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1100/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1108/city",
    "value": "México D.F."
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1124",
    "value": {
      "zip": "6162 BG",
      "city": "Sittard-geleen",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "Netherlands",
      "facility": "GSK Investigational Site"
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1126"
  }
]