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NCT00530868

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Version 20 to 21 · University of Alabama at Birmingham

Patch inspector

Version 20 to 21

10 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2018-01",
    "old_value": "2017-09",
    "delta_days": 122,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_earlier_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2018-08",
    "old_value": "2018-09",
    "delta_days": 31,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:48+00
Raw hash
357871a544cc2f788a79061fce54785d5b12f57345507d4fc0bdacd28f85928b
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2017-09
After
2018-01
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2018-09
After
2018-08
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-12
After
2017-10
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2016-12-28
After
2017-10-26
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2016-12-29
After
2017-10-30
replace /protocolSection/statusModule/lastUpdatePostDateStruct/type
Triage: Uncategorized
Uncategorized Operation 6
Before
ESTIMATED
After
ACTUAL
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 4 ops
replace /protocolSection/sponsorCollaboratorsModule/responsibleParty/type
Triage: Uncategorized
Uncategorized Operation 7
Before
SPONSOR
After
PRINCIPAL_INVESTIGATOR
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName
Triage: Uncategorized
Uncategorized Operation 8
After
Andres Forero
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle
Triage: Uncategorized
Uncategorized Operation 9
After
Professor, Medicine
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorAffiliation
Triage: Uncategorized
Uncategorized Operation 10
After
University of Alabama at Birmingham
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2018-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2018-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-10-26"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-10-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/type",
    "value": "PRINCIPAL_INVESTIGATOR"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName",
    "value": "Andres Forero"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle",
    "value": "Professor, Medicine"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorAffiliation",
    "value": "University of Alabama at Birmingham"
  }
]