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NCT00530868

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Version 24 to 25 · University of Alabama at Birmingham

Patch inspector

Version 24 to 25

8 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "high",
    "direction": "later",
    "new_value": "2021-01",
    "old_value": "2020-01",
    "delta_days": 366,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "high",
    "direction": "later",
    "new_value": "2021-01",
    "old_value": "2020-01",
    "delta_days": 366,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:49+00
Raw hash
d8b3f176109b31ef3a7e99b216599cf8df2b28c57537f24f41b165d570e386f9
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2020-01
After
2021-01
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2020-01
After
2021-01
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops
replace /protocolSection/contactsLocationsModule/overallOfficials/0/name
Triage: Uncategorized
Uncategorized Operation 8
Before
Christos Vaklavas, M.D.
After
Carolina Salvador, M.D.
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2019-02
After
2020-04
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2019-02-26
After
2020-04-15
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2019-02-28
After
2020-04-17
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 2 ops
replace /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName
Triage: Uncategorized
Uncategorized Operation 6
Before
Christos Vaklavas, MD
After
Carolina Salvador
replace /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle
Triage: Uncategorized
Uncategorized Operation 7
Before
Professor, Medicine
After
Assistant Professor, Medicine
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2021-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2021-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-04-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-04-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName",
    "value": "Carolina Salvador"
  },
  {
    "op": "replace",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle",
    "value": "Assistant Professor, Medicine"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/overallOfficials/0/name",
    "value": "Carolina Salvador, M.D."
  }
]