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NCT00530868

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Version 25 to 26 · University of Alabama at Birmingham

Patch inspector

Version 25 to 26

12 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_type_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ACTUAL",
    "old_type": null,
    "severity": "low",
    "direction": "later",
    "new_value": "2007-10-08",
    "old_value": "2007-10",
    "delta_days": 7,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2020-11-06",
    "old_value": "2021-01",
    "delta_days": 56,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2020-11-06",
    "old_value": "2021-01",
    "delta_days": 56,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:49+00
Raw hash
85a7bfb109bff1f21154597109f209894dcf10b1e5595ee8faea972c956fb151
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 11
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Timeline Start, primary completion, and completion date movement. Triage: Medium 6 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2007-10
After
2007-10-08
add /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
After
ACTUAL
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 5
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2021-01
After
2020-11-06
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 6
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 7
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2021-01
After
2020-11-06
replace /protocolSection/statusModule/completionDateStruct/type
Triage: Medium
Timeline Shift Operation 8
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-04
After
2020-11
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 9
Before
2020-04-15
After
2020-11-20
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 10
Before
2020-04-17
After
2020-11-23
add /annotationSection
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2022-01-31",
          "type": "RELEASE"
        },
        {
          "date": "2022-02-24",
          "type": "RESET"
        },
        {
          "date": "2022-04-29",
          "type": "RELEASE"
        },
        {
          "date": "2022-05-24",
          "type": "RESET"
        },
        {
          "date": "2022-06-30",
          "type": "RELEASE"
        },
        {
          "date": "2022-07-25",
          "type": "RESET"
        },
        {
          "date": "2022-08-04",
          "type": "RELEASE"
        },
        {
          "date": "2022-08-29",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "Lisle Nabell, Professor, Med-Hematology & Oncology, University of Alabama at Birmingham"
    }
  }
}
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2007-10-08"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2020-11-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2020-11-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-11-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-11-23"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "add",
    "path": "/annotationSection",
    "value": {
      "annotationModule": {
        "unpostedAnnotation": {
          "unpostedEvents": [
            {
              "date": "2022-01-31",
              "type": "RELEASE"
            },
            {
              "date": "2022-02-24",
              "type": "RESET"
            },
            {
              "date": "2022-04-29",
              "type": "RELEASE"
            },
            {
              "date": "2022-05-24",
              "type": "RESET"
            },
            {
              "date": "2022-06-30",
              "type": "RELEASE"
            },
            {
              "date": "2022-07-25",
              "type": "RESET"
            },
            {
              "date": "2022-08-04",
              "type": "RELEASE"
            },
            {
              "date": "2022-08-29",
              "type": "RESET"
            }
          ],
          "unpostedResponsibleParty": "Lisle Nabell, Professor, Med-Hematology & Oncology, University of Alabama at Birmingham"
        }
      }
    }
  }
]