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NCT00530868

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Version 26 to 27 · University of Alabama at Birmingham

Patch inspector

Version 26 to 27

22 operations 7 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "later",
    "new_value": "2022-03-01",
    "old_value": "2020-11-06",
    "delta_days": 480,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "later",
    "new_value": "2022-03-31",
    "old_value": "2020-11-06",
    "delta_days": 510,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "paths": [
      "/protocolSection/outcomesModule/primaryOutcomes/0/description",
      "/protocolSection/outcomesModule/primaryOutcomes/0/measure",
      "/protocolSection/outcomesModule/secondaryOutcomes/0/description",
      "/protocolSection/outcomesModule/secondaryOutcomes/0/measure"
    ],
    "signal": "results_reconciliation_outcome_suppression",
    "category": "results_reconciliation",
    "severity": "low"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:50+00
Raw hash
1a65655914acea12ebf116238890772099aa6fbacbdbb6c1484e688ef95482d7
Payload
Source URL
Primary outcomes Outcome measures that define the trial's primary evidence target. Triage: Critical 2 ops
replace /protocolSection/outcomesModule/primaryOutcomes/0/measure
Triage: Critical
Primary Outcome Change Operation 13
Matched rules
  • primary_outcome_any_change Any add/remove/replace under primary outcome measures is critical review priority.
Before
Pathological complete response is defined as no evidence of residual invasive tumor in the breast or axillary lymph nodes or only residual ductal carcinoma in-situ.
After
The Percentage of Participants With Pathologic Complete Response
add /protocolSection/outcomesModule/primaryOutcomes/0/description
Triage: Critical
Primary Outcome Change Operation 14
Matched rules
  • primary_outcome_any_change Any add/remove/replace under primary outcome measures is critical review priority.
After
Pathological complete response is defined as the absence of residual invasive tumor in the breast or axillary lymph nodes or if only residual ductal carcinoma in-situ was seen on review of the surgical specimen.
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
add /protocolSection/armsInterventionsModule/armGroups/0/description
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
50 evaluable patients received the combination therapy of 2.5 gm daily oral Letrozole and Avastin 15 mg/kg IV every 3 weeks for 24 weeks.
add /protocolSection/armsInterventionsModule/armGroups/1/description
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
25 evaluable patients received daily oral 2.5 mg letrozole as a single agent
Secondary outcomes Additional endpoints and outcome descriptions. Triage: High 2 ops
replace /protocolSection/outcomesModule/secondaryOutcomes/0/measure
Triage: High
Secondary Outcome Change Operation 15
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
Clinical objective response; tolerability and toxicity; biomarkers for prognostic value.
After
Letrozole +Avastin
add /protocolSection/outcomesModule/secondaryOutcomes/0/description
Triage: High
Secondary Outcome Change Operation 16
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
Radiographic objective response to the therapy are reported.
Radiographic response was assessed using RECIST criteria by ultrasound or breast MRI through the study and are reported as complete radiographic response below.
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2020-11-06
After
2022-03-01
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2020-11-06
After
2022-03-31
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops
replace /protocolSection/contactsLocationsModule/overallOfficials/0/name
Triage: Uncategorized
Uncategorized Operation 17
Before
Carolina Salvador, M.D.
After
Lisle Nabell, M.D.
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 10 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-11
After
2022-09
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-11-20
After
2022-09-23
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-11-23
After
2022-10-21
add /protocolSection/statusModule/resultsFirstSubmitDate
Triage: Uncategorized
Uncategorized Operation 6
After
2022-01-31
add /protocolSection/statusModule/resultsFirstSubmitQcDate
Triage: Uncategorized
Uncategorized Operation 7
After
2022-09-23
add /protocolSection/statusModule/resultsFirstPostDateStruct
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "date": "2022-10-21",
  "type": "ACTUAL"
}
remove /annotationSection
Triage: Uncategorized
Uncategorized Operation 19
Before
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2022-01-31",
          "type": "RELEASE"
        },
        {
          "date": "2022-02-24",
          "type": "RESET"
        },
        {
          "date": "2022-04-29",
          "type": "RELEASE"
        },
        {
          "date": "2022-05-24",
          "type": "RESET"
        },
        {
          "date": "2022-06-30",
          "type": "RELEASE"
        },
        {
          "date": "2022-07-25",
          "type": "RESET"
        },
        {
          "date": "2022-08-04",
          "type": "RELEASE"
        },
        {
          "date": "2022-08-29",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "Lisle Nabell, Professor, Med-Hematology & Oncology, University of Alabama at Birmingham"
    }
  }
}
replace /hasResults
Triage: Uncategorized
Uncategorized Operation 20
Before
false
After
true
add /resultsSection
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "moreInfoModule": {
    "pointOfContact": {
      "email": "Lnabell@uabmc.edu",
      "phone": "205 934-3061",
      "title": "Lisle Nabell",
      "organization": "UAB"
    },
    "certainAgreement": {
      "piSponsorEmployee": false,
      "restrictiveAgreement": false
    }
  },
  "adverseEventsModule": {
    "timeFrame": "24 weeks of active treatment",
    "eventGroups": [
      {
        "id": "EG000",
        "title": "Letrozole + Avastin",
        "description": "<p>Letrozole; Avastin: Letrozole 2.5 mg PO a day and Avastin 15 mg&#x2F;kg IV every 3 weeks.</p><p>Adverse events typically associated with letrozole (hot flashes, arthralgias, fatigue, myalgias) occurred in similar frequencies in the two arms.\nHypertension, headache, and proteinuria were seen exclusively in the Let&#x2F;Bev arm.</p>",
        "otherNumAtRisk": 50,
        "deathsNumAtRisk": 50,
        "otherNumAffected": 2,
        "seriousNumAtRisk": 50,
        "deathsNumAffected": 0,
        "seriousNumAffected": 2
      },
      {
        "id": "EG001",
        "title": "Letrozole Alone",
        "description": "Letrozole (Femara): Letrozole 2.5 mg PO a day for 24 weeks Adverse events typically associated with letrozole (hot flashes, arthralgias, fatigue, myalgias) occurred in similar frequencies in the two arms.\nHypertension, headache, and proteinuria were seen exclusively in the Let&#x2F;Bev arm.",
        "otherNumAtRisk": 25,
        "deathsNumAtRisk": 25,
        "otherNumAffected": 0,
        "seriousNumAtRisk": 25,
        "deathsNumAffected": 0,
        "seriousNumAffected": 0
      }
    ],
    "otherEvents": [
      {
        "term": "Headache",
        "notes": "Headache",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 50,
            "numEvents": 4,
            "numAffected": 2
          },
          {
            "groupId": "EG001",
            "numAtRisk": 25,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Nervous system disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "other"
      }
    ],
    "seriousEvents": [
      {
        "term": "Proteinuria",
        "notes": "proteinuria 4%",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 50,
            "numAffected": 2
          },
          {
            "groupId": "EG001",
            "numAtRisk": 25,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Renal and urinary disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "other"
      }
    ],
    "frequencyThreshold": "2"
  },
  "outcomeMeasuresModule": {
    "outcomeMeasures": [
      {
        "type": "PRIMARY",
        "title": "The Percentage of Participants With Pathologic Complete Response",
        "denoms": [
          {
            "units": "Participants",
            "counts": [
              {
                "value": "50",
                "groupId": "OG000"
              },
              {
                "value": "25",
                "groupId": "OG001"
              }
            ]
          }
        ],
        "groups": [
          {
            "id": "OG000",
            "title": "Letrozole + Avastin",
            "description": "Letrozole; Avastin: Letrozole 2.5 mg PO a day and Avastin 15 mg&#x2F;kg IV every 3 weeks"
          },
          {
            "id": "OG001",
            "title": "Letrozole Alone",
            "description": "Letrozole (Femara): Letrozole 2.5 mg PO a day for 24 weeks"
          }
        ],
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "11",
                    "groupId": "OG000",
                    "lowerLimit": "3.7",
                    "upperLimit": "24.1"
                  },
                  {
                    "value": "0",
                    "groupId": "OG001",
                    "lowerLimit": "0",
                    "upperLimit": "14.2"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "NUMBER",
        "timeFrame": "24 weeks",
        "description": "Pathological complete response is defined as the absence of residual invasive tumor in the breast or axillary lymph nodes or if only residual ductal carcinoma in-situ was seen on review of the surgical specimen.",
        "unitOfMeasure": "percentage of participants",
        "dispersionType": "95% Confidence Interval",
        "reportingStatus": "POSTED",
        "populationDescription": "Patients with postmenopausal hormone receptor positive breast cancer T2-4,N0-2 and M0 were randomized 2:1 to receive letrozole 2.5 mg PO daily and bevacizumab 15 mg&#x2F;kg IV for 24 weeks or daily treatment with letrozole 2.5 mg PO alone (control arm).\nThe duration of each cycle was 3 weeks for a total of 24 weeks.\nThe pCR was defined as the absence of any residual invasive cancer in the resected breast specimen and lymph nodes.\nData below is representative of the raw data."
      },
      {
        "type": "SECONDARY",
        "title": "Letrozole +Avastin",
        "denoms": [
          {
            "units": "Participants",
            "counts": [
              {
                "value": "50",
                "groupId": "OG000"
              },
              {
                "value": "25",
                "groupId": "OG001"
              }
            ]
          }
        ],
        "groups": [
          {
            "id": "OG000",
            "title": "Letrozole + Avastin",
            "description": "<p>50 evaluable patients received the combination therapy of 2.5 gm daily oral Letrozole and Avastin 15 mg&#x2F;kg IV every 3 weeks for 24 weeks.</p><p>Letrozole; Avastin: Letrozole 2.5 mg PO a day and Avastin 15 mg&#x2F;kg IV every 3 weeks</p>"
          },
          {
            "id": "OG001",
            "title": "Letrozole Alone",
            "description": "<p>25 evaluable patients received daily oral 2.5 mg letrozole as a single agent</p><p>Letrozole (Femara): Letrozole 2.5 mg PO a day for 24 weeks</p>"
          }
        ],
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "10",
                    "groupId": "OG000",
                    "lowerLimit": "3.4",
                    "upperLimit": "22"
                  },
                  {
                    "value": "4",
                    "groupId": "OG001",
                    "lowerLimit": "0",
                    "upperLimit": "20.4"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "NUMBER",
        "timeFrame": "24 weeks",
        "description": "Radiographic objective response to the therapy are reported.\nRadiographic response was assessed using RECIST criteria by ultrasound or breast MRI through the study and are reported as complete radiographic response below.",
        "unitOfMeasure": "participants",
        "dispersionType": "95% Confidence Interval",
        "reportingStatus": "POSTED",
        "populationDescription": "This was a single arm study to test the feasibility of Letrozole with Avastin in the neoadjuvant setting."
      }
    ]
  },
  "participantFlowModule": {
    "groups": [
      {
        "id": "FG000",
        "title": "Letrozole + Avastin",
        "description": "Letrozole; Avastin: Letrozole 2.5 mg PO a day and Avastin 15 mg&#x2F;kg IV every 3 weeks"
      },
      {
        "id": "FG001",
        "title": "Letrozole Alone",
        "description": "Letrozole (Femara): Letrozole 2.5 mg PO a day for 24 weeks"
      }
    ],
    "periods": [
      {
        "title": "Overall Study",
        "milestones": [
          {
            "type": "STARTED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "50"
              },
              {
                "groupId": "FG001",
                "numSubjects": "25"
              }
            ]
          },
          {
            "type": "COMPLETED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "50"
              },
              {
                "groupId": "FG001",
                "numSubjects": "25"
              }
            ]
          },
          {
            "type": "NOT COMPLETED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "0"
              },
              {
                "groupId": "FG001",
                "numSubjects": "0"
              }
            ]
          }
        ]
      }
    ]
  },
  "baselineCharacteristicsModule": {
    "denoms": [
      {
        "units": "Participants",
        "counts": [
          {
            "value": "50",
            "groupId": "BG000"
          },
          {
            "value": "25",
            "groupId": "BG001"
          },
          {
            "value": "75",
            "groupId": "BG002"
          }
        ]
      }
    ],
    "groups": [
      {
        "id": "BG000",
        "title": "Letrozole + Avastin",
        "description": "Letrozole; Avastin: Letrozole 2.5 mg PO a day and Avastin 15 mg&#x2F;kg IV every 3 weeks"
      },
      {
        "id": "BG001",
        "title": "Letrozole Alone",
        "description": "Letrozole (Femara): Letrozole 2.5 mg PO a day for 24 weeks"
      },
      {
        "id": "BG002",
        "title": "Total",
        "description": "Total of all reporting groups"
      }
    ],
    "measures": [
      {
        "title": "Age, Categorical",
        "classes": [
          {
            "categories": [
              {
                "title": "&lt;=18 years",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Between 18 and 65 years",
                "measurements": [
                  {
                    "value": "50",
                    "groupId": "BG000"
                  },
                  {
                    "value": "25",
                    "groupId": "BG001"
                  },
                  {
                    "value": "75",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "&gt;=65 years",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Age, Continuous",
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "58",
                    "spread": "0.5",
                    "groupId": "BG000"
                  },
                  {
                    "value": "58",
                    "spread": "0.5",
                    "groupId": "BG001"
                  },
                  {
                    "value": "58",
                    "spread": "0.5",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "MEDIAN",
        "unitOfMeasure": "years",
        "dispersionType": "STANDARD_DEVIATION"
      },
      {
        "title": "Sex: Female, Male",
        "classes": [
          {
            "categories": [
              {
                "title": "Female",
                "measurements": [
                  {
                    "value": "50",
                    "groupId": "BG000"
                  },
                  {
                    "value": "25",
                    "groupId": "BG001"
                  },
                  {
                    "value": "75",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Male",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Race (NIH&#x2F;OMB)",
        "classes": [
          {
            "categories": [
              {
                "title": "American Indian or Alaska Native",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Asian",
                "measurements": [
                  {
                    "value": "1",
                    "groupId": "BG000"
                  },
                  {
                    "value": "1",
                    "groupId": "BG001"
                  },
                  {
                    "value": "2",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Native Hawaiian or Other Pacific Islander",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Black or African American",
                "measurements": [
                  {
                    "value": "7",
                    "groupId": "BG000"
                  },
                  {
                    "value": "3",
                    "groupId": "BG001"
                  },
                  {
                    "value": "10",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "White",
                "measurements": [
                  {
                    "value": "40",
                    "groupId": "BG000"
                  },
                  {
                    "value": "20",
                    "groupId": "BG001"
                  },
                  {
                    "value": "60",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "More than one race",
                "measurements": [
                  {
                    "value": "2",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "2",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Unknown or Not Reported",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "1",
                    "groupId": "BG001"
                  },
                  {
                    "value": "1",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Region of Enrollment",
        "classes": [
          {
            "title": "United States",
            "categories": [
              {
                "measurements": [
                  {
                    "value": "50",
                    "groupId": "BG000"
                  },
                  {
                    "value": "25",
                    "groupId": "BG001"
                  },
                  {
                    "value": "75",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Study Participant",
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "50",
                    "groupId": "BG000"
                  },
                  {
                    "value": "25",
                    "groupId": "BG001"
                  },
                  {
                    "value": "75",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      }
    ],
    "populationDescription": "Postmenopausal women with newly diagnosed stage 2 or 3 estrogen and&#x2F;or progesterone receptor-positive, HER2-negative breast cancer were randomly assigned (2:1) between letrozole 2.5 mg PO daily plus bevacizumab 15 mg&#x2F; kg IV every 3 weeks (Let&#x2F;Bev) and letrozole 2.5 mg PO daily (Let) for 24 weeks prior to definitive surgery."
  }
}
add /documentSection
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "largeDocumentModule": {
    "largeDocs": [
      {
        "date": "2011-03-14",
        "size": 556643,
        "label": "Study Protocol and Statistical Analysis Plan",
        "hasIcf": false,
        "hasSap": true,
        "filename": "Prot_SAP_000.pdf",
        "typeAbbrev": "Prot_SAP",
        "uploadDate": "2022-01-20T14:32",
        "hasProtocol": true
      }
    ]
  }
}
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 3 ops
replace /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName
Triage: Uncategorized
Uncategorized Operation 9
Before
Carolina Salvador
After
Lisle Nabell
replace /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle
Triage: Uncategorized
Uncategorized Operation 10
Before
Assistant Professor, Medicine
After
Professor, Med-Hematology &amp; Oncology
add /protocolSection/referencesModule
Triage: Uncategorized
Uncategorized Operation 18
After
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      "comment": "Bevacizumab and Letrozole"
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Raw JSON Patch
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