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NCT00691678

Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer

Version 4 to 5 · Dawn L. Hershman

Patch inspector

Version 4 to 5

17 operations 5 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_changeenrollment_type_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "later",
    "new_value": "2012-07",
    "old_value": "2011-01",
    "delta_days": 547,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2012-07",
    "old_value": "2012-01",
    "delta_days": 182,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:38+00
Raw hash
d5c4d871d21322eb9bf93deea9b97f6165b9eab35c7973496e25aecd5d9f9199
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 3 ops
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 15
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Dietary Supplement: Glucosamine Chondroitin
After
Drug: Glucosamine Chondroitin
replace /protocolSection/armsInterventionsModule/interventions/0/type
Triage: High
Arm Intervention Change Operation 17
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
DIETARY_SUPPLEMENT
After
DRUG
Timeline Start, primary completion, and completion date movement. Triage: Medium 3 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2011-01
After
2012-07
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2012-01
After
2012-07
replace /protocolSection/statusModule/completionDateStruct/type
Triage: Medium
Timeline Shift Operation 5
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2011-07
After
2013-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 6
Before
2011-07-20
After
2013-02-19
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 7
Before
2011-07-21
After
2013-02-20
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 7 ops
remove /protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle
Triage: Uncategorized
Uncategorized Operation 8
Before
Dawn Hershman
remove /protocolSection/sponsorCollaboratorsModule/responsibleParty/oldOrganization
Triage: Uncategorized
Uncategorized Operation 9
Before
Columbia University
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/type
Triage: Uncategorized
Uncategorized Operation 10
After
SPONSOR_INVESTIGATOR
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName
Triage: Uncategorized
Uncategorized Operation 11
After
Dawn L. Hershman
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle
Triage: Uncategorized
Uncategorized Operation 12
After
Associate Professor of Medicine & Epidemiology
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorAffiliation
Triage: Uncategorized
Uncategorized Operation 13
After
Columbia University
replace /protocolSection/sponsorCollaboratorsModule/leadSponsor/name
Triage: Uncategorized
Uncategorized Operation 14
Before
Columbia University
After
Dawn L. Hershman
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2013-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2012-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2012-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2013-02-19"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2013-02-20"
  },
  {
    "op": "remove",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle"
  },
  {
    "op": "remove",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldOrganization"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/type",
    "value": "SPONSOR_INVESTIGATOR"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName",
    "value": "Dawn L. Hershman"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle",
    "value": "Associate Professor of Medicine & Epidemiology"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorAffiliation",
    "value": "Columbia University"
  },
  {
    "op": "replace",
    "path": "/protocolSection/sponsorCollaboratorsModule/leadSponsor/name",
    "value": "Dawn L. Hershman"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0",
    "value": "Drug: Glucosamine Chondroitin"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/type",
    "value": "DRUG"
  }
]