Back to trial

NCT00769379

Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy

Version 1591 to 1592 · National Cancer Institute (NCI)

Patch inspector

Version 1591 to 1592

38 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:56:54+00
Raw hash
589aaffe2fadea55a8cde2b2622f1f33faadf3bb17b1f93282bf9370d4358c04
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
remove /protocolSection/armsInterventionsModule/interventions/1/otherNames/28
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Trastuzumab Biosimilar GB221
add /protocolSection/armsInterventionsModule/interventions/1/otherNames/31
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Trastuzumab Biosimilar SIBP-01
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 32 ops
replace /protocolSection/contactsLocationsModule/locations/57/facility
Triage: Uncategorized
Uncategorized Operation 7
Before
Kaiser Permanente-Cadillac
After
Kaiser Permanente West Los Angeles
replace /protocolSection/contactsLocationsModule/locations/96/facility
Triage: Uncategorized
Uncategorized Operation 8
Before
University of California San Diego
After
UC San Diego Medical Center - Hillcrest
replace /protocolSection/contactsLocationsModule/locations/207/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
UF Cancer Center at Orlando Health
After
Orlando Health Cancer Institute
replace /protocolSection/contactsLocationsModule/locations/238/facility
Triage: Uncategorized
Uncategorized Operation 10
Before
Hawaii Cancer Care Inc-POB II
After
Hawaii Cancer Care Inc - Waterfront Plaza
replace /protocolSection/contactsLocationsModule/locations/254/facility
Triage: Uncategorized
Uncategorized Operation 11
Before
Kootenai Cancer Center
After
Kootenai Clinic Cancer Services - Post Falls
replace /protocolSection/contactsLocationsModule/locations/277/facility
Triage: Uncategorized
Uncategorized Operation 12
Before
Presence Saint Joseph Hospital-Chicago
After
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
replace /protocolSection/contactsLocationsModule/locations/299/facility
Triage: Uncategorized
Uncategorized Operation 13
Before
Joliet Oncology-Hematology Associates Limited
After
Duly Health and Care Joliet
replace /protocolSection/contactsLocationsModule/locations/318/facility
Triage: Uncategorized
Uncategorized Operation 14
Before
Community Cancer Center Foundation
After
Carle Cancer Institute Normal
replace /protocolSection/contactsLocationsModule/locations/452/facility
Triage: Uncategorized
Uncategorized Operation 15
Before
Hardin Memorial Hospital
After
Baptist Health Hardin
replace /protocolSection/contactsLocationsModule/locations/461/facility
Triage: Uncategorized
Uncategorized Operation 16
Before
Jewish Hospital Medical Center Northeast
After
UofL Health Medical Center Northeast
replace /protocolSection/contactsLocationsModule/locations/492/facility
Triage: Uncategorized
Uncategorized Operation 17
Before
Union Hospital of Cecil County
After
Christiana Care - Union Hospital
replace /protocolSection/contactsLocationsModule/locations/519/facility
Triage: Uncategorized
Uncategorized Operation 18
Before
Saint Vincent Hospital/Reliant Medical Group
After
Reliant Medical Group Inc
replace /protocolSection/contactsLocationsModule/locations/519/zip
Triage: Uncategorized
Uncategorized Operation 19
Before
01608
After
01606
replace /protocolSection/contactsLocationsModule/locations/551/facility
Triage: Uncategorized
Uncategorized Operation 20
Before
McLaren-Greater Lansing
After
Karmanos Cancer Institute at McLaren Greater Lansing
add /protocolSection/contactsLocationsModule/locations/644
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "63104",
  "city": "St Louis",
  "state": "Missouri",
  "country": "United States",
  "facility": "SSM Health Saint Louis University Hospital",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
remove /protocolSection/contactsLocationsModule/locations/646
Triage: Uncategorized
Uncategorized Operation 22
Before
{
  "zip": "63110",
  "city": "St Louis",
  "state": "Missouri",
  "country": "United States",
  "facility": "Saint Louis University Hospital",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
remove /protocolSection/contactsLocationsModule/locations/705
Triage: Uncategorized
Uncategorized Operation 23
Before
{
  "zip": "89106",
  "city": "Las Vegas",
  "state": "Nevada",
  "country": "United States",
  "facility": "Nevada Cancer Research Foundation CCOP",
  "geoPoint": {
    "lat": 36.17497,
    "lon": -115.13722
  }
}
add /protocolSection/contactsLocationsModule/locations/723
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "89169",
  "city": "Las Vegas",
  "state": "Nevada",
  "country": "United States",
  "facility": "Nevada Cancer Research Foundation NCORP",
  "geoPoint": {
    "lat": 36.17497,
    "lon": -115.13722
  }
}
replace /protocolSection/contactsLocationsModule/locations/754/facility
Triage: Uncategorized
Uncategorized Operation 25
Before
Kennedy Health Systems-Cancer Center
After
Sidney Kimmel Cancer Center Washington Township
replace /protocolSection/contactsLocationsModule/locations/817/facility
Triage: Uncategorized
Uncategorized Operation 26
Before
Rex Cancer Center
After
UNC Rex Cancer Center
replace /protocolSection/contactsLocationsModule/locations/846/facility
Triage: Uncategorized
Uncategorized Operation 27
Before
University of Cincinnati/Barrett Cancer Center
After
University of Cincinnati Cancer Center-UC Medical Center
replace /protocolSection/contactsLocationsModule/locations/909/facility
Triage: Uncategorized
Uncategorized Operation 28
Before
Mercy Saint Anne Hospital
After
Mercy Health - Saint Anne Hospital
replace /protocolSection/contactsLocationsModule/locations/913/facility
Triage: Uncategorized
Uncategorized Operation 29
Before
University Pointe
After
University of Cincinnati Cancer Center-West Chester
replace /protocolSection/contactsLocationsModule/locations/950/facility
Triage: Uncategorized
Uncategorized Operation 30
Before
Abington Memorial Hospital
After
Jefferson Abington Hospital
replace /protocolSection/contactsLocationsModule/locations/992/facility
Triage: Uncategorized
Uncategorized Operation 31
Before
Aria Health-Torresdale Campus
After
Jefferson Torresdale Hospital
add /protocolSection/contactsLocationsModule/locations/1029
Triage: Uncategorized
Uncategorized Operation 32
After
{
  "zip": "29316",
  "city": "Boiling Springs",
  "state": "South Carolina",
  "country": "United States",
  "facility": "Prisma Health Cancer Institute - Spartanburg",
  "geoPoint": {
    "lat": 35.04651,
    "lon": -81.98177
  }
}
remove /protocolSection/contactsLocationsModule/locations/1049
Triage: Uncategorized
Uncategorized Operation 33
Before
{
  "zip": "29307",
  "city": "Spartanburg",
  "state": "South Carolina",
  "country": "United States",
  "facility": "Prisma Health Cancer Institute - Spartanburg",
  "geoPoint": {
    "lat": 34.94957,
    "lon": -81.93205
  }
}
add /protocolSection/contactsLocationsModule/locations/1078
Triage: Uncategorized
Uncategorized Operation 34
After
{
  "zip": "75020",
  "city": "Denison",
  "state": "Texas",
  "country": "United States",
  "facility": "Texas Oncology - Denison Cancer Center",
  "geoPoint": {
    "lat": 33.75566,
    "lon": -96.53666
  }
}
remove /protocolSection/contactsLocationsModule/locations/1097
Triage: Uncategorized
Uncategorized Operation 35
Before
{
  "zip": "75090",
  "city": "Sherman",
  "state": "Texas",
  "country": "United States",
  "facility": "Texas Cancer Center-Sherman",
  "geoPoint": {
    "lat": 33.63566,
    "lon": -96.60888
  }
}
replace /protocolSection/contactsLocationsModule/locations/1128/zip
Triage: Uncategorized
Uncategorized Operation 36
Before
23230
After
23229
replace /protocolSection/contactsLocationsModule/locations/1166/facility
Triage: Uncategorized
Uncategorized Operation 37
Before
University of Washington Medical Center
After
University of Washington Medical Center - Montlake
replace /protocolSection/contactsLocationsModule/locations/1252/facility
Triage: Uncategorized
Uncategorized Operation 38
Before
Marshfield Clinic - Weston Center
After
Marshfield Medical Center - Weston
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2022-01
After
2022-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2022-01-31
After
2022-03-09
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-02-23
After
2022-03-17
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
remove /protocolSection/identificationModule/secondaryIdInfos/7
Triage: Uncategorized
Uncategorized Operation 1
Before
{
  "id": "UG1CA189867",
  "link": "https://reporter.nih.gov/quickSearch/UG1CA189867",
  "type": "NIH"
}
Raw JSON Patch 
[
  {
    "op": "remove",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2022-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-03-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-03-17"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/otherNames/28"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/otherNames/31",
    "value": "Trastuzumab Biosimilar SIBP-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/57/facility",
    "value": "Kaiser Permanente West Los Angeles"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/96/facility",
    "value": "UC San Diego Medical Center - Hillcrest"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/207/facility",
    "value": "Orlando Health Cancer Institute"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/238/facility",
    "value": "Hawaii Cancer Care Inc - Waterfront Plaza"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/254/facility",
    "value": "Kootenai Clinic Cancer Services - Post Falls"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/277/facility",
    "value": "UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/299/facility",
    "value": "Duly Health and Care Joliet"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/318/facility",
    "value": "Carle Cancer Institute Normal"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/452/facility",
    "value": "Baptist Health Hardin"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/461/facility",
    "value": "UofL Health Medical Center Northeast"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/492/facility",
    "value": "Christiana Care - Union Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/519/facility",
    "value": "Reliant Medical Group Inc"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/519/zip",
    "value": "01606"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/551/facility",
    "value": "Karmanos Cancer Institute at McLaren Greater Lansing"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/644",
    "value": {
      "zip": "63104",
      "city": "St Louis",
      "state": "Missouri",
      "country": "United States",
      "facility": "SSM Health Saint Louis University Hospital",
      "geoPoint": {
        "lat": 38.62727,
        "lon": -90.19789
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/646"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/705"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/723",
    "value": {
      "zip": "89169",
      "city": "Las Vegas",
      "state": "Nevada",
      "country": "United States",
      "facility": "Nevada Cancer Research Foundation NCORP",
      "geoPoint": {
        "lat": 36.17497,
        "lon": -115.13722
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/754/facility",
    "value": "Sidney Kimmel Cancer Center Washington Township"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/817/facility",
    "value": "UNC Rex Cancer Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/846/facility",
    "value": "University of Cincinnati Cancer Center-UC Medical Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/909/facility",
    "value": "Mercy Health - Saint Anne Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/913/facility",
    "value": "University of Cincinnati Cancer Center-West Chester"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/950/facility",
    "value": "Jefferson Abington Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/992/facility",
    "value": "Jefferson Torresdale Hospital"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1029",
    "value": {
      "zip": "29316",
      "city": "Boiling Springs",
      "state": "South Carolina",
      "country": "United States",
      "facility": "Prisma Health Cancer Institute - Spartanburg",
      "geoPoint": {
        "lat": 35.04651,
        "lon": -81.98177
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1049"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1078",
    "value": {
      "zip": "75020",
      "city": "Denison",
      "state": "Texas",
      "country": "United States",
      "facility": "Texas Oncology - Denison Cancer Center",
      "geoPoint": {
        "lat": 33.75566,
        "lon": -96.53666
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1097"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1128/zip",
    "value": "23229"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1166/facility",
    "value": "University of Washington Medical Center - Montlake"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1252/facility",
    "value": "Marshfield Medical Center - Weston"
  }
]