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NCT00769379

Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy

Version 688 to 689 · National Cancer Institute (NCI)

Patch inspector

Version 688 to 689

40 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:49:56+00
Raw hash
d6f6773a018cd92c7e1cab70fcfaacffa4f5d7495325cd39cbdc165ca73836c2
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 11 ops
replace /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Radiation: whole breast irradiation
After
Radiation: Whole Breast Irradiation
replace /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/1
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Other: laboratory biomarker analysis
After
Other: Laboratory Biomarker Analysis
replace /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/0
Triage: High
Arm Intervention Change Operation 8
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Biological: trastuzumab
After
Biological: Trastuzumab
replace /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1
Triage: High
Arm Intervention Change Operation 9
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Radiation: whole breast irradiation
After
Radiation: Whole Breast Irradiation
replace /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/2
Triage: High
Arm Intervention Change Operation 10
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Other: laboratory biomarker analysis
After
Other: Laboratory Biomarker Analysis
replace /protocolSection/armsInterventionsModule/interventions/0/name
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
trastuzumab
After
Trastuzumab
replace /protocolSection/armsInterventionsModule/interventions/0/otherNames/0
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
anti-c-erB-2
After
ABP 980
replace /protocolSection/armsInterventionsModule/interventions/0/otherNames/1
Triage: High
Arm Intervention Change Operation 13
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Herceptin
After
PF-05280014
replace /protocolSection/armsInterventionsModule/interventions/0/otherNames/2
Triage: High
Arm Intervention Change Operation 14
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
MOAB HER2
After
rhuMAb HER2
replace /protocolSection/armsInterventionsModule/interventions/1/name
Triage: High
Arm Intervention Change Operation 15
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
whole breast irradiation
After
Whole Breast Irradiation
replace /protocolSection/armsInterventionsModule/interventions/2/name
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
laboratory biomarker analysis
After
Laboratory Biomarker Analysis
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 24 ops
replace /protocolSection/contactsLocationsModule/locations/21/status
Triage: Uncategorized
Uncategorized Operation 17
Before
TERMINATED
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/21/contacts
Triage: Uncategorized
Uncategorized Operation 18
After
[
  {
    "name": "Stacy D. D'Andre",
    "role": "CONTACT",
    "email": "bernicl@sutterhealth.org",
    "phone": "415-209-2686"
  },
  {
    "name": "Stacy D. D'Andre",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/28/status
Triage: Uncategorized
Uncategorized Operation 19
Before
TERMINATED
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/28/contacts
Triage: Uncategorized
Uncategorized Operation 20
After
[
  {
    "name": "Stacy D. D'Andre",
    "role": "CONTACT",
    "email": "bernicl@sutterhealth.org",
    "phone": "415-209-2686"
  },
  {
    "name": "Stacy D. D'Andre",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/92/status
Triage: Uncategorized
Uncategorized Operation 21
Before
TERMINATED
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/92/contacts
Triage: Uncategorized
Uncategorized Operation 22
After
[
  {
    "name": "Stacy D. D'Andre",
    "role": "CONTACT",
    "email": "bernicl@sutterhealth.org",
    "phone": "415-209-2686"
  },
  {
    "name": "Stacy D. D'Andre",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/122/status
Triage: Uncategorized
Uncategorized Operation 23
Before
TERMINATED
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/122/contacts
Triage: Uncategorized
Uncategorized Operation 24
After
[
  {
    "name": "Stacy D. D'Andre",
    "role": "CONTACT",
    "email": "bernicl@sutterhealth.org",
    "phone": "415-209-2686"
  },
  {
    "name": "Stacy D. D'Andre",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/973/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/973/contacts
Triage: Uncategorized
Uncategorized Operation 26
Before
[
  {
    "name": "Diane M. BuchBarker",
    "role": "CONTACT",
    "phone": "724-543-8682"
  },
  {
    "name": "Diane M. BuchBarker",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1257/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1257/contacts
Triage: Uncategorized
Uncategorized Operation 28
Before
[
  {
    "name": "Zsolt Gabos",
    "role": "CONTACT",
    "phone": "780-432-8500"
  },
  {
    "name": "Zsolt Gabos",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1259/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1259/contacts
Triage: Uncategorized
Uncategorized Operation 30
Before
[
  {
    "name": "Andre Robidoux",
    "role": "CONTACT",
    "email": "marie-josee.samson.chum@ssss.gouv.qc.ca",
    "phone": "514-890-8000ext14788"
  },
  {
    "name": "Andre Robidoux",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1260/status
Triage: Uncategorized
Uncategorized Operation 31
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1260/contacts
Triage: Uncategorized
Uncategorized Operation 32
Before
[
  {
    "name": "Andre Robidoux",
    "role": "CONTACT",
    "email": "marie-josee.samson.chum@ssss.gouv.qc.ca",
    "phone": "514-890-8000ext14788"
  },
  {
    "name": "Andre Robidoux",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1261/status
Triage: Uncategorized
Uncategorized Operation 33
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1261/contacts
Triage: Uncategorized
Uncategorized Operation 34
Before
[
  {
    "name": "Henry R. Shibata",
    "role": "CONTACT",
    "phone": "514-934-1934ext48354"
  },
  {
    "name": "Henry R. Shibata",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1262/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1262/contacts
Triage: Uncategorized
Uncategorized Operation 36
Before
[
  {
    "name": "Michael P. Thirlwell",
    "role": "CONTACT",
    "email": "evelyn.ortega@muhc.mcgill.ca",
    "phone": "514-934-1934ext42953"
  },
  {
    "name": "Michael P. Thirlwell",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1263/status
Triage: Uncategorized
Uncategorized Operation 37
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1263/contacts
Triage: Uncategorized
Uncategorized Operation 38
Before
[
  {
    "name": "Richard G. Margolese",
    "role": "CONTACT",
    "phone": "514-340-8222ext8248"
  },
  {
    "name": "Richard G. Margolese",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/1264/status
Triage: Uncategorized
Uncategorized Operation 39
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1264/contacts
Triage: Uncategorized
Uncategorized Operation 40
Before
[
  {
    "name": "Louise Provencher",
    "role": "CONTACT",
    "email": "jbegin@uresp.ulaval.ca",
    "phone": "418-649-5593"
  },
  {
    "name": "Louise Provencher",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2014-11-20
After
2014-11-21
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2014-11-21
After
2014-11-24
replace /protocolSection/conditionsModule/conditions/0
Triage: Uncategorized
Uncategorized Operation 5
Before
Ductal Breast Carcinoma in Situ
After
Ductal Breast Carcinoma In Situ
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 2 ops
add /protocolSection/identificationModule/secondaryIdInfos/4
Triage: Uncategorized
Uncategorized Operation 1
After
{
  "id": "U10CA180868",
  "link": "https://reporter.nih.gov/quickSearch/U10CA180868",
  "type": "NIH"
}
remove /protocolSection/identificationModule/secondaryIdInfos/6
Triage: Uncategorized
Uncategorized Operation 2
Before
{
  "id": "U10CA180868",
  "link": "https://reporter.nih.gov/quickSearch/U10CA180868",
  "type": "NIH"
}
Raw JSON Patch 
[
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/4",
    "value": {
      "id": "U10CA180868",
      "link": "https://reporter.nih.gov/quickSearch/U10CA180868",
      "type": "NIH"
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/6"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2014-11-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2014-11-24"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/0",
    "value": "Ductal Breast Carcinoma In Situ"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0",
    "value": "Radiation: Whole Breast Irradiation"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/1",
    "value": "Other: Laboratory Biomarker Analysis"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/0",
    "value": "Biological: Trastuzumab"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1",
    "value": "Radiation: Whole Breast Irradiation"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/2",
    "value": "Other: Laboratory Biomarker Analysis"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/name",
    "value": "Trastuzumab"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/0",
    "value": "ABP 980"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/1",
    "value": "PF-05280014"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/2",
    "value": "rhuMAb HER2"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/name",
    "value": "Whole Breast Irradiation"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/2/name",
    "value": "Laboratory Biomarker Analysis"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/21/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21/contacts",
    "value": [
      {
        "name": "Stacy D. D'Andre",
        "role": "CONTACT",
        "email": "bernicl@sutterhealth.org",
        "phone": "415-209-2686"
      },
      {
        "name": "Stacy D. D'Andre",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/28/contacts",
    "value": [
      {
        "name": "Stacy D. D'Andre",
        "role": "CONTACT",
        "email": "bernicl@sutterhealth.org",
        "phone": "415-209-2686"
      },
      {
        "name": "Stacy D. D'Andre",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/92/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/92/contacts",
    "value": [
      {
        "name": "Stacy D. D'Andre",
        "role": "CONTACT",
        "email": "bernicl@sutterhealth.org",
        "phone": "415-209-2686"
      },
      {
        "name": "Stacy D. D'Andre",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/122/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/122/contacts",
    "value": [
      {
        "name": "Stacy D. D'Andre",
        "role": "CONTACT",
        "email": "bernicl@sutterhealth.org",
        "phone": "415-209-2686"
      },
      {
        "name": "Stacy D. D'Andre",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ]
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/973/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/973/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1257/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1257/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1259/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1259/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1260/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1260/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1261/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1261/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1262/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1262/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1263/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1263/contacts"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1264/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1264/contacts"
  }
]