Raw JSON Patch
[
{
"op": "replace",
"path": "/protocolSection/statusModule/statusVerifiedDate",
"value": "2010-03"
},
{
"op": "remove",
"path": "/protocolSection/statusModule/completionDateStruct"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdateSubmitDate",
"value": "2010-03-10"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
"value": "2010-03-11"
},
{
"op": "replace",
"path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle",
"value": "Dale Shuster, Ph.D"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/2/measure",
"value": "General safety assessed by monitoring all AEs and serious AEs, laboratory measurements, vital signs, and physical exams."
},
{
"op": "replace",
"path": "/protocolSection/eligibilityModule/eligibilityCriteria",
"value": "<p>Inclusion criteria:</p><p>1. Female subjects with confirmed locally recurrent or metastatic carcinoma of the breast who have received prior taxane therapy and at least one prior cytotoxic chemotherapy regimen for advanced disease.</p><p>Exclusion criteria:</p><ol><li>Subjects who have received prior ixabepilone therapy.</li><li>Subjects with prior participation in an eribulin clinical study, even if not assigned to eribulin treatment.</li><li>Subjects with pre-existing neuropathy Grade ≥ 2.</li><li>Subjects with a history of diabetes mellitus Type 1 or 2.</li><li>Subjects with bilateral mastectomy which included bilateral axillary lymph node dissection.</li><li>Subjects with missing digits required for vibration assessment.</li><li>Subjects with any other concurrent diseases or conditions that would be expected to interfere with neuropathy assessments, which may include vitamin deficiency, sequelae of cerebrovascular disease, thyroid insufficiency, lumbar or cervical radiculopathy, or alcoholic or inflammatory neuropathy.</li></ol>"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/0/contacts",
"value": [
{
"name": "Dr. Deborah * Lindquist",
"role": "CONTACT",
"phone": "928-204-4163"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/1/facility",
"value": "Healing Hands Oncology and Medical Care"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/1/status",
"value": "RECRUITING"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/1/contacts",
"value": [
{
"name": "Dr. Olukemi * Wallace",
"role": "CONTACT",
"phone": "310-644-8400"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/2/facility",
"value": "University of Southern California"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/2/city",
"value": "Los Angeles"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/2/zip",
"value": "90033"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/2/geoPoint/lat",
"value": 34.05223
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/2/geoPoint/lon",
"value": -118.24368
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/2/contacts",
"value": [
{
"name": "Dr. Agustin * Garcia",
"role": "CONTACT",
"phone": "323-865-0832"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/facility",
"value": "Comprehensive Cancer Center"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/status",
"value": "RECRUITING"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/city",
"value": "Palm Springs"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/zip",
"value": "92262"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/geoPoint/lat",
"value": 33.8303
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/3/geoPoint/lon",
"value": -116.54529
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/3/contacts",
"value": [
{
"name": "Dr. Cynthia * Leichman",
"role": "CONTACT",
"phone": "760-416-4860"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/4/status",
"value": "RECRUITING"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/4/contacts",
"value": [
{
"name": "Dr. Reshma * Mahtani",
"role": "CONTACT"
}
]
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/5/contacts",
"value": [
{
"name": "Dr. Robert * Carroll",
"role": "CONTACT",
"phone": "352-331-1747"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/6/facility",
"value": "Hematology Oncology Associates"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/6/city",
"value": "Lake Worth"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/6/zip",
"value": "33461"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/6/geoPoint/lat",
"value": 26.61708
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/6/geoPoint/lon",
"value": -80.07231
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/6/contacts",
"value": [
{
"name": "Dr. Humberto Caldera",
"role": "CONTACT",
"phone": "561-965-1864"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/facility",
"value": "Medical Specialists of the Palm Beaches"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/status",
"value": "NOT_YET_RECRUITING"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/city",
"value": "Lake Worth"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/zip",
"value": "33467"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/geoPoint/lat",
"value": 26.61708
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/7/geoPoint/lon",
"value": -80.07231
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/7/contacts",
"value": [
{
"name": "Dr. Gracy Joshua",
"role": "CONTACT",
"phone": "561-439-4682"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/facility",
"value": "Ocala Oncology Center"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/city",
"value": "Ocala"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/state",
"value": "Florida"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/zip",
"value": "34471"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/geoPoint/lat",
"value": 29.1872
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/8/geoPoint/lon",
"value": -82.14009
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/8/contacts",
"value": [
{
"name": "Dr. Craig * Reynolds",
"role": "CONTACT",
"phone": "352-732-4938"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/facility",
"value": "Hematology Oncology Associates of Treasure Coast"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/city",
"value": "Port Saint Lucie"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/state",
"value": "Florida"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/zip",
"value": "34952"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/geoPoint/lat",
"value": 27.29393
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/9/geoPoint/lon",
"value": -80.35033
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/9/contacts",
"value": [
{
"name": "Dr. Nicholas * Iannotti",
"role": "CONTACT",
"phone": "772-408-5159"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/facility",
"value": "Oncology and Hematology Associates of West Broward"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/city",
"value": "Tamarac"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/state",
"value": "Florida"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/zip",
"value": "33321"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/geoPoint/lat",
"value": 26.21286
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/10/geoPoint/lon",
"value": -80.24977
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/10/contacts",
"value": [
{
"name": "Dr. Sumit Sawhney",
"role": "CONTACT",
"phone": "954-726-0035"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/facility",
"value": "Hematology Oncology Associates of Illinois"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/city",
"value": "Chicago"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/state",
"value": "Illinois"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/zip",
"value": "60611"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/geoPoint/lat",
"value": 41.85003
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/11/geoPoint/lon",
"value": -87.65005
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/11/contacts",
"value": [
{
"name": "Dr. Stephanie * Williams",
"role": "CONTACT"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/facility",
"value": "Decatur Memorial Hospital"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/city",
"value": "Decatur"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/state",
"value": "Illinois"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/zip",
"value": "62526"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/geoPoint/lat",
"value": 39.84031
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/12/geoPoint/lon",
"value": -88.9548
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/12/contacts",
"value": [
{
"name": "Dr. James * Wade",
"role": "CONTACT",
"phone": "217-876-6634"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/facility",
"value": "Central Indiana Cancer Centers"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/status",
"value": "ACTIVE_NOT_RECRUITING"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/city",
"value": "Indianapolis"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/state",
"value": "Indiana"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/zip",
"value": "46219"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/geoPoint/lat",
"value": 39.76838
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/13/geoPoint/lon",
"value": -86.15804
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/facility",
"value": "Heartland Oncology Hematology"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/city",
"value": "Council Bluffs"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/state",
"value": "Iowa"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/zip",
"value": "51503"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/geoPoint/lat",
"value": 41.26194
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/14/geoPoint/lon",
"value": -95.86083
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/14/contacts",
"value": [
{
"name": "Dr. John * Okerbloom",
"role": "CONTACT"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/facility",
"value": "Hematology and Oncology Specialists"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/city",
"value": "Marrero"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/state",
"value": "Louisiana"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/zip",
"value": "70072"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/geoPoint/lat",
"value": 29.89937
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/15/geoPoint/lon",
"value": -90.10035
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/15/contacts",
"value": [
{
"name": "Dr. Milton * Seiler",
"role": "CONTACT",
"phone": "504-669-5987"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/facility",
"value": "Metairie Institute of Comprehensive Health"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/city",
"value": "Metairie"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/state",
"value": "Louisiana"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/zip",
"value": "70006"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/geoPoint/lat",
"value": 29.98409
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/16/geoPoint/lon",
"value": -90.15285
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/16/contacts",
"value": [
{
"name": "Dr. Jayne * Gurtler",
"role": "CONTACT",
"phone": "504-885-0577"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/facility",
"value": "Hematology and Oncology Specialists"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/city",
"value": "New Orleans"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/state",
"value": "Louisiana"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/zip",
"value": "70115"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/geoPoint/lat",
"value": 29.95465
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/17/geoPoint/lon",
"value": -90.07507
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/17/contacts",
"value": [
{
"name": "Dr. Milton * Seiler",
"role": "CONTACT",
"phone": "504-669-5987"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/facility",
"value": "Maryland Oncology Hematology, PA"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/city",
"value": "Columbia"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/state",
"value": "Maryland"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/zip",
"value": "21044"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/geoPoint/lat",
"value": 39.24038
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/18/geoPoint/lon",
"value": -76.83942
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/18/contacts",
"value": [
{
"name": "Dr. Edward * Lee",
"role": "CONTACT",
"phone": "410-964-2212"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/facility",
"value": "Washington County Hospital"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/status",
"value": "ACTIVE_NOT_RECRUITING"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/city",
"value": "Hagerstown"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/state",
"value": "Maryland"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/zip",
"value": "21740"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/geoPoint/lat",
"value": 39.64176
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/19/geoPoint/lon",
"value": -77.71999
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/20/facility",
"value": "Josephine Ford Cancer Center"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/20/city",
"value": "Brownstown"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/20/state",
"value": "Michigan"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/20/zip",
"value": "48183"
},
{
"op": "remove",
"path": "/protocolSection/contactsLocationsModule/locations/20/geoPoint"
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/20/contacts",
"value": [
{
"name": "Dr. Thomas * Doyle",
"role": "CONTACT",
"phone": "734-479-3311"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/facility",
"value": "Henry Ford Medical Center-Fairlane"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/city",
"value": "Dearborn"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/state",
"value": "Michigan"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/zip",
"value": "48126"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/geoPoint/lat",
"value": 42.32226
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/21/geoPoint/lon",
"value": -83.17631
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{
"op": "add",
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"value": [
{
"name": "Dr. Thomas * Doyle",
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"phone": "313-982-8100"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/facility",
"value": "Henry Ford Health Systems"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/city",
"value": "Detroit"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/state",
"value": "Michigan"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/zip",
"value": "48202"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/geoPoint/lat",
"value": 42.33143
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/22/geoPoint/lon",
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{
"op": "add",
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"value": [
{
"name": "Dr. Thomas * Doyle",
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"phone": "313-916-1784"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/facility",
"value": "Henry Ford Medical Center Farmington"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/city",
"value": "West Bloomfield"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/state",
"value": "Michigan"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/zip",
"value": "48322"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lat",
"value": 42.56891
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{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lon",
"value": -83.38356
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{
"op": "add",
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"value": [
{
"name": "Dr. Thomas * Doyle",
"role": "CONTACT",
"phone": "248-661-8240"
}
]
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/24/facility",
"value": "Summit Medical Group"
},
{
"op": "replace",
"path": "/protocolSection/contactsLocationsModule/locations/24/city",
"value": "Berkeley Heights"
},
{
"op": "replace",
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