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NCT01033032

Trial of Amrubicin as Treatment for Patients With HER2-Negative Metastatic Breast Cancer

Version 8 to 9 · SCRI Development Innovations, LLC

Patch inspector

Version 8 to 9

25 operations 5 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2012-07",
    "old_value": "2011-12",
    "delta_days": 213,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:41+00
Raw hash
08a87be6884012cab1af1b46275f5c0af2576dd4de2a60dc755b1b39c4879ab1
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2011-12
After
2012-07
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 17 ops
remove /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 9
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
[
  {
    "name": "Denise A Yardley, M.D.",
    "role": "CONTACT",
    "email": "dyardley@tnonc.com",
    "phone": "1-877-MY-1-SCRI"
  },
  {
    "name": "Contact askSARAH",
    "role": "CONTACT",
    "email": "asksarah@scresearch.net",
    "phone": "1-877-MY-1-SCRI"
  }
]
remove /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 12
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 14
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 16
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 17
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 18
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 19
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 20
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 22
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/13/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/14/status
Triage: Uncategorized
Uncategorized Operation 24
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/15/status
Triage: Uncategorized
Uncategorized Operation 25
Before
NOT_YET_RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2011-07
After
2012-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2011-07-05
After
2012-06-05
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2011-07-07
After
2012-06-07
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 3 ops
remove /protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle
Triage: Uncategorized
Uncategorized Operation 6
Before
Denise A. Yardley, M.D.
remove /protocolSection/sponsorCollaboratorsModule/responsibleParty/oldOrganization
Triage: Uncategorized
Uncategorized Operation 7
Before
SCRI Oncology Research Consortium
add /protocolSection/sponsorCollaboratorsModule/responsibleParty/type
Triage: Uncategorized
Uncategorized Operation 8
After
SPONSOR
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2012-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2012-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2012-06-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2012-06-07"
  },
  {
    "op": "remove",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle"
  },
  {
    "op": "remove",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldOrganization"
  },
  {
    "op": "add",
    "path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/type",
    "value": "SPONSOR"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/centralContacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/9/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/12/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/13/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/14/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/15/status"
  }
]