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NCT01142401

Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer

Version 11 to 12 · National Cancer Institute (NCI)

Patch inspector

Version 11 to 12

9 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_type_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2014-06",
    "new_type": "ACTUAL",
    "old_date": "2014-06",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 0,
    "date_struct": "primaryCompletionDateStruct"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:13:10+00
Raw hash
a2567647d7dc09359ec21ecfd708d75ae824d1990ee1ab96cda47b3cef39dd0a
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 4
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 1
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 5 ops
add /protocolSection/contactsLocationsModule/locations/9
Triage: Uncategorized
Uncategorized Operation 5
After
{
  "zip": "10016",
  "city": "New York",
  "state": "New York",
  "country": "United States",
  "facility": "New York University Langone Medical Center",
  "geoPoint": {
    "lat": 40.71427,
    "lon": -74.00597
  }
}
add /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "10025",
  "city": "New York",
  "state": "New York",
  "country": "United States",
  "facility": "Saint Luke's Roosevelt Hospital Center - Saint Luke's Division",
  "geoPoint": {
    "lat": 40.71427,
    "lon": -74.00597
  }
}
add /protocolSection/contactsLocationsModule/locations/15
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "10461",
  "city": "The Bronx",
  "state": "New York",
  "country": "United States",
  "facility": "Albert Einstein College of Medicine",
  "geoPoint": {
    "lat": 40.84985,
    "lon": -73.86641
  }
}
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "44106",
  "city": "Cleveland",
  "state": "Ohio",
  "country": "United States",
  "facility": "Case Western Reserve University",
  "geoPoint": {
    "lat": 41.4995,
    "lon": -81.69541
  }
}
add /protocolSection/contactsLocationsModule/locations/20
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "44195",
  "city": "Cleveland",
  "state": "Ohio",
  "country": "United States",
  "facility": "Cleveland Clinic Foundation",
  "geoPoint": {
    "lat": 41.4995,
    "lon": -81.69541
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2014-06-27
After
2014-07-18
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2014-06-30
After
2014-07-21
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2014-07-18"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2014-07-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/9",
    "value": {
      "zip": "10016",
      "city": "New York",
      "state": "New York",
      "country": "United States",
      "facility": "New York University Langone Medical Center",
      "geoPoint": {
        "lat": 40.71427,
        "lon": -74.00597
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/11",
    "value": {
      "zip": "10025",
      "city": "New York",
      "state": "New York",
      "country": "United States",
      "facility": "Saint Luke's Roosevelt Hospital Center - Saint Luke's Division",
      "geoPoint": {
        "lat": 40.71427,
        "lon": -74.00597
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/15",
    "value": {
      "zip": "10461",
      "city": "The Bronx",
      "state": "New York",
      "country": "United States",
      "facility": "Albert Einstein College of Medicine",
      "geoPoint": {
        "lat": 40.84985,
        "lon": -73.86641
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "44106",
      "city": "Cleveland",
      "state": "Ohio",
      "country": "United States",
      "facility": "Case Western Reserve University",
      "geoPoint": {
        "lat": 41.4995,
        "lon": -81.69541
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/20",
    "value": {
      "zip": "44195",
      "city": "Cleveland",
      "state": "Ohio",
      "country": "United States",
      "facility": "Cleveland Clinic Foundation",
      "geoPoint": {
        "lat": 41.4995,
        "lon": -81.69541
      }
    }
  }
]