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NCT01142401

Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer

Version 51 to 52 · National Cancer Institute (NCI)

Patch inspector

Version 51 to 52

16 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2015-07-30",
    "old_value": "2017-06-01",
    "delta_days": 672,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:13:19+00
Raw hash
634f341198e78a18312aa048df6e0700fbe345d3b1b73b68a33d8d96db569f79
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2017-06-01
After
2015-07-30
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 6 ops
replace /protocolSection/contactsLocationsModule/overallOfficials/0/name
Triage: Uncategorized
Uncategorized Operation 10
Before
Kerin Adelson
After
Kerin B Adelson
replace /protocolSection/contactsLocationsModule/locations/7/facility
Triage: Uncategorized
Uncategorized Operation 11
Before
Beth Israel Medical Center
After
Mount Sinai Union Square
replace /protocolSection/contactsLocationsModule/locations/9/facility
Triage: Uncategorized
Uncategorized Operation 12
Before
Saint Luke's Roosevelt Hospital Center - Roosevelt Division
After
Mount Sinai West
replace /protocolSection/contactsLocationsModule/locations/10/facility
Triage: Uncategorized
Uncategorized Operation 13
Before
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division
After
Mount Sinai Saint Luke's
replace /protocolSection/contactsLocationsModule/locations/12/facility
Triage: Uncategorized
Uncategorized Operation 14
Before
Columbia University/Herbert Irving Cancer Center
After
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
replace /protocolSection/contactsLocationsModule/locations/13/facility
Triage: Uncategorized
Uncategorized Operation 15
Before
Weill Medical College of Cornell University
After
NYP/Weill Cornell Medical Center
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 8 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2017-05
After
2020-08
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2017-10-04
After
2020-08-14
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2017-10-05
After
2020-08-17
replace /protocolSection/conditionsModule/conditions/0
Triage: Uncategorized
Uncategorized Operation 6
Before
Estrogen Receptor Positive
After
Metastatic Breast Carcinoma
replace /protocolSection/conditionsModule/conditions/1
Triage: Uncategorized
Uncategorized Operation 7
Before
Stage IIIB Breast Cancer
After
Stage IIIB Breast Cancer AJCC v7
replace /protocolSection/conditionsModule/conditions/2
Triage: Uncategorized
Uncategorized Operation 8
Before
Stage IIIC Breast Cancer
After
Stage IIIC Breast Cancer AJCC v7
replace /protocolSection/conditionsModule/conditions/3
Triage: Uncategorized
Uncategorized Operation 9
Before
Stage IV Breast Cancer
After
Stage IV Breast Cancer AJCC v6 and v7
add /annotationSection
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2021-05-11",
          "type": "RELEASE"
        },
        {
          "date": "2021-06-04",
          "type": "RESET"
        },
        {
          "date": "2021-07-08",
          "type": "RELEASE"
        },
        {
          "date": "2021-07-27",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "National Cancer Institute (NCI)"
    }
  }
}
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
add /protocolSection/identificationModule/secondaryIdInfos/2
Triage: Uncategorized
Uncategorized Operation 1
After
{
  "id": "10-01555"
}
Raw JSON Patch 
[
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/2",
    "value": {
      "id": "10-01555"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2015-07-30"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-08-14"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-08-17"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/0",
    "value": "Metastatic Breast Carcinoma"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/1",
    "value": "Stage IIIB Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/2",
    "value": "Stage IIIC Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/3",
    "value": "Stage IV Breast Cancer AJCC v6 and v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/overallOfficials/0/name",
    "value": "Kerin B Adelson"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/facility",
    "value": "Mount Sinai Union Square"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/facility",
    "value": "Mount Sinai West"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/facility",
    "value": "Mount Sinai Saint Luke's"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/facility",
    "value": "NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/13/facility",
    "value": "NYP/Weill Cornell Medical Center"
  },
  {
    "op": "add",
    "path": "/annotationSection",
    "value": {
      "annotationModule": {
        "unpostedAnnotation": {
          "unpostedEvents": [
            {
              "date": "2021-05-11",
              "type": "RELEASE"
            },
            {
              "date": "2021-06-04",
              "type": "RESET"
            },
            {
              "date": "2021-07-08",
              "type": "RELEASE"
            },
            {
              "date": "2021-07-27",
              "type": "RESET"
            }
          ],
          "unpostedResponsibleParty": "National Cancer Institute (NCI)"
        }
      }
    }
  }
]