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NCT01224678

Vitamin D and Breast Cancer Biomarkers in Female Patients

Version 109 to 110 · Alliance for Clinical Trials in Oncology

Patch inspector

Version 109 to 110

23 operations 6 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_changeenrollment_count_changeenrollment_type_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct",
    "reason": "date_unparsed_or_missing",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ACTUAL",
    "old_type": null,
    "severity": "medium",
    "direction": "unknown",
    "new_value": "2014-12",
    "old_value": null,
    "date_struct": "completionDateStruct"
  },
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 300,
    "old_value": 250,
    "pct_change": 0.2
  },
  {
    "paths": [
      "/protocolSection/outcomesModule/primaryOutcomes/0/description",
      "/protocolSection/outcomesModule/primaryOutcomes/0/measure",
      "/protocolSection/outcomesModule/primaryOutcomes/0/timeFrame"
    ],
    "signal": "results_reconciliation_outcome_suppression",
    "category": "results_reconciliation",
    "severity": "low"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:14:58+00
Raw hash
d6824a290b4655719b153b6d772b7ab7b75c6d381e60f244b5c0325e6293e99e
Payload
Source URL
Primary outcomes Outcome measures that define the trial's primary evidence target. Triage: Critical 3 ops
replace /protocolSection/outcomesModule/primaryOutcomes/0/measure
Triage: Critical
Primary Outcome Change Operation 17
Matched rules
  • primary_outcome_any_change Any add/remove/replace under primary outcome measures is critical review priority.
Before
Change (between baseline and year 1) in mammographic density by the Boyd method compared between arms
After
Percent Change (Between Baseline and Month 12) in Mammographic Density by the Boyd Method Compared Between Arms
replace /protocolSection/outcomesModule/primaryOutcomes/0/timeFrame
Triage: Critical
Primary Outcome Change Operation 18
Matched rules
  • primary_outcome_any_change Any add/remove/replace under primary outcome measures is critical review priority.
Before
Up to 12 months
After
12 months
add /protocolSection/outcomesModule/primaryOutcomes/0/description
Triage: Critical
Primary Outcome Change Operation 19
Matched rules
  • primary_outcome_any_change Any add/remove/replace under primary outcome measures is critical review priority.
After
To evaluate change in mammographic density using the Boyd method after one year of vitamin D supplementation compared to placebo in premenopausal women.
The percent change in breast density will be reported here.
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 6 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 11
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
250
After
300
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 12
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/armsInterventionsModule/armGroups/0/label
Triage: High
Arm Intervention Change Operation 13
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Arm I
After
Placebo
replace /protocolSection/armsInterventionsModule/armGroups/1/label
Triage: High
Arm Intervention Change Operation 14
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Arm II
After
Vitamin D
replace /protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/0
Triage: High
Arm Intervention Change Operation 15
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Arm II
After
Vitamin D
replace /protocolSection/armsInterventionsModule/interventions/1/armGroupLabels/0
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Arm I
After
Placebo
Secondary outcomes Additional endpoints and outcome descriptions. Triage: High 1 ops
remove /protocolSection/outcomesModule/secondaryOutcomes
Triage: High
Secondary Outcome Change Operation 20
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
[
  {
    "measure": "Change (between baseline and year 1) in serum biomarker (IGF1) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in tissue biomarker (atypia) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in tissue biomarker (Ki67) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in breast cancer biomarker (density) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in breast cancer biomarker (IGF1) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in breast cancer biomarkers (atypia) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Change (between baseline and year 1) in breast cancer biomarkers (Ki67) compared between arms",
    "timeFrame": "Up to 12 months"
  },
  {
    "measure": "Reported time spent outside as assessed using the Sunlight Questionnaire",
    "timeFrame": "Up to 12 month"
  },
  {
    "measure": "Change (between baseline and year 1) in breast density measurements",
    "timeFrame": "Up to 12 months"
  }
]
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
add /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
After
ACTUAL
add /protocolSection/statusModule/completionDateStruct
Triage: Medium
Timeline Shift Operation 7
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
After
{
  "date": "2014-12",
  "type": "ACTUAL"
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 10 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-06
After
2018-06
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2016-06-17
After
2018-06-20
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2016-06-21
After
2018-06-25
replace /protocolSection/statusModule/lastUpdatePostDateStruct/type
Triage: Uncategorized
Uncategorized Operation 6
Before
ESTIMATED
After
ACTUAL
add /protocolSection/statusModule/resultsFirstSubmitDate
Triage: Uncategorized
Uncategorized Operation 8
After
2017-03-06
add /protocolSection/statusModule/resultsFirstSubmitQcDate
Triage: Uncategorized
Uncategorized Operation 9
After
2018-06-20
add /protocolSection/statusModule/resultsFirstPostDateStruct
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "date": "2018-06-25",
  "type": "ACTUAL"
}
remove /annotationSection
Triage: Uncategorized
Uncategorized Operation 21
Before
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2017-03-06",
          "type": "RELEASE"
        },
        {
          "date": "2017-04-14",
          "type": "RESET"
        },
        {
          "date": "2017-05-16",
          "type": "RELEASE"
        },
        {
          "date": "2017-07-28",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "Alliance for Clinical Trials in Oncology"
    }
  }
}
replace /hasResults
Triage: Uncategorized
Uncategorized Operation 22
Before
false
After
true
add /resultsSection
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "moreInfoModule": {
    "pointOfContact": {
      "email": "marie.wood@uvm.edu",
      "phone": "802-656-5452",
      "title": "Marie E. Wood, M.D",
      "organization": "University of Vermont"
    },
    "certainAgreement": {
      "restrictionType": "LTE60",
      "piSponsorEmployee": false,
      "restrictiveAgreement": true
    }
  },
  "adverseEventsModule": {
    "eventGroups": [
      {
        "id": "EG000",
        "title": "Placebo",
        "description": "Patients receive oral placebo once daily for 12 months.",
        "otherNumAtRisk": 150,
        "otherNumAffected": 1,
        "seriousNumAtRisk": 150,
        "seriousNumAffected": 0
      },
      {
        "id": "EG001",
        "title": "Vitamin D",
        "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months.",
        "otherNumAtRisk": 150,
        "otherNumAffected": 1,
        "seriousNumAtRisk": 150,
        "seriousNumAffected": 0
      }
    ],
    "otherEvents": [
      {
        "term": "Vertigo",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Ear and labyrinth disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Abdominal pain",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Colitis",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Constipation",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Diarrhea",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 9,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 7,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Gastroesophageal reflux disease",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Nausea",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 20,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 18,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Vomiting",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 7,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 10,
            "numAffected": 1
          }
        ],
        "organSystem": "Gastrointestinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Pain",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "General disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Appendicitis perforated",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Infections and infestations",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Infections and infestations - Other, specify",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 2,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Infections and infestations",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "GGT increased",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Investigations",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Hypercalcemia",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Metabolism and nutrition disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Hyperglycemia",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 2,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Metabolism and nutrition disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Back pain",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 6,
            "numAffected": 1
          }
        ],
        "organSystem": "Musculoskeletal and connective tissue disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Musculoskeletal and connective tissue disorder - Other, specify",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Musculoskeletal and connective tissue disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Neck pain",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Musculoskeletal and connective tissue disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Pain in extremity",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Musculoskeletal and connective tissue disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 2,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Headache",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 50,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 49,
            "numAffected": 1
          }
        ],
        "organSystem": "Nervous system disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Intracranial hemorrhage",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Nervous system disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Unintended pregnancy",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 2,
            "numAffected": 1
          }
        ],
        "organSystem": "Pregnancy, puerperium and perinatal conditions",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Irregular menstruation",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Reproductive system and breast disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Menorrhagia",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Reproductive system and breast disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Pelvic pain",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Reproductive system and breast disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Dyspnea",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Respiratory, thoracic and mediastinal disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Rash acneiform",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Skin and subcutaneous tissue disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Hematoma",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Vascular disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Hot flashes",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          }
        ],
        "organSystem": "Vascular disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      },
      {
        "term": "Hypertension",
        "stats": [
          {
            "groupId": "EG000",
            "numAtRisk": 150,
            "numEvents": 0,
            "numAffected": 0
          },
          {
            "groupId": "EG001",
            "numAtRisk": 150,
            "numEvents": 1,
            "numAffected": 1
          }
        ],
        "organSystem": "Vascular disorders",
        "assessmentType": "SYSTEMATIC_ASSESSMENT",
        "sourceVocabulary": "MedDRA 12"
      }
    ],
    "frequencyThreshold": "0"
  },
  "outcomeMeasuresModule": {
    "outcomeMeasures": [
      {
        "type": "PRIMARY",
        "title": "Percent Change (Between Baseline and Month 12) in Mammographic Density by the Boyd Method Compared Between Arms",
        "denoms": [
          {
            "units": "Participants",
            "counts": [
              {
                "value": "46",
                "groupId": "OG000"
              },
              {
                "value": "40",
                "groupId": "OG001"
              }
            ]
          }
        ],
        "groups": [
          {
            "id": "OG000",
            "title": "Placebo",
            "description": "Patients receive oral placebo once daily for 12 months."
          },
          {
            "id": "OG001",
            "title": "Vitamin D",
            "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
          }
        ],
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "-3.4",
                    "spread": "7.1",
                    "groupId": "OG000"
                  },
                  {
                    "value": "-1.4",
                    "spread": "11.9",
                    "groupId": "OG001"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "MEAN",
        "timeFrame": "12 months",
        "description": "To evaluate change in mammographic density using the Boyd method after one year of vitamin D supplementation compared to placebo in premenopausal women.\nThe percent change in breast density will be reported here.",
        "unitOfMeasure": "percent change",
        "dispersionType": "Standard Deviation",
        "reportingStatus": "POSTED",
        "populationDescription": "86 of the 300 patients were analyzed for the primary endpoint"
      }
    ]
  },
  "participantFlowModule": {
    "groups": [
      {
        "id": "FG000",
        "title": "Placebo",
        "description": "Patients receive oral placebo once daily for 12 months."
      },
      {
        "id": "FG001",
        "title": "Vitamin D",
        "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
      }
    ],
    "periods": [
      {
        "title": "Overall Study",
        "milestones": [
          {
            "type": "STARTED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "150"
              },
              {
                "groupId": "FG001",
                "numSubjects": "150"
              }
            ]
          },
          {
            "type": "COMPLETED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "150"
              },
              {
                "groupId": "FG001",
                "numSubjects": "150"
              }
            ]
          },
          {
            "type": "NOT COMPLETED",
            "achievements": [
              {
                "groupId": "FG000",
                "numSubjects": "0"
              },
              {
                "groupId": "FG001",
                "numSubjects": "0"
              }
            ]
          }
        ]
      }
    ]
  },
  "baselineCharacteristicsModule": {
    "denoms": [
      {
        "units": "Participants",
        "counts": [
          {
            "value": "150",
            "groupId": "BG000"
          },
          {
            "value": "150",
            "groupId": "BG001"
          },
          {
            "value": "300",
            "groupId": "BG002"
          }
        ]
      }
    ],
    "groups": [
      {
        "id": "BG000",
        "title": "Placebo",
        "description": "Patients receive oral placebo once daily for 12 months."
      },
      {
        "id": "BG001",
        "title": "Vitamin D",
        "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
      },
      {
        "id": "BG002",
        "title": "Total",
        "description": "Total of all reporting groups"
      }
    ],
    "measures": [
      {
        "title": "Age, Continuous",
        "classes": [
          {
            "categories": [
              {
                "measurements": [
                  {
                    "value": "44.3",
                    "groupId": "BG000",
                    "lowerLimit": "24.8",
                    "upperLimit": "55.1"
                  },
                  {
                    "value": "42.7",
                    "groupId": "BG001",
                    "lowerLimit": "22.7",
                    "upperLimit": "59.4"
                  },
                  {
                    "value": "43",
                    "groupId": "BG002",
                    "lowerLimit": "22.7",
                    "upperLimit": "59.4"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "MEDIAN",
        "unitOfMeasure": "years",
        "dispersionType": "FULL_RANGE"
      },
      {
        "title": "Sex: Female, Male",
        "classes": [
          {
            "categories": [
              {
                "title": "Female",
                "measurements": [
                  {
                    "value": "150",
                    "groupId": "BG000"
                  },
                  {
                    "value": "150",
                    "groupId": "BG001"
                  },
                  {
                    "value": "300",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Male",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "0",
                    "groupId": "BG001"
                  },
                  {
                    "value": "0",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Ethnicity (NIH/OMB)",
        "classes": [
          {
            "categories": [
              {
                "title": "Hispanic or Latino",
                "measurements": [
                  {
                    "value": "19",
                    "groupId": "BG000"
                  },
                  {
                    "value": "23",
                    "groupId": "BG001"
                  },
                  {
                    "value": "42",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Not Hispanic or Latino",
                "measurements": [
                  {
                    "value": "129",
                    "groupId": "BG000"
                  },
                  {
                    "value": "124",
                    "groupId": "BG001"
                  },
                  {
                    "value": "253",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Unknown or Not Reported",
                "measurements": [
                  {
                    "value": "2",
                    "groupId": "BG000"
                  },
                  {
                    "value": "3",
                    "groupId": "BG001"
                  },
                  {
                    "value": "5",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Race (NIH/OMB)",
        "classes": [
          {
            "categories": [
              {
                "title": "American Indian or Alaska Native",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "1",
                    "groupId": "BG001"
                  },
                  {
                    "value": "1",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Asian",
                "measurements": [
                  {
                    "value": "9",
                    "groupId": "BG000"
                  },
                  {
                    "value": "5",
                    "groupId": "BG001"
                  },
                  {
                    "value": "14",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Native Hawaiian or Other Pacific Islander",
                "measurements": [
                  {
                    "value": "0",
                    "groupId": "BG000"
                  },
                  {
                    "value": "2",
                    "groupId": "BG001"
                  },
                  {
                    "value": "2",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Black or African American",
                "measurements": [
                  {
                    "value": "14",
                    "groupId": "BG000"
                  },
                  {
                    "value": "21",
                    "groupId": "BG001"
                  },
                  {
                    "value": "35",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "White",
                "measurements": [
                  {
                    "value": "124",
                    "groupId": "BG000"
                  },
                  {
                    "value": "114",
                    "groupId": "BG001"
                  },
                  {
                    "value": "238",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "More than one race",
                "measurements": [
                  {
                    "value": "1",
                    "groupId": "BG000"
                  },
                  {
                    "value": "4",
                    "groupId": "BG001"
                  },
                  {
                    "value": "5",
                    "groupId": "BG002"
                  }
                ]
              },
              {
                "title": "Unknown or Not Reported",
                "measurements": [
                  {
                    "value": "2",
                    "groupId": "BG000"
                  },
                  {
                    "value": "3",
                    "groupId": "BG001"
                  },
                  {
                    "value": "5",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      },
      {
        "title": "Region of Enrollment",
        "classes": [
          {
            "title": "United States",
            "categories": [
              {
                "measurements": [
                  {
                    "value": "150",
                    "groupId": "BG000"
                  },
                  {
                    "value": "150",
                    "groupId": "BG001"
                  },
                  {
                    "value": "300",
                    "groupId": "BG002"
                  }
                ]
              }
            ]
          }
        ],
        "paramType": "COUNT_OF_PARTICIPANTS",
        "unitOfMeasure": "Participants"
      }
    ],
    "populationDescription": "All patients were used for baseline analysis"
  }
}
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
Raw JSON Patch
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2018-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "COMPLETED"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2018-06-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2018-06-25"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/completionDateStruct",
    "value": {
      "date": "2014-12",
      "type": "ACTUAL"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/resultsFirstSubmitDate",
    "value": "2017-03-06"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/resultsFirstSubmitQcDate",
    "value": "2018-06-20"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/resultsFirstPostDateStruct",
    "value": {
      "date": "2018-06-25",
      "type": "ACTUAL"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 300
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/label",
    "value": "Placebo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/label",
    "value": "Vitamin D"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels/0",
    "value": "Vitamin D"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/armGroupLabels/0",
    "value": "Placebo"
  },
  {
    "op": "replace",
    "path": "/protocolSection/outcomesModule/primaryOutcomes/0/measure",
    "value": "Percent Change (Between Baseline and Month 12) in Mammographic Density by the Boyd Method Compared Between Arms"
  },
  {
    "op": "replace",
    "path": "/protocolSection/outcomesModule/primaryOutcomes/0/timeFrame",
    "value": "12 months"
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/primaryOutcomes/0/description",
    "value": "To evaluate change in mammographic density using the Boyd method after one year of vitamin D supplementation compared to placebo in premenopausal women.\nThe percent change in breast density will be reported here."
  },
  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes"
  },
  {
    "op": "remove",
    "path": "/annotationSection"
  },
  {
    "op": "replace",
    "path": "/hasResults",
    "value": true
  },
  {
    "op": "add",
    "path": "/resultsSection",
    "value": {
      "moreInfoModule": {
        "pointOfContact": {
          "email": "marie.wood@uvm.edu",
          "phone": "802-656-5452",
          "title": "Marie E. Wood, M.D",
          "organization": "University of Vermont"
        },
        "certainAgreement": {
          "restrictionType": "LTE60",
          "piSponsorEmployee": false,
          "restrictiveAgreement": true
        }
      },
      "adverseEventsModule": {
        "eventGroups": [
          {
            "id": "EG000",
            "title": "Placebo",
            "description": "Patients receive oral placebo once daily for 12 months.",
            "otherNumAtRisk": 150,
            "otherNumAffected": 1,
            "seriousNumAtRisk": 150,
            "seriousNumAffected": 0
          },
          {
            "id": "EG001",
            "title": "Vitamin D",
            "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months.",
            "otherNumAtRisk": 150,
            "otherNumAffected": 1,
            "seriousNumAtRisk": 150,
            "seriousNumAffected": 0
          }
        ],
        "otherEvents": [
          {
            "term": "Vertigo",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Ear and labyrinth disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Abdominal pain",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Colitis",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Constipation",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Diarrhea",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 9,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 7,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Gastroesophageal reflux disease",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Nausea",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 20,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 18,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Vomiting",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 7,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 10,
                "numAffected": 1
              }
            ],
            "organSystem": "Gastrointestinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Pain",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "General disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Appendicitis perforated",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Infections and infestations",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Infections and infestations - Other, specify",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 2,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Infections and infestations",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "GGT increased",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Investigations",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Hypercalcemia",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Metabolism and nutrition disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Hyperglycemia",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 2,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Metabolism and nutrition disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Back pain",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 6,
                "numAffected": 1
              }
            ],
            "organSystem": "Musculoskeletal and connective tissue disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Musculoskeletal and connective tissue disorder - Other, specify",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Musculoskeletal and connective tissue disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Neck pain",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Musculoskeletal and connective tissue disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Pain in extremity",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Musculoskeletal and connective tissue disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 2,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Neoplasms benign, malignant and unspecified (incl cysts and polyps)",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Headache",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 50,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 49,
                "numAffected": 1
              }
            ],
            "organSystem": "Nervous system disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Intracranial hemorrhage",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Nervous system disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Unintended pregnancy",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 2,
                "numAffected": 1
              }
            ],
            "organSystem": "Pregnancy, puerperium and perinatal conditions",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Irregular menstruation",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Reproductive system and breast disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Menorrhagia",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Reproductive system and breast disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Pelvic pain",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Reproductive system and breast disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Dyspnea",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Respiratory, thoracic and mediastinal disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Rash acneiform",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Skin and subcutaneous tissue disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Hematoma",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Vascular disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Hot flashes",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              }
            ],
            "organSystem": "Vascular disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          },
          {
            "term": "Hypertension",
            "stats": [
              {
                "groupId": "EG000",
                "numAtRisk": 150,
                "numEvents": 0,
                "numAffected": 0
              },
              {
                "groupId": "EG001",
                "numAtRisk": 150,
                "numEvents": 1,
                "numAffected": 1
              }
            ],
            "organSystem": "Vascular disorders",
            "assessmentType": "SYSTEMATIC_ASSESSMENT",
            "sourceVocabulary": "MedDRA 12"
          }
        ],
        "frequencyThreshold": "0"
      },
      "outcomeMeasuresModule": {
        "outcomeMeasures": [
          {
            "type": "PRIMARY",
            "title": "Percent Change (Between Baseline and Month 12) in Mammographic Density by the Boyd Method Compared Between Arms",
            "denoms": [
              {
                "units": "Participants",
                "counts": [
                  {
                    "value": "46",
                    "groupId": "OG000"
                  },
                  {
                    "value": "40",
                    "groupId": "OG001"
                  }
                ]
              }
            ],
            "groups": [
              {
                "id": "OG000",
                "title": "Placebo",
                "description": "Patients receive oral placebo once daily for 12 months."
              },
              {
                "id": "OG001",
                "title": "Vitamin D",
                "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
              }
            ],
            "classes": [
              {
                "categories": [
                  {
                    "measurements": [
                      {
                        "value": "-3.4",
                        "spread": "7.1",
                        "groupId": "OG000"
                      },
                      {
                        "value": "-1.4",
                        "spread": "11.9",
                        "groupId": "OG001"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "MEAN",
            "timeFrame": "12 months",
            "description": "To evaluate change in mammographic density using the Boyd method after one year of vitamin D supplementation compared to placebo in premenopausal women.\nThe percent change in breast density will be reported here.",
            "unitOfMeasure": "percent change",
            "dispersionType": "Standard Deviation",
            "reportingStatus": "POSTED",
            "populationDescription": "86 of the 300 patients were analyzed for the primary endpoint"
          }
        ]
      },
      "participantFlowModule": {
        "groups": [
          {
            "id": "FG000",
            "title": "Placebo",
            "description": "Patients receive oral placebo once daily for 12 months."
          },
          {
            "id": "FG001",
            "title": "Vitamin D",
            "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
          }
        ],
        "periods": [
          {
            "title": "Overall Study",
            "milestones": [
              {
                "type": "STARTED",
                "achievements": [
                  {
                    "groupId": "FG000",
                    "numSubjects": "150"
                  },
                  {
                    "groupId": "FG001",
                    "numSubjects": "150"
                  }
                ]
              },
              {
                "type": "COMPLETED",
                "achievements": [
                  {
                    "groupId": "FG000",
                    "numSubjects": "150"
                  },
                  {
                    "groupId": "FG001",
                    "numSubjects": "150"
                  }
                ]
              },
              {
                "type": "NOT COMPLETED",
                "achievements": [
                  {
                    "groupId": "FG000",
                    "numSubjects": "0"
                  },
                  {
                    "groupId": "FG001",
                    "numSubjects": "0"
                  }
                ]
              }
            ]
          }
        ]
      },
      "baselineCharacteristicsModule": {
        "denoms": [
          {
            "units": "Participants",
            "counts": [
              {
                "value": "150",
                "groupId": "BG000"
              },
              {
                "value": "150",
                "groupId": "BG001"
              },
              {
                "value": "300",
                "groupId": "BG002"
              }
            ]
          }
        ],
        "groups": [
          {
            "id": "BG000",
            "title": "Placebo",
            "description": "Patients receive oral placebo once daily for 12 months."
          },
          {
            "id": "BG001",
            "title": "Vitamin D",
            "description": "Patients receive oral vitamin D (2000 IU) once daily for 12 months."
          },
          {
            "id": "BG002",
            "title": "Total",
            "description": "Total of all reporting groups"
          }
        ],
        "measures": [
          {
            "title": "Age, Continuous",
            "classes": [
              {
                "categories": [
                  {
                    "measurements": [
                      {
                        "value": "44.3",
                        "groupId": "BG000",
                        "lowerLimit": "24.8",
                        "upperLimit": "55.1"
                      },
                      {
                        "value": "42.7",
                        "groupId": "BG001",
                        "lowerLimit": "22.7",
                        "upperLimit": "59.4"
                      },
                      {
                        "value": "43",
                        "groupId": "BG002",
                        "lowerLimit": "22.7",
                        "upperLimit": "59.4"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "MEDIAN",
            "unitOfMeasure": "years",
            "dispersionType": "FULL_RANGE"
          },
          {
            "title": "Sex: Female, Male",
            "classes": [
              {
                "categories": [
                  {
                    "title": "Female",
                    "measurements": [
                      {
                        "value": "150",
                        "groupId": "BG000"
                      },
                      {
                        "value": "150",
                        "groupId": "BG001"
                      },
                      {
                        "value": "300",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Male",
                    "measurements": [
                      {
                        "value": "0",
                        "groupId": "BG000"
                      },
                      {
                        "value": "0",
                        "groupId": "BG001"
                      },
                      {
                        "value": "0",
                        "groupId": "BG002"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "COUNT_OF_PARTICIPANTS",
            "unitOfMeasure": "Participants"
          },
          {
            "title": "Ethnicity (NIH/OMB)",
            "classes": [
              {
                "categories": [
                  {
                    "title": "Hispanic or Latino",
                    "measurements": [
                      {
                        "value": "19",
                        "groupId": "BG000"
                      },
                      {
                        "value": "23",
                        "groupId": "BG001"
                      },
                      {
                        "value": "42",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Not Hispanic or Latino",
                    "measurements": [
                      {
                        "value": "129",
                        "groupId": "BG000"
                      },
                      {
                        "value": "124",
                        "groupId": "BG001"
                      },
                      {
                        "value": "253",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Unknown or Not Reported",
                    "measurements": [
                      {
                        "value": "2",
                        "groupId": "BG000"
                      },
                      {
                        "value": "3",
                        "groupId": "BG001"
                      },
                      {
                        "value": "5",
                        "groupId": "BG002"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "COUNT_OF_PARTICIPANTS",
            "unitOfMeasure": "Participants"
          },
          {
            "title": "Race (NIH/OMB)",
            "classes": [
              {
                "categories": [
                  {
                    "title": "American Indian or Alaska Native",
                    "measurements": [
                      {
                        "value": "0",
                        "groupId": "BG000"
                      },
                      {
                        "value": "1",
                        "groupId": "BG001"
                      },
                      {
                        "value": "1",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Asian",
                    "measurements": [
                      {
                        "value": "9",
                        "groupId": "BG000"
                      },
                      {
                        "value": "5",
                        "groupId": "BG001"
                      },
                      {
                        "value": "14",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Native Hawaiian or Other Pacific Islander",
                    "measurements": [
                      {
                        "value": "0",
                        "groupId": "BG000"
                      },
                      {
                        "value": "2",
                        "groupId": "BG001"
                      },
                      {
                        "value": "2",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Black or African American",
                    "measurements": [
                      {
                        "value": "14",
                        "groupId": "BG000"
                      },
                      {
                        "value": "21",
                        "groupId": "BG001"
                      },
                      {
                        "value": "35",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "White",
                    "measurements": [
                      {
                        "value": "124",
                        "groupId": "BG000"
                      },
                      {
                        "value": "114",
                        "groupId": "BG001"
                      },
                      {
                        "value": "238",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "More than one race",
                    "measurements": [
                      {
                        "value": "1",
                        "groupId": "BG000"
                      },
                      {
                        "value": "4",
                        "groupId": "BG001"
                      },
                      {
                        "value": "5",
                        "groupId": "BG002"
                      }
                    ]
                  },
                  {
                    "title": "Unknown or Not Reported",
                    "measurements": [
                      {
                        "value": "2",
                        "groupId": "BG000"
                      },
                      {
                        "value": "3",
                        "groupId": "BG001"
                      },
                      {
                        "value": "5",
                        "groupId": "BG002"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "COUNT_OF_PARTICIPANTS",
            "unitOfMeasure": "Participants"
          },
          {
            "title": "Region of Enrollment",
            "classes": [
              {
                "title": "United States",
                "categories": [
                  {
                    "measurements": [
                      {
                        "value": "150",
                        "groupId": "BG000"
                      },
                      {
                        "value": "150",
                        "groupId": "BG001"
                      },
                      {
                        "value": "300",
                        "groupId": "BG002"
                      }
                    ]
                  }
                ]
              }
            ],
            "paramType": "COUNT_OF_PARTICIPANTS",
            "unitOfMeasure": "Participants"
          }
        ],
        "populationDescription": "All patients were used for baseline analysis"
      }
    }
  }
]