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NCT01275677

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Version 192 to 193 · National Cancer Institute (NCI)

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Version 192 to 193

530 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
eligibility_criteria_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:03:58+00
Raw hash
c8aaf325dddaca49b0abe52831b4e15e30c6b70cb2e4118315b37a1fa056bc9d
Payload
Source URL
Eligibility Criteria and population definition changes. Triage: High 1 ops
replace /protocolSection/eligibilityModule/eligibilityCriteria
Triage: High
Eligibility Change Operation 9
Matched rules
  • eligibility_criteria_change Eligibility criteria changes can alter the studied population.
Before
<p>Inclusion Criteria:</p><ul><li>The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination</li><li><p>All of the following staging criteria (according to the 7th edition of the AJCC Cancer Staging Manual) must be met:</p><ul><li>By pathologic evaluation, primary tumor must be pT1-3</li><li><p>By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b,pN1c), pN2a, pN2b, pN3a, or pN3b</p><ul><li><p>If pN0, one of the following criteria must be met:</p><ul><li>pT2 and estrogen receptor (ER) negative and progesterone receptor (PgR) negative</li><li>pT2 and ER positive (PgR status may be positive or negative) and either grade 3histology or Oncotype DX® Recurrence Score of ≥ 25; or</li><li>pT3 regardless of hormone receptor status, histologic grade, and Oncotype DX Recurrence Score</li></ul></li></ul></li></ul></li><li>No T4 tumors including inflammatory breast cancer</li><li><p>No definitive clinical or radiologic evidence of metastatic disease</p><ul><li>NOTE: Chest imaging (mandatory for all patients) and other imaging (if required) must have been performed within 90 days prior to randomization</li></ul></li><li>No synchronous or previous contralateral invasive breast cancer (patients with synchronous and&#x2F;or previous contralateral DCIS or LCIS are eligible)</li><li>No previous ipsilateral invasive breast cancer or ipsilateral DCIS (patients with synchronous or previous ipsilateral LCIS are eligible)</li><li><p>HER2 status of the primary tumor must be evaluated prior to randomization; all testing performed must indicate that the tumor is HER2-low as defined below</p><ul><li>IHC must be performed and the IHC staining results must indicate a score of 1+ (in situ hybridization [ISH] testing is not required) or 2+ (ISH must also be performed and must indicate that the tumor is HER2-low as described below)</li><li>If ISH testing is performed, test results must be as follows and IHC must be 1+ or 2+: The ratio of HER2 to CEP17 must be &lt; 2.0 or, if a ratio was not performed, the HER2 gene copy number must be &lt; 4 per nucleus</li><li>Note: If the IHC staining intensity is reported as a range, e.g., 0 to 1+ or 1+ to 2+, the higher intensity score in the range should be used to determine eligibility</li></ul></li><li><p>No primary tumor with any of the following HER2 testing results:</p><ul><li><p>IHC staining intensity:</p><ul><li>0 on all evaluations of specimens</li><li>3+ on evaluation of any specimen</li></ul></li><li>ISH with a ratio of HER2 to CEP17 &gt;= 2.0 on evaluation of any specimen</li><li>ISH result indicating HER2 gene copy number &gt;= 4 per nucleus on evaluation of any specimen</li></ul></li><li><p>The patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy) (patients who have had a nipple-sparing mastectomy are eligible)</p><ul><li>For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist; if pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible (patients with margins positive for LCIS are eligible without additional resection)</li><li>For patients who undergo mastectomy, margins must be free of gross residual tumor(patients with microscopic positive margins are eligible as long as post-mastectomy RT of the chest wall will be administered)</li><li>The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days</li></ul></li><li><p>The patient must have completed one of the procedures for evaluation of pathologic nodal status listed below:</p><ul><li><p>Sentinel lymphadenectomy alone:</p><ul><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN0 or pN1b</li><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN1mi or pN1a, the primary tumor must be T1 or T2 by pathologic evaluation and the nodal involvement must be limited to 1 or 2 positive nodes</li></ul></li><li>Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive</li><li>Axillary lymphadenectomy with or without SN isolation procedures</li></ul></li><li>The patient must have ER analysis performed on the primary tumor prior to randomization; if ER analysis is negative, then PgR analysis must also be performed (either the core biopsy or surgical resection specimen can be used for ER&#x2F;PgR testing); patients with a primary tumor that is hormone receptor-positive or receptor-negative are eligible</li><li>Pre- or postmenopausal</li><li>ECOG performance status of 0 or 1</li><li>ANC must be ≥ 1,200&#x2F;mm^3</li><li>Platelet count must be ≥ 100,000&#x2F;mm^3</li><li>Hemoglobin must be ≥ 10 g&#x2F;dL</li><li>Total bilirubin must be ≤ ULN for the lab unless the patient has a bilirubin elevation &gt; ULN to 1.5 x ULN due to Gilbert disease or similar syndrome involving slow conjugation of bilirubin</li><li>Alkaline phosphatase must be ≤ 2.5 x ULN for the lab</li><li>AST must be ≤ 1.5 x ULN for the lab (if ALT is performed instead of AST [per institution&#x27;s standard practice], the ALT value must be ≤ 1.5 x ULN; if both were performed, the AST must be ≤ 1.5 x ULN)</li><li>Alkaline phosphatase and AST may not both be &gt; the ULN</li><li>Patients with AST or alkaline phosphatase &gt; ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) performed within 90 days prior to randomization does not demonstrate metastatic disease and the above requirements are met</li><li>Patients with alkaline phosphatase that is &gt; ULN but ≤ 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease</li><li>The most recent post operative serum creatinine performed within 6 weeks prior to randomization must be ≤ ULN for the lab</li><li>Not pregnant or nursing</li><li>Negative pregnancy test</li><li><p>LVEF assessment must be performed within 90 days prior to randomization; LVEF assessment performed by 2-D echo cardiogram is preferred, however, MUGA scan maybe substituted based on institutional preferences</p><ul><li>For patients who will receive the TC chemotherapy regimen, the LVEF must be≥ 50% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>For patients who will receive the AC→WP chemotherapy regimen, the LVEF must be ≥ 55% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>NOTE: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment.
If the baseline LVEF is &gt; 70%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain.</li></ul></li><li>No history of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization</li><li><p>No cardiac disease (history of and&#x2F;or active disease) that would preclude the use of the drugs included in the treatment regimens, including, but not limited to:</p><ul><li><p>Active cardiac disease:</p><ul><li>Angina pectoris that requires the current use of anti-anginal medication</li><li>Ventricular arrhythmias except for benign premature ventricular contractions</li><li>Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication</li><li>Conduction abnormality requiring a pacemaker</li><li>Valvular disease with documented compromise in cardiac function</li><li>Symptomatic pericarditis</li></ul></li><li><p>History of cardiac disease:</p><ul><li>Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function</li><li>History of documented CHF</li><li>Documented cardiomyopathy</li></ul></li></ul></li><li><p>No hypertension defined according to the following ineligibility criteria:</p><ul><li>For patients who will receive TC (regardless of the patient&#x27;s age): uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients &lt; 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients ≥ 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg OR controlled hypertension (systolic BP ≤ 150 mm Hg and diastolic BP ≤ 90 mmHg), if anti-hypertensive medication(s) are needed</li><li>NOTE: Patients who are not eligible based on the AC→WP regimen BP criteria but who meet the TC regimen BP criteria are eligible for B-47 if the intended chemotherapy regimen is changed to TC</li></ul></li><li>No active hepatitis B or hepatitis C with abnormal liver function tests</li><li>No intrinsic lung disease resulting in dyspnea</li><li>No poorly controlled diabetes mellitus</li><li>No active infection or chronic infection requiring chronic suppressive antibiotics</li><li>No nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) ≥ grade 2, per the CTCAE v4.0</li><li>No conditions that would prohibit administration of corticosteroids</li><li>No known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate 80 and Cremophor® EL</li><li>No other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up</li><li>No psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements</li><li>Concurrent participation in NSABP-B-39 allowed</li><li>No previous therapy with anthracyclines, taxanes, or trastuzumab for any malignancy</li><li>No chemotherapy or HER2-targeted therapy administered for the currently diagnosed breast cancer prior to randomization</li><li>No whole-breast RT prior to randomization or partial-breast RT that cannot be completed on or before the date of randomization</li><li>No use of any investigational product within 30 days prior to randomization</li><li>No continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor (patients are eligible if these medications are discontinued prior to randomization)</li><li>No continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy (patients are eligible if these medications are discontinued prior to randomization)</li><li>No chronic daily treatment with corticosteroids with a dose of ≥ 10 mg&#x2F;day methylprednisol one equivalent (excluding inhaled steroids)</li><li>No other concurrent chemotherapy</li><li>No other concurrent targeted therapy for malignancy</li><li>No partial-breast irradiation following randomization</li></ul>
After
<p>Inclusion Criteria:</p><ul><li>The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination</li><li><p>All of the following staging criteria (according to the 7th edition of the American Joint Committee on Cancer [AJCC] Cancer Staging Manual) must be met:</p><ul><li>By pathologic evaluation, primary tumor must be pT1-3</li><li><p>By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b,pN1c), pN2a, pN2b, pN3a, or pN3b</p><ul><li><p>If pN0, one of the following criteria must be met:</p><ul><li>pT2 and estrogen receptor (ER) negative and progesterone receptor (PgR) negative</li><li>pT2 and ER positive (PgR status may be positive or negative) and either grade 3histology or Oncotype DX Recurrence Score of &gt;= 25; or</li><li>pT3 regardless of hormone receptor status, histologic grade, and Oncotype DX Recurrence Score</li></ul></li></ul></li></ul></li><li>No T4 tumors including inflammatory breast cancer</li><li><p>No definitive clinical or radiologic evidence of metastatic disease</p><ul><li>NOTE: Chest imaging (mandatory for all patients) and other imaging (if required) must have been performed within 90 days prior to randomization</li></ul></li><li>No synchronous or previous contralateral invasive breast cancer (patients with synchronous and&#x2F;or previous contralateral DCIS or lobular carcinoma in situ [LCIS] are eligible)</li><li>No previous ipsilateral invasive breast cancer or ipsilateral DCIS (patients with synchronous or previous ipsilateral LCIS are eligible)</li><li><p>HER2 status of the primary tumor must be evaluated prior to randomization; all testing performed must indicate that the tumor is HER2-low as defined below</p><ul><li>IHC must be performed and the IHC staining results must indicate a score of 1+ (in situ hybridization [ISH] testing is not required) or 2+ (ISH must also be performed and must indicate that the tumor is HER2-low as described below)</li><li>If ISH testing is performed, test results must be as follows and IHC must be 1+ or 2+: The ratio of HER2 to CEP17 must be &lt; 2.0 or, if a ratio was not performed, the HER2 gene copy number must be &lt; 4 per nucleus</li><li>Note: If the IHC staining intensity is reported as a range, e.g., 0 to 1+ or 1+ to 2+, the higher intensity score in the range should be used to determine eligibility</li></ul></li><li><p>No primary tumor with any of the following HER2 testing results:</p><ul><li><p>IHC staining intensity:</p><ul><li>0 on all evaluations of specimens</li><li>3+ on evaluation of any specimen</li></ul></li><li>ISH with a ratio of HER2 to CEP17 &gt;= 2.0 on evaluation of any specimen</li><li>ISH result indicating HER2 gene copy number &gt;= 4 per nucleus on evaluation of any specimen</li></ul></li><li><p>The patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy) (patients who have had a nipple-sparing mastectomy are eligible)</p><ul><li>For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist; if pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible (patients with margins positive for LCIS are eligible without additional resection)</li><li>For patients who undergo mastectomy, margins must be free of gross residual tumor(patients with microscopic positive margins are eligible as long as post-mastectomy RT of the chest wall will be administered)</li><li>The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days</li></ul></li><li><p>The patient must have completed one of the procedures for evaluation of pathologic nodal status listed below:</p><ul><li><p>Sentinel lymphadenectomy alone:</p><ul><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN0 or pN1b</li><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN1mi or pN1a, the primary tumor must be T1 or T2 by pathologic evaluation and the nodal involvement must be limited to 1 or 2 positive nodes</li></ul></li><li>Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive</li><li>Axillary lymphadenectomy with or without SN isolation procedures</li></ul></li><li>The patient must have ER analysis performed on the primary tumor prior to randomization; if ER analysis is negative, then PgR analysis must also be performed (either the core biopsy or surgical resection specimen can be used for ER&#x2F;PgR testing); patients with a primary tumor that is hormone receptor-positive or receptor-negative are eligible</li><li>Pre- or postmenopausal</li><li>Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1</li><li>Absolute neutrophil count (ANC) must be &gt;= 1,200&#x2F;mm^3</li><li>Platelet count must be &gt;= 100,000&#x2F;mm^3</li><li>Hemoglobin must be &gt;= 10 g&#x2F;dL</li><li>Total bilirubin must be =&lt; upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation &gt; ULN to 1.5 x ULN due to Gilbert disease or similar syndrome involving slow conjugation of bilirubin</li><li>Alkaline phosphatase must be =&lt; 2.5 x ULN for the lab</li><li>Aspartate aminotransferase (AST) must be =&lt; 1.5 x ULN for the lab (if alanine aminotransferase [ALT] is performed instead of AST [per institution&#x27;s standard practice], the ALT value must be =&lt; 1.5 x ULN; if both were performed, the AST must be =&lt; 1.5 x ULN)</li><li>Alkaline phosphatase and AST may not both be &gt; the ULN</li><li>Patients with AST or alkaline phosphatase &gt; ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) performed within 90 days prior to randomization does not demonstrate metastatic disease and the above requirements are met</li><li>Patients with alkaline phosphatase that is &gt; ULN but =&lt; 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, positron emission tomography (PET)-computed tomography (CT) scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease</li><li>The most recent post operative serum creatinine performed within 6 weeks prior to randomization must be =&lt; ULN for the lab</li><li>Not pregnant or nursing</li><li>Negative pregnancy test</li><li><p>Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; LVEF assessment performed by 2-dimensional (D) echo cardiogram is preferred, however, multi-gated acquisition (MUGA) scan maybe substituted based on institutional preferences</p><ul><li>For patients who will receive the TC chemotherapy regimen, the LVEF must be &gt;= 50% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>For patients who will receive the AC→WP chemotherapy regimen, the LVEF must be &gt;= 55% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>NOTE: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment.
If the baseline LVEF is &gt; 70%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain</li></ul></li><li>No history of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization</li><li><p>No cardiac disease (history of and&#x2F;or active disease) that would preclude the use of the drugs included in the treatment regimens, including, but not limited to:</p><ul><li><p>Active cardiac disease:</p><ul><li>Angina pectoris that requires the current use of anti-anginal medication</li><li>Ventricular arrhythmias except for benign premature ventricular contractions</li><li>Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication</li><li>Conduction abnormality requiring a pacemaker</li><li>Valvular disease with documented compromise in cardiac function</li><li>Symptomatic pericarditis</li></ul></li><li><p>History of cardiac disease:</p><ul><li>Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricle (LV) function</li><li>History of documented congestive heart failure (CHF)</li><li>Documented cardiomyopathy</li></ul></li></ul></li><li><p>No hypertension defined according to the following ineligibility criteria:</p><ul><li>For patients who will receive TC (regardless of the patient&#x27;s age): uncontrolled hypertension defined as sustained systolic blood pressure (BP) &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients &lt; 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients &gt;= 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg OR controlled hypertension (systolic BP =&lt; 150 mm Hg and diastolic BP =&lt; 90 mmHg), if anti-hypertensive medication(s) are needed</li><li>NOTE: Patients who are not eligible based on the AC→WP regimen BP criteria but who meet the TC regimen BP criteria are eligible for B-47 if the intended chemotherapy regimen is changed to TC</li></ul></li><li>No active hepatitis B or hepatitis C with abnormal liver function tests</li><li>No intrinsic lung disease resulting in dyspnea</li><li>No poorly controlled diabetes mellitus</li><li>No active infection or chronic infection requiring chronic suppressive antibiotics</li><li>No nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) &gt;= grade 2, per the Common Terminology Criteria for Adverse Events (CTCAE) v4.0</li><li>No conditions that would prohibit administration of corticosteroids</li><li>No known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate 80 and Cremophor EL</li><li>No other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up</li><li>No psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements</li><li>Concurrent participation in NSABP-B-39 allowed</li><li>No previous therapy with anthracyclines, taxanes, or trastuzumab for any malignancy</li><li>No chemotherapy or HER2-targeted therapy administered for the currently diagnosed breast cancer prior to randomization</li><li>No whole-breast radiation therapy (RT) prior to randomization or partial-breast RT that cannot be completed on or before the date of randomization</li><li>No use of any investigational product within 30 days prior to randomization</li><li>No continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor (patients are eligible if these medications are discontinued prior to randomization)</li><li>No continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy (patients are eligible if these medications are discontinued prior to randomization)</li><li>No chronic daily treatment with corticosteroids with a dose of &gt;= 10 mg&#x2F;day methylprednisol one equivalent (excluding inhaled steroids)</li><li>No other concurrent chemotherapy</li><li>No other concurrent targeted therapy for malignancy</li><li>No partial-breast irradiation following randomization</li></ul>
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 521 ops
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After
{
  "zip": "85016",
  "city": "Phoenix",
  "state": "Arizona",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Tania E. Cortas",
      "role": "CONTACT",
      "phone": "602-277-4868"
    },
    {
      "name": "Tania E. Cortas",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Arizona Oncology Associates-Biltmore Cancer Center",
  "geoPoint": {
    "lat": 33.44838,
    "lon": -112.07404
  }
}
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NEA Medical Center
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NEA Baptist Clinic-Matthews
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TERMINATED
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ACTIVE_NOT_RECRUITING
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Northeast Arkansas Clinic
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NEA Baptist Memorial Hospital
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RECRUITING
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TERMINATED
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[
  {
    "name": "Carroll D. Scroggin",
    "role": "CONTACT",
    "phone": "501-686-8274"
  },
  {
    "name": "Carroll D. Scroggin",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
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[
  {
    "name": "V. Suzanne Klimberg",
    "role": "CONTACT",
    "phone": "501-686-8274"
  },
  {
    "name": "V. Suzanne Klimberg",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
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ACTIVE_NOT_RECRUITING
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[
  {
    "name": "James H. Feusner",
    "role": "CONTACT",
    "phone": "510-450-7600"
  },
  {
    "name": "James H. Feusner",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
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707-429-6976
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707-646-4016
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RECRUITING
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ACTIVE_NOT_RECRUITING
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[
  {
    "name": "James H. Feusner",
    "role": "CONTACT",
    "phone": "510-450-7600"
  },
  {
    "name": "James H. Feusner",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
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info@marinspecialtycare.com
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RECRUITING
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WITHDRAWN
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[
  {
    "name": "James R. Waisman",
    "role": "CONTACT",
    "phone": "562-981-6101"
  },
  {
    "name": "James R. Waisman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
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Community Hospital of Monterey Peninsula
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Kaiser Permanente-Modesto
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Monterey
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Modesto
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93940
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95356
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Thomas P. Bradley
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Louis Fehrenbacher
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831-625-4753
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626-564-3455
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Thomas P. Bradley
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Louis Fehrenbacher
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36.60024
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37.6391
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-121.89468
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-120.99688
add /protocolSection/contactsLocationsModule/locations/38
Triage: Uncategorized
Uncategorized Operation 34
After
{
  "zip": "93940",
  "city": "Monterey",
  "state": "California",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "John Hausdorff",
      "role": "CONTACT",
      "phone": "831-625-4753"
    },
    {
      "name": "John Hausdorff",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Community Hospital of Monterey Peninsula",
  "geoPoint": {
    "lat": 36.60024,
    "lon": -121.89468
  }
}
replace /protocolSection/contactsLocationsModule/locations/46/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/46/contacts
Triage: Uncategorized
Uncategorized Operation 36
Before
[
  {
    "name": "James H. Feusner",
    "role": "CONTACT",
    "phone": "510-450-7600"
  },
  {
    "name": "James H. Feusner",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/71/status
Triage: Uncategorized
Uncategorized Operation 37
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/71/contacts
Triage: Uncategorized
Uncategorized Operation 38
Before
[
  {
    "name": "Jonathan A. Polikoff",
    "role": "CONTACT",
    "phone": "626-564-3455"
  },
  {
    "name": "Jonathan A. Polikoff",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/79/status
Triage: Uncategorized
Uncategorized Operation 39
Before
ACTIVE_NOT_RECRUITING
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/85/facility
Triage: Uncategorized
Uncategorized Operation 40
Before
Stanford University
After
Stanford University Hospitals and Clinics
replace /protocolSection/contactsLocationsModule/locations/107/status
Triage: Uncategorized
Uncategorized Operation 41
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/107/contacts
Triage: Uncategorized
Uncategorized Operation 42
Before
[
  {
    "name": "Eduardo R. Pajon",
    "role": "CONTACT",
    "phone": "888-785-6789"
  },
  {
    "name": "Eduardo R. Pajon",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/116/status
Triage: Uncategorized
Uncategorized Operation 43
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/116/contacts
Triage: Uncategorized
Uncategorized Operation 44
Before
[
  {
    "name": "Eduardo R. Pajon",
    "role": "CONTACT",
    "phone": "888-785-6789"
  },
  {
    "name": "Eduardo R. Pajon",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/120/status
Triage: Uncategorized
Uncategorized Operation 45
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/120/contacts
Triage: Uncategorized
Uncategorized Operation 46
Before
[
  {
    "name": "Michael A. Reale",
    "role": "CONTACT",
    "phone": "860-533-4000"
  },
  {
    "name": "Michael A. Reale",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/121
Triage: Uncategorized
Uncategorized Operation 47
After
{
  "zip": "06451",
  "city": "Meriden",
  "state": "Connecticut",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Patricia A. DeFusco",
      "role": "CONTACT",
      "phone": "860-545-5363"
    },
    {
      "name": "Patricia A. DeFusco",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Midstate Medical Center",
  "geoPoint": {
    "lat": 41.53815,
    "lon": -72.80704
  }
}
replace /protocolSection/contactsLocationsModule/locations/123/status
Triage: Uncategorized
Uncategorized Operation 48
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/123/contacts
Triage: Uncategorized
Uncategorized Operation 49
Before
[
  {
    "name": "Erin W. Hofstatter",
    "role": "CONTACT",
    "phone": "203-785-5702"
  },
  {
    "name": "Erin W. Hofstatter",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/125/status
Triage: Uncategorized
Uncategorized Operation 50
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/125/contacts
Triage: Uncategorized
Uncategorized Operation 51
Before
[
  {
    "name": "Iftekhar A. Khan",
    "role": "CONTACT",
    "email": "mary_ella_quillen@bayhealth.org",
    "phone": "302-744-6755"
  },
  {
    "name": "Iftekhar A. Khan",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/129/status
Triage: Uncategorized
Uncategorized Operation 52
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/129/contacts
Triage: Uncategorized
Uncategorized Operation 53
Before
[
  {
    "name": "John L. Zapas",
    "role": "CONTACT",
    "phone": "443-777-7364"
  },
  {
    "name": "John L. Zapas",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/134/status
Triage: Uncategorized
Uncategorized Operation 54
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/134/contacts
Triage: Uncategorized
Uncategorized Operation 55
Before
[
  {
    "name": "Karen C. Daily",
    "role": "CONTACT",
    "email": "trials@cancer.ufl.edu",
    "phone": "352-273-8675"
  },
  {
    "name": "Karen C. Daily",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/135/status
Triage: Uncategorized
Uncategorized Operation 56
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/135/contacts
Triage: Uncategorized
Uncategorized Operation 57
After
[
  {
    "name": "Joel A. Stone",
    "role": "CONTACT",
    "phone": "904-538-3667"
  },
  {
    "name": "Joel A. Stone",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/138/status
Triage: Uncategorized
Uncategorized Operation 58
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/138/contacts
Triage: Uncategorized
Uncategorized Operation 59
Before
[
  {
    "name": "Madhavi L. Venigalla",
    "role": "CONTACT",
    "phone": "863-904-1900"
  },
  {
    "name": "Madhavi L. Venigalla",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/141
Triage: Uncategorized
Uncategorized Operation 60
After
{
  "zip": "34471",
  "city": "Ocala",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Craig H. Reynolds",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Craig H. Reynolds",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Ocala Oncology Center",
  "geoPoint": {
    "lat": 29.1872,
    "lon": -82.14009
  }
}
replace /protocolSection/contactsLocationsModule/locations/145/zip
Triage: Uncategorized
Uncategorized Operation 61
Before
31703
After
31701
replace /protocolSection/contactsLocationsModule/locations/146/status
Triage: Uncategorized
Uncategorized Operation 62
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/146/contacts
Triage: Uncategorized
Uncategorized Operation 63
After
[
  {
    "name": "Anand P. Jillella",
    "role": "CONTACT",
    "email": "cancer@georgiahealth.edu",
    "phone": "706-721-1663"
  },
  {
    "name": "Anand P. Jillella",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/147/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 64
Before
404-727-5671
After
404-778-1868
replace /protocolSection/contactsLocationsModule/locations/148/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 65
Before
404-727-5671
After
404-778-1868
replace /protocolSection/contactsLocationsModule/locations/150/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 66
Before
404-727-5671
After
404-778-1868
replace /protocolSection/contactsLocationsModule/locations/154/facility
Triage: Uncategorized
Uncategorized Operation 67
Before
Medical College of Georgia
After
Georgia Health Sciences University
replace /protocolSection/contactsLocationsModule/locations/155/status
Triage: Uncategorized
Uncategorized Operation 68
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/155/contacts
Triage: Uncategorized
Uncategorized Operation 69
Before
[
  {
    "name": "Thomas E. Seay",
    "role": "CONTACT",
    "email": "kpackard@sjha.org",
    "phone": "678-843-7119"
  },
  {
    "name": "Thomas E. Seay",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/157/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 70
Before
Thomas E. Seay
After
Jayanthi Srinivasiah
replace /protocolSection/contactsLocationsModule/locations/157/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 71
Before
678-843-7119
After
404-501-3279
remove /protocolSection/contactsLocationsModule/locations/157/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 72
Before
kpackard@sjha.org
replace /protocolSection/contactsLocationsModule/locations/157/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 73
Before
Thomas E. Seay
After
Jayanthi Srinivasiah
replace /protocolSection/contactsLocationsModule/locations/162/status
Triage: Uncategorized
Uncategorized Operation 74
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/162/contacts
Triage: Uncategorized
Uncategorized Operation 75
Before
[
  {
    "name": "Thomas E. Seay",
    "role": "CONTACT",
    "email": "kpackard@sjha.org",
    "phone": "678-843-7119"
  },
  {
    "name": "Thomas E. Seay",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/163/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 76
Before
678-843-7119
After
404-303-3355
remove /protocolSection/contactsLocationsModule/locations/163/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 77
Before
kpackard@sjha.org
replace /protocolSection/contactsLocationsModule/locations/175/zip
Triage: Uncategorized
Uncategorized Operation 78
Before
96766-1099
After
96766
replace /protocolSection/contactsLocationsModule/locations/180/status
Triage: Uncategorized
Uncategorized Operation 79
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/180/contacts
Triage: Uncategorized
Uncategorized Operation 80
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/185/facility
Triage: Uncategorized
Uncategorized Operation 81
Before
Mountain States Tumor Institute - Twin Falls
After
Saint Luke&#x27;s Mountain States Tumor Institute-Twin Falls
replace /protocolSection/contactsLocationsModule/locations/187/status
Triage: Uncategorized
Uncategorized Operation 82
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/187/contacts
Triage: Uncategorized
Uncategorized Operation 83
Before
[
  {
    "name": "Patricia A. Johnson",
    "role": "CONTACT",
    "phone": "800-446-5532"
  },
  {
    "name": "Patricia A. Johnson",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/190/status
Triage: Uncategorized
Uncategorized Operation 84
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/190/contacts
Triage: Uncategorized
Uncategorized Operation 85
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/193/status
Triage: Uncategorized
Uncategorized Operation 86
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/193/contacts
Triage: Uncategorized
Uncategorized Operation 87
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/194/status
Triage: Uncategorized
Uncategorized Operation 88
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/194/contacts
Triage: Uncategorized
Uncategorized Operation 89
Before
[
  {
    "name": "Pam G. Khosla",
    "role": "CONTACT",
    "email": "suhi@sinai.org",
    "phone": "773-257-5960"
  },
  {
    "name": "Pam G. Khosla",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/198/status
Triage: Uncategorized
Uncategorized Operation 90
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/198/contacts
Triage: Uncategorized
Uncategorized Operation 91
Before
[
  {
    "name": "K. J. Philip",
    "role": "CONTACT",
    "phone": "773-878-8200"
  },
  {
    "name": "K. J. Philip",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/204/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 92
Before
Lucio DiNunno
After
Lucio Di Nunno
replace /protocolSection/contactsLocationsModule/locations/204/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 93
Before
Lucio DiNunno
After
Lucio Di Nunno
replace /protocolSection/contactsLocationsModule/locations/205/status
Triage: Uncategorized
Uncategorized Operation 94
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/205/contacts
Triage: Uncategorized
Uncategorized Operation 95
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/207/status
Triage: Uncategorized
Uncategorized Operation 96
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/207/contacts
Triage: Uncategorized
Uncategorized Operation 97
Before
[
  {
    "name": "K. J. Philip",
    "role": "CONTACT",
    "phone": "773-878-8200"
  },
  {
    "name": "K. J. Philip",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/208/status
Triage: Uncategorized
Uncategorized Operation 98
Before
WITHDRAWN
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/208/contacts
Triage: Uncategorized
Uncategorized Operation 99
After
[
  {
    "name": "Nguyet A. Le-Lindqwister",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "Nguyet A. Le-Lindqwister",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/210/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 100
Before
708-915-6747
After
708-915-4673
add /protocolSection/contactsLocationsModule/locations/210/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 101
After
clinicaltrials@ingalls.org
replace /protocolSection/contactsLocationsModule/locations/211/status
Triage: Uncategorized
Uncategorized Operation 102
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/211/contacts
Triage: Uncategorized
Uncategorized Operation 103
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/214/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 104
Before
708-679-2217
After
888-823-5923
add /protocolSection/contactsLocationsModule/locations/214/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 105
After
ctsucontact@westat.com
replace /protocolSection/contactsLocationsModule/locations/217/status
Triage: Uncategorized
Uncategorized Operation 106
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/217/contacts
Triage: Uncategorized
Uncategorized Operation 107
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/223/status
Triage: Uncategorized
Uncategorized Operation 108
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/223/contacts
Triage: Uncategorized
Uncategorized Operation 109
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/225/status
Triage: Uncategorized
Uncategorized Operation 110
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/225/contacts
Triage: Uncategorized
Uncategorized Operation 111
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/226/status
Triage: Uncategorized
Uncategorized Operation 112
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/226/contacts
Triage: Uncategorized
Uncategorized Operation 113
Before
[
  {
    "name": "Amar Hamad",
    "role": "CONTACT",
    "phone": "800-323-8622"
  },
  {
    "name": "Amar Hamad",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/229/status
Triage: Uncategorized
Uncategorized Operation 114
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/229/contacts
Triage: Uncategorized
Uncategorized Operation 115
Before
[
  {
    "name": "Jacob D. Bitran",
    "role": "CONTACT",
    "phone": "847-384-3621"
  },
  {
    "name": "Jacob D. Bitran",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/243/status
Triage: Uncategorized
Uncategorized Operation 116
Before
RECRUITING
After
TERMINATED
remove /protocolSection/contactsLocationsModule/locations/243/contacts
Triage: Uncategorized
Uncategorized Operation 117
Before
[
  {
    "name": "Shylendra B. Sreenivasappa",
    "role": "CONTACT",
    "phone": "815-227-2633"
  },
  {
    "name": "Shylendra B. Sreenivasappa",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/244/status
Triage: Uncategorized
Uncategorized Operation 118
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/244/contacts
Triage: Uncategorized
Uncategorized Operation 119
Before
[
  {
    "name": "John W. Kugler",
    "role": "CONTACT",
    "phone": "800-793-2262"
  },
  {
    "name": "John W. Kugler",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/246/status
Triage: Uncategorized
Uncategorized Operation 120
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/246/contacts
Triage: Uncategorized
Uncategorized Operation 121
Before
[
  {
    "name": "Patricia A. Johnson",
    "role": "CONTACT",
    "phone": "800-446-5532"
  },
  {
    "name": "Patricia A. Johnson",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/248/facility
Triage: Uncategorized
Uncategorized Operation 122
Before
Saint Francis Hospital and Health Centers
After
Saint John&#x27;s Health System Cancer Center
replace /protocolSection/contactsLocationsModule/locations/248/city
Triage: Uncategorized
Uncategorized Operation 123
Before
Beech Grove
After
Anderson
replace /protocolSection/contactsLocationsModule/locations/248/zip
Triage: Uncategorized
Uncategorized Operation 124
Before
46107
After
46016
replace /protocolSection/contactsLocationsModule/locations/248/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 125
Before
Howard M. Gross
After
Hazim I. Rimawi
replace /protocolSection/contactsLocationsModule/locations/248/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 126
Before
317-783-8918
After
765-751-5850
add /protocolSection/contactsLocationsModule/locations/248/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 127
After
alpatterson@medicalconsultantspc.com
replace /protocolSection/contactsLocationsModule/locations/248/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 128
Before
Howard M. Gross
After
Hazim I. Rimawi
replace /protocolSection/contactsLocationsModule/locations/248/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 129
Before
39.72199
After
40.10532
replace /protocolSection/contactsLocationsModule/locations/248/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 130
Before
-86.08998
After
-85.68025
add /protocolSection/contactsLocationsModule/locations/249
Triage: Uncategorized
Uncategorized Operation 131
After
{
  "zip": "46107",
  "city": "Beech Grove",
  "state": "Indiana",
  "status": "WITHDRAWN",
  "country": "United States",
  "facility": "Saint Francis Hospital and Health Centers",
  "geoPoint": {
    "lat": 39.72199,
    "lon": -86.08998
  }
}
add /protocolSection/contactsLocationsModule/locations/255
Triage: Uncategorized
Uncategorized Operation 132
After
{
  "zip": "46237",
  "city": "Indianapolis",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Howard M. Gross",
      "role": "CONTACT",
      "phone": "765-983-3000"
    },
    {
      "name": "Howard M. Gross",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Franciscan St. Francis Health",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
replace /protocolSection/contactsLocationsModule/locations/257/status
Triage: Uncategorized
Uncategorized Operation 133
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/257/contacts
Triage: Uncategorized
Uncategorized Operation 134
Before
[
  {
    "name": "Ruemu E. Birhiray",
    "role": "CONTACT",
    "phone": "317-338-2194"
  },
  {
    "name": "Ruemu E. Birhiray",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/258
Triage: Uncategorized
Uncategorized Operation 135
Before
{
  "zip": "46601",
  "city": "Indianapolis",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Naftali Bechar",
      "role": "CONTACT",
      "phone": "800-777-7775"
    },
    {
      "name": "Naftali Bechar",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Michiana Hematology Oncology Professional Corporation",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
replace /protocolSection/contactsLocationsModule/locations/259/facility
Triage: Uncategorized
Uncategorized Operation 136
Before
Laporte Hospital
After
Indiana University Health La Porte Hospital
replace /protocolSection/contactsLocationsModule/locations/260/status
Triage: Uncategorized
Uncategorized Operation 137
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/260/contacts
Triage: Uncategorized
Uncategorized Operation 138
Before
[
  {
    "name": "Patricia A. Johnson",
    "role": "CONTACT",
    "phone": "800-446-5532"
  },
  {
    "name": "Patricia A. Johnson",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/261
Triage: Uncategorized
Uncategorized Operation 139
After
{
  "zip": "46545-1470",
  "city": "Mishawaka",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Naftali Bechar",
      "role": "CONTACT",
      "phone": "800-777-7775"
    },
    {
      "name": "Naftali Bechar",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Michiana Hematology Oncology PC-Mishawaka",
  "geoPoint": {
    "lat": 41.66199,
    "lon": -86.15862
  }
}
add /protocolSection/contactsLocationsModule/locations/262
Triage: Uncategorized
Uncategorized Operation 140
After
{
  "zip": "46545-1470",
  "city": "Mishawaka",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Naftali Bechar",
      "role": "CONTACT",
      "phone": "800-777-7775"
    },
    {
      "name": "Naftali Bechar",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Joseph Regional Medical Center-Mishawaka",
  "geoPoint": {
    "lat": 41.66199,
    "lon": -86.15862
  }
}
remove /protocolSection/contactsLocationsModule/locations/270
Triage: Uncategorized
Uncategorized Operation 141
Before
{
  "zip": "46617",
  "city": "South Bend",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Naftali Bechar",
      "role": "CONTACT",
      "phone": "800-777-7775"
    },
    {
      "name": "Naftali Bechar",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Joseph&#x27;s Medical Center",
  "geoPoint": {
    "lat": 41.68338,
    "lon": -86.25001
  }
}
add /protocolSection/contactsLocationsModule/locations/272
Triage: Uncategorized
Uncategorized Operation 142
After
{
  "zip": "52402",
  "city": "Cedar Rapids",
  "state": "Iowa",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "David W. Zenk",
      "role": "CONTACT",
      "email": "cetscheidt@pcofiowa.com",
      "phone": "319-297-2900"
    },
    {
      "name": "David W. Zenk",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Iowa Blood and Cancer Care PLC",
  "geoPoint": {
    "lat": 42.00833,
    "lon": -91.64407
  }
}
add /protocolSection/contactsLocationsModule/locations/273
Triage: Uncategorized
Uncategorized Operation 143
After
{
  "zip": "52402",
  "city": "Cedar Rapids",
  "state": "Iowa",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "David W. Zenk",
      "role": "CONTACT",
      "email": "cetscheidt@pcofiowa.com",
      "phone": "319-297-2900"
    },
    {
      "name": "David W. Zenk",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Luke&#x27;s Hospital",
  "geoPoint": {
    "lat": 42.00833,
    "lon": -91.64407
  }
}
replace /protocolSection/contactsLocationsModule/locations/275/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 144
Before
Deborah W. Wilbur
After
David W. Zenk
replace /protocolSection/contactsLocationsModule/locations/275/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 145
Before
319-363-2690
After
319-297-2900
add /protocolSection/contactsLocationsModule/locations/275/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 146
After
cetscheidt@pcofiowa.com
replace /protocolSection/contactsLocationsModule/locations/275/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 147
Before
Deborah W. Wilbur
After
David W. Zenk
replace /protocolSection/contactsLocationsModule/locations/276/facility
Triage: Uncategorized
Uncategorized Operation 148
Before
Oncology Associates
After
Oncology Associates at Mercy Medical Center
replace /protocolSection/contactsLocationsModule/locations/288/facility
Triage: Uncategorized
Uncategorized Operation 149
Before
Siouxland Hematology - Oncology Associates
After
Siouxland Hematology Oncology Associates
replace /protocolSection/contactsLocationsModule/locations/291/status
Triage: Uncategorized
Uncategorized Operation 150
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/291/contacts
Triage: Uncategorized
Uncategorized Operation 151
Before
[
  {
    "name": "Mohammed T. Masri",
    "role": "CONTACT",
    "phone": "319-272-2070"
  },
  {
    "name": "Mohammed T. Masri",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/319
Triage: Uncategorized
Uncategorized Operation 152
After
{
  "zip": "40202",
  "city": "Louisville",
  "state": "Kentucky",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Janell Seeger",
      "role": "CONTACT",
      "phone": "502-629-2500"
    },
    {
      "name": "Janell Seeger",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Norton Health Care Pavilion - Downtown",
  "geoPoint": {
    "lat": 38.25424,
    "lon": -85.75941
  }
}
add /protocolSection/contactsLocationsModule/locations/320
Triage: Uncategorized
Uncategorized Operation 153
After
{
  "zip": "40202",
  "city": "Louisville",
  "state": "Kentucky",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Elizabeth C. Riley",
      "role": "CONTACT",
      "phone": "866-530-5516"
    },
    {
      "name": "Elizabeth C. Riley",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "The James Graham Brown Cancer Center at University of Louisville",
  "geoPoint": {
    "lat": 38.25424,
    "lon": -85.75941
  }
}
remove /protocolSection/contactsLocationsModule/locations/322
Triage: Uncategorized
Uncategorized Operation 154
Before
{
  "zip": "40292",
  "city": "Louisville",
  "state": "Kentucky",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Elizabeth C. Riley",
      "role": "CONTACT",
      "phone": "866-530-5516"
    },
    {
      "name": "Elizabeth C. Riley",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of Louisville",
  "geoPoint": {
    "lat": 38.25424,
    "lon": -85.75941
  }
}
replace /protocolSection/contactsLocationsModule/locations/331/facility
Triage: Uncategorized
Uncategorized Operation 155
Before
Memorial Medical Center
After
Ochsner Baptist Medical Center
replace /protocolSection/contactsLocationsModule/locations/338/facility
Triage: Uncategorized
Uncategorized Operation 156
Before
Maine Center for Cancer Medicine and Blood Disorders
After
Penobscot Bay Medical Center
replace /protocolSection/contactsLocationsModule/locations/338/city
Triage: Uncategorized
Uncategorized Operation 157
Before
Scarborough
After
Rockport
replace /protocolSection/contactsLocationsModule/locations/338/zip
Triage: Uncategorized
Uncategorized Operation 158
Before
04074
After
04856
replace /protocolSection/contactsLocationsModule/locations/338/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 159
Before
Tracey F. Weisberg
After
Thomas H. Openshaw
replace /protocolSection/contactsLocationsModule/locations/338/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 160
Before
207-396-7600
After
207-973-4274
replace /protocolSection/contactsLocationsModule/locations/338/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 161
Before
Tracey F. Weisberg
After
Thomas H. Openshaw
replace /protocolSection/contactsLocationsModule/locations/338/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 162
Before
43.57814
After
44.18452
replace /protocolSection/contactsLocationsModule/locations/338/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 163
Before
-70.32172
After
-69.07615
add /protocolSection/contactsLocationsModule/locations/339
Triage: Uncategorized
Uncategorized Operation 164
After
{
  "zip": "04074",
  "city": "Scarborough",
  "state": "Maine",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Tracey F. Weisberg",
      "role": "CONTACT",
      "phone": "207-396-7600"
    },
    {
      "name": "Tracey F. Weisberg",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Maine Center for Cancer Medicine and Blood Disorders-Scarborough",
  "geoPoint": {
    "lat": 43.57814,
    "lon": -70.32172
  }
}
replace /protocolSection/contactsLocationsModule/locations/342/status
Triage: Uncategorized
Uncategorized Operation 165
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/342/contacts
Triage: Uncategorized
Uncategorized Operation 166
Before
[
  {
    "name": "Katherine H. Tkaczuk",
    "role": "CONTACT",
    "phone": "800-888-8823"
  },
  {
    "name": "Katherine H. Tkaczuk",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/343/status
Triage: Uncategorized
Uncategorized Operation 167
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/343/contacts
Triage: Uncategorized
Uncategorized Operation 168
Before
[
  {
    "name": "David A. Riseberg",
    "role": "CONTACT",
    "email": "prc@mdmercy.com",
    "phone": "410-951-7950"
  },
  {
    "name": "David A. Riseberg",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/344/status
Triage: Uncategorized
Uncategorized Operation 169
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/344/contacts
Triage: Uncategorized
Uncategorized Operation 170
Before
[
  {
    "name": "Madhu Chaudhry",
    "role": "CONTACT",
    "phone": "443-849-3706"
  },
  {
    "name": "Madhu Chaudhry",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/346/status
Triage: Uncategorized
Uncategorized Operation 171
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/346/contacts
Triage: Uncategorized
Uncategorized Operation 172
Before
[
  {
    "name": "John L. Zapas",
    "role": "CONTACT",
    "phone": "443-777-7364"
  },
  {
    "name": "John L. Zapas",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/348/status
Triage: Uncategorized
Uncategorized Operation 173
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/348/contacts
Triage: Uncategorized
Uncategorized Operation 174
Before
[
  {
    "name": "John L. Zapas",
    "role": "CONTACT",
    "phone": "443-777-7364"
  },
  {
    "name": "John L. Zapas",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/351
Triage: Uncategorized
Uncategorized Operation 175
After
{
  "zip": "21014",
  "city": "Bel Air",
  "state": "Maryland",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Upper Chesapeake Medical Center",
  "geoPoint": {
    "lat": 39.53594,
    "lon": -76.34829
  }
}
replace /protocolSection/contactsLocationsModule/locations/353/facility
Triage: Uncategorized
Uncategorized Operation 176
Before
Western Maryland Health System - Braddock Campus
After
Walter Reed National Military Medical Center
replace /protocolSection/contactsLocationsModule/locations/353/city
Triage: Uncategorized
Uncategorized Operation 177
Before
Cumberland
After
Bethesda
replace /protocolSection/contactsLocationsModule/locations/353/zip
Triage: Uncategorized
Uncategorized Operation 178
Before
21502
After
20889-5600
replace /protocolSection/contactsLocationsModule/locations/353/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 179
Before
Alida I. Podrumar
After
David C. Van Echo
replace /protocolSection/contactsLocationsModule/locations/353/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 180
Before
240-964-1400
After
301-319-2100
replace /protocolSection/contactsLocationsModule/locations/353/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 181
Before
Alida I. Podrumar
After
David C. Van Echo
replace /protocolSection/contactsLocationsModule/locations/353/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 182
Before
39.65287
After
38.98067
replace /protocolSection/contactsLocationsModule/locations/353/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 183
Before
-78.76252
After
-77.10026
add /protocolSection/contactsLocationsModule/locations/354
Triage: Uncategorized
Uncategorized Operation 184
After
{
  "zip": "21502",
  "city": "Cumberland",
  "state": "Maryland",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Alida I. Podrumar",
      "role": "CONTACT",
      "phone": "240-964-1400"
    },
    {
      "name": "Alida I. Podrumar",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Western Maryland Health System",
  "geoPoint": {
    "lat": 39.65287,
    "lon": -78.76252
  }
}
replace /protocolSection/contactsLocationsModule/locations/357/status
Triage: Uncategorized
Uncategorized Operation 185
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/357/contacts
Triage: Uncategorized
Uncategorized Operation 186
Before
[
  {
    "name": "Brian M. O&#x27;Connor",
    "role": "CONTACT",
    "email": "clinicaltrials@fmh.org",
    "phone": "240-566-3584"
  },
  {
    "name": "Brian M. O&#x27;Connor",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/359/status
Triage: Uncategorized
Uncategorized Operation 187
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/359/contacts
Triage: Uncategorized
Uncategorized Operation 188
Before
[
  {
    "name": "Michael J. McCormack",
    "role": "CONTACT",
    "email": "susan.smith@wchsys.org",
    "phone": "800-411-3901"
  },
  {
    "name": "Michael J. McCormack",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/364/status
Triage: Uncategorized
Uncategorized Operation 189
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/364/contacts
Triage: Uncategorized
Uncategorized Operation 190
Before
[
  {
    "name": "Cheryl A. Aylesworth",
    "role": "CONTACT",
    "email": "Bsquiller@suburbanhospital.org",
    "phone": "301-896-2719"
  },
  {
    "name": "Cheryl A. Aylesworth",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/367
Triage: Uncategorized
Uncategorized Operation 191
After
{
  "zip": "02114",
  "city": "Boston",
  "state": "Massachusetts",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Amy H. Comander",
      "role": "CONTACT",
      "phone": "617-667-9925"
    },
    {
      "name": "Amy H. Comander",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Massachusetts General Hospital Cancer Center",
  "geoPoint": {
    "lat": 42.35843,
    "lon": -71.05977
  }
}
add /protocolSection/contactsLocationsModule/locations/368
Triage: Uncategorized
Uncategorized Operation 192
After
{
  "zip": "02115",
  "city": "Boston",
  "state": "Massachusetts",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Dana-Farber Cancer Institute",
  "geoPoint": {
    "lat": 42.35843,
    "lon": -71.05977
  }
}
replace /protocolSection/contactsLocationsModule/locations/370/status
Triage: Uncategorized
Uncategorized Operation 193
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/370/contacts
Triage: Uncategorized
Uncategorized Operation 194
Before
[
  {
    "name": "Neela Natarajan",
    "role": "CONTACT",
    "phone": "781-744-8027"
  },
  {
    "name": "Neela Natarajan",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/374/status
Triage: Uncategorized
Uncategorized Operation 195
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/374/contacts
Triage: Uncategorized
Uncategorized Operation 196
Before
[
  {
    "name": "Blair Ardman",
    "role": "CONTACT",
    "email": "ghincks@lowellgeneral.org",
    "phone": "978-788-7084"
  },
  {
    "name": "Blair Ardman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/376
Triage: Uncategorized
Uncategorized Operation 197
After
{
  "zip": "01960",
  "city": "Peabody",
  "state": "Massachusetts",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Amy H. Comander",
      "role": "CONTACT",
      "phone": "617-667-9925"
    },
    {
      "name": "Amy H. Comander",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "North Shore Medical Center Cancer Center",
  "geoPoint": {
    "lat": 42.52787,
    "lon": -70.92866
  }
}
replace /protocolSection/contactsLocationsModule/locations/383/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 198
Before
Daniel F. Hayes
After
Anne F. Schott
replace /protocolSection/contactsLocationsModule/locations/383/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 199
Before
Daniel F. Hayes
After
Anne F. Schott
add /protocolSection/contactsLocationsModule/locations/387
Triage: Uncategorized
Uncategorized Operation 200
After
{
  "zip": "48346",
  "city": "Clarkston",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Justin F. Klamerus",
      "role": "CONTACT",
      "phone": "800-248-6777"
    },
    {
      "name": "Justin F. Klamerus",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Great Lakes Cancer Institute",
  "geoPoint": {
    "lat": 42.73586,
    "lon": -83.41883
  }
}
replace /protocolSection/contactsLocationsModule/locations/389/zip
Triage: Uncategorized
Uncategorized Operation 201
Before
48123
After
48124
replace /protocolSection/contactsLocationsModule/locations/391/status
Triage: Uncategorized
Uncategorized Operation 202
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/391/contacts
Triage: Uncategorized
Uncategorized Operation 203
Before
[
  {
    "name": "Lawrence E. Flaherty",
    "role": "CONTACT",
    "phone": "313-576-9363"
  },
  {
    "name": "Lawrence E. Flaherty",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/393
Triage: Uncategorized
Uncategorized Operation 204
Before
{
  "zip": "48824-1313",
  "city": "East Lansing",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Deimante M. Tamkus",
      "role": "CONTACT",
      "phone": "517-334-2765"
    },
    {
      "name": "Deimante M. Tamkus",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Michigan State University - Breslin Cancer Center",
  "geoPoint": {
    "lat": 42.73698,
    "lon": -84.48387
  }
}
replace /protocolSection/contactsLocationsModule/locations/400/status
Triage: Uncategorized
Uncategorized Operation 205
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/400/contacts
Triage: Uncategorized
Uncategorized Operation 206
Before
[
  {
    "name": "Philip J. Stella",
    "role": "CONTACT",
    "phone": "734-712-3456"
  },
  {
    "name": "Philip J. Stella",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/410
Triage: Uncategorized
Uncategorized Operation 207
After
{
  "zip": "48910",
  "city": "Lansing",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Deimante M. Tamkus",
      "role": "CONTACT",
      "phone": "517-334-2765"
    },
    {
      "name": "Deimante M. Tamkus",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Michigan State University - Breslin Cancer Center",
  "geoPoint": {
    "lat": 42.73253,
    "lon": -84.55553
  }
}
replace /protocolSection/contactsLocationsModule/locations/420/status
Triage: Uncategorized
Uncategorized Operation 208
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/428/facility
Triage: Uncategorized
Uncategorized Operation 209
Before
Lakeside Cancer Specialists PLLC
After
Marie Yeager Cancer Center
replace /protocolSection/contactsLocationsModule/locations/429/status
Triage: Uncategorized
Uncategorized Operation 210
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/429/contacts
Triage: Uncategorized
Uncategorized Operation 211
Before
[
  {
    "name": "Anibal Drelichman",
    "role": "CONTACT",
    "email": "jaswinder.grewal@stjohn.org",
    "phone": "248-849-5337"
  },
  {
    "name": "Anibal Drelichman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/432/status
Triage: Uncategorized
Uncategorized Operation 212
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/434/facility
Triage: Uncategorized
Uncategorized Operation 213
Before
Merit Care Clinic Bemidji
After
Sanford Clinic North-Bemidgi
replace /protocolSection/contactsLocationsModule/locations/435/facility
Triage: Uncategorized
Uncategorized Operation 214
Before
Saint Joseph&#x27;s Medical Center
After
Essentia Health Saint Joseph&#x27;s Medical Center
add /protocolSection/contactsLocationsModule/locations/439
Triage: Uncategorized
Uncategorized Operation 215
After
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Daniel A. Nikcevich",
      "role": "CONTACT",
      "phone": "888-203-7267"
    },
    {
      "name": "Daniel A. Nikcevich",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Essentia Health Saint Mary&#x27;s Medical Center",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
remove /protocolSection/contactsLocationsModule/locations/442
Triage: Uncategorized
Uncategorized Operation 216
Before
{
  "zip": "55805",
  "city": "Duluth",
  "state": "Minnesota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Daniel A. Nikcevich",
      "role": "CONTACT",
      "phone": "888-203-7267"
    },
    {
      "name": "Daniel A. Nikcevich",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Mary&#x27;s Medical Center",
  "geoPoint": {
    "lat": 46.78327,
    "lon": -92.10658
  }
}
replace /protocolSection/contactsLocationsModule/locations/472/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 217
Before
Elizabeth C. Kent
After
John H. Vu
remove /protocolSection/contactsLocationsModule/locations/472/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 218
Before
adyoung@freemanhealth.com
replace /protocolSection/contactsLocationsModule/locations/472/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 219
Before
Elizabeth C. Kent
After
John H. Vu
replace /protocolSection/contactsLocationsModule/locations/473/status
Triage: Uncategorized
Uncategorized Operation 220
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
add /protocolSection/contactsLocationsModule/locations/483
Triage: Uncategorized
Uncategorized Operation 221
After
{
  "zip": "65401",
  "city": "Rolla",
  "state": "Missouri",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Robert L. Carolla",
      "role": "CONTACT",
      "phone": "417-269-4520"
    },
    {
      "name": "Robert L. Carolla",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint John&#x27;s Clinic-Rolla-Cancer and Hematology",
  "geoPoint": {
    "lat": 37.95143,
    "lon": -91.77127
  }
}
replace /protocolSection/contactsLocationsModule/locations/489/facility
Triage: Uncategorized
Uncategorized Operation 222
Before
Saint Louis Cancer and Breast Institute
After
Saint Louis Cancer and Breast Institute-South City
replace /protocolSection/contactsLocationsModule/locations/490/facility
Triage: Uncategorized
Uncategorized Operation 223
Before
Saint Anthony&#x27;s Medical Center
After
Washington University School of Medicine
replace /protocolSection/contactsLocationsModule/locations/490/zip
Triage: Uncategorized
Uncategorized Operation 224
Before
63128
After
63110
replace /protocolSection/contactsLocationsModule/locations/490/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 225
Before
Minxiang (Michael) Gu
After
Timothy J. Pluard
replace /protocolSection/contactsLocationsModule/locations/490/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 226
Before
888-823-5923
After
800-600-3606
replace /protocolSection/contactsLocationsModule/locations/490/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 227
Before
ctsucontact@westat.com
After
info@siteman.wustl.edu
replace /protocolSection/contactsLocationsModule/locations/490/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 228
Before
Minxiang (Michael) Gu
After
Timothy J. Pluard
add /protocolSection/contactsLocationsModule/locations/491
Triage: Uncategorized
Uncategorized Operation 229
After
{
  "zip": "63128",
  "city": "St Louis",
  "state": "Missouri",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Saint Anthony&#x27;s Medical Center",
  "geoPoint": {
    "lat": 38.62727,
    "lon": -90.19789
  }
}
replace /protocolSection/contactsLocationsModule/locations/503/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 230
Before
Benjamin T. Marchello
After
Grant W. Harrer
replace /protocolSection/contactsLocationsModule/locations/503/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 231
Before
800-648-6274
After
406-731-8217
replace /protocolSection/contactsLocationsModule/locations/503/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 232
Before
Benjamin T. Marchello
After
Grant W. Harrer
replace /protocolSection/contactsLocationsModule/locations/504/status
Triage: Uncategorized
Uncategorized Operation 233
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/504/contacts
Triage: Uncategorized
Uncategorized Operation 234
Before
[
  {
    "name": "Grant W. Harrer",
    "role": "CONTACT",
    "phone": "406-731-8217"
  },
  {
    "name": "Grant W. Harrer",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/505/status
Triage: Uncategorized
Uncategorized Operation 235
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/505/contacts
Triage: Uncategorized
Uncategorized Operation 236
Before
[
  {
    "name": "Benjamin T. Marchello",
    "role": "CONTACT",
    "phone": "800-648-6274"
  },
  {
    "name": "Benjamin T. Marchello",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/508/status
Triage: Uncategorized
Uncategorized Operation 237
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/508/contacts
Triage: Uncategorized
Uncategorized Operation 238
Before
[
  {
    "name": "Benjamin T. Marchello",
    "role": "CONTACT",
    "phone": "800-648-6274"
  },
  {
    "name": "Benjamin T. Marchello",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/509/status
Triage: Uncategorized
Uncategorized Operation 239
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/509/contacts
Triage: Uncategorized
Uncategorized Operation 240
Before
[
  {
    "name": "Benjamin T. Marchello",
    "role": "CONTACT",
    "phone": "800-648-6274"
  },
  {
    "name": "Benjamin T. Marchello",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/524/status
Triage: Uncategorized
Uncategorized Operation 241
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/524/contacts
Triage: Uncategorized
Uncategorized Operation 242
Before
[
  {
    "name": "Michael S. Buff",
    "role": "CONTACT",
    "phone": "800-339-6484"
  },
  {
    "name": "Michael S. Buff",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/526/status
Triage: Uncategorized
Uncategorized Operation 243
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/526/contacts
Triage: Uncategorized
Uncategorized Operation 244
Before
[
  {
    "name": "Mary D. Chamberlin",
    "role": "CONTACT",
    "email": "cancerhelp@dartmouth.edu",
    "phone": "603-650-7609"
  },
  {
    "name": "Mary D. Chamberlin",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/528/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 245
Before
603-650-7609
After
800-639-6918
replace /protocolSection/contactsLocationsModule/locations/528/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 246
Before
cancerhelp@dartmouth.edu
After
cancer.research.nurse@dartmouth.edu
replace /protocolSection/contactsLocationsModule/locations/529/status
Triage: Uncategorized
Uncategorized Operation 247
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/529/zip
Triage: Uncategorized
Uncategorized Operation 248
Before
03104
After
03102
remove /protocolSection/contactsLocationsModule/locations/529/contacts
Triage: Uncategorized
Uncategorized Operation 249
Before
[
  {
    "name": "Mary D. Chamberlin",
    "role": "CONTACT",
    "email": "cancerhelp@dartmouth.edu",
    "phone": "603-650-7609"
  },
  {
    "name": "Mary D. Chamberlin",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/536/status
Triage: Uncategorized
Uncategorized Operation 250
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/536/contacts
Triage: Uncategorized
Uncategorized Operation 251
Before
[
  {
    "name": "Kenneth D. Nahum",
    "role": "CONTACT",
    "phone": "732-776-4240"
  },
  {
    "name": "Kenneth D. Nahum",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/546
Triage: Uncategorized
Uncategorized Operation 252
After
{
  "zip": "87102",
  "city": "Albuquerque",
  "state": "New Mexico",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Melanie E. Royce",
      "role": "CONTACT",
      "phone": "505-727-8000"
    },
    {
      "name": "Melanie E. Royce",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of New Mexico at Lovelace Medical Center",
  "geoPoint": {
    "lat": 35.08449,
    "lon": -106.65114
  }
}
replace /protocolSection/contactsLocationsModule/locations/548/facility
Triage: Uncategorized
Uncategorized Operation 253
Before
University of New Mexico Cancer Center
After
University of New Mexico
replace /protocolSection/contactsLocationsModule/locations/553/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 254
Before
203-937-3421
After
518-525-1547
remove /protocolSection/contactsLocationsModule/locations/553/contacts/0/phoneExt
Triage: Uncategorized
Uncategorized Operation 255
Before
2832
replace /protocolSection/contactsLocationsModule/locations/560/status
Triage: Uncategorized
Uncategorized Operation 256
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/560/contacts
Triage: Uncategorized
Uncategorized Operation 257
After
[
  {
    "name": "Robert W. Sponzo",
    "role": "CONTACT",
    "phone": "518-926-6700"
  },
  {
    "name": "Robert W. Sponzo",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/563/status
Triage: Uncategorized
Uncategorized Operation 258
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/563/contacts
Triage: Uncategorized
Uncategorized Operation 259
Before
[
  {
    "name": "Iuliana Shapira",
    "role": "CONTACT",
    "phone": "516-562-3467"
  },
  {
    "name": "Iuliana Shapira",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/565/facility
Triage: Uncategorized
Uncategorized Operation 260
Before
North Shore University Hospital CCOP
After
North Shore University Hospital
replace /protocolSection/contactsLocationsModule/locations/565/status
Triage: Uncategorized
Uncategorized Operation 261
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/565/contacts
Triage: Uncategorized
Uncategorized Operation 262
Before
[
  {
    "name": "Lora R. Weiselberg",
    "role": "CONTACT",
    "phone": "516-562-3467"
  },
  {
    "name": "Lora R. Weiselberg",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/566/facility
Triage: Uncategorized
Uncategorized Operation 263
Before
North Shore University Hospital
After
North Shore-LIJ Health System CCOP
replace /protocolSection/contactsLocationsModule/locations/566/status
Triage: Uncategorized
Uncategorized Operation 264
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/566/contacts
Triage: Uncategorized
Uncategorized Operation 265
Before
[
  {
    "name": "Iuliana Shapira",
    "role": "CONTACT",
    "phone": "516-562-3467"
  },
  {
    "name": "Iuliana Shapira",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/569/facility
Triage: Uncategorized
Uncategorized Operation 266
Before
Long Island Jewish Medical Center
After
Mount Kisco Medical Group at Northern Westchester Hospital
replace /protocolSection/contactsLocationsModule/locations/569/city
Triage: Uncategorized
Uncategorized Operation 267
Before
New Hyde Park
After
Mount Kisco
replace /protocolSection/contactsLocationsModule/locations/569/zip
Triage: Uncategorized
Uncategorized Operation 268
Before
11040
After
10549-3417
replace /protocolSection/contactsLocationsModule/locations/569/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 269
Before
Iuliana Shapira
After
Jonathan S. Goldberg
replace /protocolSection/contactsLocationsModule/locations/569/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 270
Before
516-562-3467
After
914-666-1366
add /protocolSection/contactsLocationsModule/locations/569/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 271
After
skloiber@nwhc.net
replace /protocolSection/contactsLocationsModule/locations/569/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 272
Before
Iuliana Shapira
After
Jonathan S. Goldberg
replace /protocolSection/contactsLocationsModule/locations/569/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 273
Before
40.7351
After
41.20426
replace /protocolSection/contactsLocationsModule/locations/569/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 274
Before
-73.68791
After
-73.72708
add /protocolSection/contactsLocationsModule/locations/570
Triage: Uncategorized
Uncategorized Operation 275
After
{
  "zip": "11040",
  "city": "New Hyde Park",
  "state": "New York",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Long Island Jewish Medical Center",
  "geoPoint": {
    "lat": 40.7351,
    "lon": -73.68791
  }
}
replace /protocolSection/contactsLocationsModule/locations/573/status
Triage: Uncategorized
Uncategorized Operation 276
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/573/contacts
Triage: Uncategorized
Uncategorized Operation 277
Before
[
  {
    "name": "Kevin M. Kalinsky",
    "role": "CONTACT",
    "phone": "212-305-8615"
  },
  {
    "name": "Kevin M. Kalinsky",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/581/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 278
Before
Meekoo Dhar
After
Terenig O. Terjanian
replace /protocolSection/contactsLocationsModule/locations/581/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 279
Before
Meekoo Dhar
After
Terenig O. Terjanian
replace /protocolSection/contactsLocationsModule/locations/593/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 280
Before
Mark J. Mogul
After
Justin P. Favaro
replace /protocolSection/contactsLocationsModule/locations/593/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 281
Before
304-399-6617
After
704-384-5369
replace /protocolSection/contactsLocationsModule/locations/593/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 282
Before
Mark J. Mogul
After
Justin P. Favaro
replace /protocolSection/contactsLocationsModule/locations/599/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 283
Before
828-696-1341
After
828-696-4716
add /protocolSection/contactsLocationsModule/locations/603
Triage: Uncategorized
Uncategorized Operation 284
After
{
  "zip": "28112",
  "city": "Monroe",
  "state": "North Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Steven A. Limentani",
      "role": "CONTACT",
      "phone": "704-355-2884"
    },
    {
      "name": "Steven A. Limentani",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Carolinas Medical Center-Union",
  "geoPoint": {
    "lat": 34.98543,
    "lon": -80.54951
  }
}
add /protocolSection/contactsLocationsModule/locations/611
Triage: Uncategorized
Uncategorized Operation 285
After
{
  "zip": "28150",
  "city": "Shelby",
  "state": "North Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Steven A. Limentani",
      "role": "CONTACT",
      "phone": "704-355-2884"
    },
    {
      "name": "Steven A. Limentani",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Cleveland Regional Medical Center",
  "geoPoint": {
    "lat": 35.29235,
    "lon": -81.53565
  }
}
remove /protocolSection/contactsLocationsModule/locations/616
Triage: Uncategorized
Uncategorized Operation 286
Before
{
  "zip": "58501",
  "city": "Bismarck",
  "state": "North Dakota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "John T. Reynolds",
      "role": "CONTACT",
      "email": "tfischer@mohs.org",
      "phone": "701-323-5760"
    },
    {
      "name": "John T. Reynolds",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Medcenter One Health Systems",
  "geoPoint": {
    "lat": 46.80833,
    "lon": -100.78374
  }
}
replace /protocolSection/contactsLocationsModule/locations/618/facility
Triage: Uncategorized
Uncategorized Operation 287
Before
Innovis Health South University
After
Sanford Bismarck Medical Center
replace /protocolSection/contactsLocationsModule/locations/618/city
Triage: Uncategorized
Uncategorized Operation 288
Before
Fargo
After
Bismarck
replace /protocolSection/contactsLocationsModule/locations/618/zip
Triage: Uncategorized
Uncategorized Operation 289
Before
58103
After
58501
replace /protocolSection/contactsLocationsModule/locations/618/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 290
Before
Daniel A. Nikcevich
After
John T. Reynolds
replace /protocolSection/contactsLocationsModule/locations/618/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 291
Before
888-203-7267
After
701-323-5760
add /protocolSection/contactsLocationsModule/locations/618/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 292
After
tfischer@mohs.org
replace /protocolSection/contactsLocationsModule/locations/618/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 293
Before
Daniel A. Nikcevich
After
John T. Reynolds
replace /protocolSection/contactsLocationsModule/locations/618/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 294
Before
46.87719
After
46.80833
replace /protocolSection/contactsLocationsModule/locations/618/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 295
Before
-96.7898
After
-100.78374
replace /protocolSection/contactsLocationsModule/locations/619/facility
Triage: Uncategorized
Uncategorized Operation 296
Before
Meritcare Hospital
After
Essentia Health Cancer Center-South University Clinic
replace /protocolSection/contactsLocationsModule/locations/619/zip
Triage: Uncategorized
Uncategorized Operation 297
Before
58122
After
58103
replace /protocolSection/contactsLocationsModule/locations/619/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 298
Before
Preston D. Steen
After
Daniel A. Nikcevich
replace /protocolSection/contactsLocationsModule/locations/619/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 299
Before
701-234-6161
After
888-203-7267
replace /protocolSection/contactsLocationsModule/locations/619/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 300
Before
Preston D. Steen
After
Daniel A. Nikcevich
remove /protocolSection/contactsLocationsModule/locations/620
Triage: Uncategorized
Uncategorized Operation 301
Before
{
  "zip": "58122",
  "city": "Fargo",
  "state": "North Dakota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Preston D. Steen",
      "role": "CONTACT",
      "phone": "701-234-6161"
    },
    {
      "name": "Preston D. Steen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "MeritCare Medical Group",
  "geoPoint": {
    "lat": 46.87719,
    "lon": -96.7898
  }
}
add /protocolSection/contactsLocationsModule/locations/621
Triage: Uncategorized
Uncategorized Operation 302
After
{
  "zip": "58122",
  "city": "Fargo",
  "state": "North Dakota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Preston D. Steen",
      "role": "CONTACT",
      "phone": "701-234-6161"
    },
    {
      "name": "Preston D. Steen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Sanford Clinic North-Fargo",
  "geoPoint": {
    "lat": 46.87719,
    "lon": -96.7898
  }
}
add /protocolSection/contactsLocationsModule/locations/622
Triage: Uncategorized
Uncategorized Operation 303
After
{
  "zip": "58122",
  "city": "Fargo",
  "state": "North Dakota",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Preston D. Steen",
      "role": "CONTACT",
      "phone": "701-234-6161"
    },
    {
      "name": "Preston D. Steen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Sanford Medical Center-Fargo",
  "geoPoint": {
    "lat": 46.87719,
    "lon": -96.7898
  }
}
replace /protocolSection/contactsLocationsModule/locations/624/status
Triage: Uncategorized
Uncategorized Operation 304
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/624/contacts
Triage: Uncategorized
Uncategorized Operation 305
Before
[
  {
    "name": "Patanit Watanaboonyakhet",
    "role": "CONTACT",
    "phone": "800-862-0005"
  },
  {
    "name": "Patanit Watanaboonyakhet",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/625/facility
Triage: Uncategorized
Uncategorized Operation 306
Before
Akron City Hospital
After
Summa Akron City Hospital
replace /protocolSection/contactsLocationsModule/locations/628/facility
Triage: Uncategorized
Uncategorized Operation 307
Before
Wood County Oncology Center
After
Toledo Clinic Cancer Centers-Bowling Green
replace /protocolSection/contactsLocationsModule/locations/629/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 308
Before
Eleftherios P. Mamounas
After
Shruti Trehan
replace /protocolSection/contactsLocationsModule/locations/629/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 309
Before
Eleftherios P. Mamounas
After
Shruti Trehan
replace /protocolSection/contactsLocationsModule/locations/635/facility
Triage: Uncategorized
Uncategorized Operation 310
Before
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
After
Ohio State University Medical Center
replace /protocolSection/contactsLocationsModule/locations/649/status
Triage: Uncategorized
Uncategorized Operation 311
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/649/contacts
Triage: Uncategorized
Uncategorized Operation 312
Before
[
  {
    "name": "Rex B. Mowat",
    "role": "CONTACT",
    "phone": "517-265-0116"
  },
  {
    "name": "Rex B. Mowat",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/656/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 313
Before
888-823-5923
After
419-226-9617
remove /protocolSection/contactsLocationsModule/locations/656/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 314
Before
ctsucontact@westat.com
replace /protocolSection/contactsLocationsModule/locations/660/facility
Triage: Uncategorized
Uncategorized Operation 315
Before
Northwest Ohio Oncology Center
After
Toledo Clinic Cancer Centers-Maumee
replace /protocolSection/contactsLocationsModule/locations/669/status
Triage: Uncategorized
Uncategorized Operation 316
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/669/contacts
Triage: Uncategorized
Uncategorized Operation 317
Before
[
  {
    "name": "Rex B. Mowat",
    "role": "CONTACT",
    "phone": "517-265-0116"
  },
  {
    "name": "Rex B. Mowat",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/670/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 318
Before
502-361-8496
After
614-566-3275
replace /protocolSection/contactsLocationsModule/locations/673/facility
Triage: Uncategorized
Uncategorized Operation 319
Before
The Toledo Hospital
After
The Toledo Hospital&#x2F;Toledo Children&#x27;s Hospital
replace /protocolSection/contactsLocationsModule/locations/678/facility
Triage: Uncategorized
Uncategorized Operation 320
Before
Toledo Clinic
After
Toledo Clinic Cancer Centers-Toledo
replace /protocolSection/contactsLocationsModule/locations/687/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 321
Before
Shubham Pant
After
Carla Kurkjian
replace /protocolSection/contactsLocationsModule/locations/687/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 322
Before
Shubham Pant
After
Carla Kurkjian
add /protocolSection/contactsLocationsModule/locations/688
Triage: Uncategorized
Uncategorized Operation 323
After
{
  "zip": "73142",
  "city": "Oklahoma City",
  "state": "Oklahoma",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Romeo A. Mandanas",
      "role": "CONTACT",
      "phone": "405-949-3870"
    },
    {
      "name": "Romeo A. Mandanas",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Integris Cancer Institute of Oklahoma",
  "geoPoint": {
    "lat": 35.46756,
    "lon": -97.51643
  }
}
replace /protocolSection/contactsLocationsModule/locations/693/status
Triage: Uncategorized
Uncategorized Operation 324
Before
RECRUITING
After
TERMINATED
remove /protocolSection/contactsLocationsModule/locations/693/contacts
Triage: Uncategorized
Uncategorized Operation 325
Before
[
  {
    "name": "Charles R. Dibb",
    "role": "CONTACT",
    "phone": "541-789-6176"
  },
  {
    "name": "Charles R. Dibb",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/698/status
Triage: Uncategorized
Uncategorized Operation 326
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/698/contacts
Triage: Uncategorized
Uncategorized Operation 327
Before
[
  {
    "name": "Jay C. Andersen",
    "role": "CONTACT",
    "phone": "800-220-4937"
  },
  {
    "name": "Jay C. Andersen",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/712
Triage: Uncategorized
Uncategorized Operation 328
After
{
  "zip": "18042",
  "city": "Easton",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Rajen P. Oza",
      "role": "CONTACT",
      "phone": "610-250-4000"
    },
    {
      "name": "Rajen P. Oza",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Easton Hospital",
  "geoPoint": {
    "lat": 40.68843,
    "lon": -75.22073
  }
}
replace /protocolSection/contactsLocationsModule/locations/714/facility
Triage: Uncategorized
Uncategorized Operation 329
Before
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
After
PinnacleHealth Fox Chase Regional Cancer Center at Polyclinic Hospital
add /protocolSection/contactsLocationsModule/locations/718
Triage: Uncategorized
Uncategorized Operation 330
After
{
  "zip": "19046",
  "city": "Meadowbrook",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Pallav Mehta",
      "role": "CONTACT",
      "phone": "215-938-3551"
    },
    {
      "name": "Pallav Mehta",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Holy Redeemer Hospital and Medical Center",
  "geoPoint": {
    "lat": 39.87285,
    "lon": -79.7156
  }
}
replace /protocolSection/contactsLocationsModule/locations/722/facility
Triage: Uncategorized
Uncategorized Operation 331
Before
Norristown Regional Cancer Center
After
Mercy Suburban Cancer Center
remove /protocolSection/contactsLocationsModule/locations/729
Triage: Uncategorized
Uncategorized Operation 332
Before
{
  "zip": "15212-5234",
  "city": "Pittsburgh",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Louis Fehrenbacher",
      "role": "CONTACT",
      "email": "lou.fehrenbacher@kp.org",
      "phone": "707-651-2787"
    },
    {
      "name": "Louis Fehrenbacher",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "National Surgical Adjuvant Breast and Bowel Project",
  "geoPoint": {
    "lat": 40.44062,
    "lon": -79.99589
  }
}
remove /protocolSection/contactsLocationsModule/locations/730
Triage: Uncategorized
Uncategorized Operation 333
Before
{
  "zip": "15213",
  "city": "Pittsburgh",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Adam M. Brufsky",
      "role": "CONTACT",
      "phone": "412-647-2811"
    },
    {
      "name": "Adam M. Brufsky",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of Pittsburgh",
  "geoPoint": {
    "lat": 40.44062,
    "lon": -79.99589
  }
}
replace /protocolSection/contactsLocationsModule/locations/731/facility
Triage: Uncategorized
Uncategorized Operation 334
Before
Pottstown Memorial Medical Center
After
University of Pittsburgh
replace /protocolSection/contactsLocationsModule/locations/731/city
Triage: Uncategorized
Uncategorized Operation 335
Before
Pottstown
After
Pittsburgh
replace /protocolSection/contactsLocationsModule/locations/731/zip
Triage: Uncategorized
Uncategorized Operation 336
Before
19464
After
15232
replace /protocolSection/contactsLocationsModule/locations/731/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 337
Before
Wei (. Song
After
Adam M. Brufsky
replace /protocolSection/contactsLocationsModule/locations/731/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 338
Before
610-327-7544
After
412-647-2811
replace /protocolSection/contactsLocationsModule/locations/731/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 339
Before
Wei (. Song
After
Adam M. Brufsky
replace /protocolSection/contactsLocationsModule/locations/731/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 340
Before
40.24537
After
40.44062
replace /protocolSection/contactsLocationsModule/locations/731/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 341
Before
-75.64963
After
-79.99589
add /protocolSection/contactsLocationsModule/locations/732
Triage: Uncategorized
Uncategorized Operation 342
After
{
  "zip": "19464",
  "city": "Pottstown",
  "state": "Pennsylvania",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Wei F. Song",
      "role": "CONTACT",
      "phone": "610-327-7544"
    },
    {
      "name": "Wei F. Song",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Pottstown Memorial Medical Center",
  "geoPoint": {
    "lat": 40.24537,
    "lon": -75.64963
  }
}
replace /protocolSection/contactsLocationsModule/locations/743/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 343
Before
Terrence P. Cescon
After
Debra M. Ray
replace /protocolSection/contactsLocationsModule/locations/743/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 344
Before
610-988-9323
After
732-923-7689
replace /protocolSection/contactsLocationsModule/locations/743/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 345
Before
Terrence P. Cescon
After
Debra M. Ray
add /protocolSection/contactsLocationsModule/locations/757
Triage: Uncategorized
Uncategorized Operation 346
After
{
  "zip": "29440",
  "city": "Georgetown",
  "state": "South Carolina",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Rita M. Kramer",
      "role": "CONTACT",
      "phone": "843-792-9321"
    },
    {
      "name": "Rita M. Kramer",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Georgetown Hospital System",
  "geoPoint": {
    "lat": 33.37683,
    "lon": -79.2945
  }
}
replace /protocolSection/contactsLocationsModule/locations/763/facility
Triage: Uncategorized
Uncategorized Operation 347
Before
Self Memorial Hospital
After
Self Regional Healthcare
replace /protocolSection/contactsLocationsModule/locations/763/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 348
Before
Joanna K. Metzner-Sadurski
After
Rita M. Kramer
replace /protocolSection/contactsLocationsModule/locations/763/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 349
Before
864-725-4771
After
843-792-9321
replace /protocolSection/contactsLocationsModule/locations/763/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 350
Before
Joanna K. Metzner-Sadurski
After
Rita M. Kramer
replace /protocolSection/contactsLocationsModule/locations/771/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 351
Before
Richard C. Tenglin
After
Mark T. Schroeder
replace /protocolSection/contactsLocationsModule/locations/771/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 352
Before
Richard C. Tenglin
After
Mark T. Schroeder
replace /protocolSection/contactsLocationsModule/locations/774/facility
Triage: Uncategorized
Uncategorized Operation 353
Before
Sanford University of South Dakota Medical Center
After
Sanford USD Medical Center - Sioux Falls
add /protocolSection/contactsLocationsModule/locations/775
Triage: Uncategorized
Uncategorized Operation 354
After
{
  "zip": "37620",
  "city": "Bristol",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Asheesh Shipstone",
      "role": "CONTACT",
      "phone": "423-578-8538"
    },
    {
      "name": "Asheesh Shipstone",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Blue Ridge Medical Specialists PC",
  "geoPoint": {
    "lat": 36.59511,
    "lon": -82.18874
  }
}
add /protocolSection/contactsLocationsModule/locations/776
Triage: Uncategorized
Uncategorized Operation 355
After
{
  "zip": "37620",
  "city": "Bristol",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Asheesh Shipstone",
      "role": "CONTACT",
      "phone": "423-578-8538"
    },
    {
      "name": "Asheesh Shipstone",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Wellmont Bristol Regional Medical Center",
  "geoPoint": {
    "lat": 36.59511,
    "lon": -82.18874
  }
}
replace /protocolSection/contactsLocationsModule/locations/779/status
Triage: Uncategorized
Uncategorized Operation 356
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/779/contacts
Triage: Uncategorized
Uncategorized Operation 357
After
[
  {
    "name": "John J. Murray",
    "role": "CONTACT",
    "email": "jmurray@mmc.edu",
    "phone": "615-327-5724"
  },
  {
    "name": "John J. Murray",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/781
Triage: Uncategorized
Uncategorized Operation 358
After
{
  "zip": "79106",
  "city": "Amarillo",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Srini B. Reddy",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Srini B. Reddy",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology PA - Amarillo",
  "geoPoint": {
    "lat": 35.222,
    "lon": -101.8313
  }
}
replace /protocolSection/contactsLocationsModule/locations/783/facility
Triage: Uncategorized
Uncategorized Operation 359
Before
University of Texas Medical Branch
After
Texas Oncology PA - Bedford
replace /protocolSection/contactsLocationsModule/locations/783/city
Triage: Uncategorized
Uncategorized Operation 360
Before
Galveston
After
Bedford
replace /protocolSection/contactsLocationsModule/locations/783/zip
Triage: Uncategorized
Uncategorized Operation 361
Before
77555-0565
After
76022
replace /protocolSection/contactsLocationsModule/locations/783/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 362
Before
Techksell M. McKnight
After
Thomas C. Anderson
replace /protocolSection/contactsLocationsModule/locations/783/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 363
Before
409-772-1950
After
817-685-4700
remove /protocolSection/contactsLocationsModule/locations/783/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 364
Before
clinical.research@utmb.edu
replace /protocolSection/contactsLocationsModule/locations/783/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 365
Before
Techksell M. McKnight
After
Thomas C. Anderson
replace /protocolSection/contactsLocationsModule/locations/783/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 366
Before
29.30135
After
32.84402
replace /protocolSection/contactsLocationsModule/locations/783/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 367
Before
-94.7977
After
-97.14307
add /protocolSection/contactsLocationsModule/locations/784
Triage: Uncategorized
Uncategorized Operation 368
After
{
  "zip": "75230",
  "city": "Dallas",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Michael A. Savin",
      "role": "CONTACT",
      "phone": "972-566-7790"
    },
    {
      "name": "Michael A. Savin",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Cancer Center - Medical City Dallas",
  "geoPoint": {
    "lat": 32.78306,
    "lon": -96.80667
  }
}
add /protocolSection/contactsLocationsModule/locations/785
Triage: Uncategorized
Uncategorized Operation 369
After
{
  "zip": "75231",
  "city": "Dallas",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Kristi J. McIntyre",
      "role": "CONTACT",
      "phone": "214-345-8382"
    },
    {
      "name": "Kristi J. McIntyre",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Health Presbyterian Hospital Dallas",
  "geoPoint": {
    "lat": 32.78306,
    "lon": -96.80667
  }
}
add /protocolSection/contactsLocationsModule/locations/786
Triage: Uncategorized
Uncategorized Operation 370
After
{
  "zip": "75390",
  "city": "Dallas",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Barbara Jean B. Haley",
      "role": "CONTACT",
      "phone": "214-648-7097"
    },
    {
      "name": "Barbara Jean B. Haley",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of Texas Southwestern Medical Center",
  "geoPoint": {
    "lat": 32.78306,
    "lon": -96.80667
  }
}
add /protocolSection/contactsLocationsModule/locations/787
Triage: Uncategorized
Uncategorized Operation 371
After
{
  "zip": "76210",
  "city": "Denton",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Sharad K. Jain",
      "role": "CONTACT",
      "phone": "940-382-1022"
    },
    {
      "name": "Sharad K. Jain",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology-Denton South",
  "geoPoint": {
    "lat": 33.21484,
    "lon": -97.13307
  }
}
add /protocolSection/contactsLocationsModule/locations/788
Triage: Uncategorized
Uncategorized Operation 372
After
{
  "zip": "79915",
  "city": "El Paso",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Juan Herrada",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Juan Herrada",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology-El Paso",
  "geoPoint": {
    "lat": 31.75872,
    "lon": -106.48693
  }
}
add /protocolSection/contactsLocationsModule/locations/789
Triage: Uncategorized
Uncategorized Operation 373
After
{
  "zip": "75028",
  "city": "Flower Mound",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Derrick D. Nguyen",
      "role": "CONTACT",
      "phone": "972-537-4100"
    },
    {
      "name": "Derrick D. Nguyen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology-Flower Mound",
  "geoPoint": {
    "lat": 33.01457,
    "lon": -97.09696
  }
}
add /protocolSection/contactsLocationsModule/locations/790
Triage: Uncategorized
Uncategorized Operation 374
After
{
  "zip": "76104",
  "city": "Fort Worth",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Sanjay P. Oommen",
      "role": "CONTACT",
      "phone": "800-422-9567"
    },
    {
      "name": "Sanjay P. Oommen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology Fort Worth at 12th Avenue",
  "geoPoint": {
    "lat": 32.72541,
    "lon": -97.32085
  }
}
add /protocolSection/contactsLocationsModule/locations/791
Triage: Uncategorized
Uncategorized Operation 375
After
{
  "zip": "77555-0565",
  "city": "Galveston",
  "state": "Texas",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "University of Texas Medical Branch",
  "geoPoint": {
    "lat": 29.30135,
    "lon": -94.7977
  }
}
add /protocolSection/contactsLocationsModule/locations/792
Triage: Uncategorized
Uncategorized Operation 376
After
{
  "zip": "75042",
  "city": "Garland",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Manish Gupta",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Manish Gupta",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology - Garland",
  "geoPoint": {
    "lat": 32.91262,
    "lon": -96.63888
  }
}
replace /protocolSection/contactsLocationsModule/locations/795/status
Triage: Uncategorized
Uncategorized Operation 377
Before
RECRUITING
After
WITHDRAWN
remove /protocolSection/contactsLocationsModule/locations/795/contacts
Triage: Uncategorized
Uncategorized Operation 378
Before
[
  {
    "name": "Eduardo Miranda",
    "role": "CONTACT",
    "email": "ctsucontact@westat.com",
    "phone": "888-823-5923"
  },
  {
    "name": "Eduardo Miranda",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/796
Triage: Uncategorized
Uncategorized Operation 379
After
{
  "zip": "75067",
  "city": "Lewisville",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Derrick D. Nguyen",
      "role": "CONTACT",
      "phone": "972-537-4100"
    },
    {
      "name": "Derrick D. Nguyen",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology - Lewisville",
  "geoPoint": {
    "lat": 33.04623,
    "lon": -96.99417
  }
}
add /protocolSection/contactsLocationsModule/locations/797
Triage: Uncategorized
Uncategorized Operation 380
After
{
  "zip": "78503",
  "city": "McAllen",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Billiee J. Marek",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Billiee J. Marek",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology-McAllen",
  "geoPoint": {
    "lat": 26.20341,
    "lon": -98.23001
  }
}
add /protocolSection/contactsLocationsModule/locations/798
Triage: Uncategorized
Uncategorized Operation 381
After
{
  "zip": "75075",
  "city": "Plano",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Christopher T. Stokoe",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Christopher T. Stokoe",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "North Texas Regional Cancer Center",
  "geoPoint": {
    "lat": 33.01984,
    "lon": -96.69889
  }
}
add /protocolSection/contactsLocationsModule/locations/799
Triage: Uncategorized
Uncategorized Operation 382
After
{
  "zip": "78681",
  "city": "Round Rock",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Beth A. Hellerstedt",
      "role": "CONTACT",
      "phone": "512-341-8724"
    },
    {
      "name": "Beth A. Hellerstedt",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology - Round Rock Cancer Center",
  "geoPoint": {
    "lat": 30.50826,
    "lon": -97.6789
  }
}
add /protocolSection/contactsLocationsModule/locations/800
Triage: Uncategorized
Uncategorized Operation 383
After
{
  "zip": "78217",
  "city": "San Antonio",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Sharon T. Wilks",
      "role": "CONTACT",
      "phone": "210-656-7177"
    },
    {
      "name": "Sharon T. Wilks",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Cancer Care Centers of South Texas- Northeast",
  "geoPoint": {
    "lat": 29.42412,
    "lon": -98.49363
  }
}
add /protocolSection/contactsLocationsModule/locations/802
Triage: Uncategorized
Uncategorized Operation 384
After
{
  "zip": "78229",
  "city": "San Antonio",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Alexander Zweibach",
      "role": "CONTACT",
      "phone": "210-595-5300"
    },
    {
      "name": "Alexander Zweibach",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Hematology Oncology Association of San Antonio Texas",
  "geoPoint": {
    "lat": 29.42412,
    "lon": -98.49363
  }
}
add /protocolSection/contactsLocationsModule/locations/803
Triage: Uncategorized
Uncategorized Operation 385
After
{
  "zip": "75090",
  "city": "Sherman",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Tammy E. Roque",
      "role": "CONTACT",
      "phone": "903-868-4700"
    },
    {
      "name": "Tammy E. Roque",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Cancer Center-Sherman",
  "geoPoint": {
    "lat": 33.63566,
    "lon": -96.60888
  }
}
add /protocolSection/contactsLocationsModule/locations/805
Triage: Uncategorized
Uncategorized Operation 386
After
{
  "zip": "77380",
  "city": "The Woodlands",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Christopher T. Stokoe",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Christopher T. Stokoe",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "US Oncology Research LLC-The Woodlands",
  "geoPoint": {
    "lat": 30.15799,
    "lon": -95.48938
  }
}
add /protocolSection/contactsLocationsModule/locations/806
Triage: Uncategorized
Uncategorized Operation 387
After
{
  "zip": "75702",
  "city": "Tyler",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Donald A. Richards",
      "role": "CONTACT",
      "phone": "903-579-9800"
    },
    {
      "name": "Donald A. Richards",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Tyler Cancer Center",
  "geoPoint": {
    "lat": 32.35126,
    "lon": -95.30106
  }
}
add /protocolSection/contactsLocationsModule/locations/807
Triage: Uncategorized
Uncategorized Operation 388
After
{
  "zip": "76712",
  "city": "Waco",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Carlos A. Encarnacion",
      "role": "CONTACT",
      "email": "Mary.ketner@nsabp.org",
      "phone": "412-330-4624"
    },
    {
      "name": "Carlos A. Encarnacion",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology PA",
  "geoPoint": {
    "lat": 31.54933,
    "lon": -97.14667
  }
}
add /protocolSection/contactsLocationsModule/locations/808
Triage: Uncategorized
Uncategorized Operation 389
After
{
  "zip": "76310",
  "city": "Wichita Falls",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Brian K. Ulrich",
      "role": "CONTACT",
      "phone": "940-691-8271"
    },
    {
      "name": "Brian K. Ulrich",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology-Wichita Falls Texoma Cancer Center",
  "geoPoint": {
    "lat": 33.91371,
    "lon": -98.49339
  }
}
replace /protocolSection/contactsLocationsModule/locations/814/zip
Triage: Uncategorized
Uncategorized Operation 390
Before
84603
After
84604-3337
replace /protocolSection/contactsLocationsModule/locations/820/status
Triage: Uncategorized
Uncategorized Operation 391
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/820/contacts
Triage: Uncategorized
Uncategorized Operation 392
Before
[
  {
    "name": "Allan D. Eisemann",
    "role": "CONTACT",
    "phone": "802-775-7111"
  },
  {
    "name": "Allan D. Eisemann",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/821
Triage: Uncategorized
Uncategorized Operation 393
After
{
  "zip": "05819",
  "city": "Saint Johnsbury",
  "state": "Vermont",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Mary D. Chamberlin",
      "role": "CONTACT",
      "email": "cancer.research.nurse@dartmouth.edu",
      "phone": "800-639-6918"
    },
    {
      "name": "Mary D. Chamberlin",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Norris Cotton Cancer Center-North",
  "geoPoint": {
    "lat": 44.41922,
    "lon": -72.01509
  }
}
add /protocolSection/contactsLocationsModule/locations/822
Triage: Uncategorized
Uncategorized Operation 394
After
{
  "zip": "22015",
  "city": "Burke",
  "state": "Virginia",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Leon C. Hwang",
      "role": "CONTACT",
      "phone": "301-816-7446"
    },
    {
      "name": "Leon C. Hwang",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Kaiser Permanente-Burke Medical Center",
  "geoPoint": {
    "lat": 38.79345,
    "lon": -77.27165
  }
}
replace /protocolSection/contactsLocationsModule/locations/834/status
Triage: Uncategorized
Uncategorized Operation 395
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/834/contacts
Triage: Uncategorized
Uncategorized Operation 396
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/836/status
Triage: Uncategorized
Uncategorized Operation 397
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/836/contacts
Triage: Uncategorized
Uncategorized Operation 398
Before
[
  {
    "name": "Tanya A. Wahl",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "425-688-5407"
  },
  {
    "name": "Tanya A. Wahl",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/837/facility
Triage: Uncategorized
Uncategorized Operation 399
Before
Saint Joseph Hospital
After
PeaceHealth Saint Joseph Medical Center
replace /protocolSection/contactsLocationsModule/locations/839/status
Triage: Uncategorized
Uncategorized Operation 400
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/839/contacts
Triage: Uncategorized
Uncategorized Operation 401
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/840/status
Triage: Uncategorized
Uncategorized Operation 402
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/840/contacts
Triage: Uncategorized
Uncategorized Operation 403
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/841/facility
Triage: Uncategorized
Uncategorized Operation 404
Before
Providence Regional Cancer Partnership
After
Puget Sound Cancer Center
replace /protocolSection/contactsLocationsModule/locations/841/city
Triage: Uncategorized
Uncategorized Operation 405
Before
Everett
After
Edmonds
replace /protocolSection/contactsLocationsModule/locations/841/zip
Triage: Uncategorized
Uncategorized Operation 406
Before
98201
After
98026
replace /protocolSection/contactsLocationsModule/locations/841/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 407
Before
Yoshio Inoue
After
J. Samuel Tolman
replace /protocolSection/contactsLocationsModule/locations/841/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 408
Before
253-403-2394
After
206-368-1608
replace /protocolSection/contactsLocationsModule/locations/841/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 409
Before
Yoshio Inoue
After
J. Samuel Tolman
replace /protocolSection/contactsLocationsModule/locations/841/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 410
Before
47.97898
After
47.81065
replace /protocolSection/contactsLocationsModule/locations/841/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 411
Before
-122.20208
After
-122.37736
replace /protocolSection/contactsLocationsModule/locations/842/facility
Triage: Uncategorized
Uncategorized Operation 412
Before
Saint Francis Hospital
After
Swedish Medical Center-Edmonds
replace /protocolSection/contactsLocationsModule/locations/842/city
Triage: Uncategorized
Uncategorized Operation 413
Before
Federal Way
After
Edmonds
replace /protocolSection/contactsLocationsModule/locations/842/zip
Triage: Uncategorized
Uncategorized Operation 414
Before
98003
After
98026
replace /protocolSection/contactsLocationsModule/locations/842/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 415
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/842/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 416
Before
253-403-2394
After
206-386-2323
add /protocolSection/contactsLocationsModule/locations/842/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 417
After
patra.grevstad@swedish.org
replace /protocolSection/contactsLocationsModule/locations/842/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 418
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/842/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 419
Before
47.32232
After
47.81065
replace /protocolSection/contactsLocationsModule/locations/842/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 420
Before
-122.31262
After
-122.37736
add /protocolSection/contactsLocationsModule/locations/843
Triage: Uncategorized
Uncategorized Operation 421
After
{
  "zip": "98201",
  "city": "Everett",
  "state": "Washington",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Providence Regional Cancer Partnership",
  "geoPoint": {
    "lat": 47.97898,
    "lon": -122.20208
  }
}
add /protocolSection/contactsLocationsModule/locations/844
Triage: Uncategorized
Uncategorized Operation 422
After
{
  "zip": "98003",
  "city": "Federal Way",
  "state": "Washington",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Saint Francis Hospital",
  "geoPoint": {
    "lat": 47.32232,
    "lon": -122.31262
  }
}
replace /protocolSection/contactsLocationsModule/locations/846/status
Triage: Uncategorized
Uncategorized Operation 423
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/846/contacts
Triage: Uncategorized
Uncategorized Operation 424
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/847/status
Triage: Uncategorized
Uncategorized Operation 425
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/847/contacts
Triage: Uncategorized
Uncategorized Operation 426
Before
[
  {
    "name": "Craig R. Nichols",
    "role": "CONTACT",
    "phone": "503-215-6412"
  },
  {
    "name": "Craig R. Nichols",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/848/facility
Triage: Uncategorized
Uncategorized Operation 427
Before
Skagit Valley Hospital
After
Cascade Cancer Center
replace /protocolSection/contactsLocationsModule/locations/848/status
Triage: Uncategorized
Uncategorized Operation 428
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/848/city
Triage: Uncategorized
Uncategorized Operation 429
Before
Mount Vernon
After
Kirkland
replace /protocolSection/contactsLocationsModule/locations/848/zip
Triage: Uncategorized
Uncategorized Operation 430
Before
98273
After
98034
replace /protocolSection/contactsLocationsModule/locations/848/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 431
Before
48.42122
After
47.68149
replace /protocolSection/contactsLocationsModule/locations/848/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 432
Before
-122.33405
After
-122.20874
add /protocolSection/contactsLocationsModule/locations/848/contacts
Triage: Uncategorized
Uncategorized Operation 433
After
[
  {
    "name": "Craig R. Nichols",
    "role": "CONTACT",
    "phone": "503-215-6412"
  },
  {
    "name": "Craig R. Nichols",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/850/facility
Triage: Uncategorized
Uncategorized Operation 434
Before
Providence - Saint Peter Hospital
After
Skagit Valley Hospital
replace /protocolSection/contactsLocationsModule/locations/850/city
Triage: Uncategorized
Uncategorized Operation 435
Before
Olympia
After
Mount Vernon
replace /protocolSection/contactsLocationsModule/locations/850/zip
Triage: Uncategorized
Uncategorized Operation 436
Before
98506-5166
After
98274
replace /protocolSection/contactsLocationsModule/locations/850/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 437
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/850/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 438
Before
253-403-2394
After
206-386-2323
add /protocolSection/contactsLocationsModule/locations/850/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 439
After
patra.grevstad@swedish.org
replace /protocolSection/contactsLocationsModule/locations/850/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 440
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/850/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 441
Before
47.04491
After
48.42122
replace /protocolSection/contactsLocationsModule/locations/850/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 442
Before
-122.90169
After
-122.33405
replace /protocolSection/contactsLocationsModule/locations/851/facility
Triage: Uncategorized
Uncategorized Operation 443
Before
Harrison Poulsbo Hematology and Oncology
After
Providence - Saint Peter Hospital
replace /protocolSection/contactsLocationsModule/locations/851/city
Triage: Uncategorized
Uncategorized Operation 444
Before
Poulsbo
After
Olympia
replace /protocolSection/contactsLocationsModule/locations/851/zip
Triage: Uncategorized
Uncategorized Operation 445
Before
98370
After
98506-5166
replace /protocolSection/contactsLocationsModule/locations/851/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 446
Before
47.73593
After
47.04491
replace /protocolSection/contactsLocationsModule/locations/851/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 447
Before
-122.64654
After
-122.90169
replace /protocolSection/contactsLocationsModule/locations/852/facility
Triage: Uncategorized
Uncategorized Operation 448
Before
Good Samaritan Community Hospital
After
Harrison Poulsbo Hematology and Oncology
replace /protocolSection/contactsLocationsModule/locations/852/city
Triage: Uncategorized
Uncategorized Operation 449
Before
Puyallup
After
Poulsbo
replace /protocolSection/contactsLocationsModule/locations/852/zip
Triage: Uncategorized
Uncategorized Operation 450
Before
98372
After
98370
replace /protocolSection/contactsLocationsModule/locations/852/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 451
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/852/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 452
Before
253-403-2394
After
206-386-2323
add /protocolSection/contactsLocationsModule/locations/852/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 453
After
patra.grevstad@swedish.org
replace /protocolSection/contactsLocationsModule/locations/852/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 454
Before
Yoshio Inoue
After
Gary E. Goodman
replace /protocolSection/contactsLocationsModule/locations/852/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 455
Before
47.18538
After
47.73593
replace /protocolSection/contactsLocationsModule/locations/852/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 456
Before
-122.2929
After
-122.64654
add /protocolSection/contactsLocationsModule/locations/853
Triage: Uncategorized
Uncategorized Operation 457
After
{
  "zip": "98372",
  "city": "Puyallup",
  "state": "Washington",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United States",
  "facility": "Good Samaritan Community Hospital",
  "geoPoint": {
    "lat": 47.18538,
    "lon": -122.2929
  }
}
replace /protocolSection/contactsLocationsModule/locations/856/status
Triage: Uncategorized
Uncategorized Operation 458
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/856/contacts
Triage: Uncategorized
Uncategorized Operation 459
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/857/status
Triage: Uncategorized
Uncategorized Operation 460
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/857/contacts
Triage: Uncategorized
Uncategorized Operation 461
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/860/facility
Triage: Uncategorized
Uncategorized Operation 462
Before
Puget Sound Oncology Consortium
After
Group Health Cooperative of Puget Sound Oncology Consortium
replace /protocolSection/contactsLocationsModule/locations/861/status
Triage: Uncategorized
Uncategorized Operation 463
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/861/contacts
Triage: Uncategorized
Uncategorized Operation 464
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/862/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 465
Before
Saul E. Rivkin
After
Tanya A. Wahl
replace /protocolSection/contactsLocationsModule/locations/862/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 466
Before
206-386-2323
After
425-688-5407
replace /protocolSection/contactsLocationsModule/locations/862/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 467
Before
Saul E. Rivkin
After
Tanya A. Wahl
replace /protocolSection/contactsLocationsModule/locations/864/status
Triage: Uncategorized
Uncategorized Operation 468
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/864/contacts
Triage: Uncategorized
Uncategorized Operation 469
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/865/status
Triage: Uncategorized
Uncategorized Operation 470
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/865/contacts
Triage: Uncategorized
Uncategorized Operation 471
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/867
Triage: Uncategorized
Uncategorized Operation 472
After
{
  "zip": "99202",
  "city": "Spokane",
  "state": "Washington",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Gary E. Goodman",
      "role": "CONTACT",
      "email": "patra.grevstad@swedish.org",
      "phone": "206-386-2323"
    },
    {
      "name": "Gary E. Goodman",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Cancer Care Northwest - Spokane South",
  "geoPoint": {
    "lat": 47.65966,
    "lon": -117.42908
  }
}
replace /protocolSection/contactsLocationsModule/locations/870/status
Triage: Uncategorized
Uncategorized Operation 473
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/870/contacts
Triage: Uncategorized
Uncategorized Operation 474
After
[
  {
    "name": "Gary E. Goodman",
    "role": "CONTACT",
    "email": "patra.grevstad@swedish.org",
    "phone": "206-386-2323"
  },
  {
    "name": "Gary E. Goodman",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/872/status
Triage: Uncategorized
Uncategorized Operation 475
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/872/contacts
Triage: Uncategorized
Uncategorized Operation 476
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/874/status
Triage: Uncategorized
Uncategorized Operation 477
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/874/contacts
Triage: Uncategorized
Uncategorized Operation 478
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/875/status
Triage: Uncategorized
Uncategorized Operation 479
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/875/contacts
Triage: Uncategorized
Uncategorized Operation 480
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/876/status
Triage: Uncategorized
Uncategorized Operation 481
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/876/contacts
Triage: Uncategorized
Uncategorized Operation 482
Before
[
  {
    "name": "Yoshio Inoue",
    "role": "CONTACT",
    "phone": "253-403-2394"
  },
  {
    "name": "Yoshio Inoue",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
add /protocolSection/contactsLocationsModule/locations/880
Triage: Uncategorized
Uncategorized Operation 483
After
{
  "zip": "98902",
  "city": "Yakima",
  "state": "Washington",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Vicky E. Jones",
      "role": "CONTACT",
      "phone": "877-902-3324"
    },
    {
      "name": "Vicky E. Jones",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "North Star Lodge Cancer Center at Yakima Valley Memorial Hospital",
  "geoPoint": {
    "lat": 46.60207,
    "lon": -120.5059
  }
}
add /protocolSection/contactsLocationsModule/locations/881
Triage: Uncategorized
Uncategorized Operation 484
After
{
  "zip": "26330",
  "city": "Bridgeport",
  "state": "West Virginia",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Paul M. Brager",
      "role": "CONTACT",
      "phone": "681-342-1000"
    },
    {
      "name": "Paul M. Brager",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "United Hospital Center",
  "geoPoint": {
    "lat": 39.28648,
    "lon": -80.2562
  }
}
remove /protocolSection/contactsLocationsModule/locations/883
Triage: Uncategorized
Uncategorized Operation 485
Before
{
  "zip": "26301",
  "city": "Clarksburg",
  "state": "West Virginia",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Craig J. Coonley",
      "role": "CONTACT",
      "phone": "681-342-1000"
    },
    {
      "name": "Craig J. Coonley",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "United Hospital Center",
  "geoPoint": {
    "lat": 39.28065,
    "lon": -80.34453
  }
}
replace /protocolSection/contactsLocationsModule/locations/887/status
Triage: Uncategorized
Uncategorized Operation 486
Before
TERMINATED
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/896/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 487
Before
Catherine G. Thieblemont
After
Sayeh M. Lavasani
replace /protocolSection/contactsLocationsModule/locations/896/contacts/0/phone
Triage: Uncategorized
Uncategorized Operation 488
Before
888-823-5923
After
313-576-9363
remove /protocolSection/contactsLocationsModule/locations/896/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 489
Before
ctsucontact@westat.com
replace /protocolSection/contactsLocationsModule/locations/896/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 490
Before
Catherine G. Thieblemont
After
Sayeh M. Lavasani
replace /protocolSection/contactsLocationsModule/locations/904/status
Triage: Uncategorized
Uncategorized Operation 491
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/904/contacts
Triage: Uncategorized
Uncategorized Operation 492
After
[
  {
    "name": "Kurt Oettel",
    "role": "CONTACT",
    "email": "cancerctr@gundluth.org",
    "phone": "608-775-2385"
  },
  {
    "name": "Kurt Oettel",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/905
Triage: Uncategorized
Uncategorized Operation 493
Before
{
  "zip": "53715",
  "city": "Madison",
  "state": "Wisconsin",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Pamela Vanderwall",
      "role": "CONTACT",
      "phone": "920-433-8889"
    },
    {
      "name": "Pamela Vanderwall",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Nicholas Hospital",
  "geoPoint": {
    "lat": 43.07305,
    "lon": -89.40123
  }
}
remove /protocolSection/contactsLocationsModule/locations/913/contacts/0/email
Triage: Uncategorized
Uncategorized Operation 494
Before
Kelli.holton@wfhc.org
add /protocolSection/contactsLocationsModule/locations/917
Triage: Uncategorized
Uncategorized Operation 495
After
{
  "zip": "54017",
  "city": "New Richmond",
  "state": "Wisconsin",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Joseph W. Leach",
      "role": "CONTACT",
      "email": "MMCCOP@parknicollet.com",
      "phone": "952-993-1517"
    },
    {
      "name": "Joseph W. Leach",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Cancer Center of Western Wisconsin",
  "geoPoint": {
    "lat": 45.12302,
    "lon": -92.53659
  }
}
add /protocolSection/contactsLocationsModule/locations/925
Triage: Uncategorized
Uncategorized Operation 496
After
{
  "zip": "53081",
  "city": "Sheboygan",
  "state": "Wisconsin",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Pamela Vanderwall",
      "role": "CONTACT",
      "phone": "920-433-8889"
    },
    {
      "name": "Pamela Vanderwall",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Nicholas Hospital",
  "geoPoint": {
    "lat": 43.75083,
    "lon": -87.71453
  }
}
replace /protocolSection/contactsLocationsModule/locations/939/status
Triage: Uncategorized
Uncategorized Operation 497
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/939/contacts
Triage: Uncategorized
Uncategorized Operation 498
Before
[
  {
    "name": "Ronnie J. Kirschling",
    "role": "CONTACT",
    "phone": "877-405-6866"
  },
  {
    "name": "Ronnie J. Kirschling",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/941/status
Triage: Uncategorized
Uncategorized Operation 499
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/941/contacts
Triage: Uncategorized
Uncategorized Operation 500
After
[
  {
    "name": "Benjamin T. Marchello",
    "role": "CONTACT",
    "phone": "800-648-6274"
  },
  {
    "name": "Benjamin T. Marchello",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
remove /protocolSection/contactsLocationsModule/locations/945
Triage: Uncategorized
Uncategorized Operation 501
Before
{
  "zip": "H3A 1A1",
  "city": "Montreal",
  "state": "Quebec",
  "status": "RECRUITING",
  "country": "Canada",
  "contacts": [
    {
      "name": "Stephen I. Shibata",
      "role": "CONTACT",
      "email": "becomingapatient@coh.org",
      "phone": "800-826-4673"
    },
    {
      "name": "Stephen I. Shibata",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Royal Victoria Hospital",
  "geoPoint": {
    "lat": 45.50884,
    "lon": -73.58781
  }
}
replace /protocolSection/contactsLocationsModule/locations/947/contacts/0/name
Triage: Uncategorized
Uncategorized Operation 502
Before
Donna Stern
After
Jaroslav F. Prchal
replace /protocolSection/contactsLocationsModule/locations/947/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 503
Before
Donna Stern
After
Jaroslav F. Prchal
add /protocolSection/contactsLocationsModule/locations/951
Triage: Uncategorized
Uncategorized Operation 504
After
{
  "zip": "4",
  "city": "Dublin",
  "state": "Co Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Vincents Hospital",
  "geoPoint": {
    "lat": 53.33306,
    "lon": -6.24889
  }
}
add /protocolSection/contactsLocationsModule/locations/952
Triage: Uncategorized
Uncategorized Operation 505
After
{
  "zip": "7",
  "city": "Dublin",
  "state": "Co Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Mater Misericordiae University Hospital",
  "geoPoint": {
    "lat": 53.33306,
    "lon": -6.24889
  }
}
add /protocolSection/contactsLocationsModule/locations/953
Triage: Uncategorized
Uncategorized Operation 506
After
{
  "zip": "7",
  "city": "Dublin",
  "state": "Co Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Mater Private Hospital",
  "geoPoint": {
    "lat": 53.33306,
    "lon": -6.24889
  }
}
add /protocolSection/contactsLocationsModule/locations/955
Triage: Uncategorized
Uncategorized Operation 507
After
{
  "zip": "4",
  "city": "Mount Merrion",
  "state": "Co Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Vincent&#x27;s Private Hospital",
  "geoPoint": {
    "lat": 53.30008,
    "lon": -6.21504
  }
}
add /protocolSection/contactsLocationsModule/locations/957
Triage: Uncategorized
Uncategorized Operation 508
After
{
  "city": "Sligo",
  "state": "Co Sligo",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Sligo General Hospital",
  "geoPoint": {
    "lat": 54.26969,
    "lon": -8.46943
  }
}
remove /protocolSection/contactsLocationsModule/locations/959
Triage: Uncategorized
Uncategorized Operation 509
Before
{
  "zip": "4",
  "city": "Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Saint Vincents Hospital",
  "geoPoint": {
    "lat": 53.33306,
    "lon": -6.24889
  }
}
remove /protocolSection/contactsLocationsModule/locations/959
Triage: Uncategorized
Uncategorized Operation 510
Before
{
  "zip": "7",
  "city": "Dublin",
  "status": "RECRUITING",
  "country": "Ireland",
  "contacts": [
    {
      "name": "John A. Crown",
      "role": "CONTACT",
      "phone": "353 1 2638380"
    },
    {
      "name": "John A. Crown",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Mater Private Hospital",
  "geoPoint": {
    "lat": 53.33306,
    "lon": -6.24889
  }
}
replace /protocolSection/contactsLocationsModule/locations/960/facility
Triage: Uncategorized
Uncategorized Operation 511
Before
Mater Misericordiae University Hospital
After
Letterkenny General Hospital
replace /protocolSection/contactsLocationsModule/locations/960/city
Triage: Uncategorized
Uncategorized Operation 512
Before
Dublin
After
Letterkenny
replace /protocolSection/contactsLocationsModule/locations/960/zip
Triage: Uncategorized
Uncategorized Operation 513
Before
Dublin 7
After
Co Donegal
replace /protocolSection/contactsLocationsModule/locations/960/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 514
Before
53.33306
After
54.95
replace /protocolSection/contactsLocationsModule/locations/960/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 515
Before
-6.24889
After
-7.73333
remove /protocolSection/contactsLocationsModule/locations/961
Triage: Uncategorized
Uncategorized Operation 516
Before
{
  "zip": "Co Donegal",
  "city": "Letterkenny",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Ireland",
  "facility": "Letterkenny General Hospital",
  "geoPoint": {
    "lat": 54.95,
    "lon": -7.73333
  }
}
replace /protocolSection/contactsLocationsModule/locations/962/facility
Triage: Uncategorized
Uncategorized Operation 517
Before
Sligo General Hospital
After
http:&#x2F;&#x2F;www.hse.ie&#x2F;eng&#x2F;services&#x2F;Find_a_Service&#x2F;National_Cancer_Control_Programme&#x2F;
replace /protocolSection/contactsLocationsModule/locations/962/city
Triage: Uncategorized
Uncategorized Operation 518
Before
Sligo
After
Waterford
replace /protocolSection/contactsLocationsModule/locations/962/zip
Triage: Uncategorized
Uncategorized Operation 519
Before
Sligo
After
0009
replace /protocolSection/contactsLocationsModule/locations/962/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 520
Before
54.26969
After
52.25833
replace /protocolSection/contactsLocationsModule/locations/962/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 521
Before
-8.46943
After
-7.11194
replace /protocolSection/contactsLocationsModule/locations/963/facility
Triage: Uncategorized
Uncategorized Operation 522
Before
Waterford Regional Hospital
After
San Juan City Hospital
replace /protocolSection/contactsLocationsModule/locations/963/status
Triage: Uncategorized
Uncategorized Operation 523
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/963/city
Triage: Uncategorized
Uncategorized Operation 524
Before
Waterford
After
San Juan
replace /protocolSection/contactsLocationsModule/locations/963/zip
Triage: Uncategorized
Uncategorized Operation 525
Before
0009
After
00936
replace /protocolSection/contactsLocationsModule/locations/963/country
Triage: Uncategorized
Uncategorized Operation 526
Before
Ireland
After
Puerto Rico
remove /protocolSection/contactsLocationsModule/locations/963/contacts
Triage: Uncategorized
Uncategorized Operation 527
Before
[
  {
    "name": "John A. Crown",
    "role": "CONTACT",
    "phone": "353 1 2638380"
  },
  {
    "name": "John A. Crown",
    "role": "PRINCIPAL_INVESTIGATOR"
  }
]
replace /protocolSection/contactsLocationsModule/locations/963/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 528
Before
52.25833
After
18.46633
replace /protocolSection/contactsLocationsModule/locations/963/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 529
Before
-7.11194
After
-66.10572
remove /protocolSection/contactsLocationsModule/locations/964
Triage: Uncategorized
Uncategorized Operation 530
Before
{
  "zip": "00928",
  "city": "San Juan",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Puerto Rico",
  "facility": "San Juan City Hospital",
  "geoPoint": {
    "lat": 18.46633,
    "lon": -66.10572
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 5 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2012-12
After
2013-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2012-12-04
After
2013-05-06
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2012-12-05
After
2013-05-07
replace /protocolSection/descriptionModule/briefSummary
Triage: Uncategorized
Uncategorized Operation 7
Before
This randomized phase III clinical trial is studying chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer.
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Giving more than one drug (combination chemotherapy) and giving chemotherapy after surgery may kill more tumor cells.
Monoclonal antibodies, such as trastuzumab, can block cancer growth in different ways.
Some block the ability of cancer cells to grow and spread.
Others find cancer cells and help kill them or carry cancer-killing substances to them.
It is not yet known whether combination chemotherapy is more effective with trastuzumab in treating breast cancer
After
This randomized phase III clinical trial is studying chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer.
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Giving more than one drug (combination chemotherapy) and giving chemotherapy after surgery may kill more tumor cells.
Monoclonal antibodies, such as trastuzumab, can block cancer growth in different ways.
Some block the ability of cancer cells to grow and spread.
Others find cancer cells and help kill them or carry cancer-killing substances to them.
It is not yet known whether combination chemotherapy is more effective with trastuzumab in treating breast cancer.
replace /protocolSection/descriptionModule/detailedDescription
Triage: Uncategorized
Uncategorized Operation 8
Before
<p>PRIMARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>SECONDARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves disease-free survival (DFS)-DCIS of women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>II.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves breast cancer-free survival (BCFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>III.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves recurrence-free interval (RFI) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>IV.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves distant RFI in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>V. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves overall survival (OS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>VI.
To evaluate the associations between amenorrhea and circulating reproductive hormone levels, and the associations between chemotherapy regimen, amenorrhea, and IDFS benefit in premenopausal women eligible at baseline for the menstrual history assessments.</p><p>VII.
To evaluate the toxicity associated with each of the regimens.
VIII.
To test the hypothesis that the HER2 mRNA level is the predictor of the degree of benefit from trastuzumab and the threshold for benefit in the adjuvant setting is lower than defined by current ASCO&#x2F;CAP Guidelines for HER2 assays (IHC and FISH).</p><p>IX.
To identify and&#x2F;or validate molecular predictors of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>X. To test the alternative hypothesis that the main determinant of trastuzumab response in the adjuvant setting of HER2-low breast cancer is through ADCC by demonstrating that the polymorphism of the Fcγ receptor gene is predictive of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>XI.
To examine the relationship between behavioral host factors (obesity, tobacco, alcohol) and comorbid conditions that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XII.
To examine the relationship between medication exposures that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XIII.
To examine the relationship between comorbid conditions, medication exposures, and behavioral host factors together and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>OUTLINE: This is a multicenter study.
Patients are stratified according to IHC score (1+ vs 2+), number of positive nodes (0-3 vs 4-9 vs 10+), hormone receptor status (ER-positive and&#x2F;or PgR-positive vs ER- and PgR-negative), and intended chemotherapy regimen* (docetaxel and cyclophosphamide vs doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel).
Patients are randomized to 1 of 2 treatment arms.</p><p>NOTE: *Chemotherapy regimen is based on the investigator&#x27;s preference.</p><p>ARM I:</p><p>GROUP A: Patients receive docetaxel IV over 60 minutes and cyclophosphamide IV over 30 minutes on day 1.
Treatment repeats every 3 weeks for 6 courses.</p><p>GROUP B: Patients receive doxorubicin hydrochloride IV over 15 minutes and cyclophosphamide IV over 30 minutes on day 1.</p><p>Treatment repeats every 2 or 3 weeks (at the investigator&#x27;s discretion) for 4 courses.
Patients then receive paclitaxel IV over 60 minutes once weekly for 12 doses.</p><p>ARM II:</p><p>GROUP A: Patients receive chemotherapy as in arm IA.
Patients also receive trastuzumab IV over 30-90 minutes on day 1.
Trastuzumab treatment repeats every 3 weeks for 11 courses.</p><p>GROUP B: Patients receive chemotherapy as in arm IB.
Patients also receive trastuzumab IV over 30-90 minutes weekly for 12 doses.
After completion of paclitaxel, patients receive trastuzumab IV over 30-90 minutes on day 1.</p><p>Treatment repeats every 3 weeks for 13 courses.
Tumor and blood samples may be collected periodically during study treatment for correlative studies.</p><p>After completion of study treatment, patients are followed up every 6 months for 5 years and then every 12 months for 5 years.</p>
After
<p>PRIMARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as human epidermal growth factor receptor (HER)2-low by all HER2 testing performed.</p><p>SECONDARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves disease-free survival (DFS)-ductal carcinoma in situ (DCIS) of women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>II.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves breast cancer-free survival (BCFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>III.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves recurrence-free interval (RFI) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>IV.
To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves distant RFI in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>V. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves overall survival (OS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>VI.
To evaluate the associations between amenorrhea and circulating reproductive hormone levels, and the associations between chemotherapy regimen, amenorrhea, and IDFS benefit in premenopausal women eligible at baseline for the menstrual history assessments.</p><p>VII.
To evaluate the toxicity associated with each of the regimens.
VIII.
To test the hypothesis that the HER2 mRNA level is the predictor of the degree of benefit from trastuzumab and the threshold for benefit in the adjuvant setting is lower than defined by current ASCO&#x2F;CAP Guidelines for HER2 assays (immunohistochemistry [IHC] and fluorescent in situ hybridization [FISH]).</p><p>IX.
To identify and&#x2F;or validate molecular predictors of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>X. To test the alternative hypothesis that the main determinant of trastuzumab response in the adjuvant setting of HER2-low breast cancer is through antibody-dependent cellular cytotoxicity (ADCC) by demonstrating that the polymorphism of the Fcγ receptor gene is predictive of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>XI.
To examine the relationship between behavioral host factors (obesity, tobacco, alcohol) and comorbid conditions that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XII.
To examine the relationship between medication exposures that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XIII.
To examine the relationship between comorbid conditions, medication exposures, and behavioral host factors together and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>OUTLINE: This is a multicenter study.
Patients are stratified according to IHC score (1+ vs 2+), number of positive nodes (0-3 vs 4-9 vs 10+), hormone receptor status (estrogen [ER]-positive and&#x2F;or progesterone receptor [PgR]-positive vs ER- and PgR-negative), and intended chemotherapy regimen* (docetaxel and cyclophosphamide vs doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel).
Patients are randomized to 1 of 2 treatment arms.</p><p>NOTE: *Chemotherapy regimen is based on the investigator&#x27;s preference.</p><p>ARM I:</p><p>GROUP A: Patients receive docetaxel intravenously (IV) over 60 minutes and cyclophosphamide IV over 30 minutes on day 1.
Treatment repeats every 3 weeks for 6 courses.</p><p>GROUP B: Patients receive doxorubicin hydrochloride IV over 15 minutes and cyclophosphamide IV over 30 minutes on day 1.</p><p>Treatment repeats every 2 or 3 weeks (at the investigator&#x27;s discretion) for 4 courses.
Patients then receive paclitaxel IV over 60 minutes once weekly for 12 doses.</p><p>ARM II:</p><p>GROUP A: Patients receive chemotherapy as in arm IA.
Patients also receive trastuzumab IV over 30-90 minutes on day 1.
Trastuzumab treatment repeats every 3 weeks for 11 courses.</p><p>GROUP B: Patients receive chemotherapy as in arm IB.
Patients also receive trastuzumab IV over 30-90 minutes weekly for 12 doses.
After completion of paclitaxel, patients receive trastuzumab IV over 30-90 minutes on day 1.</p><p>Treatment repeats every 3 weeks for 13 courses.
Tumor and blood samples may be collected periodically during study treatment for correlative studies.</p><p>After completion of study treatment, patients are followed up every 6 months for 5 years and then every 12 months for 5 years.</p>
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 3 ops
add /protocolSection/identificationModule/secondaryIdInfos/0
Triage: Uncategorized
Uncategorized Operation 1
After
{
  "id": "NSABP B-47"
}
add /protocolSection/identificationModule/secondaryIdInfos/2
Triage: Uncategorized
Uncategorized Operation 2
After
{
  "id": "CDR0000692574"
}
remove /protocolSection/identificationModule/secondaryIdInfos/4
Triage: Uncategorized
Uncategorized Operation 3
Before
{
  "id": "CDR0000692574",
  "type": "REGISTRY",
  "domain": "PDQ (Physician Data Query)"
}
Raw JSON Patch 
[
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/0",
    "value": {
      "id": "NSABP B-47"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/2",
    "value": {
      "id": "CDR0000692574"
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/4"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2013-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2013-05-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2013-05-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/descriptionModule/briefSummary",
    "value": "This randomized phase III clinical trial is studying chemotherapy with or without trastuzumab after surgery to see how well they work in treating women with invasive breast cancer.\nDrugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.\nGiving more than one drug (combination chemotherapy) and giving chemotherapy after surgery may kill more tumor cells.\nMonoclonal antibodies, such as trastuzumab, can block cancer growth in different ways.\nSome block the ability of cancer cells to grow and spread.\nOthers find cancer cells and help kill them or carry cancer-killing substances to them.\nIt is not yet known whether combination chemotherapy is more effective with trastuzumab in treating breast cancer."
  },
  {
    "op": "replace",
    "path": "/protocolSection/descriptionModule/detailedDescription",
    "value": "<p>PRIMARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as human epidermal growth factor receptor (HER)2-low by all HER2 testing performed.</p><p>SECONDARY OBJECTIVES:</p><p>I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves disease-free survival (DFS)-ductal carcinoma in situ (DCIS) of women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>II.\nTo determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves breast cancer-free survival (BCFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>III.\nTo determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves recurrence-free interval (RFI) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>IV.\nTo determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves distant RFI in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>V. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves overall survival (OS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed.</p><p>VI.\nTo evaluate the associations between amenorrhea and circulating reproductive hormone levels, and the associations between chemotherapy regimen, amenorrhea, and IDFS benefit in premenopausal women eligible at baseline for the menstrual history assessments.</p><p>VII.\nTo evaluate the toxicity associated with each of the regimens.\nVIII.\nTo test the hypothesis that the HER2 mRNA level is the predictor of the degree of benefit from trastuzumab and the threshold for benefit in the adjuvant setting is lower than defined by current ASCO&#x2F;CAP Guidelines for HER2 assays (immunohistochemistry [IHC] and fluorescent in situ hybridization [FISH]).</p><p>IX.\nTo identify and&#x2F;or validate molecular predictors of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>X. To test the alternative hypothesis that the main determinant of trastuzumab response in the adjuvant setting of HER2-low breast cancer is through antibody-dependent cellular cytotoxicity (ADCC) by demonstrating that the polymorphism of the Fcγ receptor gene is predictive of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP).</p><p>XI.\nTo examine the relationship between behavioral host factors (obesity, tobacco, alcohol) and comorbid conditions that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XII.\nTo examine the relationship between medication exposures that may influence systemic inflammation and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>XIII.\nTo examine the relationship between comorbid conditions, medication exposures, and behavioral host factors together and breast cancer outcomes, controlling for tumor&#x2F;stage characteristics and treatment assignment.</p><p>OUTLINE: This is a multicenter study.\nPatients are stratified according to IHC score (1+ vs 2+), number of positive nodes (0-3 vs 4-9 vs 10+), hormone receptor status (estrogen [ER]-positive and&#x2F;or progesterone receptor [PgR]-positive vs ER- and PgR-negative), and intended chemotherapy regimen* (docetaxel and cyclophosphamide vs doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel).\nPatients are randomized to 1 of 2 treatment arms.</p><p>NOTE: *Chemotherapy regimen is based on the investigator&#x27;s preference.</p><p>ARM I:</p><p>GROUP A: Patients receive docetaxel intravenously (IV) over 60 minutes and cyclophosphamide IV over 30 minutes on day 1.\nTreatment repeats every 3 weeks for 6 courses.</p><p>GROUP B: Patients receive doxorubicin hydrochloride IV over 15 minutes and cyclophosphamide IV over 30 minutes on day 1.</p><p>Treatment repeats every 2 or 3 weeks (at the investigator&#x27;s discretion) for 4 courses.\nPatients then receive paclitaxel IV over 60 minutes once weekly for 12 doses.</p><p>ARM II:</p><p>GROUP A: Patients receive chemotherapy as in arm IA.\nPatients also receive trastuzumab IV over 30-90 minutes on day 1.\nTrastuzumab treatment repeats every 3 weeks for 11 courses.</p><p>GROUP B: Patients receive chemotherapy as in arm IB.\nPatients also receive trastuzumab IV over 30-90 minutes weekly for 12 doses.\nAfter completion of paclitaxel, patients receive trastuzumab IV over 30-90 minutes on day 1.</p><p>Treatment repeats every 3 weeks for 13 courses.\nTumor and blood samples may be collected periodically during study treatment for correlative studies.</p><p>After completion of study treatment, patients are followed up every 6 months for 5 years and then every 12 months for 5 years.</p>"
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    "path": "/protocolSection/eligibilityModule/eligibilityCriteria",
    "value": "<p>Inclusion Criteria:</p><ul><li>The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination</li><li><p>All of the following staging criteria (according to the 7th edition of the American Joint Committee on Cancer [AJCC] Cancer Staging Manual) must be met:</p><ul><li>By pathologic evaluation, primary tumor must be pT1-3</li><li><p>By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b,pN1c), pN2a, pN2b, pN3a, or pN3b</p><ul><li><p>If pN0, one of the following criteria must be met:</p><ul><li>pT2 and estrogen receptor (ER) negative and progesterone receptor (PgR) negative</li><li>pT2 and ER positive (PgR status may be positive or negative) and either grade 3histology or Oncotype DX Recurrence Score of &gt;= 25; or</li><li>pT3 regardless of hormone receptor status, histologic grade, and Oncotype DX Recurrence Score</li></ul></li></ul></li></ul></li><li>No T4 tumors including inflammatory breast cancer</li><li><p>No definitive clinical or radiologic evidence of metastatic disease</p><ul><li>NOTE: Chest imaging (mandatory for all patients) and other imaging (if required) must have been performed within 90 days prior to randomization</li></ul></li><li>No synchronous or previous contralateral invasive breast cancer (patients with synchronous and&#x2F;or previous contralateral DCIS or lobular carcinoma in situ [LCIS] are eligible)</li><li>No previous ipsilateral invasive breast cancer or ipsilateral DCIS (patients with synchronous or previous ipsilateral LCIS are eligible)</li><li><p>HER2 status of the primary tumor must be evaluated prior to randomization; all testing performed must indicate that the tumor is HER2-low as defined below</p><ul><li>IHC must be performed and the IHC staining results must indicate a score of 1+ (in situ hybridization [ISH] testing is not required) or 2+ (ISH must also be performed and must indicate that the tumor is HER2-low as described below)</li><li>If ISH testing is performed, test results must be as follows and IHC must be 1+ or 2+: The ratio of HER2 to CEP17 must be &lt; 2.0 or, if a ratio was not performed, the HER2 gene copy number must be &lt; 4 per nucleus</li><li>Note: If the IHC staining intensity is reported as a range, e.g., 0 to 1+ or 1+ to 2+, the higher intensity score in the range should be used to determine eligibility</li></ul></li><li><p>No primary tumor with any of the following HER2 testing results:</p><ul><li><p>IHC staining intensity:</p><ul><li>0 on all evaluations of specimens</li><li>3+ on evaluation of any specimen</li></ul></li><li>ISH with a ratio of HER2 to CEP17 &gt;= 2.0 on evaluation of any specimen</li><li>ISH result indicating HER2 gene copy number &gt;= 4 per nucleus on evaluation of any specimen</li></ul></li><li><p>The patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy) (patients who have had a nipple-sparing mastectomy are eligible)</p><ul><li>For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist; if pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible (patients with margins positive for LCIS are eligible without additional resection)</li><li>For patients who undergo mastectomy, margins must be free of gross residual tumor(patients with microscopic positive margins are eligible as long as post-mastectomy RT of the chest wall will be administered)</li><li>The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days</li></ul></li><li><p>The patient must have completed one of the procedures for evaluation of pathologic nodal status listed below:</p><ul><li><p>Sentinel lymphadenectomy alone:</p><ul><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN0 or pN1b</li><li>If pathologic nodal staging based on sentinel lymphadenectomy is pN1mi or pN1a, the primary tumor must be T1 or T2 by pathologic evaluation and the nodal involvement must be limited to 1 or 2 positive nodes</li></ul></li><li>Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive</li><li>Axillary lymphadenectomy with or without SN isolation procedures</li></ul></li><li>The patient must have ER analysis performed on the primary tumor prior to randomization; if ER analysis is negative, then PgR analysis must also be performed (either the core biopsy or surgical resection specimen can be used for ER&#x2F;PgR testing); patients with a primary tumor that is hormone receptor-positive or receptor-negative are eligible</li><li>Pre- or postmenopausal</li><li>Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1</li><li>Absolute neutrophil count (ANC) must be &gt;= 1,200&#x2F;mm^3</li><li>Platelet count must be &gt;= 100,000&#x2F;mm^3</li><li>Hemoglobin must be &gt;= 10 g&#x2F;dL</li><li>Total bilirubin must be =&lt; upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation &gt; ULN to 1.5 x ULN due to Gilbert disease or similar syndrome involving slow conjugation of bilirubin</li><li>Alkaline phosphatase must be =&lt; 2.5 x ULN for the lab</li><li>Aspartate aminotransferase (AST) must be =&lt; 1.5 x ULN for the lab (if alanine aminotransferase [ALT] is performed instead of AST [per institution&#x27;s standard practice], the ALT value must be =&lt; 1.5 x ULN; if both were performed, the AST must be =&lt; 1.5 x ULN)</li><li>Alkaline phosphatase and AST may not both be &gt; the ULN</li><li>Patients with AST or alkaline phosphatase &gt; ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) performed within 90 days prior to randomization does not demonstrate metastatic disease and the above requirements are met</li><li>Patients with alkaline phosphatase that is &gt; ULN but =&lt; 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, positron emission tomography (PET)-computed tomography (CT) scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease</li><li>The most recent post operative serum creatinine performed within 6 weeks prior to randomization must be =&lt; ULN for the lab</li><li>Not pregnant or nursing</li><li>Negative pregnancy test</li><li><p>Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; LVEF assessment performed by 2-dimensional (D) echo cardiogram is preferred, however, multi-gated acquisition (MUGA) scan maybe substituted based on institutional preferences</p><ul><li>For patients who will receive the TC chemotherapy regimen, the LVEF must be &gt;= 50% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>For patients who will receive the AC→WP chemotherapy regimen, the LVEF must be &gt;= 55% regardless of the cardiac-imaging facility&#x27;s lower limit of normal</li><li>NOTE: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment.\nIf the baseline LVEF is &gt; 70%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain</li></ul></li><li>No history of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization</li><li><p>No cardiac disease (history of and&#x2F;or active disease) that would preclude the use of the drugs included in the treatment regimens, including, but not limited to:</p><ul><li><p>Active cardiac disease:</p><ul><li>Angina pectoris that requires the current use of anti-anginal medication</li><li>Ventricular arrhythmias except for benign premature ventricular contractions</li><li>Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication</li><li>Conduction abnormality requiring a pacemaker</li><li>Valvular disease with documented compromise in cardiac function</li><li>Symptomatic pericarditis</li></ul></li><li><p>History of cardiac disease:</p><ul><li>Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricle (LV) function</li><li>History of documented congestive heart failure (CHF)</li><li>Documented cardiomyopathy</li></ul></li></ul></li><li><p>No hypertension defined according to the following ineligibility criteria:</p><ul><li>For patients who will receive TC (regardless of the patient&#x27;s age): uncontrolled hypertension defined as sustained systolic blood pressure (BP) &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients &lt; 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)</li><li>For patients &gt;= 50 years old who will receive AC→WP: uncontrolled hypertension defined as sustained systolic BP &gt; 150 mm Hg or diastolic BP &gt; 90 mm Hg OR controlled hypertension (systolic BP =&lt; 150 mm Hg and diastolic BP =&lt; 90 mmHg), if anti-hypertensive medication(s) are needed</li><li>NOTE: Patients who are not eligible based on the AC→WP regimen BP criteria but who meet the TC regimen BP criteria are eligible for B-47 if the intended chemotherapy regimen is changed to TC</li></ul></li><li>No active hepatitis B or hepatitis C with abnormal liver function tests</li><li>No intrinsic lung disease resulting in dyspnea</li><li>No poorly controlled diabetes mellitus</li><li>No active infection or chronic infection requiring chronic suppressive antibiotics</li><li>No nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) &gt;= grade 2, per the Common Terminology Criteria for Adverse Events (CTCAE) v4.0</li><li>No conditions that would prohibit administration of corticosteroids</li><li>No known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate 80 and Cremophor EL</li><li>No other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up</li><li>No psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements</li><li>Concurrent participation in NSABP-B-39 allowed</li><li>No previous therapy with anthracyclines, taxanes, or trastuzumab for any malignancy</li><li>No chemotherapy or HER2-targeted therapy administered for the currently diagnosed breast cancer prior to randomization</li><li>No whole-breast radiation therapy (RT) prior to randomization or partial-breast RT that cannot be completed on or before the date of randomization</li><li>No use of any investigational product within 30 days prior to randomization</li><li>No continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor (patients are eligible if these medications are discontinued prior to randomization)</li><li>No continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy (patients are eligible if these medications are discontinued prior to randomization)</li><li>No chronic daily treatment with corticosteroids with a dose of &gt;= 10 mg&#x2F;day methylprednisol one equivalent (excluding inhaled steroids)</li><li>No other concurrent chemotherapy</li><li>No other concurrent targeted therapy for malignancy</li><li>No partial-breast irradiation following randomization</li></ul>"
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        {
          "name": "Tania E. Cortas",
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          "name": "Tania E. Cortas",
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        "name": "Joel A. Stone",
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      {
        "name": "Joel A. Stone",
        "role": "PRINCIPAL_INVESTIGATOR"
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          "name": "Craig H. Reynolds",
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          "email": "Mary.ketner@nsabp.org",
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