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NCT01275677

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Version 843 to 844 · National Cancer Institute (NCI)

Patch inspector

Version 843 to 844

7 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:09:26+00
Raw hash
2293c36e4f6fcb6cb61849f4397079cc883909219cca72cfcd01802f5911ae5f
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 5 ops
remove /protocolSection/armsInterventionsModule/interventions/0/otherNames
Triage: High
Arm Intervention Change Operation 3
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
[
  "(-)-Cyclophosphamide",
  "2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate",
  "Carloxan",
  "Ciclofosfamida",
  "Ciclofosfamide",
  "Cicloxal",
  "Clafen",
  "Claphene",
  "CP monohydrate",
  "CTX",
  "CYCLO-cell",
  "Cycloblastin",
  "Cycloblastine",
  "Cyclophospham",
  "Cyclophosphamid monohydrate",
  "Cyclophosphamidum",
  "Cyclophosphan",
  "Cyclophosphane",
  "Cyclophosphanum",
  "Cyclostin",
  "Cyclostine",
  "Cytophosphan",
  "Cytophosphane",
  "Cytoxan",
  "Fosfaseron",
  "Genoxal",
  "Genuxal",
  "Ledoxina",
  "Mitoxan",
  "Neosar",
  "Revimmune",
  "Syklofosfamid",
  "WR- 138719"
]
remove /protocolSection/armsInterventionsModule/interventions/1/otherNames
Triage: High
Arm Intervention Change Operation 4
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
[
  "Docecad",
  "RP56976",
  "Taxotere",
  "Taxotere Injection Concentrate"
]
remove /protocolSection/armsInterventionsModule/interventions/2/otherNames
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
[
  "5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)",
  "ADM",
  "Adriacin",
  "Adriamycin",
  "Adriamycin hydrochloride",
  "Adriamycin PFS",
  "Adriamycin RDF",
  "ADRIAMYCIN, HYDROCHLORIDE",
  "Adriamycine",
  "Adriblastina",
  "Adriblastine",
  "Adrimedac",
  "Chloridrato de Doxorrubicina",
  "DOX",
  "DOXO-CELL",
  "Doxolem",
  "Doxorubicin.HCl",
  "Doxorubin",
  "Farmiblastina",
  "FI 106",
  "FI-106",
  "hydroxydaunorubicin",
  "Rubex"
]
remove /protocolSection/armsInterventionsModule/interventions/4/otherNames
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
[
  "Anzatax",
  "Asotax",
  "Bristaxol",
  "Praxel",
  "Taxol",
  "Taxol Konzentrat"
]
remove /protocolSection/armsInterventionsModule/interventions/6/otherNames
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
[
  "ABP 980",
  "Anti-c-ERB-2",
  "Anti-c-erbB2 Monoclonal Antibody",
  "Anti-ERB-2",
  "Anti-erbB-2",
  "Anti-erbB2 Monoclonal Antibody",
  "Anti-HER2/c-erbB2 Monoclonal Antibody",
  "Anti-p185-HER2",
  "c-erb-2 Monoclonal Antibody",
  "HER2 Monoclonal Antibody",
  "Herceptin",
  "Herceptin Biosimilar PF-05280014",
  "Herceptin Trastuzumab Biosimilar PF-05280014",
  "MoAb HER2",
  "Monoclonal Antibody c-erb-2",
  "Monoclonal Antibody HER2",
  "PF-05280014",
  "rhuMAb HER2",
  "RO0452317",
  "Trastuzumab Biosimilar ABP 980",
  "Trastuzumab Biosimilar PF-05280014"
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 2 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-08-11
After
2017-08-14
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2017-08-14
After
2017-08-15
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-08-14"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-08-15"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/otherNames"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/2/otherNames"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/4/otherNames"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/6/otherNames"
  }
]