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NCT01275677

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Version 858 to 859 · National Cancer Institute (NCI)

Patch inspector

Version 858 to 859

145 operations 6 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_changeenrollment_count_changeenrollment_type_changesecondary_outcome_any_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actualized_earlier",
    "category": "timeline_actualized_earlier",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2017-07-31",
    "old_value": "2017-08-31",
    "delta_days": 31,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:09:33+00
Raw hash
7e9bcf4e59f3d395c01f640bafd70d0264a904648fa87d518d0659183f4d2380
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 7 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 13
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
3260
After
3296
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 14
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
add /protocolSection/armsInterventionsModule/interventions/0/otherNames
Triage: High
Arm Intervention Change Operation 15
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
[
  "(-)-Cyclophosphamide",
  "2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate",
  "Carloxan",
  "Ciclofosfamida",
  "Ciclofosfamide",
  "Cicloxal",
  "Clafen",
  "Claphene",
  "CP monohydrate",
  "CTX",
  "CYCLO-cell",
  "Cycloblastin",
  "Cycloblastine",
  "Cyclophospham",
  "Cyclophosphamid monohydrate",
  "Cyclophosphamidum",
  "Cyclophosphan",
  "Cyclophosphane",
  "Cyclophosphanum",
  "Cyclostin",
  "Cyclostine",
  "Cytophosphan",
  "Cytophosphane",
  "Cytoxan",
  "Fosfaseron",
  "Genoxal",
  "Genuxal",
  "Ledoxina",
  "Mitoxan",
  "Neosar",
  "Revimmune",
  "Syklofosfamid",
  "WR- 138719"
]
add /protocolSection/armsInterventionsModule/interventions/1/otherNames
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
[
  "Docecad",
  "RP56976",
  "Taxotere",
  "Taxotere Injection Concentrate"
]
add /protocolSection/armsInterventionsModule/interventions/2/otherNames
Triage: High
Arm Intervention Change Operation 17
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
[
  "5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)",
  "ADM",
  "Adriacin",
  "Adriamycin",
  "Adriamycin Hydrochloride",
  "Adriamycin PFS",
  "Adriamycin RDF",
  "ADRIAMYCIN, HYDROCHLORIDE",
  "Adriamycine",
  "Adriblastina",
  "Adriblastine",
  "Adrimedac",
  "Chloridrato de Doxorrubicina",
  "DOX",
  "DOXO-CELL",
  "Doxolem",
  "Doxorubicin.HCl",
  "Doxorubin",
  "Farmiblastina",
  "FI 106",
  "FI-106",
  "hydroxydaunorubicin",
  "Rubex"
]
add /protocolSection/armsInterventionsModule/interventions/4/otherNames
Triage: High
Arm Intervention Change Operation 18
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
[
  "Anzatax",
  "Asotax",
  "Bristaxol",
  "Praxel",
  "Taxol",
  "Taxol Konzentrat"
]
add /protocolSection/armsInterventionsModule/interventions/6/otherNames
Triage: High
Arm Intervention Change Operation 19
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
[
  "ABP 980",
  "Anti-c-ERB-2",
  "Anti-c-erbB2 Monoclonal Antibody",
  "Anti-ERB-2",
  "Anti-erbB-2",
  "Anti-erbB2 Monoclonal Antibody",
  "Anti-HER2/c-erbB2 Monoclonal Antibody",
  "Anti-p185-HER2",
  "c-erb-2 Monoclonal Antibody",
  "HER2 Monoclonal Antibody",
  "Herceptin",
  "Herceptin Biosimilar PF-05280014",
  "Herceptin Trastuzumab Biosimilar PF-05280014",
  "MoAb HER2",
  "Monoclonal Antibody c-erb-2",
  "Monoclonal Antibody HER2",
  "Ogivri",
  "PF-05280014",
  "rhuMAb HER2",
  "RO0452317",
  "Trastuzumab Biosimilar ABP 980",
  "Trastuzumab Biosimilar PF-05280014",
  "Trastuzumab-dkst"
]
Secondary outcomes Additional endpoints and outcome descriptions. Triage: High 10 ops
add /protocolSection/outcomesModule/secondaryOutcomes/0
Triage: High
Secondary Outcome Change Operation 20
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
{
  "measure": "DFS-DCIS",
  "timeFrame": "Up to 10 years"
}
add /protocolSection/outcomesModule/secondaryOutcomes/2
Triage: High
Secondary Outcome Change Operation 21
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
{
  "measure": "RFI",
  "timeFrame": "From randomization until invasive local, regional, or distant recurrence, or death from breast cancer, assessed up to 10 years"
}
add /protocolSection/outcomesModule/secondaryOutcomes/3
Triage: High
Secondary Outcome Change Operation 22
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
{
  "measure": "DRFI",
  "timeFrame": "From randomization until the first diagnosis of distant metastasis or death from breast cancer, assessed up to 10 years"
}
add /protocolSection/outcomesModule/secondaryOutcomes/4
Triage: High
Secondary Outcome Change Operation 23
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
{
  "measure": "OS",
  "timeFrame": "From randomization to death from any cause, assessed up to 10 years"
}
add /protocolSection/outcomesModule/secondaryOutcomes/5
Triage: High
Secondary Outcome Change Operation 24
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
After
{
  "measure": "Incidence of adverse events using the National Cancer Institute CTCAE v4.0",
  "timeFrame": "Up to 30 days",
  "description": "The frequency and severity of adverse events will be graded."
}
remove /protocolSection/outcomesModule/secondaryOutcomes/7
Triage: High
Secondary Outcome Change Operation 25
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
{
  "measure": "DFS-DCIS",
  "timeFrame": "Up to 10 years"
}
remove /protocolSection/outcomesModule/secondaryOutcomes/7
Triage: High
Secondary Outcome Change Operation 26
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
{
  "measure": "DRFI",
  "timeFrame": "From randomization until the first diagnosis of distant metastasis or death from breast cancer, assessed up to 10 years"
}
remove /protocolSection/outcomesModule/secondaryOutcomes/8
Triage: High
Secondary Outcome Change Operation 27
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
{
  "measure": "Incidence of adverse events using the National Cancer Institute CTCAE v4.0",
  "timeFrame": "Up to 30 days",
  "description": "The frequency and severity of adverse events will be graded."
}
remove /protocolSection/outcomesModule/secondaryOutcomes/8
Triage: High
Secondary Outcome Change Operation 28
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
{
  "measure": "OS",
  "timeFrame": "From randomization to death from any cause, assessed up to 10 years"
}
remove /protocolSection/outcomesModule/secondaryOutcomes/8
Triage: High
Secondary Outcome Change Operation 29
Matched rules
  • secondary_outcome_any_change Any add/remove/replace under secondary outcome measures is high review priority.
Before
{
  "measure": "RFI",
  "timeFrame": "From randomization until invasive local, regional, or distant recurrence, or death from breast cancer, assessed up to 10 years"
}
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2017-08-31
After
2017-07-31
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 116 ops
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 30
After
{
  "zip": "36688",
  "city": "Mobile",
  "state": "Alabama",
  "country": "United States",
  "facility": "University of South Alabama Mitchell Cancer Institute",
  "geoPoint": {
    "lat": 30.69436,
    "lon": -88.04305
  }
}
replace /protocolSection/contactsLocationsModule/locations/10/facility
Triage: Uncategorized
Uncategorized Operation 31
Before
Pinnacle Oncology Hematology
After
Virginia G Piper Cancer Care-Del Camino
add /protocolSection/contactsLocationsModule/locations/16
Triage: Uncategorized
Uncategorized Operation 32
After
{
  "zip": "93420",
  "city": "Arroyo Grande",
  "state": "California",
  "country": "United States",
  "facility": "PCR Oncology",
  "geoPoint": {
    "lat": 35.11859,
    "lon": -120.59073
  }
}
replace /protocolSection/contactsLocationsModule/locations/32/facility
Triage: Uncategorized
Uncategorized Operation 33
Before
Kaiser Permanente Hospital
After
Kaiser Permanente-Fontana
replace /protocolSection/contactsLocationsModule/locations/35/facility
Triage: Uncategorized
Uncategorized Operation 34
Before
Kaiser Permanente
After
Kaiser Permanente-Fresno
add /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 35
After
{
  "zip": "94040",
  "city": "Mountain View",
  "state": "California",
  "country": "United States",
  "facility": "Palo Alto Medical Foundation-Camino Division",
  "geoPoint": {
    "lat": 37.38605,
    "lon": -122.08385
  }
}
add /protocolSection/contactsLocationsModule/locations/62
Triage: Uncategorized
Uncategorized Operation 36
After
{
  "zip": "94301",
  "city": "Palo Alto",
  "state": "California",
  "country": "United States",
  "facility": "Palo Alto Medical Foundation Health Care",
  "geoPoint": {
    "lat": 37.44188,
    "lon": -122.14302
  }
}
remove /protocolSection/contactsLocationsModule/locations/65
Triage: Uncategorized
Uncategorized Operation 37
Before
{
  "zip": "93449",
  "city": "Pismo Beach",
  "state": "California",
  "country": "United States",
  "facility": "PCR Oncology",
  "geoPoint": {
    "lat": 35.14275,
    "lon": -120.64128
  }
}
add /protocolSection/contactsLocationsModule/locations/66
Triage: Uncategorized
Uncategorized Operation 38
After
{
  "zip": "91767",
  "city": "Pomona",
  "state": "California",
  "country": "United States",
  "facility": "Pomona Valley Hospital Medical Center",
  "geoPoint": {
    "lat": 34.05529,
    "lon": -117.75228
  }
}
replace /protocolSection/contactsLocationsModule/locations/89/zip
Triage: Uncategorized
Uncategorized Operation 39
Before
92069
After
92078
add /protocolSection/contactsLocationsModule/locations/92
Triage: Uncategorized
Uncategorized Operation 40
After
{
  "zip": "92705",
  "city": "Santa Ana",
  "state": "California",
  "country": "United States",
  "facility": "Breastlink Medical Group Inc",
  "geoPoint": {
    "lat": 33.74557,
    "lon": -117.86783
  }
}
add /protocolSection/contactsLocationsModule/locations/94
Triage: Uncategorized
Uncategorized Operation 41
After
{
  "zip": "95065",
  "city": "Santa Cruz",
  "state": "California",
  "country": "United States",
  "facility": "Palo Alto Medical Foundation-Santa Cruz",
  "geoPoint": {
    "lat": 36.97412,
    "lon": -122.0308
  }
}
add /protocolSection/contactsLocationsModule/locations/101
Triage: Uncategorized
Uncategorized Operation 42
After
{
  "zip": "94086",
  "city": "Sunnyvale",
  "state": "California",
  "country": "United States",
  "facility": "Palo Alto Medical Foundation-Sunnyvale",
  "geoPoint": {
    "lat": 37.36883,
    "lon": -122.03635
  }
}
replace /protocolSection/contactsLocationsModule/locations/109/facility
Triage: Uncategorized
Uncategorized Operation 43
Before
Kaiser Permanente
After
Kaiser Permanente-Woodland Hills
replace /protocolSection/contactsLocationsModule/locations/111/facility
Triage: Uncategorized
Uncategorized Operation 44
Before
University of Colorado Cancer Center - Anschutz Cancer Pavilion
After
University of Colorado Hospital
replace /protocolSection/contactsLocationsModule/locations/116/facility
Triage: Uncategorized
Uncategorized Operation 45
Before
Memorial Hospital Central
After
UCHealth Memorial Hospital Central
add /protocolSection/contactsLocationsModule/locations/175
Triage: Uncategorized
Uncategorized Operation 46
After
{
  "zip": "32114",
  "city": "Daytona Beach",
  "state": "Florida",
  "country": "United States",
  "facility": "Halifax Health Medical Center-Centers for Oncology",
  "geoPoint": {
    "lat": 29.21081,
    "lon": -81.02283
  }
}
replace /protocolSection/contactsLocationsModule/locations/178/facility
Triage: Uncategorized
Uncategorized Operation 47
Before
University of Florida
After
Broward Health Medical Center
replace /protocolSection/contactsLocationsModule/locations/178/city
Triage: Uncategorized
Uncategorized Operation 48
Before
Gainesville
After
Fort Lauderdale
replace /protocolSection/contactsLocationsModule/locations/178/zip
Triage: Uncategorized
Uncategorized Operation 49
Before
32610
After
33316
replace /protocolSection/contactsLocationsModule/locations/178/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 50
Before
29.65163
After
26.12231
replace /protocolSection/contactsLocationsModule/locations/178/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 51
Before
-82.32483
After
-80.14338
add /protocolSection/contactsLocationsModule/locations/179
Triage: Uncategorized
Uncategorized Operation 52
After
{
  "zip": "32610",
  "city": "Gainesville",
  "state": "Florida",
  "country": "United States",
  "facility": "University of Florida Health Science Center - Gainesville",
  "geoPoint": {
    "lat": 29.65163,
    "lon": -82.32483
  }
}
add /protocolSection/contactsLocationsModule/locations/180
Triage: Uncategorized
Uncategorized Operation 53
After
{
  "zip": "32204",
  "city": "Jacksonville",
  "state": "Florida",
  "country": "United States",
  "facility": "Saint Vincent's Medical Center",
  "geoPoint": {
    "lat": 30.33218,
    "lon": -81.65565
  }
}
add /protocolSection/contactsLocationsModule/locations/181
Triage: Uncategorized
Uncategorized Operation 54
After
{
  "zip": "32207",
  "city": "Jacksonville",
  "state": "Florida",
  "country": "United States",
  "facility": "Baptist MD Anderson Cancer Center",
  "geoPoint": {
    "lat": 30.33218,
    "lon": -81.65565
  }
}
add /protocolSection/contactsLocationsModule/locations/184
Triage: Uncategorized
Uncategorized Operation 55
After
{
  "zip": "33805",
  "city": "Lakeland",
  "state": "Florida",
  "country": "United States",
  "facility": "Lakeland Regional Health Hollis Cancer Center",
  "geoPoint": {
    "lat": 28.03947,
    "lon": -81.9498
  }
}
add /protocolSection/contactsLocationsModule/locations/198
Triage: Uncategorized
Uncategorized Operation 56
After
{
  "zip": "30303",
  "city": "Atlanta",
  "state": "Georgia",
  "country": "United States",
  "facility": "Grady Health System",
  "geoPoint": {
    "lat": 33.749,
    "lon": -84.38798
  }
}
add /protocolSection/contactsLocationsModule/locations/199
Triage: Uncategorized
Uncategorized Operation 57
After
{
  "zip": "30308",
  "city": "Atlanta",
  "state": "Georgia",
  "country": "United States",
  "facility": "Emory University Hospital Midtown",
  "geoPoint": {
    "lat": 33.749,
    "lon": -84.38798
  }
}
add /protocolSection/contactsLocationsModule/locations/201
Triage: Uncategorized
Uncategorized Operation 58
After
{
  "zip": "30322",
  "city": "Atlanta",
  "state": "Georgia",
  "country": "United States",
  "facility": "Emory University Hospital/Winship Cancer Institute",
  "geoPoint": {
    "lat": 33.749,
    "lon": -84.38798
  }
}
add /protocolSection/contactsLocationsModule/locations/203
Triage: Uncategorized
Uncategorized Operation 59
After
{
  "zip": "30342",
  "city": "Atlanta",
  "state": "Georgia",
  "country": "United States",
  "facility": "Emory Saint Joseph's Hospital",
  "geoPoint": {
    "lat": 33.749,
    "lon": -84.38798
  }
}
remove /protocolSection/contactsLocationsModule/locations/205
Triage: Uncategorized
Uncategorized Operation 60
Before
{
  "zip": "30342",
  "city": "Atlanta",
  "state": "Georgia",
  "country": "United States",
  "facility": "Saint Joseph's Hospital of Atlanta",
  "geoPoint": {
    "lat": 33.749,
    "lon": -84.38798
  }
}
add /protocolSection/contactsLocationsModule/locations/209
Triage: Uncategorized
Uncategorized Operation 61
After
{
  "zip": "31021",
  "city": "Dublin",
  "state": "Georgia",
  "country": "United States",
  "facility": "Dublin Hematology Oncology Care PC",
  "geoPoint": {
    "lat": 32.54044,
    "lon": -82.90375
  }
}
replace /protocolSection/contactsLocationsModule/locations/216/facility
Triage: Uncategorized
Uncategorized Operation 62
Before
Memorial University Medical Center
After
Memorial Health University Medical Center
replace /protocolSection/contactsLocationsModule/locations/259/facility
Triage: Uncategorized
Uncategorized Operation 63
Before
Cancer Care Center of Decatur
After
Cancer Care Specialists of Central Illinois
add /protocolSection/contactsLocationsModule/locations/287
Triage: Uncategorized
Uncategorized Operation 64
After
{
  "zip": "60540",
  "city": "Naperville",
  "state": "Illinois",
  "country": "United States",
  "facility": "AMG Oncology - Naperville",
  "geoPoint": {
    "lat": 41.78586,
    "lon": -88.14729
  }
}
remove /protocolSection/contactsLocationsModule/locations/289
Triage: Uncategorized
Uncategorized Operation 65
Before
{
  "zip": "60540",
  "city": "Naperville",
  "state": "Illinois",
  "country": "United States",
  "facility": "Hematology Oncology Consultants Limited",
  "geoPoint": {
    "lat": 41.78586,
    "lon": -88.14729
  }
}
remove /protocolSection/contactsLocationsModule/locations/299
Triage: Uncategorized
Uncategorized Operation 66
Before
{
  "zip": "61603",
  "city": "Peoria",
  "state": "Illinois",
  "country": "United States",
  "facility": "Methodist Medical Center of Illinois",
  "geoPoint": {
    "lat": 40.69365,
    "lon": -89.58899
  }
}
add /protocolSection/contactsLocationsModule/locations/302
Triage: Uncategorized
Uncategorized Operation 67
After
{
  "zip": "61636",
  "city": "Peoria",
  "state": "Illinois",
  "country": "United States",
  "facility": "Methodist Medical Center of Illinois",
  "geoPoint": {
    "lat": 40.69365,
    "lon": -89.58899
  }
}
add /protocolSection/contactsLocationsModule/locations/310
Triage: Uncategorized
Uncategorized Operation 68
After
{
  "zip": "61104",
  "city": "Rockford",
  "state": "Illinois",
  "country": "United States",
  "facility": "Swedish American Hospital",
  "geoPoint": {
    "lat": 42.27113,
    "lon": -89.094
  }
}
add /protocolSection/contactsLocationsModule/locations/321
Triage: Uncategorized
Uncategorized Operation 69
After
{
  "zip": "46107",
  "city": "Beech Grove",
  "state": "Indiana",
  "country": "United States",
  "facility": "Franciscan Saint Francis Health-Beech Grove",
  "geoPoint": {
    "lat": 39.72199,
    "lon": -86.08998
  }
}
add /protocolSection/contactsLocationsModule/locations/327
Triage: Uncategorized
Uncategorized Operation 70
After
{
  "zip": "46237",
  "city": "Indianapolis",
  "state": "Indiana",
  "country": "United States",
  "facility": "Franciscan Health Indianapolis",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
add /protocolSection/contactsLocationsModule/locations/329
Triage: Uncategorized
Uncategorized Operation 71
After
{
  "zip": "46260",
  "city": "Indianapolis",
  "state": "Indiana",
  "country": "United States",
  "facility": "Saint Vincent Hospital and Health Care Center",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
add /protocolSection/contactsLocationsModule/locations/444
Triage: Uncategorized
Uncategorized Operation 72
After
{
  "zip": "21202",
  "city": "Baltimore",
  "state": "Maryland",
  "country": "United States",
  "facility": "Mercy Medical Center",
  "geoPoint": {
    "lat": 39.29038,
    "lon": -76.61219
  }
}
add /protocolSection/contactsLocationsModule/locations/464
Triage: Uncategorized
Uncategorized Operation 73
After
{
  "zip": "20850",
  "city": "Rockville",
  "state": "Maryland",
  "country": "United States",
  "facility": "Kaiser Permanente - Shady Grove Medical Center",
  "geoPoint": {
    "lat": 39.084,
    "lon": -77.15276
  }
}
add /protocolSection/contactsLocationsModule/locations/475
Triage: Uncategorized
Uncategorized Operation 74
After
{
  "zip": "01805",
  "city": "Burlington",
  "state": "Massachusetts",
  "country": "United States",
  "facility": "Lahey Hospital and Medical Center",
  "geoPoint": {
    "lat": 42.50482,
    "lon": -71.19561
  }
}
remove /protocolSection/contactsLocationsModule/locations/491
Triage: Uncategorized
Uncategorized Operation 75
Before
{
  "zip": "48106-0995",
  "city": "Ann Arbor",
  "state": "Michigan",
  "country": "United States",
  "facility": "Saint Joseph Mercy Hospital",
  "geoPoint": {
    "lat": 42.27756,
    "lon": -83.74088
  }
}
add /protocolSection/contactsLocationsModule/locations/492
Triage: Uncategorized
Uncategorized Operation 76
After
{
  "zip": "48106",
  "city": "Ann Arbor",
  "state": "Michigan",
  "country": "United States",
  "facility": "Saint Joseph Mercy Hospital",
  "geoPoint": {
    "lat": 42.27756,
    "lon": -83.74088
  }
}
replace /protocolSection/contactsLocationsModule/locations/495/facility
Triage: Uncategorized
Uncategorized Operation 77
Before
McLaren-Bay Region
After
McLaren Cancer Institute-Bay City
replace /protocolSection/contactsLocationsModule/locations/497/facility
Triage: Uncategorized
Uncategorized Operation 78
Before
Great Lakes Cancer Institute
After
McLaren Cancer Institute-Clarkston
replace /protocolSection/contactsLocationsModule/locations/498/city
Triage: Uncategorized
Uncategorized Operation 79
Before
Clinton
After
Clinton Township
replace /protocolSection/contactsLocationsModule/locations/498/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 80
Before
42.07199
After
42.58698
replace /protocolSection/contactsLocationsModule/locations/498/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 81
Before
-83.97161
After
-82.91992
replace /protocolSection/contactsLocationsModule/locations/506/facility
Triage: Uncategorized
Uncategorized Operation 82
Before
Botsford General Hospital
After
Botsford Hospital
replace /protocolSection/contactsLocationsModule/locations/506/zip
Triage: Uncategorized
Uncategorized Operation 83
Before
48334
After
48336-5919
remove /protocolSection/contactsLocationsModule/locations/508
Triage: Uncategorized
Uncategorized Operation 84
Before
{
  "zip": "48502",
  "city": "Flint",
  "state": "Michigan",
  "country": "United States",
  "facility": "Hurley Medical Center",
  "geoPoint": {
    "lat": 43.01253,
    "lon": -83.68746
  }
}
add /protocolSection/contactsLocationsModule/locations/509
Triage: Uncategorized
Uncategorized Operation 85
After
{
  "zip": "48503",
  "city": "Flint",
  "state": "Michigan",
  "country": "United States",
  "facility": "Hurley Medical Center",
  "geoPoint": {
    "lat": 43.01253,
    "lon": -83.68746
  }
}
replace /protocolSection/contactsLocationsModule/locations/584/facility
Triage: Uncategorized
Uncategorized Operation 86
Before
Central Care Cancer Center-Carrie J Babb Cancer Center
After
Central Care Cancer Center - Bolivar
replace /protocolSection/contactsLocationsModule/locations/586/facility
Triage: Uncategorized
Uncategorized Operation 87
Before
CoxHealth Cancer Center
After
Cox Cancer Center Branson
replace /protocolSection/contactsLocationsModule/locations/594/facility
Triage: Uncategorized
Uncategorized Operation 88
Before
Mercy Hospital-Joplin
After
Mercy Hospital Joplin
replace /protocolSection/contactsLocationsModule/locations/603/facility
Triage: Uncategorized
Uncategorized Operation 89
Before
Saint John's Clinic-Rolla-Cancer and Hematology
After
Mercy Clinic-Rolla-Cancer and Hematology
replace /protocolSection/contactsLocationsModule/locations/604/zip
Triage: Uncategorized
Uncategorized Operation 90
Before
64506
After
64507
replace /protocolSection/contactsLocationsModule/locations/614/facility
Triage: Uncategorized
Uncategorized Operation 91
Before
Christian Hospital
After
Siteman Cancer Center at Christian Hospital
replace /protocolSection/contactsLocationsModule/locations/643/facility
Triage: Uncategorized
Uncategorized Operation 92
Before
Faith Regional Medical Offices West
After
Faith Regional Health Services Carson Cancer Center
replace /protocolSection/contactsLocationsModule/locations/644/facility
Triage: Uncategorized
Uncategorized Operation 93
Before
Great Plains Regional Medical Center
After
Great Plains Health Callahan Cancer Center
replace /protocolSection/contactsLocationsModule/locations/644/zip
Triage: Uncategorized
Uncategorized Operation 94
Before
69103
After
69101
replace /protocolSection/contactsLocationsModule/locations/648/facility
Triage: Uncategorized
Uncategorized Operation 95
Before
Hemotology and Oncology Consultants PC
After
Hematology and Oncology Consultants PC
replace /protocolSection/contactsLocationsModule/locations/650/facility
Triage: Uncategorized
Uncategorized Operation 96
Before
Oncology Hematology West
After
Nebraska Cancer Specialists - Omaha
replace /protocolSection/contactsLocationsModule/locations/656/facility
Triage: Uncategorized
Uncategorized Operation 97
Before
Regional West Medical Center
After
Regional West Medical Center Cancer Center
replace /protocolSection/contactsLocationsModule/locations/660/facility
Triage: Uncategorized
Uncategorized Operation 98
Before
21st Century Oncology - Henderson
After
21st Century Oncology-Henderson
add /protocolSection/contactsLocationsModule/locations/671
Triage: Uncategorized
Uncategorized Operation 99
After
{
  "zip": "89128",
  "city": "Las Vegas",
  "state": "Nevada",
  "country": "United States",
  "facility": "21st Century Oncology-Vegas Tenaya",
  "geoPoint": {
    "lat": 36.17497,
    "lon": -115.13722
  }
}
replace /protocolSection/contactsLocationsModule/locations/678/facility
Triage: Uncategorized
Uncategorized Operation 100
Before
21st Century Oncology - Fort Apache
After
21st Century Oncology-Fort Apache
remove /protocolSection/contactsLocationsModule/locations/683
Triage: Uncategorized
Uncategorized Operation 101
Before
{
  "zip": "89182",
  "city": "Las Vegas",
  "state": "Nevada",
  "country": "United States",
  "facility": "21st Century Oncology - Vegas Tenaya",
  "geoPoint": {
    "lat": 36.17497,
    "lon": -115.13722
  }
}
add /protocolSection/contactsLocationsModule/locations/684
Triage: Uncategorized
Uncategorized Operation 102
After
{
  "zip": "03833",
  "city": "Exeter",
  "state": "New Hampshire",
  "country": "United States",
  "facility": "Exeter Hospital",
  "geoPoint": {
    "lat": 42.98148,
    "lon": -70.94783
  }
}
replace /protocolSection/contactsLocationsModule/locations/736/zip
Triage: Uncategorized
Uncategorized Operation 103
Before
11040
After
11042
replace /protocolSection/contactsLocationsModule/locations/737/facility
Triage: Uncategorized
Uncategorized Operation 104
Before
Beth Israel Medical Center
After
Mount Sinai Union Square
replace /protocolSection/contactsLocationsModule/locations/739/facility
Triage: Uncategorized
Uncategorized Operation 105
Before
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division
After
Mount Sinai West
replace /protocolSection/contactsLocationsModule/locations/739/zip
Triage: Uncategorized
Uncategorized Operation 106
Before
10025
After
10019
replace /protocolSection/contactsLocationsModule/locations/754/zip
Triage: Uncategorized
Uncategorized Operation 107
Before
10467-2490
After
10467
replace /protocolSection/contactsLocationsModule/locations/764/zip
Triage: Uncategorized
Uncategorized Operation 108
Before
28612
After
28712
replace /protocolSection/contactsLocationsModule/locations/777/zip
Triage: Uncategorized
Uncategorized Operation 109
Before
28744
After
28734
replace /protocolSection/contactsLocationsModule/locations/787/facility
Triage: Uncategorized
Uncategorized Operation 110
Before
Park Ridge Hospital Breast Health Center
After
Park Ridge Health
replace /protocolSection/contactsLocationsModule/locations/796/zip
Triage: Uncategorized
Uncategorized Operation 111
Before
28754
After
28752
add /protocolSection/contactsLocationsModule/locations/804
Triage: Uncategorized
Uncategorized Operation 112
After
{
  "zip": "28374",
  "city": "Pinehurst",
  "state": "North Carolina",
  "country": "United States",
  "facility": "FirstHealth of the Carolinas-Moore Regional Hospital",
  "geoPoint": {
    "lat": 35.19543,
    "lon": -79.46948
  }
}
add /protocolSection/contactsLocationsModule/locations/811
Triage: Uncategorized
Uncategorized Operation 113
After
{
  "zip": "28139",
  "city": "Rutherfordton",
  "state": "North Carolina",
  "country": "United States",
  "facility": "Rutherford Hospital",
  "geoPoint": {
    "lat": 35.36929,
    "lon": -81.95677
  }
}
add /protocolSection/contactsLocationsModule/locations/835
Triage: Uncategorized
Uncategorized Operation 114
After
{
  "zip": "44304",
  "city": "Akron",
  "state": "Ohio",
  "country": "United States",
  "facility": "Summa Akron City Hospital/Cooper Cancer Center",
  "geoPoint": {
    "lat": 41.08144,
    "lon": -81.51901
  }
}
add /protocolSection/contactsLocationsModule/locations/836
Triage: Uncategorized
Uncategorized Operation 115
After
{
  "zip": "44203",
  "city": "Barberton",
  "state": "Ohio",
  "country": "United States",
  "facility": "Summa Barberton Hospital",
  "geoPoint": {
    "lat": 41.01283,
    "lon": -81.60512
  }
}
replace /protocolSection/contactsLocationsModule/locations/844/facility
Triage: Uncategorized
Uncategorized Operation 116
Before
Geaugra Hospital
After
Geauga Hospital
replace /protocolSection/contactsLocationsModule/locations/927/facility
Triage: Uncategorized
Uncategorized Operation 117
Before
UH-Seidman Cancer Center at Saint John Medical Center
After
UH Seidman Cancer Center at Saint John Medical Center
add /protocolSection/contactsLocationsModule/locations/941
Triage: Uncategorized
Uncategorized Operation 118
After
{
  "zip": "97701",
  "city": "Bend",
  "state": "Oregon",
  "country": "United States",
  "facility": "Saint Charles Health System",
  "geoPoint": {
    "lat": 44.05817,
    "lon": -121.31531
  }
}
add /protocolSection/contactsLocationsModule/locations/944
Triage: Uncategorized
Uncategorized Operation 119
After
{
  "zip": "97527",
  "city": "Grants Pass",
  "state": "Oregon",
  "country": "United States",
  "facility": "Three Rivers Community Hospital",
  "geoPoint": {
    "lat": 42.43933,
    "lon": -123.33067
  }
}
add /protocolSection/contactsLocationsModule/locations/947
Triage: Uncategorized
Uncategorized Operation 120
After
{
  "zip": "97504",
  "city": "Medford",
  "state": "Oregon",
  "country": "United States",
  "facility": "Providence Medford Medical Center",
  "geoPoint": {
    "lat": 42.32652,
    "lon": -122.87559
  }
}
add /protocolSection/contactsLocationsModule/locations/948
Triage: Uncategorized
Uncategorized Operation 121
After
{
  "zip": "97504",
  "city": "Medford",
  "state": "Oregon",
  "country": "United States",
  "facility": "Rogue Valley Medical Center",
  "geoPoint": {
    "lat": 42.32652,
    "lon": -122.87559
  }
}
add /protocolSection/contactsLocationsModule/locations/970
Triage: Uncategorized
Uncategorized Operation 122
After
{
  "zip": "15801",
  "city": "DuBois",
  "state": "Pennsylvania",
  "country": "United States",
  "facility": "Oncology Hematology Associates of Northern Pennsylvania",
  "geoPoint": {
    "lat": 41.11923,
    "lon": -78.76003
  }
}
replace /protocolSection/contactsLocationsModule/locations/979/facility
Triage: Uncategorized
Uncategorized Operation 123
Before
PinnacleHealth Cancer Center-Community Campus
After
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
add /protocolSection/contactsLocationsModule/locations/998
Triage: Uncategorized
Uncategorized Operation 124
After
{
  "zip": "19460",
  "city": "Phoenixville",
  "state": "Pennsylvania",
  "country": "United States",
  "facility": "Phoenixville Hospital",
  "geoPoint": {
    "lat": 40.13038,
    "lon": -75.51491
  }
}
replace /protocolSection/contactsLocationsModule/locations/1009/facility
Triage: Uncategorized
Uncategorized Operation 125
Before
Pottstown Memorial Medical Center
After
Pottstown Hospital
replace /protocolSection/contactsLocationsModule/locations/1026/facility
Triage: Uncategorized
Uncategorized Operation 126
Before
Susquehanna Cancer Center
After
UPMC Susquehanna
add /protocolSection/contactsLocationsModule/locations/1035
Triage: Uncategorized
Uncategorized Operation 127
After
{
  "zip": "29621",
  "city": "Anderson",
  "state": "South Carolina",
  "country": "United States",
  "facility": "AnMed Health Hospital",
  "geoPoint": {
    "lat": 34.50344,
    "lon": -82.65013
  }
}
replace /protocolSection/contactsLocationsModule/locations/1040/facility
Triage: Uncategorized
Uncategorized Operation 128
Before
Charleston Hematology Oncology Associates PA-St. Francis
After
Charleston Hematology Oncology Associates PA-Saint Francis
add /protocolSection/contactsLocationsModule/locations/1050
Triage: Uncategorized
Uncategorized Operation 129
After
{
  "zip": "29646",
  "city": "Greenwood",
  "state": "South Carolina",
  "country": "United States",
  "facility": "Self Regional Healthcare",
  "geoPoint": {
    "lat": 34.1954,
    "lon": -82.16179
  }
}
replace /protocolSection/contactsLocationsModule/locations/1062/facility
Triage: Uncategorized
Uncategorized Operation 130
Before
Sanford Cancer Center-Oncology Clinic
After
Sanford Cancer Center Oncology Clinic
add /protocolSection/contactsLocationsModule/locations/1101
Triage: Uncategorized
Uncategorized Operation 131
After
{
  "zip": "78041",
  "city": "Laredo",
  "state": "Texas",
  "country": "United States",
  "facility": "Doctor's Hospital of Laredo",
  "geoPoint": {
    "lat": 27.50641,
    "lon": -99.50754
  }
}
replace /protocolSection/contactsLocationsModule/locations/1153/facility
Triage: Uncategorized
Uncategorized Operation 132
Before
Shenandoah Oncology Associates PC
After
Shenandoah Oncology PC
replace /protocolSection/contactsLocationsModule/locations/1185/facility
Triage: Uncategorized
Uncategorized Operation 133
Before
Group Health Cooperative-Seattle
After
Kaiser Permanente Washington
replace /protocolSection/contactsLocationsModule/locations/1188/facility
Triage: Uncategorized
Uncategorized Operation 134
Before
United General Hospital
After
PeaceHealth United General Medical Center
add /protocolSection/contactsLocationsModule/locations/1216
Triage: Uncategorized
Uncategorized Operation 135
After
{
  "zip": "26101",
  "city": "Parkersburg",
  "state": "West Virginia",
  "country": "United States",
  "facility": "Camden-Clark Memorial Hospital",
  "geoPoint": {
    "lat": 39.26674,
    "lon": -81.56151
  }
}
add /protocolSection/contactsLocationsModule/locations/1218
Triage: Uncategorized
Uncategorized Operation 136
After
{
  "zip": "26003",
  "city": "Wheeling",
  "state": "West Virginia",
  "country": "United States",
  "facility": "Wheeling Hospital/Schiffler Cancer Center",
  "geoPoint": {
    "lat": 40.06396,
    "lon": -80.72091
  }
}
add /protocolSection/contactsLocationsModule/locations/1225
Triage: Uncategorized
Uncategorized Operation 137
After
{
  "zip": "54935",
  "city": "Fond du Lac",
  "state": "Wisconsin",
  "country": "United States",
  "facility": "Saint Agnes Hospital/Agnesian Cancer Center",
  "geoPoint": {
    "lat": 43.775,
    "lon": -88.43883
  }
}
replace /protocolSection/contactsLocationsModule/locations/1241/facility
Triage: Uncategorized
Uncategorized Operation 138
Before
Saint Joseph's Hospital
After
Marshfield Medical Center
replace /protocolSection/contactsLocationsModule/locations/1252/facility
Triage: Uncategorized
Uncategorized Operation 139
Before
Marshfield Clinic at James Beck Cancer Center
After
Wheaton Franciscan Cancer Care - All Saints
replace /protocolSection/contactsLocationsModule/locations/1252/city
Triage: Uncategorized
Uncategorized Operation 140
Before
Rhinelander
After
Racine
replace /protocolSection/contactsLocationsModule/locations/1252/zip
Triage: Uncategorized
Uncategorized Operation 141
Before
54501
After
53405
replace /protocolSection/contactsLocationsModule/locations/1252/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 142
Before
45.63662
After
42.72613
replace /protocolSection/contactsLocationsModule/locations/1252/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 143
Before
-89.41208
After
-87.78285
add /protocolSection/contactsLocationsModule/locations/1253
Triage: Uncategorized
Uncategorized Operation 144
After
{
  "zip": "54501",
  "city": "Rhinelander",
  "state": "Wisconsin",
  "country": "United States",
  "facility": "Ascension Saint Mary's Hospital",
  "geoPoint": {
    "lat": 45.63662,
    "lon": -89.41208
  }
}
replace /protocolSection/contactsLocationsModule/locations/1258/facility
Triage: Uncategorized
Uncategorized Operation 145
Before
Marshfield Clinic Cancer Care at Saint Michael's Hospital
After
Ascension Saint Michael's Hospital
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 9 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2017-08
After
2017-11
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2017-09-01
After
2018-04-09
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2017-09-05
After
2018-04-10
replace /protocolSection/conditionsModule/conditions/6
Triage: Uncategorized
Uncategorized Operation 7
Before
Stage IA Breast Cancer
After
Stage IA Breast Cancer AJCC v7
replace /protocolSection/conditionsModule/conditions/7
Triage: Uncategorized
Uncategorized Operation 8
Before
Stage IB Breast Cancer
After
Stage IB Breast Cancer AJCC v7
replace /protocolSection/conditionsModule/conditions/8
Triage: Uncategorized
Uncategorized Operation 9
Before
Stage IIA Breast Cancer
After
Stage IIA Breast Cancer AJCC v6 and v7
replace /protocolSection/conditionsModule/conditions/9
Triage: Uncategorized
Uncategorized Operation 10
Before
Stage IIB Breast Cancer
After
Stage IIB Breast Cancer AJCC v6 and v7
replace /protocolSection/conditionsModule/conditions/10
Triage: Uncategorized
Uncategorized Operation 11
Before
Stage IIIA Breast Cancer
After
Stage IIIA Breast Cancer AJCC v7
replace /protocolSection/conditionsModule/conditions/11
Triage: Uncategorized
Uncategorized Operation 12
Before
Stage IIIC Breast Cancer
After
Stage IIIC Breast Cancer AJCC v7
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
add /protocolSection/identificationModule/secondaryIdInfos/2
Triage: Uncategorized
Uncategorized Operation 1
After
{
  "id": "S13-00177"
}
Raw JSON Patch 
[
  {
    "op": "add",
    "path": "/protocolSection/identificationModule/secondaryIdInfos/2",
    "value": {
      "id": "S13-00177"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2017-07-31"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2018-04-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2018-04-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/6",
    "value": "Stage IA Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/7",
    "value": "Stage IB Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/8",
    "value": "Stage IIA Breast Cancer AJCC v6 and v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/9",
    "value": "Stage IIB Breast Cancer AJCC v6 and v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/10",
    "value": "Stage IIIA Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/11",
    "value": "Stage IIIC Breast Cancer AJCC v7"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 3296
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames",
    "value": [
      "(-)-Cyclophosphamide",
      "2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate",
      "Carloxan",
      "Ciclofosfamida",
      "Ciclofosfamide",
      "Cicloxal",
      "Clafen",
      "Claphene",
      "CP monohydrate",
      "CTX",
      "CYCLO-cell",
      "Cycloblastin",
      "Cycloblastine",
      "Cyclophospham",
      "Cyclophosphamid monohydrate",
      "Cyclophosphamidum",
      "Cyclophosphan",
      "Cyclophosphane",
      "Cyclophosphanum",
      "Cyclostin",
      "Cyclostine",
      "Cytophosphan",
      "Cytophosphane",
      "Cytoxan",
      "Fosfaseron",
      "Genoxal",
      "Genuxal",
      "Ledoxina",
      "Mitoxan",
      "Neosar",
      "Revimmune",
      "Syklofosfamid",
      "WR- 138719"
    ]
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/otherNames",
    "value": [
      "Docecad",
      "RP56976",
      "Taxotere",
      "Taxotere Injection Concentrate"
    ]
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/2/otherNames",
    "value": [
      "5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)",
      "ADM",
      "Adriacin",
      "Adriamycin",
      "Adriamycin Hydrochloride",
      "Adriamycin PFS",
      "Adriamycin RDF",
      "ADRIAMYCIN, HYDROCHLORIDE",
      "Adriamycine",
      "Adriblastina",
      "Adriblastine",
      "Adrimedac",
      "Chloridrato de Doxorrubicina",
      "DOX",
      "DOXO-CELL",
      "Doxolem",
      "Doxorubicin.HCl",
      "Doxorubin",
      "Farmiblastina",
      "FI 106",
      "FI-106",
      "hydroxydaunorubicin",
      "Rubex"
    ]
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/4/otherNames",
    "value": [
      "Anzatax",
      "Asotax",
      "Bristaxol",
      "Praxel",
      "Taxol",
      "Taxol Konzentrat"
    ]
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/6/otherNames",
    "value": [
      "ABP 980",
      "Anti-c-ERB-2",
      "Anti-c-erbB2 Monoclonal Antibody",
      "Anti-ERB-2",
      "Anti-erbB-2",
      "Anti-erbB2 Monoclonal Antibody",
      "Anti-HER2/c-erbB2 Monoclonal Antibody",
      "Anti-p185-HER2",
      "c-erb-2 Monoclonal Antibody",
      "HER2 Monoclonal Antibody",
      "Herceptin",
      "Herceptin Biosimilar PF-05280014",
      "Herceptin Trastuzumab Biosimilar PF-05280014",
      "MoAb HER2",
      "Monoclonal Antibody c-erb-2",
      "Monoclonal Antibody HER2",
      "Ogivri",
      "PF-05280014",
      "rhuMAb HER2",
      "RO0452317",
      "Trastuzumab Biosimilar ABP 980",
      "Trastuzumab Biosimilar PF-05280014",
      "Trastuzumab-dkst"
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  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/0",
    "value": {
      "measure": "DFS-DCIS",
      "timeFrame": "Up to 10 years"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/2",
    "value": {
      "measure": "RFI",
      "timeFrame": "From randomization until invasive local, regional, or distant recurrence, or death from breast cancer, assessed up to 10 years"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/3",
    "value": {
      "measure": "DRFI",
      "timeFrame": "From randomization until the first diagnosis of distant metastasis or death from breast cancer, assessed up to 10 years"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/4",
    "value": {
      "measure": "OS",
      "timeFrame": "From randomization to death from any cause, assessed up to 10 years"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/5",
    "value": {
      "measure": "Incidence of adverse events using the National Cancer Institute CTCAE v4.0",
      "timeFrame": "Up to 30 days",
      "description": "The frequency and severity of adverse events will be graded."
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/7"
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  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/7"
  },
  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/8"
  },
  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/8"
  },
  {
    "op": "remove",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/8"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "36688",
      "city": "Mobile",
      "state": "Alabama",
      "country": "United States",
      "facility": "University of South Alabama Mitchell Cancer Institute",
      "geoPoint": {
        "lat": 30.69436,
        "lon": -88.04305
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    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/10/facility",
    "value": "Virginia G Piper Cancer Care-Del Camino"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/16",
    "value": {
      "zip": "93420",
      "city": "Arroyo Grande",
      "state": "California",
      "country": "United States",
      "facility": "PCR Oncology",
      "geoPoint": {
        "lat": 35.11859,
        "lon": -120.59073
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    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/facility",
    "value": "Kaiser Permanente-Fontana"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/35/facility",
    "value": "Kaiser Permanente-Fresno"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/49",
    "value": {
      "zip": "94040",
      "city": "Mountain View",
      "state": "California",
      "country": "United States",
      "facility": "Palo Alto Medical Foundation-Camino Division",
      "geoPoint": {
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    "op": "add",
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      "state": "California",
      "country": "United States",
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  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/65"
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    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/66",
    "value": {
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      "state": "California",
      "country": "United States",
      "facility": "Pomona Valley Hospital Medical Center",
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  },
  {
    "op": "replace",
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    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/92",
    "value": {
      "zip": "92705",
      "city": "Santa Ana",
      "state": "California",
      "country": "United States",
      "facility": "Breastlink Medical Group Inc",
      "geoPoint": {
        "lat": 33.74557,
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    }
  },
  {
    "op": "add",
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    "value": {
      "zip": "95065",
      "city": "Santa Cruz",
      "state": "California",
      "country": "United States",
      "facility": "Palo Alto Medical Foundation-Santa Cruz",
      "geoPoint": {
        "lat": 36.97412,
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  },
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    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/101",
    "value": {
      "zip": "94086",
      "city": "Sunnyvale",
      "state": "California",
      "country": "United States",
      "facility": "Palo Alto Medical Foundation-Sunnyvale",
      "geoPoint": {
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/109/facility",
    "value": "Kaiser Permanente-Woodland Hills"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/111/facility",
    "value": "University of Colorado Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/116/facility",
    "value": "UCHealth Memorial Hospital Central"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/175",
    "value": {
      "zip": "32114",
      "city": "Daytona Beach",
      "state": "Florida",
      "country": "United States",
      "facility": "Halifax Health Medical Center-Centers for Oncology",
      "geoPoint": {
        "lat": 29.21081,
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/facility",
    "value": "Broward Health Medical Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/city",
    "value": "Fort Lauderdale"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/zip",
    "value": "33316"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/geoPoint/lat",
    "value": 26.12231
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/geoPoint/lon",
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    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/179",
    "value": {
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      "city": "Gainesville",
      "state": "Florida",
      "country": "United States",
      "facility": "University of Florida Health Science Center - Gainesville",
      "geoPoint": {
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    }
  },
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    "op": "add",
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    "value": {
      "zip": "32204",
      "city": "Jacksonville",
      "state": "Florida",
      "country": "United States",
      "facility": "Saint Vincent's Medical Center",
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  },
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    "op": "add",
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    "value": {
      "zip": "32207",
      "city": "Jacksonville",
      "state": "Florida",
      "country": "United States",
      "facility": "Baptist MD Anderson Cancer Center",
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  },
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    "op": "add",
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    "value": {
      "zip": "33805",
      "city": "Lakeland",
      "state": "Florida",
      "country": "United States",
      "facility": "Lakeland Regional Health Hollis Cancer Center",
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  },
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    "op": "add",
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      "city": "Atlanta",
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      "country": "United States",
      "facility": "Grady Health System",
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        "lat": 33.749,
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  },
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    "op": "add",
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    "value": {
      "zip": "30308",
      "city": "Atlanta",
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  },
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    "op": "add",
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    "op": "add",
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    "op": "remove",
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    "op": "add",
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    "op": "replace",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/259/facility",
    "value": "Cancer Care Specialists of Central Illinois"
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    "op": "add",
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      "city": "Naperville",
      "state": "Illinois",
      "country": "United States",
      "facility": "AMG Oncology - Naperville",
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  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/289"
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  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/299"
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    "op": "add",
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  },
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    "op": "add",
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    "op": "add",
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    "op": "add",
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    "op": "replace",
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    "op": "replace",
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    "op": "replace",
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    "op": "replace",
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