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NCT01275677

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Version 943 to 944 · National Cancer Institute (NCI)

Patch inspector

Version 943 to 944

24 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct",
    "reason": "date_unparsed_or_missing",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": null,
    "severity": "medium",
    "direction": "unknown",
    "new_value": "2024-07-12",
    "old_value": null,
    "date_struct": "completionDateStruct"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:10:24+00
Raw hash
b376dc86e32415139e6fa40b16ff0a4f90fe61da9676dec859e4fdc7fd576d98
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 13 ops
replace /protocolSection/armsInterventionsModule/interventions/7/otherNames/2
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-c-ERB-2
After
CT-P06
replace /protocolSection/armsInterventionsModule/interventions/7/otherNames/3
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-c-erbB2 Monoclonal Antibody
After
CT-P6
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-ERB-2
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 8
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-erbB-2
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 9
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-erbB2 Monoclonal Antibody
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 10
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-HER2/c-erbB2 Monoclonal Antibody
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Anti-p185-HER2
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
c-erb-2 Monoclonal Antibody
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/4
Triage: High
Arm Intervention Change Operation 13
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
HER2 Monoclonal Antibody
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/9
Triage: High
Arm Intervention Change Operation 14
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
MoAb HER2
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/9
Triage: High
Arm Intervention Change Operation 15
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Monoclonal Antibody c-erb-2
remove /protocolSection/armsInterventionsModule/interventions/7/otherNames/9
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Monoclonal Antibody HER2
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/20
Triage: High
Arm Intervention Change Operation 17
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Trastuzumab Biosimilar CT-P6
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
add /protocolSection/statusModule/completionDateStruct
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
After
{
  "date": "2024-07-12",
  "type": "ESTIMATED"
}
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 7 ops
replace /protocolSection/contactsLocationsModule/locations/347/facility
Triage: Uncategorized
Uncategorized Operation 18
Before
McFarland Clinic PC - Ames
After
McFarland Clinic - Ames
replace /protocolSection/contactsLocationsModule/locations/348/facility
Triage: Uncategorized
Uncategorized Operation 19
Before
McFarland Clinic PC-Boone
After
McFarland Clinic - Boone
replace /protocolSection/contactsLocationsModule/locations/362/facility
Triage: Uncategorized
Uncategorized Operation 20
Before
McFarland Clinic PC-Trinity Cancer Center
After
McFarland Clinic - Trinity Cancer Center
replace /protocolSection/contactsLocationsModule/locations/364/facility
Triage: Uncategorized
Uncategorized Operation 21
Before
McFarland Clinic PC-Jefferson
After
McFarland Clinic - Jefferson
replace /protocolSection/contactsLocationsModule/locations/365/facility
Triage: Uncategorized
Uncategorized Operation 22
Before
McFarland Clinic PC-Marshalltown
After
McFarland Clinic - Marshalltown
replace /protocolSection/contactsLocationsModule/locations/589/facility
Triage: Uncategorized
Uncategorized Operation 23
Before
University of Missouri - Ellis Fischel
After
MU Health - University Hospital/Ellis Fischel Cancer Center
replace /protocolSection/contactsLocationsModule/locations/1080/facility
Triage: Uncategorized
Uncategorized Operation 24
Before
Texas Oncology PA Beaumont
After
Texas Oncology - Beaumont
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2023-01
After
2023-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2023-06-16
After
2023-08-15
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2023-07-13
After
2023-09-07
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2023-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2023-08-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2023-09-07"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/completionDateStruct",
    "value": {
      "date": "2024-07-12",
      "type": "ESTIMATED"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/2",
    "value": "CT-P06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/3",
    "value": "CT-P6"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/4"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/9"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/9"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/9"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/20",
    "value": "Trastuzumab Biosimilar CT-P6"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/347/facility",
    "value": "McFarland Clinic - Ames"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/348/facility",
    "value": "McFarland Clinic - Boone"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/362/facility",
    "value": "McFarland Clinic - Trinity Cancer Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/364/facility",
    "value": "McFarland Clinic - Jefferson"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/365/facility",
    "value": "McFarland Clinic - Marshalltown"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/589/facility",
    "value": "MU Health - University Hospital/Ellis Fischel Cancer Center"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1080/facility",
    "value": "Texas Oncology - Beaumont"
  }
]