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NCT01275677

Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Version 956 to 957 · National Cancer Institute (NCI)

Patch inspector

Version 956 to 957

23 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2025-07-12",
    "old_value": "2024-07-12",
    "delta_days": 365,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:10:31+00
Raw hash
b5158718e79bf921ff316b7ed717075cb7c2d4fb4c4ee412cdb5a965ce2cafd7
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 12 ops
add /protocolSection/armsInterventionsModule/interventions/0/otherNames/3
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
B 518
add /protocolSection/armsInterventionsModule/interventions/0/otherNames/5
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
B518
add /protocolSection/armsInterventionsModule/interventions/0/otherNames/37
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
WR 138719
add /protocolSection/armsInterventionsModule/interventions/0/otherNames/40
Triage: High
Arm Intervention Change Operation 8
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
WR138719
add /protocolSection/armsInterventionsModule/interventions/1/otherNames/2
Triage: High
Arm Intervention Change Operation 9
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
RP-56976
add /protocolSection/armsInterventionsModule/interventions/3/otherNames/22
Triage: High
Arm Intervention Change Operation 10
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
FI106
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/9
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Hercessi
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/12
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Herwenda
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/36
Triage: High
Arm Intervention Change Operation 13
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Trastuzumab-herw
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/39
Triage: High
Arm Intervention Change Operation 14
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Trastuzumab-strf
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/40
Triage: High
Arm Intervention Change Operation 15
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Trastuzumab-zerc
add /protocolSection/armsInterventionsModule/interventions/7/otherNames/42
Triage: High
Arm Intervention Change Operation 16
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Zercepac
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2024-07-12
After
2025-07-12
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 7 ops
replace /protocolSection/contactsLocationsModule/locations/499/facility
Triage: Uncategorized
Uncategorized Operation 17
Before
Beaumont Hospital - Dearborn
After
Corewell Health Dearborn Hospital
replace /protocolSection/contactsLocationsModule/locations/506/facility
Triage: Uncategorized
Uncategorized Operation 18
Before
Beaumont Hospital - Farmington Hills
After
Corewell Health Farmington Hills Hospital
replace /protocolSection/contactsLocationsModule/locations/537/facility
Triage: Uncategorized
Uncategorized Operation 19
Before
William Beaumont Hospital-Royal Oak
After
Corewell Health William Beaumont University Hospital
replace /protocolSection/contactsLocationsModule/locations/543/facility
Triage: Uncategorized
Uncategorized Operation 20
Before
William Beaumont Hospital - Troy
After
Corewell Health Beaumont Troy Hospital
add /protocolSection/contactsLocationsModule/locations/801
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "28659",
  "city": "North Wilkesboro",
  "state": "North Carolina",
  "country": "United States",
  "facility": "Novant Health Cancer Institute - Wilkesboro",
  "geoPoint": {
    "lat": 36.15847,
    "lon": -81.14758
  }
}
remove /protocolSection/contactsLocationsModule/locations/819
Triage: Uncategorized
Uncategorized Operation 22
Before
{
  "zip": "28659",
  "city": "Wilkesboro",
  "state": "North Carolina",
  "country": "United States",
  "facility": "Novant Health Cancer Institute - Wilkesboro",
  "geoPoint": {
    "lat": 36.14596,
    "lon": -81.16064
  }
}
replace /protocolSection/contactsLocationsModule/locations/1228/facility
Triage: Uncategorized
Uncategorized Operation 23
Before
University of Wisconsin Carbone Cancer Center Johnson Creek
After
University of Wisconsin Carbone Cancer Center - Johnson Creek
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2024-01
After
2024-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2024-05-18
After
2024-07-13
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2024-05-21
After
2024-08-06
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2024-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2025-07-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2024-07-13"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2024-08-06"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/3",
    "value": "B 518"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/5",
    "value": "B518"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/37",
    "value": "WR 138719"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/40",
    "value": "WR138719"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/1/otherNames/2",
    "value": "RP-56976"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/3/otherNames/22",
    "value": "FI106"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/9",
    "value": "Hercessi"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/12",
    "value": "Herwenda"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/36",
    "value": "Trastuzumab-herw"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/39",
    "value": "Trastuzumab-strf"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/40",
    "value": "Trastuzumab-zerc"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/7/otherNames/42",
    "value": "Zercepac"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/499/facility",
    "value": "Corewell Health Dearborn Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/506/facility",
    "value": "Corewell Health Farmington Hills Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/537/facility",
    "value": "Corewell Health William Beaumont University Hospital"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/543/facility",
    "value": "Corewell Health Beaumont Troy Hospital"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/801",
    "value": {
      "zip": "28659",
      "city": "North Wilkesboro",
      "state": "North Carolina",
      "country": "United States",
      "facility": "Novant Health Cancer Institute - Wilkesboro",
      "geoPoint": {
        "lat": 36.15847,
        "lon": -81.14758
      }
    }
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/819"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1228/facility",
    "value": "University of Wisconsin Carbone Cancer Center - Johnson Creek"
  }
]