NCT01471106

Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer

Version 1 to 2 · M.D. Anderson Cancer Center

Patch inspector

Version 1 to 2

6 operations 3 path groups ctgov_internal_history

Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.

Plain-language summary

Manual review pending.

Rules fired

arms_or_interventions_change

Value signals

[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": null,
    "old_type": null,
    "severity": "medium",
    "direction": "later",
    "new_value": "2013-01",
    "old_value": "2012-07",
    "delta_days": 184,
    "date_struct": "startDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2017-01",
    "old_value": "2016-07",
    "delta_days": 184,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]

Provenance

Source: ctgov_internal_history
Fetched: 2026-06-18 19:11:11+00
Raw hash: c7998ecea31cdf5ce69828d8c60881dcda95d3c97a6a6b62dbcf803619fe3905
Payload: Source URL

Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops

replace /protocolSection/armsInterventionsModule/armGroups/1/type

Triage: High

Arm Intervention Change Operation 6

Matched rules

arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.

Before

NO_INTERVENTION

After

PLACEBO_COMPARATOR

Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops

replace /protocolSection/statusModule/startDateStruct/date

Triage: Medium

Timeline Shift Operation 2

Matched rules

start_timeline_change Start date changes are operational timeline signals.

Before

2012-07

After

2013-01

replace /protocolSection/statusModule/primaryCompletionDateStruct/date

Triage: Medium

Timeline Shift Operation 3

Matched rules

primary_completion_timeline_change Primary completion date changes are operational timeline signals.

Before

2016-07

After

2017-01

Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops

replace /protocolSection/statusModule/statusVerifiedDate

Triage: Uncategorized

Uncategorized Operation 1

Before

2012-02

After

2012-09

replace /protocolSection/statusModule/lastUpdateSubmitDate

Triage: Uncategorized

Uncategorized Operation 4

Before

2012-02-27

After

2012-09-05

replace /protocolSection/statusModule/lastUpdatePostDateStruct/date

Triage: Uncategorized

Uncategorized Operation 5

Before

2012-02-28

After

2012-09-06

Raw JSON Patch

[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2012-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2013-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2017-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2012-09-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2012-09-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/type",
    "value": "PLACEBO_COMPARATOR"
  }
]