Raw JSON Patch
[
{
"op": "replace",
"path": "/protocolSection/identificationModule/organization/fullName",
"value": "Alliance for Clinical Trials in Oncology"
},
{
"op": "replace",
"path": "/protocolSection/identificationModule/organization/class",
"value": "OTHER"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/statusVerifiedDate",
"value": "2013-11"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdateSubmitDate",
"value": "2013-11-20"
},
{
"op": "replace",
"path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
"value": "2013-11-21"
},
{
"op": "remove",
"path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldNameTitle"
},
{
"op": "remove",
"path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/oldOrganization"
},
{
"op": "add",
"path": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/type",
"value": "SPONSOR"
},
{
"op": "replace",
"path": "/protocolSection/sponsorCollaboratorsModule/leadSponsor/name",
"value": "Alliance for Clinical Trials in Oncology"
},
{
"op": "replace",
"path": "/protocolSection/descriptionModule/detailedDescription",
"value": "<p>OBJECTIVES:</p><p>Primary</p><ul><li>To assess the local recurrence (LR) rate with breast-conservation in patients with multiple ipsilateral primary breast cancer (MIBC).</li></ul><p>Secondary</p><ul><li>To examine the conversion rate to mastectomy secondary to persistent positive margins; poor cosmesis within the first year of attempting breast-conservation surgery (BCS) or inability to satisfy the radiation dose constraints on the boost to the lumpectomy bed of each site of disease.</li><li>To assess whether patients who did not undergo re-excision for close margins (< 2 mm) have a higher local recurrence (LR) rate than patients for whom negative margins were achieved.</li><li>To assess patient's perception of cosmesis and incidence of breast lymphedema.</li><li>To examine the type and severity of adverse effects of BCS and radiation for women with MIBC.</li><li>To assess incidence of breast lymphedema</li><li>To examine the radiation-related side effects of whole-breast radiation with a boost to 1 large or > 1 lumpectomy site.</li></ul><p>OUTLINE: This is a multicenter study.</p><p>Patients undergo breast-conserving surgery (BCS) with all lesions resected to negative margins using 1 lumpectomy or 2-3 separate lumpectomy incisions at the discretion of the surgeon.\nPatients receive adjuvant chemotherapy and/or endocrine therapy at the discretion of the treating medical oncologist based on tumor characteristics.</p><p>Within 6-10 weeks after surgery or 8 weeks after completion of cytotoxic chemotherapy, patients undergo adjuvant whole-breast irradiation (WBI) with a boost to the lumpectomy bed of each site of disease 5 days a week for approximately 6 weeks at the discretion of the surgeon.</p><p>Patients complete the Breast-Conserving Therapy Module (BREAST-Q© subscales) questionnaire 5-30 days after surgery and every 6 months for the first 2 years and the yearly for the next 3 years after WBI.\nPatients' surgeons also complete the questionnaire 5-30 days after performing final surgery to assess cosmetic outcomes.</p><p>After completion of study treatment, patients are followed up every 6 months for 2 years and then yearly for years 3-5.</p>"
},
{
"op": "add",
"path": "/protocolSection/designModule/designInfo/allocation",
"value": "NA"
},
{
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"path": "/protocolSection/designModule/designInfo/interventionModel",
"value": "SINGLE_GROUP"
},
{
"op": "replace",
"path": "/protocolSection/armsInterventionsModule/interventions/0/type",
"value": "PROCEDURE"
},
{
"op": "replace",
"path": "/protocolSection/armsInterventionsModule/interventions/0/name",
"value": "therapeutic conventional surgery"
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/interventions/0/armGroupLabels",
"value": [
"Breast conservation surgery and radiation therapy"
]
},
{
"op": "replace",
"path": "/protocolSection/armsInterventionsModule/interventions/1/type",
"value": "RADIATION"
},
{
"op": "replace",
"path": "/protocolSection/armsInterventionsModule/interventions/1/name",
"value": "whole breast irradiation"
},
{
"op": "add",
"path": "/protocolSection/armsInterventionsModule/interventions/1/armGroupLabels",
"value": [
"Breast conservation surgery and radiation therapy"
]
},
{
"op": "remove",
"path": "/protocolSection/armsInterventionsModule/interventions/2"
},
{
"op": "remove",
"path": "/protocolSection/armsInterventionsModule/interventions/2"
},
{
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"path": "/protocolSection/armsInterventionsModule/interventions/2"
},
{
"op": "remove",
"path": "/protocolSection/armsInterventionsModule/interventions/2"
},
{
"op": "remove",
"path": "/protocolSection/armsInterventionsModule/interventions/2"
},
{
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"path": "/protocolSection/armsInterventionsModule/interventions/2"
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{
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"path": "/protocolSection/armsInterventionsModule/armGroups",
"value": [
{
"type": "EXPERIMENTAL",
"label": "Breast conservation surgery and radiation therapy",
"description": "Patients undergo breast conserving surgery with all lesions resected to negative margins using one lumpectomy or 2-3 separate lumpectomy incisions at the discretion of the surgeon.\nPatients receive adjuvant chemotherapy and/or endocrine therapy at the discretion of the treating medical oncologist based on tumor characteristics.\nWithin 6-10 weeks after surgery or 8 weeks after completion of cytotoxic chemotherapy, patients undergo adjuvant whole breast irradiation with a boost to the lumpectomy bed of each site of disease 5 days per week for approximately 6 weeks.",
"interventionNames": [
"Procedure: therapeutic conventional surgery",
"Radiation: whole breast irradiation"
]
}
]
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/primaryOutcomes/0/timeFrame",
"value": "Up to 5 years post-treatment"
},
{
"op": "replace",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/0/measure",
"value": "Conversion rate to mastectomy secondary to persistent positive margins assessed"
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/0/timeFrame",
"value": "Up to 5 years post-treatment"
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/1/timeFrame",
"value": "Up to 30 days post-treatment"
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/2/timeFrame",
"value": "Up to 30 days post-treatment"
},
{
"op": "add",
"path": "/protocolSection/outcomesModule/secondaryOutcomes/3/timeFrame",
"value": "Up to 2 years post-treatment"
},
{
"op": "replace",
"path": "/protocolSection/eligibilityModule/eligibilityCriteria",
"value": "<p>Registration Inclusion Criteria:</p><ol><li>Age ≥ 40 years per National Comprehensive Cancer Network (NCCN) recommendations for breast conservation.</li><li>Life Expectancy of at least 5 years, excluding diagnosis of breast cancer (Comorbid conditions should be taken into consideration, but breast cancer diagnosis is not a consideration)</li><li><p>Female Gender - Men are excluded from this study.\nMale breast cancer is a rare event.</p><p>Men are rarely candidates for breast conservation surgery due to small breast size.\nMen are less likely to be candidates for breast conservation surgery if found to have MIBC.</p></li><li><p>Foci of Breast Cancer - Upon clinical exam and pre-operative imaging by both MRI and mammogram, two or three foci of biopsy proven breast cancer separated by > 2 cm of normal breast tissue.\nFoci must include at least one focus of invasive breast carcinoma with another focus of either invasive breast carcinoma or ductal carcinoma in situ (DCIS).</p><p>No more than 2 quadrants with biopsy proven breast cancer.</p><p>Note: Patient is eligible for study if lesion is not visualized on both imaging modalities (i.e., any of the lesion(s) is/are visualized on MRI but not on mammogram OR visualized on mammogram but not on MRI).\nUltrasound cannot be used to determine patient eligibility; eligibility to be determined by bilateral mammogram and MRI only.\nPatient may remain on study if, upon pathological assessment, two or three lesions identified on pre-operative imaging represent one contiguous lesion.</p></li><li>Mammogram Imaging - Bilateral mammogram ≤ 60 days prior to registration</li><li>MRI Imaging - Bilateral breast MRI ≤ 60 days prior to registration</li><li>Staging of Cancer - cN0 or cN1 disease</li><li><p>ECOG Performance Status (PS) - 0, 1, or 2.</p><p>Note: An ECOG PS scale is available on the Cancer Trial Support Unit (CTSU) website.</p></li><li><p>Hemoglobin and Platelet Count - The following laboratory values obtained ≤ 21 days prior to registration:</p><ul><li>Hemoglobin (Hgb) ≥ 8 g/dL</li><li>Peripheral platelet count (PLT) ≥ 50,000/mm3</li></ul></li><li>Pregnancy for Women of Childbearing Potential - Negative urine or serum pregnancy test result ≤ 7 days prior to registration for women of childbearing potential only.</li><li>Ability to Complete Questionnaires by themselves or with assistance.</li><li>Ability to Provide Written Informed Consent</li><li>Willing to return to enrolling institution for follow-up during the Active Monitoring Phase (the active treatment and observation portions) of the study.\nPatients are encouraged to return to the enrolling institution; however, patients may receive radiation therapy at a different institution other than the enrolling institution.</li></ol><p>Registration Exclusion Criteria:</p><ol><li><p>Pregnancy, Nursing and Requirement for Contraception Any of the following because this study involves radiation therapy (WBI) that has known genotoxic, mutagenic and teratogenic effects:</p><ul><li>Pregnant women</li><li>Nursing women</li><li>Women of childbearing potential who are unwilling to employ adequate contraception (as determined by the treating physician)</li></ul></li><li>Size of Single Focus of Disease - Largest single focus of disease > 5 centimeters by either mammogram or MRI or both.\nNote: Measurement of the largest single focus should include any satellite lesions within 1centimeter of the index lesion.</li><li><p>Prior Staging Procedure - Surgical axillary staging procedure prior to study entry.</p><p>Note: FNA or core needle biopsy of axillary node is permitted.</p></li><li>Evidence of Metastatic Disease - Clinical or radiographic evidence of metastatic disease</li><li>Prior history of ipsilateral breast cancer [DCIS, LCIS (lobular cancer in situ) or invasive]</li><li>Staging of Cancer - cNX, cN2, or cN3 disease</li><li><p>Breast Implants at time of diagnosis.</p><p>Note: Patients who have had implants previously removed prior to diagnosis are eligible.</p></li><li>Systemic Illnesses or Concurrent Disease - Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would interfere significantly with whole breast irradiation (such as connective tissue disorders, lupus, scleroderma).</li><li>Uncontrolled Intercurrent Illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.</li><li>Bilateral Breast Cancer Prior or current LCIS, DCIS or invasive breast cancer in the opposite breast (i.e., bilateral disease is not allowed).</li><li>Disallowed Prior Treatments - Treatment including radiation therapy, chemotherapy, biotherapy, hormonal therapy for this cancer prior to registration.</li><li>Chemotherapy or Endocrine Therapy Prior to Surgery - Neoadjuvant chemotherapy or neoadjuvant endocrine therapy (in other words, no chemotherapy or endocrine therapy prior to surgery) for this cancer.</li><li>Partial Breast Radiation - Planned partial breast radiation.</li><li>Investigational Agents - Administration of any investigational agent ≤ 30 days prior to registration.</li><li>Known BRCA Mutations - Patients with known BRCA mutations.</li><li>Other Active Malignancies - Other active malignancy ≤ 5 years prior to registration.</li></ol><p>Exceptions: Non-melanotic skin cancer or carcinoma-in-situ of the cervix.\nNote: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer.</p>"
},
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"value": {
"zip": "94546",
"city": "Castro Valley",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "James H. Feusner, MD",
"role": "CONTACT",
"phone": "510-428-3689"
}
],
"facility": "East Bay Radiation Oncology Center",
"geoPoint": {
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"lon": -122.08635
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"zip": "92093",
"city": "La Jolla",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Sarah Blair, M.D.",
"role": "CONTACT",
"phone": "858-822-5354"
}
],
"facility": "UC San Diego Moores Cancer Center",
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"zip": "90048",
"city": "Los Angeles",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Armando Giuliano, M.D.",
"role": "CONTACT",
"phone": "310-423-9331"
}
],
"facility": "Cedars-Sinai Medical Center",
"geoPoint": {
"lat": 34.05223,
"lon": -118.24368
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"value": {
"zip": "94609",
"city": "Oakland",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "James Feusner, M.D.",
"role": "CONTACT",
"phone": "510-450-7600"
}
],
"facility": "Alta Bates Summit Medical Center - Summit Campus",
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"zip": "95661",
"city": "Roseville",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jay Owens, M.D.",
"role": "CONTACT",
"phone": "916-454-6500"
}
],
"facility": "Sutter Roseville Medical Center",
"geoPoint": {
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"lon": -121.28801
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"zip": "95816",
"city": "Sacramento",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jay Owens, M.D.",
"role": "CONTACT",
"phone": "916-454-6500"
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],
"facility": "Sutter General Hospital",
"geoPoint": {
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"zip": "92123",
"city": "San Diego",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Robert M. Barone, MD, FACS",
"role": "CONTACT",
"phone": "858-637-7888"
}
],
"facility": "Sharp Memorial Hospital",
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"zip": "94305",
"city": "Stanford",
"state": "California",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Frederick Dirbas, M.D.",
"role": "CONTACT",
"phone": "650-498-7061"
}
],
"facility": "Stanford University Hospitals and Clinics",
"geoPoint": {
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"zip": "80045",
"city": "Aurora",
"state": "Colorado",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Nicole Kounalakis, M.D.",
"role": "CONTACT",
"phone": "720-848-0650"
}
],
"facility": "University of Colorado Cancer Center - Anschutz Cancer Pavilion",
"geoPoint": {
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"lon": -104.83192
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}
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"zip": "06606",
"city": "Bridgeport",
"state": "Connecticut",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Anthy Demestihas, M.D.",
"role": "CONTACT",
"phone": "888-823-5923"
}
],
"facility": "Saint Vincent's Medical Center",
"geoPoint": {
"lat": 41.17923,
"lon": -73.18945
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}
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"zip": "19718",
"city": "Newark",
"state": "Delaware",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Diana Dickson-Witmer, M.D.",
"role": "CONTACT",
"phone": "302-733-6227"
}
],
"facility": "Christiana Care Health System-Christiana Hospital",
"geoPoint": {
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"lon": -75.74966
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}
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"zip": "33756",
"city": "Clearwater",
"state": "Florida",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Peter W. Blumencranz, MD",
"role": "CONTACT",
"phone": "727-462-2131"
}
],
"facility": "Morton Plant Hospital",
"geoPoint": {
"lat": 27.96585,
"lon": -82.8001
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}
},
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"zip": "33308",
"city": "Fort Lauderdale",
"state": "Florida",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Michael Schwartz, M.D.",
"role": "CONTACT",
"phone": "305-674-2625"
}
],
"facility": "Holy Cross Hospital",
"geoPoint": {
"lat": 26.12231,
"lon": -80.14338
}
}
},
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"zip": "33458",
"city": "Jupiter",
"state": "Florida",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Michael Schwartz, M.D.",
"role": "CONTACT",
"phone": "305-674-2625"
}
],
"facility": "Jupiter Medical Center",
"geoPoint": {
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"lon": -80.09421
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}
},
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"zip": "33140",
"city": "Miami Beach",
"state": "Florida",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Michael Schwartz, M.D.",
"role": "CONTACT",
"phone": "305-674-2625"
}
],
"facility": "Mount Sinai Medical Center CCOP",
"geoPoint": {
"lat": 25.79065,
"lon": -80.13005
}
}
},
{
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"value": {
"zip": "30033",
"city": "Decatur",
"state": "Georgia",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "John Kennedy, M.D.",
"role": "CONTACT",
"phone": "404-501-3279"
}
],
"facility": "Dekalb Medical Center",
"geoPoint": {
"lat": 33.77483,
"lon": -84.29631
}
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/25",
"value": {
"zip": "96813",
"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey Berenberg, M.D.",
"role": "CONTACT",
"phone": "808-586-2979"
}
],
"facility": "Oncare Hawaii Inc-POB II",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
}
}
},
{
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"value": {
"zip": "96813",
"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey Berenberg, M.D.",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "Queen's Medical Center",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
}
}
},
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"value": {
"zip": "96813",
"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey L. Berenberg, MD",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "Straub Clinic and Hospital, Incorporated",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
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}
},
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"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey Berenberg, M.D.",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "University of Hawaii",
"geoPoint": {
"lat": 21.30694,
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}
}
},
{
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"path": "/protocolSection/contactsLocationsModule/locations/29",
"value": {
"zip": "96817",
"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey L. Berenberg, MD",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "OnCare Hawaii, Incorporated - Kuakini",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
}
}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/30",
"value": {
"zip": "96817",
"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey Berenberg, M.D.",
"role": "CONTACT",
"phone": "808-524-6115"
}
],
"facility": "OnCare Hawaii-Liliha",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
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}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/31",
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"city": "Honolulu",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey L. Berenberg, MD",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "Kapiolani Medical Center for Women and Children",
"geoPoint": {
"lat": 21.30694,
"lon": -157.85833
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}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/32",
"value": {
"zip": "96734",
"city": "Kailua",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey L. Berenberg, MD",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "Castle Medical Center",
"geoPoint": {
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"lon": -157.74054
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}
},
{
"op": "add",
"path": "/protocolSection/contactsLocationsModule/locations/33",
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"zip": "96766",
"city": "Lihue",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
"contacts": [
{
"name": "Jeffrey Berenberg, M.D.",
"role": "CONTACT",
"phone": "808-433-4089"
}
],
"facility": "Wilcox Memorial Hospital and Kauai Medical Clinic",
"geoPoint": {
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"lon": -159.3721
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}
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"zip": "96701",
"city": "‘Aiea",
"state": "Hawaii",
"status": "RECRUITING",
"country": "United States",
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