Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer

[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2026-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2026-05-19"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2026-06-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/1/measure",
    "value": "Severity of Adverse Effects"
  },
  {
    "op": "replace",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/1/timeFrame",
    "value": "17 monhts"
  },
  {
    "op": "add",
    "path": "/protocolSection/outcomesModule/secondaryOutcomes/1/description",
    "value": "Severity of adverse effects of breast-conserving surgery and radiation as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be reported as the percentage of patients that experienced a grade 3 or higher adverse event."
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/43/city",
    "value": "Couer D'Alene"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/43/geoPoint"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/172/city",
    "value": "Cape Giradeau"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/172/geoPoint"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/237/city",
    "value": "East White Plains"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/237/geoPoint/lat",
    "value": 41.03899
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/237/geoPoint/lon",
    "value": -73.74763
  },
  {
    "op": "replace",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/title",
    "value": "Severity of Adverse Effects"
  },
  {
    "op": "replace",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/reportingStatus",
    "value": "POSTED"
  },
  {
    "op": "replace",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/timeFrame",
    "value": "17 monhts"
  },
  {
    "op": "remove",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/denomUnitsSelected"
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/description",
    "value": "Severity of adverse effects of breast-conserving surgery and radiation as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be reported as the percentage of patients that experienced a grade 3 or higher adverse event."
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/paramType",
    "value": "NUMBER"
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/unitOfMeasure",
    "value": "percentage of patients"
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/groups",
    "value": [
      {
        "id": "OG000",
        "title": "Breast Conservation Surgery and Radiation Therapy",
        "description": "Patients undergo breast conserving surgery.\nPatients receive adjuvant chemotherapy at the physician's discretion.\nPatients receiving chemotherapy will start treatment within 12 weeks following surgery.\nPatients receive radiation therapy within 8 weeks following the last dose of chemotherapy or within 10 weeks following surgery if not receiving chemotherapy.\nPatients receive endocrine therapy at the physician's discretion.\nPatient observation will occur every 6 months until 5 years after the end of radiation therapy."
      }
    ]
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/denoms",
    "value": [
      {
        "units": "Participants",
        "counts": [
          {
            "value": "270",
            "groupId": "OG000"
          }
        ]
      }
    ]
  },
  {
    "op": "add",
    "path": "/resultsSection/outcomeMeasuresModule/outcomeMeasures/2/classes",
    "value": [
      {
        "categories": [
          {
            "measurements": [
              {
                "value": "4.8",
                "groupId": "OG000"
              }
            ]
          }
        ]
      }
    ]
  },
  {
    "op": "replace",
    "path": "/resultsSection/adverseEventsModule/otherEvents/6/organSystem",
    "value": "General disorders and administration site conditions"
  },
  {
    "op": "replace",
    "path": "/resultsSection/adverseEventsModule/otherEvents/7/organSystem",
    "value": "General disorders and administration site conditions"
  },
  {
    "op": "replace",
    "path": "/resultsSection/adverseEventsModule/otherEvents/8/organSystem",
    "value": "General disorders and administration site conditions"
  },
  {
    "op": "replace",
    "path": "/resultsSection/adverseEventsModule/otherEvents/9/organSystem",
    "value": "General disorders and administration site conditions"
  },
  {
    "op": "replace",
    "path": "/resultsSection/adverseEventsModule/otherEvents/10/organSystem",
    "value": "General disorders and administration site conditions"
  }
]