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NCT01818063

Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer

Version 12 to 13 · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Patch inspector

Version 12 to 13

11 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_count_changeenrollment_type_changewhy_stopped_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/whyStopped",
    "signal": "why_stopped_empty",
    "category": "status_termination",
    "severity": "critical"
  },
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ACTUAL",
    "old_type": null,
    "severity": "low",
    "direction": "later",
    "new_value": "2013-04-25",
    "old_value": "2013-04",
    "delta_days": 24,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct",
    "reason": "date_unparsed_or_missing",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": null,
    "severity": "medium",
    "direction": "unknown",
    "new_value": "2019-01",
    "old_value": null,
    "date_struct": "completionDateStruct"
  },
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 9,
    "old_value": 80,
    "pct_change": 0.8875
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:14:20+00
Raw hash
940b6bcf139ca21599b682e3de269c5cfafff6b239701f40033ccdedce82d537
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 10
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
80
After
9
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 11
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: High 2 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
SUSPENDED
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/statusModule/whyStopped
Triage: High
Status Termination Operation 3
Matched rules
  • why_stopped_change Why-stopped changes explain discontinuation and need review.
Before
Lack of funding
Timeline Start, primary completion, and completion date movement. Triage: Medium 3 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2013-04
After
2013-04-25
add /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 5
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
After
ACTUAL
add /protocolSection/statusModule/completionDateStruct
Triage: Medium
Timeline Shift Operation 9
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
After
{
  "date": "2019-01",
  "type": "ESTIMATED"
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-10
After
2017-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 6
Before
2016-10-19
After
2017-05-10
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 7
Before
2016-10-21
After
2017-05-11
replace /protocolSection/statusModule/lastUpdatePostDateStruct/type
Triage: Uncategorized
Uncategorized Operation 8
Before
ESTIMATED
After
ACTUAL
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/statusModule/whyStopped"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2013-04-25"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-05-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-05-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/completionDateStruct",
    "value": {
      "date": "2019-01",
      "type": "ESTIMATED"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 9
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  }
]