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NCT02154529

Study of the Combination of KD019 and Trastuzumab in Subjects With HER2-Positive Metastatic Breast Cancer

Version 19 to 20 · Kadmon Corporation, LLC

Patch inspector

Version 19 to 20

14 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:56+00
Raw hash
72f5c979b669a463881ba6c90ace10a5519fd349ba065c12b102369513658dd7
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 10 ops
replace /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/0
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/2/interventionNames/0
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/3/interventionNames/0
Triage: High
Arm Intervention Change Operation 8
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/4/interventionNames/0
Triage: High
Arm Intervention Change Operation 9
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/5/interventionNames/0
Triage: High
Arm Intervention Change Operation 10
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/6/interventionNames/0
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/armGroups/7/interventionNames/0
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Drug: Tesevatinib in combination with Trastuzumab
After
Drug: Tesevatinib
replace /protocolSection/armsInterventionsModule/interventions/0/name
Triage: High
Arm Intervention Change Operation 13
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Tesevatinib in combination with Trastuzumab
After
Tesevatinib
remove /protocolSection/armsInterventionsModule/interventions/0/otherNames/2
Triage: High
Arm Intervention Change Operation 14
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
Before
Herceptin
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-08-28
After
2018-03-08
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 2
Before
2017-08-30
After
2018-03-09
add /protocolSection/statusModule/dispFirstSubmitQcDate
Triage: Uncategorized
Uncategorized Operation 3
After
2018-03-08
add /protocolSection/statusModule/dispFirstPostDateStruct
Triage: Uncategorized
Uncategorized Operation 4
After
{
  "date": "2018-03-09",
  "type": "ACTUAL"
}
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2018-03-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2018-03-09"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/dispFirstSubmitQcDate",
    "value": "2018-03-08"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/dispFirstPostDateStruct",
    "value": {
      "date": "2018-03-09",
      "type": "ACTUAL"
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/2/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/3/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/4/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/5/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/6/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/armGroups/7/interventionNames/0",
    "value": "Drug: Tesevatinib"
  },
  {
    "op": "replace",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/name",
    "value": "Tesevatinib"
  },
  {
    "op": "remove",
    "path": "/protocolSection/armsInterventionsModule/interventions/0/otherNames/2"
  }
]