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NCT02154529

Study of the Combination of KD019 and Trastuzumab in Subjects With HER2-Positive Metastatic Breast Cancer

Version 20 to 21 · Kadmon Corporation, LLC

Patch inspector

Version 20 to 21

12 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
arms_or_interventions_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:57+00
Raw hash
674122e0b9c1601ab2dd8038199b53bc05c8051160f73eb73fafeb80d8e534a8
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 9 ops
add /protocolSection/armsInterventionsModule/armGroups/0/interventionNames/1
Triage: High
Arm Intervention Change Operation 4
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1
Triage: High
Arm Intervention Change Operation 5
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/2/interventionNames/1
Triage: High
Arm Intervention Change Operation 6
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/3/interventionNames/1
Triage: High
Arm Intervention Change Operation 7
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/4/interventionNames/1
Triage: High
Arm Intervention Change Operation 8
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/5/interventionNames/1
Triage: High
Arm Intervention Change Operation 9
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/6/interventionNames/1
Triage: High
Arm Intervention Change Operation 10
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/armGroups/7/interventionNames/1
Triage: High
Arm Intervention Change Operation 11
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
Drug: Trastuzumab
add /protocolSection/armsInterventionsModule/interventions/1
Triage: High
Arm Intervention Change Operation 12
Matched rules
  • arms_or_interventions_change Arms or interventions changes can alter treatment/comparator structure.
After
{
  "name": "Trastuzumab",
  "type": "DRUG",
  "armGroupLabels": [
    "Phase 1b, Arm 1",
    "Phase 1b, Arm 2",
    "Phase 1b, Arm 3",
    "Phase 1b, Arm 4",
    "Phase 1b, Arm 5",
    "Phase 2a, Group 1",
    "Phase 2a, Group 2",
    "Phase 2a, Group 3"
  ]
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-02
After
2021-04
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2018-03-08
After
2021-04-01
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2018-03-09
After
2021-04-06
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-04"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-04-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-04-06"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/0/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/1/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/2/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/3/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/4/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/5/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/6/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/armGroups/7/interventionNames/1",
    "value": "Drug: Trastuzumab"
  },
  {
    "op": "add",
    "path": "/protocolSection/armsInterventionsModule/interventions/1",
    "value": {
      "name": "Trastuzumab",
      "type": "DRUG",
      "armGroupLabels": [
        "Phase 1b, Arm 1",
        "Phase 1b, Arm 2",
        "Phase 1b, Arm 3",
        "Phase 1b, Arm 4",
        "Phase 1b, Arm 5",
        "Phase 2a, Group 1",
        "Phase 2a, Group 2",
        "Phase 2a, Group 3"
      ]
    }
  }
]