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NCT02297412

Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel

Version 11 to 12 · Academic and Community Cancer Research United

Patch inspector

Version 11 to 12

6 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
phase_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "earlier",
    "new_value": "2015-10-13",
    "old_value": "2016-06",
    "delta_days": 232,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:44:39+00
Raw hash
1e9a860816c25e418abe287b6d36befe3cbed7fb2431f6d12c592169414a7a14
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/phases/0
Triage: High
Design Change Operation 5
Matched rules
  • phase_change Trial phase changes are high review-priority design changes.
Before
NA
After
PHASE2
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2016-06
After
2015-10-13
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 4 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-08
After
2018-01
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2017-08-08
After
2018-01-09
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2017-08-10
After
2018-01-10
add /annotationSection
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "annotationModule": {
    "unpostedAnnotation": {
      "unpostedEvents": [
        {
          "date": "2018-08-17",
          "type": "RELEASE"
        },
        {
          "date": "2018-09-18",
          "type": "RESET"
        }
      ],
      "unpostedResponsibleParty": "Academic and Community Cancer Research United"
    }
  }
}
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2018-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2015-10-13"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2018-01-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2018-01-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/phases/0",
    "value": "PHASE2"
  },
  {
    "op": "add",
    "path": "/annotationSection",
    "value": {
      "annotationModule": {
        "unpostedAnnotation": {
          "unpostedEvents": [
            {
              "date": "2018-08-17",
              "type": "RELEASE"
            },
            {
              "date": "2018-09-18",
              "type": "RESET"
            }
          ],
          "unpostedResponsibleParty": "Academic and Community Cancer Research United"
        }
      }
    }
  }
]