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NCT02340221

A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy

Version 24 to 25 · Hoffmann-La Roche

Patch inspector

Version 24 to 25

38 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:48+00
Raw hash
20732ad0feac26f8d829f9712b06ce147d5287dab33f87c6b234cc7ba61c7193
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 35 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
888-662-6728 (U.S. Only)
After
888-662-6728 (U.S. and Canada)
replace /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 5
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 6
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 7
Before
COMPLETED
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 8
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 9
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/20/status
Triage: Uncategorized
Uncategorized Operation 10
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/22/status
Triage: Uncategorized
Uncategorized Operation 11
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/33/status
Triage: Uncategorized
Uncategorized Operation 12
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/42/status
Triage: Uncategorized
Uncategorized Operation 13
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/47/status
Triage: Uncategorized
Uncategorized Operation 14
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/50/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
After
NOT_YET_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/50/city
Triage: Uncategorized
Uncategorized Operation 16
Before
Clermont-Ferrand
After
Kuopio
replace /protocolSection/contactsLocationsModule/locations/50/zip
Triage: Uncategorized
Uncategorized Operation 17
Before
63011
After
70211
replace /protocolSection/contactsLocationsModule/locations/50/country
Triage: Uncategorized
Uncategorized Operation 18
Before
France
After
Finland
replace /protocolSection/contactsLocationsModule/locations/50/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 19
Before
45.77969
After
62.89238
replace /protocolSection/contactsLocationsModule/locations/50/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 20
Before
3.08682
After
27.67703
add /protocolSection/contactsLocationsModule/locations/51
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "33520",
  "city": "Tampere",
  "status": "NOT_YET_RECRUITING",
  "country": "Finland",
  "geoPoint": {
    "lat": 61.49911,
    "lon": 23.78712
  }
}
add /protocolSection/contactsLocationsModule/locations/52
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "20520",
  "city": "Turku",
  "status": "NOT_YET_RECRUITING",
  "country": "Finland",
  "geoPoint": {
    "lat": 60.45148,
    "lon": 22.26869
  }
}
add /protocolSection/contactsLocationsModule/locations/53
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "63011",
  "city": "Clermont-Ferrand",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "France",
  "geoPoint": {
    "lat": 45.77969,
    "lon": 3.08682
  }
}
replace /protocolSection/contactsLocationsModule/locations/56/status
Triage: Uncategorized
Uncategorized Operation 24
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/57/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/70/status
Triage: Uncategorized
Uncategorized Operation 26
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/84/status
Triage: Uncategorized
Uncategorized Operation 27
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/85
Triage: Uncategorized
Uncategorized Operation 28
After
{
  "zip": "56025",
  "city": "Pontedera",
  "state": "Tuscany",
  "status": "NOT_YET_RECRUITING",
  "country": "Italy",
  "geoPoint": {
    "lat": 43.66141,
    "lon": 10.63067
  }
}
replace /protocolSection/contactsLocationsModule/locations/100/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/102/status
Triage: Uncategorized
Uncategorized Operation 30
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
replace /protocolSection/contactsLocationsModule/locations/104/status
Triage: Uncategorized
Uncategorized Operation 31
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/106/status
Triage: Uncategorized
Uncategorized Operation 32
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/115
Triage: Uncategorized
Uncategorized Operation 33
After
{
  "zip": "400015",
  "city": "Cluj-Napoca",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Romania",
  "geoPoint": {
    "lat": 46.76667,
    "lon": 23.6
  }
}
replace /protocolSection/contactsLocationsModule/locations/117/status
Triage: Uncategorized
Uncategorized Operation 34
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/118/status
Triage: Uncategorized
Uncategorized Operation 35
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/130/status
Triage: Uncategorized
Uncategorized Operation 36
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/132/status
Triage: Uncategorized
Uncategorized Operation 37
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/133/status
Triage: Uncategorized
Uncategorized Operation 38
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-02
After
2016-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2016-02-01
After
2016-03-01
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2016-02-02
After
2016-03-02
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2016-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2016-03-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2016-03-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/phone",
    "value": "888-662-6728 (U.S. and Canada)"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/20/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/22/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/33/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/42/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/47/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/status",
    "value": "NOT_YET_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/city",
    "value": "Kuopio"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/zip",
    "value": "70211"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/country",
    "value": "Finland"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/geoPoint/lat",
    "value": 62.89238
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/50/geoPoint/lon",
    "value": 27.67703
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/51",
    "value": {
      "zip": "33520",
      "city": "Tampere",
      "status": "NOT_YET_RECRUITING",
      "country": "Finland",
      "geoPoint": {
        "lat": 61.49911,
        "lon": 23.78712
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/52",
    "value": {
      "zip": "20520",
      "city": "Turku",
      "status": "NOT_YET_RECRUITING",
      "country": "Finland",
      "geoPoint": {
        "lat": 60.45148,
        "lon": 22.26869
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/53",
    "value": {
      "zip": "63011",
      "city": "Clermont-Ferrand",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "France",
      "geoPoint": {
        "lat": 45.77969,
        "lon": 3.08682
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/57/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/70/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/84/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/85",
    "value": {
      "zip": "56025",
      "city": "Pontedera",
      "state": "Tuscany",
      "status": "NOT_YET_RECRUITING",
      "country": "Italy",
      "geoPoint": {
        "lat": 43.66141,
        "lon": 10.63067
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/100/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/102/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/104/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/106/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/115",
    "value": {
      "zip": "400015",
      "city": "Cluj-Napoca",
      "status": "ACTIVE_NOT_RECRUITING",
      "country": "Romania",
      "geoPoint": {
        "lat": 46.76667,
        "lon": 23.6
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/117/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/118/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/130/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/132/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/133/status",
    "value": "ACTIVE_NOT_RECRUITING"
  }
]