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NCT02340221

A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy

Version 28 to 29 · Hoffmann-La Roche

Patch inspector

Version 28 to 29

33 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2018-07",
    "old_value": "2018-06",
    "delta_days": 30,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2018-07",
    "old_value": "2018-06",
    "delta_days": 30,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:49+00
Raw hash
32545225b257ec9f662c293804c47807a35d45d8aaefd6902442fb8ac7847456
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2018-06
After
2018-07
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2018-06
After
2018-07
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 28 ops
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "94115",
  "city": "San Francisco",
  "state": "California",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "geoPoint": {
    "lat": 37.77493,
    "lon": -122.41942
  }
}
add /protocolSection/contactsLocationsModule/locations/14
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "07601",
  "city": "Hackensack",
  "state": "New Jersey",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "geoPoint": {
    "lat": 40.88593,
    "lon": -74.04347
  }
}
add /protocolSection/contactsLocationsModule/locations/22
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "17110",
  "city": "Harrisburg",
  "state": "Pennsylvania",
  "status": "NOT_YET_RECRUITING",
  "country": "United States",
  "geoPoint": {
    "lat": 40.2737,
    "lon": -76.88442
  }
}
replace /protocolSection/contactsLocationsModule/locations/32/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/39/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/41/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
add /protocolSection/contactsLocationsModule/locations/42
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "V3V 1Z2",
  "city": "Surrey",
  "state": "British Columbia",
  "status": "RECRUITING",
  "country": "Canada",
  "geoPoint": {
    "lat": 49.10635,
    "lon": -122.82509
  }
}
replace /protocolSection/contactsLocationsModule/locations/46/status
Triage: Uncategorized
Uncategorized Operation 13
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/52/status
Triage: Uncategorized
Uncategorized Operation 14
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/53/status
Triage: Uncategorized
Uncategorized Operation 15
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/56/city
Triage: Uncategorized
Uncategorized Operation 16
Before
Kuopio
After
Sädesairaala
replace /protocolSection/contactsLocationsModule/locations/56/zip
Triage: Uncategorized
Uncategorized Operation 17
Before
70211
After
70210
remove /protocolSection/contactsLocationsModule/locations/56/geoPoint
Triage: Uncategorized
Uncategorized Operation 18
Before
{
  "lat": 62.89238,
  "lon": 27.67703
}
replace /protocolSection/contactsLocationsModule/locations/57/status
Triage: Uncategorized
Uncategorized Operation 19
Before
NOT_YET_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/58/status
Triage: Uncategorized
Uncategorized Operation 20
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/60
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "21079",
  "city": "Dijon",
  "status": "NOT_YET_RECRUITING",
  "country": "France",
  "geoPoint": {
    "lat": 47.31344,
    "lon": 5.01391
  }
}
replace /protocolSection/contactsLocationsModule/locations/63/status
Triage: Uncategorized
Uncategorized Operation 22
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/66/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/80/status
Triage: Uncategorized
Uncategorized Operation 24
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/86/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/93/status
Triage: Uncategorized
Uncategorized Operation 26
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/95/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/103/status
Triage: Uncategorized
Uncategorized Operation 28
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/113/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/114/status
Triage: Uncategorized
Uncategorized Operation 30
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/141/status
Triage: Uncategorized
Uncategorized Operation 31
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/153/status
Triage: Uncategorized
Uncategorized Operation 32
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/178/status
Triage: Uncategorized
Uncategorized Operation 33
Before
NOT_YET_RECRUITING
After
RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-06
After
2016-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2016-06-01
After
2016-07-01
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2016-06-02
After
2016-07-04
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2016-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2018-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2018-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2016-07-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2016-07-04"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "94115",
      "city": "San Francisco",
      "state": "California",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "geoPoint": {
        "lat": 37.77493,
        "lon": -122.41942
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/14",
    "value": {
      "zip": "07601",
      "city": "Hackensack",
      "state": "New Jersey",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "geoPoint": {
        "lat": 40.88593,
        "lon": -74.04347
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/22",
    "value": {
      "zip": "17110",
      "city": "Harrisburg",
      "state": "Pennsylvania",
      "status": "NOT_YET_RECRUITING",
      "country": "United States",
      "geoPoint": {
        "lat": 40.2737,
        "lon": -76.88442
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/39/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/42",
    "value": {
      "zip": "V3V 1Z2",
      "city": "Surrey",
      "state": "British Columbia",
      "status": "RECRUITING",
      "country": "Canada",
      "geoPoint": {
        "lat": 49.10635,
        "lon": -122.82509
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/46/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/52/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/53/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/city",
    "value": "Sädesairaala"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/56/zip",
    "value": "70210"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/56/geoPoint"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/57/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/58/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/60",
    "value": {
      "zip": "21079",
      "city": "Dijon",
      "status": "NOT_YET_RECRUITING",
      "country": "France",
      "geoPoint": {
        "lat": 47.31344,
        "lon": 5.01391
      }
    }
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/63/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/66/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/80/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/86/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/93/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/95/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/103/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/113/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/114/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/141/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/153/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/178/status",
    "value": "RECRUITING"
  }
]