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NCT02340221

A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy

Version 36 to 37 · Hoffmann-La Roche

Patch inspector

Version 36 to 37

37 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_actual_date_correction",
    "category": "timeline_actual_date_correction",
    "new_type": "ACTUAL",
    "old_type": "ACTUAL",
    "severity": "low",
    "direction": "later",
    "new_value": "2015-04-09",
    "old_value": "2015-04-08",
    "delta_days": 1,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:51+00
Raw hash
60176198298dc1c27c2eeea65f7de0b049acf0b9050b47789d0dd601f7831ab8
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2015-04-08
After
2015-04-09
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 33 ops
replace /protocolSection/contactsLocationsModule/locations/18/zip
Triage: Uncategorized
Uncategorized Operation 5
Before
7748
After
07748
replace /protocolSection/contactsLocationsModule/locations/32/status
Triage: Uncategorized
Uncategorized Operation 6
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/40/status
Triage: Uncategorized
Uncategorized Operation 7
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/41/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/43/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/54/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/68/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/71/status
Triage: Uncategorized
Uncategorized Operation 12
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/78/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/86/status
Triage: Uncategorized
Uncategorized Operation 14
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/93/status
Triage: Uncategorized
Uncategorized Operation 15
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/100/status
Triage: Uncategorized
Uncategorized Operation 16
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/105/status
Triage: Uncategorized
Uncategorized Operation 17
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/117/status
Triage: Uncategorized
Uncategorized Operation 18
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/122/status
Triage: Uncategorized
Uncategorized Operation 19
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/123/status
Triage: Uncategorized
Uncategorized Operation 20
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/127/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/128/status
Triage: Uncategorized
Uncategorized Operation 22
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/130/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/147/status
Triage: Uncategorized
Uncategorized Operation 24
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/148/status
Triage: Uncategorized
Uncategorized Operation 25
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/149
Triage: Uncategorized
Uncategorized Operation 26
Before
{
  "zip": "400015",
  "city": "Cluj-Napoca",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "Romania",
  "facility": "Prof. Dr. I. Chiricuta Institute of Oncology",
  "geoPoint": {
    "lat": 46.76667,
    "lon": 23.6
  }
}
replace /protocolSection/contactsLocationsModule/locations/150/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/155/status
Triage: Uncategorized
Uncategorized Operation 28
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/158/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/163/status
Triage: Uncategorized
Uncategorized Operation 30
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/164/status
Triage: Uncategorized
Uncategorized Operation 31
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/167/status
Triage: Uncategorized
Uncategorized Operation 32
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/169/status
Triage: Uncategorized
Uncategorized Operation 33
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/180/status
Triage: Uncategorized
Uncategorized Operation 34
Before
RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/181/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/203/status
Triage: Uncategorized
Uncategorized Operation 36
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/207/status
Triage: Uncategorized
Uncategorized Operation 37
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-06
After
2017-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2017-06-14
After
2017-07-10
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2017-06-15
After
2017-07-11
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2015-04-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-07-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-07-11"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/18/zip",
    "value": "07748"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/40/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/41/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/43/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/54/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/68/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/71/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/78/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/86/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/93/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/100/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/105/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/117/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/122/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/123/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/127/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/128/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/130/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/147/status",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/148/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/149"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/150/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/155/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/158/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/163/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/164/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/167/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/169/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/180/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/181/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/203/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/207/status",
    "value": "ACTIVE_NOT_RECRUITING"
  }
]