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NCT02340221

A Study of Taselisib + Fulvestrant Versus Placebo + Fulvestrant in Participants With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy

Version 39 to 40 · Hoffmann-La Roche

Patch inspector

Version 39 to 40

24 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2019-07-06",
    "old_value": "2018-06-30",
    "delta_days": 371,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2019-07-06",
    "old_value": "2018-06-30",
    "delta_days": 371,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:52+00
Raw hash
377015291e8e92bd8daac40846b37b2999ca353348b14b1ef5973adf336261ed
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2018-06-30
After
2019-07-06
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2018-06-30
After
2019-07-06
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 19 ops
replace /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 6
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 7
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 8
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/13/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/15/status
Triage: Uncategorized
Uncategorized Operation 10
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/18/status
Triage: Uncategorized
Uncategorized Operation 11
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/21/status
Triage: Uncategorized
Uncategorized Operation 12
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/29/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/84/status
Triage: Uncategorized
Uncategorized Operation 14
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/92/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/102/status
Triage: Uncategorized
Uncategorized Operation 16
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
replace /protocolSection/contactsLocationsModule/locations/118/status
Triage: Uncategorized
Uncategorized Operation 17
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/146/status
Triage: Uncategorized
Uncategorized Operation 18
Before
ACTIVE_NOT_RECRUITING
After
COMPLETED
replace /protocolSection/contactsLocationsModule/locations/154/facility
Triage: Uncategorized
Uncategorized Operation 19
Before
FSBI "Scientific Research Institute of Oncology named after N.N.Petrov" Ministry of Health of RF
After
FSBI"National Medical Research Center of Oncology named after N.N.Petrov" MHRF
replace /protocolSection/contactsLocationsModule/locations/174/status
Triage: Uncategorized
Uncategorized Operation 20
Before
RECRUITING
After
TERMINATED
replace /protocolSection/contactsLocationsModule/locations/191/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/192/status
Triage: Uncategorized
Uncategorized Operation 22
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/193/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/204/status
Triage: Uncategorized
Uncategorized Operation 24
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-08
After
2017-09
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2017-08-22
After
2017-09-21
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2017-08-23
After
2017-09-25
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2019-07-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2019-07-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-09-21"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-09-25"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/9/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/12/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/13/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/15/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/18/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/21/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/84/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/92/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/102/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/118/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/146/status",
    "value": "COMPLETED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/154/facility",
    "value": "FSBI"National Medical Research Center of Oncology named after N.N.Petrov" MHRF"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/174/status",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/191/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/192/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/193/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/204/status",
    "value": "ACTIVE_NOT_RECRUITING"
  }
]