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NCT02384239

A Study of Palbociclib in Combination With Fulvestrant or Tamoxifen as Treatment for Metastatic Breast Cancer

Version 0 to 1 · University of California, San Francisco

Patch inspector

Version 0 to 1

9 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": null,
    "old_type": null,
    "severity": "medium",
    "direction": "later",
    "new_value": "2015-10",
    "old_value": "2015-03",
    "delta_days": 214,
    "date_struct": "startDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:33+00
Raw hash
4df5399062cdc014b50caa46ab19c82aae177535843474f966fde0a69d0217e4
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2015-03
After
2015-10
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 4 ops
replace /protocolSection/contactsLocationsModule/centralContacts/1/name
Triage: Low
Administrative Contact Change Operation 6
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
Stephanie N Ezrati, B.S
After
Amy N DeLuca, B.S
replace /protocolSection/contactsLocationsModule/centralContacts/1/phone
Triage: Low
Administrative Contact Change Operation 7
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
415-353-7857
After
415-353-7288
replace /protocolSection/contactsLocationsModule/centralContacts/1/email
Triage: Low
Administrative Contact Change Operation 8
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
Stephanie.Ezrati@ucsf.edu
After
Amy.DeLuca@ucsf.edu
add /protocolSection/contactsLocationsModule/locations
Triage: Uncategorized
Uncategorized Operation 9
After
[
  {
    "zip": "94143",
    "city": "San Francisco",
    "state": "California",
    "status": "RECRUITING",
    "country": "United States",
    "contacts": [
      {
        "name": "Amy DeLuca",
        "role": "CONTACT",
        "email": "Amy.DeLuca@ucsf.edu",
        "phone": "415-353-7288"
      },
      {
        "name": "Ivy Wong",
        "role": "CONTACT",
        "email": "Ivy.Wong@ucsf.edu",
        "phone": "415-353-7873"
      },
      {
        "name": "Hope Rugo, M.D.",
        "role": "PRINCIPAL_INVESTIGATOR"
      }
    ],
    "facility": "UCSF Helen Diller Family Comprehensive Cancer Center",
    "geoPoint": {
      "lat": 37.77493,
      "lon": -122.41942
    }
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2015-03
After
2016-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2015-03-09
After
2016-02-10
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2015-03-10
After
2016-02-12
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
NOT_YET_RECRUITING
After
RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2016-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2015-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2016-02-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2016-02-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/1/name",
    "value": "Amy N DeLuca, B.S"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/1/phone",
    "value": "415-353-7288"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/1/email",
    "value": "Amy.DeLuca@ucsf.edu"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations",
    "value": [
      {
        "zip": "94143",
        "city": "San Francisco",
        "state": "California",
        "status": "RECRUITING",
        "country": "United States",
        "contacts": [
          {
            "name": "Amy DeLuca",
            "role": "CONTACT",
            "email": "Amy.DeLuca@ucsf.edu",
            "phone": "415-353-7288"
          },
          {
            "name": "Ivy Wong",
            "role": "CONTACT",
            "email": "Ivy.Wong@ucsf.edu",
            "phone": "415-353-7873"
          },
          {
            "name": "Hope Rugo, M.D.",
            "role": "PRINCIPAL_INVESTIGATOR"
          }
        ],
        "facility": "UCSF Helen Diller Family Comprehensive Cancer Center",
        "geoPoint": {
          "lat": 37.77493,
          "lon": -122.41942
        }
      }
    ]
  }
]