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NCT02384239

A Study of Palbociclib in Combination With Fulvestrant or Tamoxifen as Treatment for Metastatic Breast Cancer

Version 3 to 4 · University of California, San Francisco

Patch inspector

Version 3 to 4

9 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2018-08",
    "old_value": "2016-08",
    "delta_days": 730,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_major_slip",
    "category": "timeline_major_slip",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2020-08",
    "old_value": "2017-08",
    "delta_days": 1096,
    "date_struct": "completionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:33+00
Raw hash
9d9fbfb0568a80f634c9901348f10d1b17028533ab8264c4e2b8d417d19c85a3
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2016-08
After
2018-08
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2017-08
After
2020-08
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 4 ops
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "46202",
  "city": "Indianapolis",
  "state": "Indiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Robbie Comito",
      "role": "CONTACT",
      "email": "rcomito@iupui.edu",
      "phone": "317-274-0935"
    },
    {
      "name": "Anna Maria Storniolo, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Indiana University",
  "geoPoint": {
    "lat": 39.76838,
    "lon": -86.15804
  }
}
add /protocolSection/contactsLocationsModule/locations/5
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "02215",
  "city": "Boston",
  "state": "Massachusetts",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Lauren Fisher",
      "role": "CONTACT",
      "email": "lfisher7@partners.org",
      "phone": "617-632-4321"
    },
    {
      "name": "Nicole Ryabin",
      "role": "CONTACT",
      "email": "Nicole_Ryabin@dfci.harvard.edu",
      "phone": "617-632-6767"
    },
    {
      "name": "Erica Mayer, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Dana-Farber Cancer Institute",
  "geoPoint": {
    "lat": 42.35843,
    "lon": -71.05977
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "48109",
  "city": "Ann Arbor",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Richelle Pelton",
      "role": "CONTACT",
      "email": "peltonr@med.umich.edu",
      "phone": "734-763-2960"
    },
    {
      "name": "Catherine Van Poznak, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of Michigan",
  "geoPoint": {
    "lat": 42.27756,
    "lon": -83.74088
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "37240",
  "city": "Nashville",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Mikala Barnes",
      "role": "CONTACT",
      "email": "mikala.barnes@vanderbilt.edu",
      "phone": "615-875-0072"
    },
    {
      "name": "Kathleen Sanders",
      "role": "CONTACT",
      "email": "kathleen.sanders@Vanderbilt.Edu",
      "phone": "615-343-4091"
    },
    {
      "name": "Ingrid Mayer, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Vanderbilt University",
  "geoPoint": {
    "lat": 36.16589,
    "lon": -86.78444
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2016-05
After
2016-12
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2016-05-06
After
2016-12-28
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2016-05-09
After
2016-12-29
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2016-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2018-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2020-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2016-12-28"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2016-12-29"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "46202",
      "city": "Indianapolis",
      "state": "Indiana",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Robbie Comito",
          "role": "CONTACT",
          "email": "rcomito@iupui.edu",
          "phone": "317-274-0935"
        },
        {
          "name": "Anna Maria Storniolo, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Indiana University",
      "geoPoint": {
        "lat": 39.76838,
        "lon": -86.15804
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5",
    "value": {
      "zip": "02215",
      "city": "Boston",
      "state": "Massachusetts",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Lauren Fisher",
          "role": "CONTACT",
          "email": "lfisher7@partners.org",
          "phone": "617-632-4321"
        },
        {
          "name": "Nicole Ryabin",
          "role": "CONTACT",
          "email": "Nicole_Ryabin@dfci.harvard.edu",
          "phone": "617-632-6767"
        },
        {
          "name": "Erica Mayer, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Dana-Farber Cancer Institute",
      "geoPoint": {
        "lat": 42.35843,
        "lon": -71.05977
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "zip": "48109",
      "city": "Ann Arbor",
      "state": "Michigan",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Richelle Pelton",
          "role": "CONTACT",
          "email": "peltonr@med.umich.edu",
          "phone": "734-763-2960"
        },
        {
          "name": "Catherine Van Poznak, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "University of Michigan",
      "geoPoint": {
        "lat": 42.27756,
        "lon": -83.74088
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "zip": "37240",
      "city": "Nashville",
      "state": "Tennessee",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Mikala Barnes",
          "role": "CONTACT",
          "email": "mikala.barnes@vanderbilt.edu",
          "phone": "615-875-0072"
        },
        {
          "name": "Kathleen Sanders",
          "role": "CONTACT",
          "email": "kathleen.sanders@Vanderbilt.Edu",
          "phone": "615-343-4091"
        },
        {
          "name": "Ingrid Mayer, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Vanderbilt University",
      "geoPoint": {
        "lat": 36.16589,
        "lon": -86.78444
      }
    }
  }
]