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NCT03025035

Pembrolizumab in Combination With Olaparib in Advanced BRCA-mutated or HDR-defect Breast Cancer

Version 2 to 3 · Yuan Yuan

Patch inspector

Version 2 to 3

10 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2017-09-10",
    "old_value": "2017-06-08",
    "delta_days": 94,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:38+00
Raw hash
b67eb2ea6c538f8ac032e7dd512124424d09c9e1f60d070657113ffcd1c60dc5
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2017-06-08
After
2017-09-10
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 5 ops
add /protocolSection/contactsLocationsModule/locations/0/contacts/2
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "name": "Julie A Dunhill, MD",
  "role": "SUB_INVESTIGATOR"
}
add /protocolSection/contactsLocationsModule/locations/0/contacts/3
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "name": "Philomena McAndrew, MD",
  "role": "SUB_INVESTIGATOR"
}
add /protocolSection/contactsLocationsModule/locations/0/contacts/4
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "name": "Heather MCArthur, MD",
  "role": "SUB_INVESTIGATOR"
}
add /protocolSection/contactsLocationsModule/locations/0/contacts/5
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "name": "Dorothy Park, MD",
  "role": "SUB_INVESTIGATOR"
}
add /protocolSection/contactsLocationsModule/locations/0/contacts/6
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "name": "Greg Sarna, MD",
  "role": "SUB_INVESTIGATOR"
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2017-06
After
2017-12
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2017-06-07
After
2017-12-12
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2017-06-09
After
2017-12-14
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2017-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2017-09-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2017-12-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2017-12-14"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/2",
    "value": {
      "name": "Julie A Dunhill, MD",
      "role": "SUB_INVESTIGATOR"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/3",
    "value": {
      "name": "Philomena McAndrew, MD",
      "role": "SUB_INVESTIGATOR"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/4",
    "value": {
      "name": "Heather MCArthur, MD",
      "role": "SUB_INVESTIGATOR"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/5",
    "value": {
      "name": "Dorothy Park, MD",
      "role": "SUB_INVESTIGATOR"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts/6",
    "value": {
      "name": "Greg Sarna, MD",
      "role": "SUB_INVESTIGATOR"
    }
  }
]