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NCT03094169

AVID100 in Advanced Epithelial Carcinomas

Version 9 to 10 · Formation Biologics

Patch inspector

Version 9 to 10

9 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
enrollment_count_changeenrollment_type_changeterminal_status_changewhy_stopped_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2020-11-28",
    "new_type": "ACTUAL",
    "old_date": "2020-11-28",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 0,
    "date_struct": "primaryCompletionDateStruct"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2021-01-30",
    "new_type": "ACTUAL",
    "old_date": "2021-01-30",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 0,
    "date_struct": "completionDateStruct"
  },
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 49,
    "old_value": 90,
    "pct_change": 0.4556
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:58:19+00
Raw hash
7a407320577e57e161a58a987c0153e56a0c320469176102bc07d6056026d710
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 2 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 8
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
90
After
49
replace /protocolSection/designModule/enrollmentInfo/type
Triage: High
Enrollment Change Operation 9
Matched rules
  • enrollment_type_change Enrollment type changes from anticipated to actual or similar are high review priority.
Before
ESTIMATED
After
ACTUAL
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: High 2 ops
replace /protocolSection/statusModule/overallStatus
Triage: High
Status Termination Operation 2
Matched rules
  • terminal_status_change Status changed to terminated, suspended, or withdrawn; whyStopped content determines whether critical review is warranted.
Before
ACTIVE_NOT_RECRUITING
After
TERMINATED
add /protocolSection/statusModule/whyStopped
Triage: High
Status Termination Operation 7
Matched rules
  • why_stopped_change Why-stopped changes explain discontinuation and need review.
After
lack of efficacy
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
replace /protocolSection/statusModule/completionDateStruct/type
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-10
After
2021-03
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-10-21
After
2021-03-22
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2020-10-23
After
2021-03-24
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "TERMINATED"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-03-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-03-24"
  },
  {
    "op": "add",
    "path": "/protocolSection/statusModule/whyStopped",
    "value": "lack of efficacy"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 49
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/type",
    "value": "ACTUAL"
  }
]