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NCT03283384

Tailoring NEOadjuvant Therapy in Hormone Receptor Positive, HER2 Negative, Luminal Breast Cancer.

Version 6 to 7 · Borstkanker Onderzoek Groep

Patch inspector

Version 6 to 7

64 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2021-12",
    "old_value": "2021-01",
    "delta_days": 334,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:11:35+00
Raw hash
5d9309fe59a92788f14766a15f1da3999c74b1ab8e75a3a8db30dcd88e92fe53
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2021-01
After
2021-12
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 59 ops
remove /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 6
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
[
  {
    "name": "Judith R Kroep, MD PhD",
    "role": "CONTACT",
    "email": "j.r.kroep@lumc.nl",
    "phone": "+31715263464"
  },
  {
    "name": "A F de Groot, MD",
    "role": "CONTACT",
    "email": "a.f.de_groot@lumc.nl",
    "phone": "+31715299126"
  }
]
remove /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 7
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/0/contacts
Triage: Uncategorized
Uncategorized Operation 8
Before
[
  {
    "name": "J. Tol",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 9
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/1/contacts
Triage: Uncategorized
Uncategorized Operation 10
Before
[
  {
    "name": "E. Siemerink",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 11
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/2/contacts
Triage: Uncategorized
Uncategorized Operation 12
Before
[
  {
    "name": "A. van Zweeden",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 13
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/3/contacts
Triage: Uncategorized
Uncategorized Operation 14
Before
[
  {
    "name": "S. Linn",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 15
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/4/contacts
Triage: Uncategorized
Uncategorized Operation 16
Before
[
  {
    "name": "E. Kerver",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 17
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/5/contacts
Triage: Uncategorized
Uncategorized Operation 18
Before
[
  {
    "name": "S. Tromp - van Driel",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 19
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/6/contacts
Triage: Uncategorized
Uncategorized Operation 20
Before
[
  {
    "name": "J. Heijns",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 21
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/7/contacts
Triage: Uncategorized
Uncategorized Operation 22
Before
[
  {
    "name": "M. van Bekkum",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 23
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/8/contacts
Triage: Uncategorized
Uncategorized Operation 24
Before
[
  {
    "name": "L. Kessels",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 25
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/9/contacts
Triage: Uncategorized
Uncategorized Operation 26
Before
[
  {
    "name": "B. Vriens",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 27
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/10/contacts
Triage: Uncategorized
Uncategorized Operation 28
Before
[
  {
    "name": "M. Dercksen",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 29
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/11/contacts
Triage: Uncategorized
Uncategorized Operation 30
Before
[
  {
    "name": "J. Hokken",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 31
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/12/contacts
Triage: Uncategorized
Uncategorized Operation 32
Before
[
  {
    "name": "P. Kuijer",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/13/status
Triage: Uncategorized
Uncategorized Operation 33
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/13/contacts
Triage: Uncategorized
Uncategorized Operation 34
Before
[
  {
    "name": "J. Ropela",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/14/status
Triage: Uncategorized
Uncategorized Operation 35
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/14/contacts
Triage: Uncategorized
Uncategorized Operation 36
Before
[
  {
    "name": "S. Luykx-de Bakker",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/15/status
Triage: Uncategorized
Uncategorized Operation 37
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/15/contacts
Triage: Uncategorized
Uncategorized Operation 38
Before
[
  {
    "name": "S. van den Heiligenberg",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/16/status
Triage: Uncategorized
Uncategorized Operation 39
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/16/contacts
Triage: Uncategorized
Uncategorized Operation 40
Before
[
  {
    "name": "Judith R Kroep, MD PhD",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/17/status
Triage: Uncategorized
Uncategorized Operation 41
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/17/contacts
Triage: Uncategorized
Uncategorized Operation 42
Before
[
  {
    "name": "M. de Boer",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/18/status
Triage: Uncategorized
Uncategorized Operation 43
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/18/contacts
Triage: Uncategorized
Uncategorized Operation 44
Before
[
  {
    "name": "C. Mandigers",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/19/status
Triage: Uncategorized
Uncategorized Operation 45
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/19/contacts
Triage: Uncategorized
Uncategorized Operation 46
Before
[
  {
    "name": "K. Aaldering",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/20/status
Triage: Uncategorized
Uncategorized Operation 47
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/20/contacts
Triage: Uncategorized
Uncategorized Operation 48
Before
[
  {
    "name": "H. Droogendijk",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/21/status
Triage: Uncategorized
Uncategorized Operation 49
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/21/contacts
Triage: Uncategorized
Uncategorized Operation 50
Before
[
  {
    "name": "G. Veldhuis",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/22/status
Triage: Uncategorized
Uncategorized Operation 51
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/22/contacts
Triage: Uncategorized
Uncategorized Operation 52
Before
[
  {
    "name": "H. Oosterkamp",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/23/status
Triage: Uncategorized
Uncategorized Operation 53
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/23/contacts
Triage: Uncategorized
Uncategorized Operation 54
Before
[
  {
    "name": "D. Houtsma",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/24/status
Triage: Uncategorized
Uncategorized Operation 55
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/24/contacts
Triage: Uncategorized
Uncategorized Operation 56
Before
[
  {
    "name": "C. Kruijtzer-Schimmel",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/25/status
Triage: Uncategorized
Uncategorized Operation 57
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/25/contacts
Triage: Uncategorized
Uncategorized Operation 58
Before
[
  {
    "name": "J. van Riel",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/26/status
Triage: Uncategorized
Uncategorized Operation 59
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/26/contacts
Triage: Uncategorized
Uncategorized Operation 60
Before
[
  {
    "name": "A. van de Wouw",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/27/status
Triage: Uncategorized
Uncategorized Operation 61
Before
RECRUITING
remove /protocolSection/contactsLocationsModule/locations/27/contacts
Triage: Uncategorized
Uncategorized Operation 62
Before
[
  {
    "name": "P. Schiphorst",
    "role": "CONTACT"
  }
]
remove /protocolSection/contactsLocationsModule/locations/28/status
Triage: Uncategorized
Uncategorized Operation 63
Before
NOT_YET_RECRUITING
remove /protocolSection/contactsLocationsModule/locations/28/contacts
Triage: Uncategorized
Uncategorized Operation 64
Before
[
  {
    "name": "A. Honkoop",
    "role": "CONTACT"
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-01
After
2021-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-01-16
After
2021-07-22
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-01-18
After
2021-07-23
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
RECRUITING
After
ACTIVE_NOT_RECRUITING
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2021-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2021-12"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2021-07-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2021-07-23"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/centralContacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/0/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/1/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/2/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/3/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/4/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/5/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/6/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/7/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/8/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/9/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/9/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/10/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/11/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/12/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/12/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/13/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/13/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/14/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/14/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/15/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/15/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/16/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/16/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/17/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/17/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/18/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/18/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/19/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/19/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/20/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/20/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/21/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/21/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/22/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/22/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/23/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/23/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/24/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/24/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/25/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/25/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/26/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/26/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/27/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/27/contacts"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/28/status"
  },
  {
    "op": "remove",
    "path": "/protocolSection/contactsLocationsModule/locations/28/contacts"
  }
]