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NCT03584009

A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy

Version 16 to 17 · Hoffmann-La Roche

Patch inspector

Version 16 to 17

116 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_earlier_shift",
    "category": "timeline_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "earlier",
    "new_value": "2020-08-05",
    "old_value": "2022-02-02",
    "delta_days": 546,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "later",
    "new_value": "2022-02-05",
    "old_value": "2022-02-02",
    "delta_days": 3,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:50+00
Raw hash
f33cc2ea5ea217d740eeda5f67c0efb276d920abf12cae369dbbd04bf3293253
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2022-02-02
After
2020-08-05
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 4
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2022-02-02
After
2022-02-05
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 110 ops
add /protocolSection/contactsLocationsModule/locations/0/status
Triage: Uncategorized
Uncategorized Operation 7
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/1/status
Triage: Uncategorized
Uncategorized Operation 8
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/2/status
Triage: Uncategorized
Uncategorized Operation 9
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/3/status
Triage: Uncategorized
Uncategorized Operation 10
After
COMPLETED
add /protocolSection/contactsLocationsModule/locations/4/status
Triage: Uncategorized
Uncategorized Operation 11
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 12
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/6/status
Triage: Uncategorized
Uncategorized Operation 13
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/7/status
Triage: Uncategorized
Uncategorized Operation 14
After
ACTIVE_NOT_RECRUITING
add /protocolSection/contactsLocationsModule/locations/8/status
Triage: Uncategorized
Uncategorized Operation 15
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/9/status
Triage: Uncategorized
Uncategorized Operation 16
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/10/status
Triage: Uncategorized
Uncategorized Operation 17
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/11/status
Triage: Uncategorized
Uncategorized Operation 18
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/12/status
Triage: Uncategorized
Uncategorized Operation 19
After
ACTIVE_NOT_RECRUITING
add /protocolSection/contactsLocationsModule/locations/13/status
Triage: Uncategorized
Uncategorized Operation 20
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/14/status
Triage: Uncategorized
Uncategorized Operation 21
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/15/status
Triage: Uncategorized
Uncategorized Operation 22
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/16/status
Triage: Uncategorized
Uncategorized Operation 23
After
ACTIVE_NOT_RECRUITING
add /protocolSection/contactsLocationsModule/locations/17/status
Triage: Uncategorized
Uncategorized Operation 24
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/18/status
Triage: Uncategorized
Uncategorized Operation 25
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/19/status
Triage: Uncategorized
Uncategorized Operation 26
After
ACTIVE_NOT_RECRUITING
add /protocolSection/contactsLocationsModule/locations/20/status
Triage: Uncategorized
Uncategorized Operation 27
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/21/status
Triage: Uncategorized
Uncategorized Operation 28
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/22/status
Triage: Uncategorized
Uncategorized Operation 29
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/23/status
Triage: Uncategorized
Uncategorized Operation 30
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/24/status
Triage: Uncategorized
Uncategorized Operation 31
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/25/status
Triage: Uncategorized
Uncategorized Operation 32
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/26/status
Triage: Uncategorized
Uncategorized Operation 33
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/27/status
Triage: Uncategorized
Uncategorized Operation 34
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/28/facility
Triage: Uncategorized
Uncategorized Operation 35
Before
Hämato-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg
After
Centre Léon Bérard
replace /protocolSection/contactsLocationsModule/locations/28/city
Triage: Uncategorized
Uncategorized Operation 36
Before
Aschaffenburg
After
Lyon
replace /protocolSection/contactsLocationsModule/locations/28/zip
Triage: Uncategorized
Uncategorized Operation 37
Before
63739
After
69373
replace /protocolSection/contactsLocationsModule/locations/28/country
Triage: Uncategorized
Uncategorized Operation 38
Before
Germany
After
France
replace /protocolSection/contactsLocationsModule/locations/28/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 39
Before
49.97704
After
45.74906
replace /protocolSection/contactsLocationsModule/locations/28/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 40
Before
9.15214
After
4.84789
add /protocolSection/contactsLocationsModule/locations/28/status
Triage: Uncategorized
Uncategorized Operation 41
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/29/facility
Triage: Uncategorized
Uncategorized Operation 42
Before
Universitätsklinikum Erlangen; Frauenklinik
After
Hôpital Saint-Louis
replace /protocolSection/contactsLocationsModule/locations/29/city
Triage: Uncategorized
Uncategorized Operation 43
Before
Erlangen
After
Paris
replace /protocolSection/contactsLocationsModule/locations/29/zip
Triage: Uncategorized
Uncategorized Operation 44
Before
91054
After
75475
replace /protocolSection/contactsLocationsModule/locations/29/country
Triage: Uncategorized
Uncategorized Operation 45
Before
Germany
After
France
replace /protocolSection/contactsLocationsModule/locations/29/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 46
Before
49.59099
After
48.85341
replace /protocolSection/contactsLocationsModule/locations/29/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 47
Before
11.00783
After
2.3488
add /protocolSection/contactsLocationsModule/locations/29/status
Triage: Uncategorized
Uncategorized Operation 48
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/30/facility
Triage: Uncategorized
Uncategorized Operation 49
Before
Klinikum Frankfurt Höchst GmbH
After
Institut Claudius Régaud
replace /protocolSection/contactsLocationsModule/locations/30/city
Triage: Uncategorized
Uncategorized Operation 50
Before
Frankfurt
After
Toulouse
replace /protocolSection/contactsLocationsModule/locations/30/zip
Triage: Uncategorized
Uncategorized Operation 51
Before
65929
After
31059
replace /protocolSection/contactsLocationsModule/locations/30/country
Triage: Uncategorized
Uncategorized Operation 52
Before
Germany
After
France
replace /protocolSection/contactsLocationsModule/locations/30/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 53
Before
49.68333
After
43.60426
replace /protocolSection/contactsLocationsModule/locations/30/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 54
Before
10.53333
After
1.44367
add /protocolSection/contactsLocationsModule/locations/30/status
Triage: Uncategorized
Uncategorized Operation 55
After
WITHDRAWN
replace /protocolSection/contactsLocationsModule/locations/31/facility
Triage: Uncategorized
Uncategorized Operation 56
Before
Facharztzentrum Eppendorf, Studien GbR
After
Hämato-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg
replace /protocolSection/contactsLocationsModule/locations/31/city
Triage: Uncategorized
Uncategorized Operation 57
Before
Hamburg
After
Aschaffenburg
replace /protocolSection/contactsLocationsModule/locations/31/zip
Triage: Uncategorized
Uncategorized Operation 58
Before
20249
After
63739
replace /protocolSection/contactsLocationsModule/locations/31/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 59
Before
53.55073
After
49.97704
replace /protocolSection/contactsLocationsModule/locations/31/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 60
Before
9.99302
After
9.15214
add /protocolSection/contactsLocationsModule/locations/31/status
Triage: Uncategorized
Uncategorized Operation 61
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/32/facility
Triage: Uncategorized
Uncategorized Operation 62
Before
Rotkreuzklinikum München; Frauenklinik
After
Universitätsklinikum Erlangen; Frauenklinik
replace /protocolSection/contactsLocationsModule/locations/32/city
Triage: Uncategorized
Uncategorized Operation 63
Before
München
After
Erlangen
replace /protocolSection/contactsLocationsModule/locations/32/zip
Triage: Uncategorized
Uncategorized Operation 64
Before
80637
After
91054
replace /protocolSection/contactsLocationsModule/locations/32/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 65
Before
51.60698
After
49.59099
replace /protocolSection/contactsLocationsModule/locations/32/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 66
Before
13.31243
After
11.00783
add /protocolSection/contactsLocationsModule/locations/32/status
Triage: Uncategorized
Uncategorized Operation 67
After
ACTIVE_NOT_RECRUITING
replace /protocolSection/contactsLocationsModule/locations/33/facility
Triage: Uncategorized
Uncategorized Operation 68
Before
Gemeinschaftspraxis für Hämatologie und Onkologie GbR; Dechow & Decker & Nonnenbroich
After
Klinikum Frankfurt Höchst GmbH
replace /protocolSection/contactsLocationsModule/locations/33/city
Triage: Uncategorized
Uncategorized Operation 69
Before
Ravensburg
After
Frankfurt
replace /protocolSection/contactsLocationsModule/locations/33/zip
Triage: Uncategorized
Uncategorized Operation 70
Before
88212
After
65929
replace /protocolSection/contactsLocationsModule/locations/33/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 71
Before
47.78198
After
49.68333
replace /protocolSection/contactsLocationsModule/locations/33/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 72
Before
9.61062
After
10.53333
add /protocolSection/contactsLocationsModule/locations/33/status
Triage: Uncategorized
Uncategorized Operation 73
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/34/facility
Triage: Uncategorized
Uncategorized Operation 74
Before
Klinikum Südstadt Rostock
After
Facharztzentrum Eppendorf, Studien GbR
replace /protocolSection/contactsLocationsModule/locations/34/city
Triage: Uncategorized
Uncategorized Operation 75
Before
Rostock
After
Hamburg
replace /protocolSection/contactsLocationsModule/locations/34/zip
Triage: Uncategorized
Uncategorized Operation 76
Before
18059
After
20249
replace /protocolSection/contactsLocationsModule/locations/34/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 77
Before
54.0887
After
53.55073
replace /protocolSection/contactsLocationsModule/locations/34/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 78
Before
12.14049
After
9.99302
add /protocolSection/contactsLocationsModule/locations/34/status
Triage: Uncategorized
Uncategorized Operation 79
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/35/facility
Triage: Uncategorized
Uncategorized Operation 80
Before
Royal United Hospital Bath NHS Trust
After
Rotkreuzklinikum München; Frauenklinik
replace /protocolSection/contactsLocationsModule/locations/35/city
Triage: Uncategorized
Uncategorized Operation 81
Before
Bath
After
München
replace /protocolSection/contactsLocationsModule/locations/35/zip
Triage: Uncategorized
Uncategorized Operation 82
Before
BA1 3NG
After
80637
replace /protocolSection/contactsLocationsModule/locations/35/country
Triage: Uncategorized
Uncategorized Operation 83
Before
United Kingdom
After
Germany
replace /protocolSection/contactsLocationsModule/locations/35/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 84
Before
51.3751
After
51.60698
replace /protocolSection/contactsLocationsModule/locations/35/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 85
Before
-2.36172
After
13.31243
add /protocolSection/contactsLocationsModule/locations/35/status
Triage: Uncategorized
Uncategorized Operation 86
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/36/facility
Triage: Uncategorized
Uncategorized Operation 87
Before
Royal Sussex County Hospital
After
Gemeinschaftspraxis für Hämatologie und Onkologie GbR; Dechow & Decker & Nonnenbroich
replace /protocolSection/contactsLocationsModule/locations/36/city
Triage: Uncategorized
Uncategorized Operation 88
Before
Brighton
After
Ravensburg
replace /protocolSection/contactsLocationsModule/locations/36/zip
Triage: Uncategorized
Uncategorized Operation 89
Before
BN2 5BE
After
88212
replace /protocolSection/contactsLocationsModule/locations/36/country
Triage: Uncategorized
Uncategorized Operation 90
Before
United Kingdom
After
Germany
replace /protocolSection/contactsLocationsModule/locations/36/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 91
Before
50.82838
After
47.78198
replace /protocolSection/contactsLocationsModule/locations/36/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 92
Before
-0.13947
After
9.61062
add /protocolSection/contactsLocationsModule/locations/36/status
Triage: Uncategorized
Uncategorized Operation 93
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/37/facility
Triage: Uncategorized
Uncategorized Operation 94
Before
Barts Health NHS Trust - St Bartholomew's Hospital
After
Klinikum Südstadt Rostock
replace /protocolSection/contactsLocationsModule/locations/37/city
Triage: Uncategorized
Uncategorized Operation 95
Before
London
After
Rostock
replace /protocolSection/contactsLocationsModule/locations/37/zip
Triage: Uncategorized
Uncategorized Operation 96
Before
EC1A 7BE
After
18059
replace /protocolSection/contactsLocationsModule/locations/37/country
Triage: Uncategorized
Uncategorized Operation 97
Before
United Kingdom
After
Germany
replace /protocolSection/contactsLocationsModule/locations/37/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 98
Before
51.50853
After
54.0887
replace /protocolSection/contactsLocationsModule/locations/37/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 99
Before
-0.12574
After
12.14049
add /protocolSection/contactsLocationsModule/locations/37/status
Triage: Uncategorized
Uncategorized Operation 100
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/38/facility
Triage: Uncategorized
Uncategorized Operation 101
Before
The Christie NHS Foundation Trust
After
Royal United Hospital Bath NHS Trust
replace /protocolSection/contactsLocationsModule/locations/38/city
Triage: Uncategorized
Uncategorized Operation 102
Before
Manchester
After
Bath
replace /protocolSection/contactsLocationsModule/locations/38/zip
Triage: Uncategorized
Uncategorized Operation 103
Before
M20 4BX
After
BA1 3NG
replace /protocolSection/contactsLocationsModule/locations/38/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 104
Before
53.48095
After
51.3751
replace /protocolSection/contactsLocationsModule/locations/38/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 105
Before
-2.23743
After
-2.36172
add /protocolSection/contactsLocationsModule/locations/38/status
Triage: Uncategorized
Uncategorized Operation 106
After
RECRUITING
replace /protocolSection/contactsLocationsModule/locations/39/facility
Triage: Uncategorized
Uncategorized Operation 107
Before
Nottingham University Hospitals NHS Trust - City Hospital
After
Royal Sussex County Hospital
replace /protocolSection/contactsLocationsModule/locations/39/city
Triage: Uncategorized
Uncategorized Operation 108
Before
Nottingham
After
Brighton
replace /protocolSection/contactsLocationsModule/locations/39/zip
Triage: Uncategorized
Uncategorized Operation 109
Before
NG5 1PB
After
BN2 5BE
replace /protocolSection/contactsLocationsModule/locations/39/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 110
Before
52.9536
After
50.82838
replace /protocolSection/contactsLocationsModule/locations/39/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 111
Before
-1.15047
After
-0.13947
add /protocolSection/contactsLocationsModule/locations/39/status
Triage: Uncategorized
Uncategorized Operation 112
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/40
Triage: Uncategorized
Uncategorized Operation 113
After
{
  "zip": "EC1A 7BE",
  "city": "London",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "facility": "Barts Health NHS Trust - St Bartholomew's Hospital",
  "geoPoint": {
    "lat": 51.50853,
    "lon": -0.12574
  }
}
add /protocolSection/contactsLocationsModule/locations/41
Triage: Uncategorized
Uncategorized Operation 114
After
{
  "zip": "M20 4BX",
  "city": "Manchester",
  "status": "ACTIVE_NOT_RECRUITING",
  "country": "United Kingdom",
  "facility": "The Christie NHS Foundation Trust",
  "geoPoint": {
    "lat": 53.48095,
    "lon": -2.23743
  }
}
add /protocolSection/contactsLocationsModule/locations/42
Triage: Uncategorized
Uncategorized Operation 115
After
{
  "zip": "NG5 1PB",
  "city": "Nottingham",
  "status": "RECRUITING",
  "country": "United Kingdom",
  "facility": "Nottingham University Hospitals NHS Trust - City Hospital",
  "geoPoint": {
    "lat": 52.9536,
    "lon": -1.15047
  }
}
add /protocolSection/contactsLocationsModule/centralContacts
Triage: Low
Administrative Contact Change Operation 116
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
After
[
  {
    "name": "Reference Study ID Number: WO40181 www.roche.com/about_roche/roche_worldwide.htm",
    "role": "CONTACT",
    "email": "global-roche-genentech-trials@gene.com",
    "phone": "888-662-6728 (U.S. and Canada)"
  }
]
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-04
After
2020-07
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 5
Before
2020-04-20
After
2020-07-03
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 6
Before
2020-04-21
After
2020-07-07
Status and stopping reason Recruitment status, termination, suspension, withdrawal, or why-stopped text. Triage: Uncategorized 1 ops
replace /protocolSection/statusModule/overallStatus
Triage: Uncategorized
Uncategorized Operation 2
Before
ACTIVE_NOT_RECRUITING
After
RECRUITING
Raw JSON Patch
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/overallStatus",
    "value": "RECRUITING"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2020-08-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2022-02-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-07-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-07-07"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/1/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3/status",
    "value": "COMPLETED"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/4/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7/status",
    "value": "ACTIVE_NOT_RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/8/status",
    "value": "RECRUITING"
  },
  {
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    "op": "add",
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    "op": "add",
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    "op": "add",
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    "op": "add",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/city",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/zip",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/country",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/geoPoint/lat",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/28/geoPoint/lon",
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    "op": "add",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/facility",
    "value": "Hôpital Saint-Louis"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/city",
    "value": "Paris"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/zip",
    "value": "75475"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/country",
    "value": "France"
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/geoPoint/lat",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/29/geoPoint/lon",
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  {
    "op": "add",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/facility",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/city",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/zip",
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  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/country",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/geoPoint/lat",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/30/geoPoint/lon",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/31/facility",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/31/city",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/31/zip",
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    "op": "replace",
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    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/facility",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/city",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/zip",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/32/geoPoint/lat",
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  {
    "op": "replace",
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    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/33/city",
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  {
    "op": "replace",
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    "path": "/protocolSection/contactsLocationsModule/locations/34/city",
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  {
    "op": "replace",
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    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/35/city",
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  {
    "op": "replace",
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    "op": "replace",
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    "op": "replace",
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    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "replace",
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  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/36/country",
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    "path": "/protocolSection/contactsLocationsModule/locations/36/geoPoint/lat",
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    "op": "replace",
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    "op": "replace",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/37/city",
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  {
    "op": "replace",
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  {
    "op": "replace",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/38/city",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/38/zip",
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    "op": "replace",
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    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/39/zip",
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  },
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  },
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    "op": "add",
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]