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NCT03584009

A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy

Version 18 to 19 · Hoffmann-La Roche

Patch inspector

Version 18 to 19

22 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2020-08-05",
    "new_type": "ACTUAL",
    "old_date": "2020-08-05",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 0,
    "date_struct": "primaryCompletionDateStruct"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:59:51+00
Raw hash
644689341af36631941a40c8bacb77dbdda70aebb708a0ade3ee8b40075dc380
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/type
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 18 ops
replace /protocolSection/contactsLocationsModule/locations/1/city
Triage: Uncategorized
Uncategorized Operation 5
Before
Fayetteville
After
Springdale
replace /protocolSection/contactsLocationsModule/locations/1/zip
Triage: Uncategorized
Uncategorized Operation 6
Before
72703
After
72762
replace /protocolSection/contactsLocationsModule/locations/1/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 7
Before
36.06258
After
36.18674
replace /protocolSection/contactsLocationsModule/locations/1/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 8
Before
-94.15743
After
-94.12881
replace /protocolSection/contactsLocationsModule/locations/5/facility
Triage: Uncategorized
Uncategorized Operation 9
Before
Sylvester Comprehensive Cancer Center - Deerfield Beach; Sylvester Cancer Center
After
Sylvester Comprehensive Cent.
replace /protocolSection/contactsLocationsModule/locations/5/city
Triage: Uncategorized
Uncategorized Operation 10
Before
Deerfield Beach
After
Miami
replace /protocolSection/contactsLocationsModule/locations/5/zip
Triage: Uncategorized
Uncategorized Operation 11
Before
33442
After
33136
replace /protocolSection/contactsLocationsModule/locations/5/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 12
Before
26.31841
After
25.77427
replace /protocolSection/contactsLocationsModule/locations/5/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 13
Before
-80.09977
After
-80.19366
replace /protocolSection/contactsLocationsModule/locations/11/city
Triage: Uncategorized
Uncategorized Operation 14
Before
Danvers
After
Peabody
replace /protocolSection/contactsLocationsModule/locations/11/zip
Triage: Uncategorized
Uncategorized Operation 15
Before
01923
After
01960
replace /protocolSection/contactsLocationsModule/locations/11/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 16
Before
42.57509
After
42.52787
replace /protocolSection/contactsLocationsModule/locations/11/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 17
Before
-70.93005
After
-70.92866
replace /protocolSection/contactsLocationsModule/locations/23/city
Triage: Uncategorized
Uncategorized Operation 18
Before
Melbourne
After
East Melbourne
replace /protocolSection/contactsLocationsModule/locations/23/zip
Triage: Uncategorized
Uncategorized Operation 19
Before
3000
After
3002
replace /protocolSection/contactsLocationsModule/locations/23/geoPoint/lat
Triage: Uncategorized
Uncategorized Operation 20
Before
-37.814
After
-37.81667
replace /protocolSection/contactsLocationsModule/locations/23/geoPoint/lon
Triage: Uncategorized
Uncategorized Operation 21
Before
144.96332
After
144.9879
replace /protocolSection/contactsLocationsModule/locations/27/facility
Triage: Uncategorized
Uncategorized Operation 22
Before
CHUS - Hôpital Fleurimont
After
Centre Hospitalier Universitaire de Sherbrooke - Hopital Fleurimont
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2020-08
After
2020-10
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2020-08-03
After
2020-10-22
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-08-04
After
2020-10-23
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-10-22"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-10-23"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/city",
    "value": "Springdale"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/zip",
    "value": "72762"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/geoPoint/lat",
    "value": 36.18674
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/geoPoint/lon",
    "value": -94.12881
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/facility",
    "value": "Sylvester Comprehensive Cent."
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/city",
    "value": "Miami"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/zip",
    "value": "33136"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/geoPoint/lat",
    "value": 25.77427
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/geoPoint/lon",
    "value": -80.19366
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/city",
    "value": "Peabody"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/zip",
    "value": "01960"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/geoPoint/lat",
    "value": 42.52787
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/11/geoPoint/lon",
    "value": -70.92866
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/city",
    "value": "East Melbourne"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/zip",
    "value": "3002"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lat",
    "value": -37.81667
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/23/geoPoint/lon",
    "value": 144.9879
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/27/facility",
    "value": "Centre Hospitalier Universitaire de Sherbrooke - Hopital Fleurimont"
  }
]