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NCT03734029

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Version 15 to 16 · Daiichi Sankyo

Patch inspector

Version 15 to 16

24 operations 2 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_change
Value signals

None recorded.

Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:46+00
Raw hash
0c6b846b0a787a29a4476de6c2dc574a1b593528067abc7d886f6e1a9e4ac4ee
Payload
Source URL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 21 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/name
Triage: Low
Administrative Contact Change Operation 4
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
(for Asia Sites Only) Daiichi Sankyo Contact for Clinical Trial Information
After
(Asia Sites Only) Daiichi Sankyo Contact for Clinical Trial Information
add /protocolSection/contactsLocationsModule/centralContacts/1
Triage: Low
Administrative Contact Change Operation 5
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
After
{
  "name": "(US sites) Contact for Clinical Trial Information",
  "role": "CONTACT",
  "email": "CTRinfo@dsi.com",
  "phone": "908-992-6400"
}
add /protocolSection/contactsLocationsModule/locations/11
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "33139",
  "city": "Tampa",
  "state": "Florida",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Moffitt Cancer Center -Tampa",
  "geoPoint": {
    "lat": 27.94752,
    "lon": -82.45843
  }
}
add /protocolSection/contactsLocationsModule/locations/18
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "48202",
  "city": "Detroit",
  "state": "Michigan",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Henry Ford Hospital",
  "geoPoint": {
    "lat": 42.33143,
    "lon": -83.04575
  }
}
add /protocolSection/contactsLocationsModule/locations/21
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "10065",
  "city": "New York",
  "state": "New York",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Weill Cornell Medicine Breast Center",
  "geoPoint": {
    "lat": 40.71427,
    "lon": -74.00597
  }
}
add /protocolSection/contactsLocationsModule/locations/28
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "38120",
  "city": "Memphis",
  "state": "Tennessee",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Baptist Cancer Center",
  "geoPoint": {
    "lat": 35.14953,
    "lon": -90.04898
  }
}
add /protocolSection/contactsLocationsModule/locations/44
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "350025",
  "city": "Fuzhou",
  "state": "Fujian",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA",
  "geoPoint": {
    "lat": 26.06139,
    "lon": 119.30611
  }
}
add /protocolSection/contactsLocationsModule/locations/45
Triage: Uncategorized
Uncategorized Operation 11
After
{
  "zip": "510120",
  "city": "Guangzhou",
  "state": "Guangdong",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Sun Yat-sen Memorial hospital, Sun Yat-sen University",
  "geoPoint": {
    "lat": 23.11667,
    "lon": 113.25
  }
}
add /protocolSection/contactsLocationsModule/locations/47
Triage: Uncategorized
Uncategorized Operation 12
After
{
  "zip": "430079",
  "city": "Wuhan",
  "state": "Hubei",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Hubei Cancer Hospital",
  "geoPoint": {
    "lat": 30.58333,
    "lon": 114.26667
  }
}
add /protocolSection/contactsLocationsModule/locations/48
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "110042",
  "city": "Shenyang",
  "state": "Liaoning",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Liaoning Cancer Hospital & Institute",
  "geoPoint": {
    "lat": 41.79222,
    "lon": 123.43278
  }
}
add /protocolSection/contactsLocationsModule/locations/49
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "276001",
  "city": "Linyi",
  "state": "Shandong",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Linyi Cancer Hospital",
  "geoPoint": {
    "lat": 35.06306,
    "lon": 118.34278
  }
}
add /protocolSection/contactsLocationsModule/locations/50
Triage: Uncategorized
Uncategorized Operation 15
After
{
  "zip": "200080",
  "city": "Shanghai",
  "state": "Shanghai Municipality",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Shanghai General Hospital",
  "geoPoint": {
    "lat": 31.22222,
    "lon": 121.45806
  }
}
add /protocolSection/contactsLocationsModule/locations/51
Triage: Uncategorized
Uncategorized Operation 16
After
{
  "zip": "610041",
  "city": "Chengdu",
  "state": "Sichuan",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "West China Hospital, Sichuan University",
  "geoPoint": {
    "lat": 30.66667,
    "lon": 104.06667
  }
}
add /protocolSection/contactsLocationsModule/locations/53
Triage: Uncategorized
Uncategorized Operation 17
After
{
  "zip": "310022",
  "city": "Hangzhou",
  "state": "Zhejiang",
  "status": "RECRUITING",
  "country": "China",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Zhejiang Cancer Hospital",
  "geoPoint": {
    "lat": 30.29365,
    "lon": 120.16142
  }
}
add /protocolSection/contactsLocationsModule/locations/54
Triage: Uncategorized
Uncategorized Operation 18
After
{
  "zip": "13009",
  "city": "Marseille",
  "state": "Bouches-du-Rhône",
  "status": "RECRUITING",
  "country": "France",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Institut Paoli Calmettes",
  "geoPoint": {
    "lat": 43.29695,
    "lon": 5.38107
  }
}
add /protocolSection/contactsLocationsModule/locations/58
Triage: Uncategorized
Uncategorized Operation 19
After
{
  "zip": "33076",
  "city": "Bordeaux",
  "state": "Gironde",
  "status": "RECRUITING",
  "country": "France",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Institut Bergonié",
  "geoPoint": {
    "lat": 44.84124,
    "lon": -0.58046
  }
}
add /protocolSection/contactsLocationsModule/locations/97
Triage: Uncategorized
Uncategorized Operation 20
After
{
  "zip": "00133",
  "city": "Roma",
  "status": "RECRUITING",
  "country": "Italy",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Azienda Ospedaliera Universitaria Policlinico Tor Vergata",
  "geoPoint": {
    "lat": 44.99364,
    "lon": 11.10642
  }
}
add /protocolSection/contactsLocationsModule/locations/111
Triage: Uncategorized
Uncategorized Operation 21
After
{
  "zip": "362-0806",
  "city": "Kitaadachi-gun",
  "state": "Saitama",
  "status": "RECRUITING",
  "country": "Japan",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Saitama Cancer Center"
}
add /protocolSection/contactsLocationsModule/locations/125
Triage: Uncategorized
Uncategorized Operation 22
After
{
  "zip": "41404",
  "city": "Daegu",
  "status": "RECRUITING",
  "country": "South Korea",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Kyungpook National University Chilgok Hospital",
  "geoPoint": {
    "lat": 35.87028,
    "lon": 128.59111
  }
}
add /protocolSection/contactsLocationsModule/locations/147
Triage: Uncategorized
Uncategorized Operation 23
After
{
  "zip": "7000",
  "city": "Chur",
  "status": "RECRUITING",
  "country": "Switzerland",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Kantonsspital Graubuenden",
  "geoPoint": {
    "lat": 46.84986,
    "lon": 9.53287
  }
}
add /protocolSection/contactsLocationsModule/locations/148
Triage: Uncategorized
Uncategorized Operation 24
After
{
  "zip": "1011",
  "city": "Lausanne",
  "status": "RECRUITING",
  "country": "Switzerland",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT"
    }
  ],
  "facility": "Centre Hospitalier Universitaire Vaudois",
  "geoPoint": {
    "lat": 46.516,
    "lon": 6.63282
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2019-12
After
2020-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2019-12-02
After
2020-02-03
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 3
Before
2019-12-03
After
2020-02-05
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-02-03"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-02-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/name",
    "value": "(Asia Sites Only) Daiichi Sankyo Contact for Clinical Trial Information"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/1",
    "value": {
      "name": "(US sites) Contact for Clinical Trial Information",
      "role": "CONTACT",
      "email": "CTRinfo@dsi.com",
      "phone": "908-992-6400"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/11",
    "value": {
      "zip": "33139",
      "city": "Tampa",
      "state": "Florida",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Moffitt Cancer Center -Tampa",
      "geoPoint": {
        "lat": 27.94752,
        "lon": -82.45843
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/18",
    "value": {
      "zip": "48202",
      "city": "Detroit",
      "state": "Michigan",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Henry Ford Hospital",
      "geoPoint": {
        "lat": 42.33143,
        "lon": -83.04575
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/21",
    "value": {
      "zip": "10065",
      "city": "New York",
      "state": "New York",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Weill Cornell Medicine Breast Center",
      "geoPoint": {
        "lat": 40.71427,
        "lon": -74.00597
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/28",
    "value": {
      "zip": "38120",
      "city": "Memphis",
      "state": "Tennessee",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Baptist Cancer Center",
      "geoPoint": {
        "lat": 35.14953,
        "lon": -90.04898
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/44",
    "value": {
      "zip": "350025",
      "city": "Fuzhou",
      "state": "Fujian",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA",
      "geoPoint": {
        "lat": 26.06139,
        "lon": 119.30611
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/45",
    "value": {
      "zip": "510120",
      "city": "Guangzhou",
      "state": "Guangdong",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Sun Yat-sen Memorial hospital, Sun Yat-sen University",
      "geoPoint": {
        "lat": 23.11667,
        "lon": 113.25
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/47",
    "value": {
      "zip": "430079",
      "city": "Wuhan",
      "state": "Hubei",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Hubei Cancer Hospital",
      "geoPoint": {
        "lat": 30.58333,
        "lon": 114.26667
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/48",
    "value": {
      "zip": "110042",
      "city": "Shenyang",
      "state": "Liaoning",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Liaoning Cancer Hospital & Institute",
      "geoPoint": {
        "lat": 41.79222,
        "lon": 123.43278
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/49",
    "value": {
      "zip": "276001",
      "city": "Linyi",
      "state": "Shandong",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Linyi Cancer Hospital",
      "geoPoint": {
        "lat": 35.06306,
        "lon": 118.34278
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/50",
    "value": {
      "zip": "200080",
      "city": "Shanghai",
      "state": "Shanghai Municipality",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Shanghai General Hospital",
      "geoPoint": {
        "lat": 31.22222,
        "lon": 121.45806
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/51",
    "value": {
      "zip": "610041",
      "city": "Chengdu",
      "state": "Sichuan",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "West China Hospital, Sichuan University",
      "geoPoint": {
        "lat": 30.66667,
        "lon": 104.06667
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/53",
    "value": {
      "zip": "310022",
      "city": "Hangzhou",
      "state": "Zhejiang",
      "status": "RECRUITING",
      "country": "China",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Zhejiang Cancer Hospital",
      "geoPoint": {
        "lat": 30.29365,
        "lon": 120.16142
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/54",
    "value": {
      "zip": "13009",
      "city": "Marseille",
      "state": "Bouches-du-Rhône",
      "status": "RECRUITING",
      "country": "France",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Institut Paoli Calmettes",
      "geoPoint": {
        "lat": 43.29695,
        "lon": 5.38107
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/58",
    "value": {
      "zip": "33076",
      "city": "Bordeaux",
      "state": "Gironde",
      "status": "RECRUITING",
      "country": "France",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Institut Bergonié",
      "geoPoint": {
        "lat": 44.84124,
        "lon": -0.58046
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/97",
    "value": {
      "zip": "00133",
      "city": "Roma",
      "status": "RECRUITING",
      "country": "Italy",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Azienda Ospedaliera Universitaria Policlinico Tor Vergata",
      "geoPoint": {
        "lat": 44.99364,
        "lon": 11.10642
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/111",
    "value": {
      "zip": "362-0806",
      "city": "Kitaadachi-gun",
      "state": "Saitama",
      "status": "RECRUITING",
      "country": "Japan",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Saitama Cancer Center"
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/125",
    "value": {
      "zip": "41404",
      "city": "Daegu",
      "status": "RECRUITING",
      "country": "South Korea",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Kyungpook National University Chilgok Hospital",
      "geoPoint": {
        "lat": 35.87028,
        "lon": 128.59111
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/147",
    "value": {
      "zip": "7000",
      "city": "Chur",
      "status": "RECRUITING",
      "country": "Switzerland",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Kantonsspital Graubuenden",
      "geoPoint": {
        "lat": 46.84986,
        "lon": 9.53287
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/148",
    "value": {
      "zip": "1011",
      "city": "Lausanne",
      "status": "RECRUITING",
      "country": "Switzerland",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT"
        }
      ],
      "facility": "Centre Hospitalier Universitaire Vaudois",
      "geoPoint": {
        "lat": 46.516,
        "lon": 6.63282
      }
    }
  }
]