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NCT03734029

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Version 2 to 3 · Daiichi Sankyo

Patch inspector

Version 2 to 3

6 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ACTUAL",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "later",
    "new_value": "2018-12-27",
    "old_value": "2018-12",
    "delta_days": 26,
    "date_struct": "startDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "signal": "milestone_realized",
    "category": "milestone_realized",
    "new_date": "2018-12-27",
    "new_type": "ACTUAL",
    "old_date": "2018-12",
    "old_type": "ESTIMATED",
    "severity": "low",
    "delta_days": 26,
    "date_struct": "startDateStruct"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:42+00
Raw hash
f72cbc3d7e559bd7fa0416dbc693c45d6228289bf1f58214cd2a412679fa5764
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/startDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
2018-12
After
2018-12-27
replace /protocolSection/statusModule/startDateStruct/type
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • start_timeline_change Start date changes are operational timeline signals.
Before
ESTIMATED
After
ACTUAL
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 1 ops
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "892-0833",
  "city": "Kagoshima",
  "state": "Kagoshima-ken",
  "status": "RECRUITING",
  "country": "Japan",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Hakuaikai Sagara Hospital",
  "geoPoint": {
    "lat": 31.56667,
    "lon": 130.55
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2018-12
After
2019-01
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2018-12-19
After
2019-01-07
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2018-12-21
After
2019-01-09
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2019-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/date",
    "value": "2018-12-27"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/startDateStruct/type",
    "value": "ACTUAL"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2019-01-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2019-01-09"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "892-0833",
      "city": "Kagoshima",
      "state": "Kagoshima-ken",
      "status": "RECRUITING",
      "country": "Japan",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Hakuaikai Sagara Hospital",
      "geoPoint": {
        "lat": 31.56667,
        "lon": 130.55
      }
    }
  }
]