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NCT03734029

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Version 31 to 32 · Daiichi Sankyo

Patch inspector

Version 31 to 32

7 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2026-08-01",
    "old_value": "2025-10-01",
    "delta_days": 304,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "day"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:51+00
Raw hash
2f751a0aab2213055a2dcb93ad838d6bd62c020d1bf7596063878092fa8478be
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2025-10-01
After
2026-08-01
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 3 ops
replace /protocolSection/contactsLocationsModule/locations/1/zip
Triage: Uncategorized
Uncategorized Operation 5
Before
85234-2165
After
85234
replace /protocolSection/contactsLocationsModule/locations/3/zip
Triage: Uncategorized
Uncategorized Operation 6
Before
90095-1690
After
90095
replace /protocolSection/contactsLocationsModule/locations/24/zip
Triage: Uncategorized
Uncategorized Operation 7
Before
10065-6007
After
10065
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2024-04
After
2025-09
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2024-04-09
After
2025-09-16
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2024-04-11
After
2025-10-06
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2025-09"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2026-08-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2025-09-16"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2025-10-06"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/1/zip",
    "value": "85234"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/3/zip",
    "value": "90095"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/24/zip",
    "value": "10065"
  }
]