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NCT03734029

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]

Version 4 to 5 · Daiichi Sankyo

Patch inspector

Version 4 to 5

10 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "same",
    "new_value": "2022-01-01",
    "old_value": "2022-01",
    "delta_days": 0,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  },
  {
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "signal": "timeline_minor_adjustment",
    "category": "timeline_minor_adjustment",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "low",
    "direction": "same",
    "new_value": "2022-01-01",
    "old_value": "2022-01",
    "delta_days": 0,
    "date_struct": "completionDateStruct",
    "new_precision": "day",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 19:12:43+00
Raw hash
b653bdc264afe207f0bdb741ee2e71823afb2dfa12fc3f5f011914d17930554d
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 2 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2022-01
After
2022-01-01
replace /protocolSection/statusModule/completionDateStruct/date
Triage: Medium
Timeline Shift Operation 3
Matched rules
  • completion_timeline_change Completion date changes are operational timeline signals.
Before
2022-01
After
2022-01-01
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 5 ops
add /protocolSection/contactsLocationsModule/locations/0
Triage: Uncategorized
Uncategorized Operation 6
After
{
  "zip": "70115",
  "city": "New Orleans",
  "state": "Louisiana",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT",
      "email": "scott.sonnier@touro.com",
      "phone": "504-894-7115"
    }
  ],
  "facility": "Touro Infirmary",
  "geoPoint": {
    "lat": 29.95465,
    "lon": -90.07507
  }
}
add /protocolSection/contactsLocationsModule/locations/2
Triage: Uncategorized
Uncategorized Operation 7
After
{
  "zip": "80637",
  "city": "Munich",
  "state": "Bavaria",
  "status": "RECRUITING",
  "country": "Germany",
  "contacts": [
    {
      "name": "Principal Investigator",
      "role": "CONTACT",
      "email": "claus.hanusch@swmbrk.de",
      "phone": "+49 8915706621"
    }
  ],
  "facility": "Rotkreuzklinikum Muenchen gGmbH",
  "geoPoint": {
    "lat": 48.13743,
    "lon": 11.57549
  }
}
add /protocolSection/contactsLocationsModule/locations/3
Triage: Uncategorized
Uncategorized Operation 8
After
{
  "zip": "464-8681",
  "city": "Nagoya",
  "state": "Aichi-ken",
  "status": "RECRUITING",
  "country": "Japan",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Aichi Cancer Center Hospital",
  "geoPoint": {
    "lat": 35.18147,
    "lon": 136.90641
  }
}
add /protocolSection/contactsLocationsModule/locations/6
Triage: Uncategorized
Uncategorized Operation 9
After
{
  "zip": "241-8515",
  "city": "Yokohama",
  "state": "Kanagawa",
  "status": "RECRUITING",
  "country": "Japan",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Kanagawa Cancer Center",
  "geoPoint": {
    "lat": 35.43333,
    "lon": 139.65
  }
}
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 10
After
{
  "zip": "135-8550",
  "city": "Kōtoku",
  "state": "Tokyo-To",
  "status": "RECRUITING",
  "country": "Japan",
  "contacts": [
    {
      "name": "See Central Contact",
      "role": "CONTACT"
    }
  ],
  "facility": "Cancer Institute Hospital of JFCR",
  "geoPoint": {
    "lat": 42.50417,
    "lon": 143.14297
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2019-01
After
2019-02
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 4
Before
2019-02-08
After
2019-02-15
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 5
Before
2019-02-12
After
2019-02-18
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2019-02"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2022-01-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/completionDateStruct/date",
    "value": "2022-01-01"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2019-02-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2019-02-18"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/0",
    "value": {
      "zip": "70115",
      "city": "New Orleans",
      "state": "Louisiana",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT",
          "email": "scott.sonnier@touro.com",
          "phone": "504-894-7115"
        }
      ],
      "facility": "Touro Infirmary",
      "geoPoint": {
        "lat": 29.95465,
        "lon": -90.07507
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/2",
    "value": {
      "zip": "80637",
      "city": "Munich",
      "state": "Bavaria",
      "status": "RECRUITING",
      "country": "Germany",
      "contacts": [
        {
          "name": "Principal Investigator",
          "role": "CONTACT",
          "email": "claus.hanusch@swmbrk.de",
          "phone": "+49 8915706621"
        }
      ],
      "facility": "Rotkreuzklinikum Muenchen gGmbH",
      "geoPoint": {
        "lat": 48.13743,
        "lon": 11.57549
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/3",
    "value": {
      "zip": "464-8681",
      "city": "Nagoya",
      "state": "Aichi-ken",
      "status": "RECRUITING",
      "country": "Japan",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Aichi Cancer Center Hospital",
      "geoPoint": {
        "lat": 35.18147,
        "lon": 136.90641
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/6",
    "value": {
      "zip": "241-8515",
      "city": "Yokohama",
      "state": "Kanagawa",
      "status": "RECRUITING",
      "country": "Japan",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Kanagawa Cancer Center",
      "geoPoint": {
        "lat": 35.43333,
        "lon": 139.65
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "zip": "135-8550",
      "city": "Kōtoku",
      "state": "Tokyo-To",
      "status": "RECRUITING",
      "country": "Japan",
      "contacts": [
        {
          "name": "See Central Contact",
          "role": "CONTACT"
        }
      ],
      "facility": "Cancer Institute Hospital of JFCR",
      "geoPoint": {
        "lat": 42.50417,
        "lon": 143.14297
      }
    }
  }
]