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NCT03735680

A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer

Version 2 to 3 · OncoNano Medicine, Inc.

Patch inspector

Version 2 to 3

9 operations 4 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired
contact_admin_changeenrollment_count_change
Value signals
[
  {
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "signal": "enrollment_count_change_ge_20pct",
    "category": "enrollment_change",
    "severity": "high",
    "new_value": 60,
    "old_value": 45,
    "pct_change": 0.3333
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:36+00
Raw hash
ac4eaa01374c85a394b5d62943121a18ebd6757566ef8c40c0b148ee5d94a613
Payload
Source URL
Design Trial model, phase, allocation, masking, arms, or interventions. Triage: High 1 ops
replace /protocolSection/designModule/enrollmentInfo/count
Triage: High
Enrollment Change Operation 5
Matched rules
  • enrollment_count_change Enrollment count changes can signal scope or feasibility shifts.
Before
45
After
60
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Low 4 ops
replace /protocolSection/contactsLocationsModule/centralContacts/0/name
Triage: Low
Administrative Contact Change Operation 6
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
Yalia Jayalakshmi, PhD
After
Trials@OncoNanoMed.com
replace /protocolSection/contactsLocationsModule/centralContacts/0/phone
Triage: Low
Administrative Contact Change Operation 7
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
650-861-0608
After
+1(682)285-1411
replace /protocolSection/contactsLocationsModule/centralContacts/0/email
Triage: Low
Administrative Contact Change Operation 8
Matched rules
  • contact_admin_change Central contact updates are usually administrative.
Before
jaya@onconanomed.com
After
Trials@OncoNanoMed.com
replace /protocolSection/contactsLocationsModule/overallOfficials/0/name
Triage: Uncategorized
Uncategorized Operation 9
Before
Yalia Jayalakshmi, PhD
After
Trials@OncoNanoMed.com
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 3 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 2
Before
2020-02
After
2020-08
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2020-02-12
After
2020-08-05
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2020-02-13
After
2020-08-07
Sponsor and administrative fields Sponsor, collaborator, oversight, or registry maintenance changes. Triage: Uncategorized 1 ops
replace /protocolSection/identificationModule/officialTitle
Triage: Uncategorized
Uncategorized Operation 1
Before
A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance, Safety, and Timing of Postdose Imaging of ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Solid Tumors Undergoing Routine Surgery
After
A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance, Safety & Timing of Postdose Imaging of ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Solid Tumors Undergoing Routine Surgery
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/identificationModule/officialTitle",
    "value": "A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance, Safety & Timing of Postdose Imaging of ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Solid Tumors Undergoing Routine Surgery"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2020-08"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2020-08-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2020-08-07"
  },
  {
    "op": "replace",
    "path": "/protocolSection/designModule/enrollmentInfo/count",
    "value": 60
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/name",
    "value": "Trials@OncoNanoMed.com"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/phone",
    "value": "+1(682)285-1411"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/centralContacts/0/email",
    "value": "Trials@OncoNanoMed.com"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/overallOfficials/0/name",
    "value": "Trials@OncoNanoMed.com"
  }
]