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NCT04478279

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Version 10 to 11 · Sapience Therapeutics

Patch inspector

Version 10 to 11

14 operations 3 path groups ctgov_internal_history
ClinicalTrials.gov
Severity is deterministic uncalibrated triage metadata, not validated review priority. Operation-level severity is inferred from deterministic path rules. Rule matches shown per operation are approximate previews (they skip the pipeline's suppression passes); the authoritative classification is the stored event record.
Plain-language summary

Manual review pending.

Rules fired

None recorded.

Value signals
[
  {
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "signal": "timeline_significant_shift",
    "category": "timeline_significant_shift",
    "new_type": "ESTIMATED",
    "old_type": "ESTIMATED",
    "severity": "medium",
    "direction": "later",
    "new_value": "2023-10",
    "old_value": "2022-10",
    "delta_days": 365,
    "date_struct": "primaryCompletionDateStruct",
    "new_precision": "month",
    "old_precision": "month"
  }
]
Provenance
Source
ctgov_internal_history
Fetched
2026-06-18 18:57:41+00
Raw hash
ccd0bd6d6558b8d0ec9c35149daf7ad7486afd2242c78f19a9b7c486822073a9
Payload
Source URL
Timeline Start, primary completion, and completion date movement. Triage: Medium 1 ops
replace /protocolSection/statusModule/primaryCompletionDateStruct/date
Triage: Medium
Timeline Shift Operation 2
Matched rules
  • primary_completion_timeline_change Primary completion date changes are operational timeline signals.
Before
2022-10
After
2023-10
Contacts and locations Site, contact, and location updates that are usually operational. Triage: Uncategorized 4 ops
replace /protocolSection/contactsLocationsModule/locations/4/contacts/1/name
Triage: Uncategorized
Uncategorized Operation 11
Before
Emerson Lim, MD
After
Fabio Iwamoto, MD
replace /protocolSection/contactsLocationsModule/locations/5/status
Triage: Uncategorized
Uncategorized Operation 12
Before
NOT_YET_RECRUITING
After
RECRUITING
add /protocolSection/contactsLocationsModule/locations/7
Triage: Uncategorized
Uncategorized Operation 13
After
{
  "zip": "75246",
  "city": "Dallas",
  "state": "Texas",
  "status": "RECRUITING",
  "country": "United States",
  "contacts": [
    {
      "name": "Julie Morehouse",
      "role": "CONTACT",
      "email": "Julie.morehouse@usoncology.com",
      "phone": "214-370-1238"
    },
    {
      "name": "Joyce O'Shaughnessy, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "Texas Oncology - Baylor Charles A. Sammons Cancer Center",
  "geoPoint": {
    "lat": 32.78306,
    "lon": -96.80667
  }
}
add /protocolSection/contactsLocationsModule/locations/10
Triage: Uncategorized
Uncategorized Operation 14
After
{
  "zip": "LS9 7TF",
  "city": "Leeds",
  "status": "NOT_YET_RECRUITING",
  "country": "United Kingdom",
  "contacts": [
    {
      "name": "Yudish Rughooputh",
      "role": "CONTACT",
      "email": "yudish.rughooputh@nhs.net"
    },
    {
      "name": "Alan Anthoney, MD",
      "role": "PRINCIPAL_INVESTIGATOR"
    }
  ],
  "facility": "University of Leeds",
  "geoPoint": {
    "lat": 53.79648,
    "lon": -1.54785
  }
}
Other registry fields Changes outside the current high-signal rule families. Triage: Uncategorized 9 ops
replace /protocolSection/statusModule/statusVerifiedDate
Triage: Uncategorized
Uncategorized Operation 1
Before
2022-01
After
2022-05
replace /protocolSection/statusModule/lastUpdateSubmitDate
Triage: Uncategorized
Uncategorized Operation 3
Before
2022-01-12
After
2022-05-15
replace /protocolSection/statusModule/lastUpdatePostDateStruct/date
Triage: Uncategorized
Uncategorized Operation 4
Before
2022-01-13
After
2022-05-20
replace /protocolSection/conditionsModule/conditions/0
Triage: Uncategorized
Uncategorized Operation 5
Before
Advanced Solid Tumor
After
Glioblastoma
add /protocolSection/conditionsModule/conditions/1
Triage: Uncategorized
Uncategorized Operation 6
After
Melanoma Stage IV
add /protocolSection/conditionsModule/conditions/2
Triage: Uncategorized
Uncategorized Operation 7
After
Melanoma Recurrent
add /protocolSection/conditionsModule/conditions/3
Triage: Uncategorized
Uncategorized Operation 8
After
Breast Cancer
add /protocolSection/conditionsModule/conditions/4
Triage: Uncategorized
Uncategorized Operation 9
After
Prostate Cancer
add /protocolSection/conditionsModule/conditions/5
Triage: Uncategorized
Uncategorized Operation 10
After
Glioblastoma Multiforme
Raw JSON Patch 
[
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/statusVerifiedDate",
    "value": "2022-05"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/primaryCompletionDateStruct/date",
    "value": "2023-10"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdateSubmitDate",
    "value": "2022-05-15"
  },
  {
    "op": "replace",
    "path": "/protocolSection/statusModule/lastUpdatePostDateStruct/date",
    "value": "2022-05-20"
  },
  {
    "op": "replace",
    "path": "/protocolSection/conditionsModule/conditions/0",
    "value": "Glioblastoma"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/conditions/1",
    "value": "Melanoma Stage IV"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/conditions/2",
    "value": "Melanoma Recurrent"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/conditions/3",
    "value": "Breast Cancer"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/conditions/4",
    "value": "Prostate Cancer"
  },
  {
    "op": "add",
    "path": "/protocolSection/conditionsModule/conditions/5",
    "value": "Glioblastoma Multiforme"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/4/contacts/1/name",
    "value": "Fabio Iwamoto, MD"
  },
  {
    "op": "replace",
    "path": "/protocolSection/contactsLocationsModule/locations/5/status",
    "value": "RECRUITING"
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/7",
    "value": {
      "zip": "75246",
      "city": "Dallas",
      "state": "Texas",
      "status": "RECRUITING",
      "country": "United States",
      "contacts": [
        {
          "name": "Julie Morehouse",
          "role": "CONTACT",
          "email": "Julie.morehouse@usoncology.com",
          "phone": "214-370-1238"
        },
        {
          "name": "Joyce O'Shaughnessy, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "Texas Oncology - Baylor Charles A. Sammons Cancer Center",
      "geoPoint": {
        "lat": 32.78306,
        "lon": -96.80667
      }
    }
  },
  {
    "op": "add",
    "path": "/protocolSection/contactsLocationsModule/locations/10",
    "value": {
      "zip": "LS9 7TF",
      "city": "Leeds",
      "status": "NOT_YET_RECRUITING",
      "country": "United Kingdom",
      "contacts": [
        {
          "name": "Yudish Rughooputh",
          "role": "CONTACT",
          "email": "yudish.rughooputh@nhs.net"
        },
        {
          "name": "Alan Anthoney, MD",
          "role": "PRINCIPAL_INVESTIGATOR"
        }
      ],
      "facility": "University of Leeds",
      "geoPoint": {
        "lat": 53.79648,
        "lon": -1.54785
      }
    }
  }
]